{"id":"https://openalex.org/W2039941306","doi":"https://doi.org/10.1038/nsmb0704-580","title":"'Screw-cap' clamp loader proteins that thread","display_name":"'Screw-cap' clamp loader proteins that thread","publication_year":2004,"publication_date":"2004-06-25","ids":{"openalex":"https://openalex.org/W2039941306","doi":"https://doi.org/10.1038/nsmb0704-580","mag":"2039941306","pmid":"https://pubmed.ncbi.nlm.nih.gov/15221017"},"language":"en","primary_location":{"id":"doi:10.1038/nsmb0704-580","doi":"https://doi.org/10.1038/nsmb0704-580","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nsmb0704-580","pdf_url":null,"source":{"id":"https://openalex.org/S139253143","display_name":"Nature Structural & Molecular Biology","issn_l":"1545-9985","issn":["1545-9985","1545-9993"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Structural & Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090254750","display_name":"Zhihao Zhuang","orcid":"https://orcid.org/0000-0001-5047-9222","observed_orcids":["https://orcid.org/0000-0001-5047-9222"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhihao Zhuang","raw_affiliation_strings":["Department of Chemistry, 415 Wartik Laboratory, The Pennsylvania State University, University Park, 16802, Pennsylvania, USA","Department of Chemistry, 415 Wartik Laboratory, The Pennsylvania State University, University Park, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, 415 Wartik Laboratory, The Pennsylvania State University, University Park, 16802, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Chemistry, 415 Wartik Laboratory, The Pennsylvania State University, University Park, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079105544","display_name":"Michelle M. Spiering","orcid":"https://orcid.org/0000-0002-6222-980X","observed_orcids":["https://orcid.org/0000-0002-6222-980X"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle M Spiering","raw_affiliation_strings":["Department of Chemistry, 415 Wartik Laboratory, The Pennsylvania State University, University Park, 16802, Pennsylvania, USA","Department of Chemistry, 415 Wartik Laboratory, The Pennsylvania State University, University Park, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, 415 Wartik Laboratory, The Pennsylvania State University, University Park, 16802, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Chemistry, 415 Wartik Laboratory, The Pennsylvania State University, University Park, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058712621","display_name":"Anthony J. Berdis","orcid":"https://orcid.org/0000-0003-0318-0951","observed_orcids":["https://orcid.org/0000-0003-0318-0951"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony J Berdis","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, 44106, Ohio, USA","Department of Pharmacology; School of Medicine; Case Western Reserve University; Cleveland USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, 44106, Ohio, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Pharmacology; School of Medicine; Case Western Reserve University; Cleveland USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088662521","display_name":"Michael A. Trakselis","orcid":"https://orcid.org/0000-0001-7054-8475","observed_orcids":["https://orcid.org/0000-0001-7054-8475"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210089716","display_name":"MRC Cancer Unit","ror":"https://ror.org/015nth639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210106569","display_name":"Hutchison/MRC Research Centre","ror":"https://ror.org/01ajt3179","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210106569","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael A Trakselis","raw_affiliation_strings":["MRC Cancer Cell Unit, Hutchinson/MRC Research Centre, Hills Road, Cambridge, CB2 2XZ, UK","University of Cambridge,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Cancer Cell Unit, Hutchinson/MRC Research Centre, Hills Road, Cambridge, CB2 2XZ, UK","institution_ids":["https://openalex.org/I4210089716","https://openalex.org/I4210106569"]},{"raw_affiliation_string":"University of Cambridge,","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057047461","display_name":"Stephen J. Benkovic","orcid":"https://orcid.org/0000-0003-3680-3481","observed_orcids":["https://orcid.org/0000-0003-3680-3481"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J Benkovic","raw_affiliation_strings":["Department of Chemistry, 415 Wartik Laboratory, The Pennsylvania State University, University Park, 16802, Pennsylvania, USA","Department of Chemistry, 415 Wartik Laboratory, The Pennsylvania State University, University Park, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, 415 Wartik Laboratory, The Pennsylvania State University, University Park, 16802, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Chemistry, 415 Wartik Laboratory, The Pennsylvania State University, University Park, USA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":0.3551,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.54895873,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"7","first_page":"580","last_page":"581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.05739999935030937,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.04050000011920929,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clamp-loader","display_name":"clamp loader","score":0.9419999718666077},{"id":"https://openalex.org/keywords/dna-clamp","display_name":"DNA clamp","score":0.5920000076293945},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.6499999761581421},{"id":"https://openalex.org/keywords/replisome","display_name":"replisome","score":0.8730000257492065},{"id":"https://openalex.org/keywords/dna-polymerase","display_name":"DNA polymerase","score":0.7559999823570251},{"id":"https://openalex.org/keywords/helicase","display_name":"helicase","score":0.6159999966621399},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.5139999985694885},{"id":"https://openalex.org/keywords/dna-helix","display_name":"DNA helix","score":0.43799999356269836},{"id":"https://openalex.org/keywords/protein-scaffolds","display_name":"protein scaffolds","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C2776161997","wikidata":"https://www.wikidata.org/wiki/Q846600","display_name":"Clamp","level":3,"score":0.9114924669265747},{"id":"https://openalex.org/C2779041774","wikidata":"https://www.wikidata.org/wiki/Q650550","display_name":"Loader","level":2,"score":0.8077613115310669},{"id":"https://openalex.org/C31254050","wikidata":"https://www.wikidata.org/wiki/Q22328799","display_name":"DNA clamp","level":5,"score":0.6815986633300781},{"id":"https://openalex.org/C138101251","wikidata":"https://www.wikidata.org/wiki/Q213092","display_name":"Thread (computing)","level":2,"score":0.6346793174743652},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.6274943351745605},{"id":"https://openalex.org/C149187182","wikidata":"https://www.wikidata.org/wiki/Q22325217","display_name":"Replisome","level":5,"score":0.5742928981781006},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.5077251195907593},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4425343871116638},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.4149106740951538},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4088277518749237},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38880565762519836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36773625016212463},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.33493924140930176},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2579163610935211},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1908911168575287},{"id":"https://openalex.org/C58167604","wikidata":"https://www.wikidata.org/wiki/Q5121654","display_name":"Circular bacterial chromosome","level":4,"score":0.11702042818069458},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.1106012761592865},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0958123505115509},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.08652269840240479},{"id":"https://openalex.org/C84111939","wikidata":"https://www.wikidata.org/wiki/Q5125465","display_name":"Clamping","level":2,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/nsmb0704-580","doi":"https://doi.org/10.1038/nsmb0704-580","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nsmb0704-580","pdf_url":null,"source":{"id":"https://openalex.org/S139253143","display_name":"Nature Structural & Molecular Biology","issn_l":"1545-9985","issn":["1545-9985","1545-9993"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Structural & Molecular Biology","raw_type":"journal-article"},{"id":"pmid:15221017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15221017","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature structural & molecular biology","raw_type":"Comment"},{"id":"pmh:oai:engagedscholarship.csuohio.edu:scichem_facpub-1276","doi":null,"is_oa":false,"landing_page_url":"http://www.nature.com/nsmb/journal/v11/n7/full/nsmb0704-580.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400889","display_name":"EngagedScholarship @ Cleveland State University (Cleveland State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102607778","host_organization_name":"Cleveland State University","host_organization_lineage":["https://openalex.org/I102607778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemistry Faculty Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1875835053","https://openalex.org/W1944079546","https://openalex.org/W1965822554","https://openalex.org/W1993651081","https://openalex.org/W2001190338","https://openalex.org/W2016556669","https://openalex.org/W2031333036","https://openalex.org/W2031747438","https://openalex.org/W2033224916","https://openalex.org/W2052079265","https://openalex.org/W2061628677","https://openalex.org/W2065014822","https://openalex.org/W2066912176","https://openalex.org/W2074266134","https://openalex.org/W2093072087","https://openalex.org/W2104247890","https://openalex.org/W2122748184","https://openalex.org/W2144305828","https://openalex.org/W2147557127","https://openalex.org/W2166903547","https://openalex.org/W2167059685"],"related_works":["https://openalex.org/W1967708487","https://openalex.org/W2011074932","https://openalex.org/W2119344497","https://openalex.org/W2053743037","https://openalex.org/W1993190637","https://openalex.org/W2087521093","https://openalex.org/W2031747438","https://openalex.org/W6990157637","https://openalex.org/W1559394669","https://openalex.org/W2165160924"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}