{"id":"https://openalex.org/W2039924752","doi":"https://doi.org/10.1136/ard.45.9.732","title":"Cyclosporin A (CyA) in primary Sj\u00f6gren's syndrome: a double blind study.","display_name":"Cyclosporin A (CyA) in primary Sj\u00f6gren's syndrome: a double blind study.","publication_year":1986,"publication_date":"1986-09-01","ids":{"openalex":"https://openalex.org/W2039924752","doi":"https://doi.org/10.1136/ard.45.9.732","mag":"2039924752","pmid":"https://pubmed.ncbi.nlm.nih.gov/3532967","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1001978"},"language":"en","primary_location":{"id":"doi:10.1136/ard.45.9.732","doi":"https://doi.org/10.1136/ard.45.9.732","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ard.45.9.732","pdf_url":"https://ard.bmj.com/content/annrheumdis/45/9/732.full.pdf","source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ard.bmj.com/content/annrheumdis/45/9/732.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112409100","display_name":"Alexandros A. Drosos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A.A Drosos","raw_affiliation_strings":["Department of Medicine, Medical School, University of loannina, 453 32 Ioannina-Greece","From the Departments of'Medicine and 2Pathology, Medical School, University ofloannina, loannina-Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical School, University of loannina, 453 32 Ioannina-Greece","institution_ids":["https://openalex.org/I194019607"]},{"raw_affiliation_string":"From the Departments of'Medicine and 2Pathology, Medical School, University ofloannina, loannina-Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024273038","display_name":"Fotini N. Skopouli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"F.N Skopouli","raw_affiliation_strings":["Department of Medicine, Medical School, University of loannina, 453 32 Ioannina-Greece","From the Departments of'Medicine and 2Pathology, Medical School, University ofloannina, loannina-Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical School, University of loannina, 453 32 Ioannina-Greece","institution_ids":["https://openalex.org/I194019607"]},{"raw_affiliation_string":"From the Departments of'Medicine and 2Pathology, Medical School, University ofloannina, loannina-Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024170299","display_name":"John S. Costopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"J.S Costopoulos","raw_affiliation_strings":["Departments of'Medicine and 2Pathology , Medical School , University ofloannina , loannina-Greece","Department of Medicine, Medical School, University of loannina, 453 32 Ioannina-Greece","From the Departments of'Medicine and 2Pathology, Medical School, University ofloannina, loannina-Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of'Medicine and 2Pathology , Medical School , University ofloannina , loannina-Greece","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Medical School, University of loannina, 453 32 Ioannina-Greece","institution_ids":["https://openalex.org/I194019607"]},{"raw_affiliation_string":"From the Departments of'Medicine and 2Pathology, Medical School, University ofloannina, loannina-Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"C.S Papadimitriou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"C.S Papadimitriou","raw_affiliation_strings":["Departments of'Medicine and 2Pathology , Medical School , University ofloannina , loannina-Greece","Department of Medicine, Medical School, University of loannina, 453 32 Ioannina-Greece","From the Departments of'Medicine and 2Pathology, Medical School, University ofloannina, loannina-Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of'Medicine and 2Pathology , Medical School , University ofloannina , loannina-Greece","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Medical School, University of loannina, 453 32 Ioannina-Greece","institution_ids":["https://openalex.org/I194019607"]},{"raw_affiliation_string":"From the Departments of'Medicine and 2Pathology, Medical School, University ofloannina, loannina-Greece","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113545149","display_name":"Haralampos M. Moutsopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"H.M Moutsopoulos","raw_affiliation_strings":["Department of Medicine, Medical School, University of loannina, 453 32 Ioannina-Greece","From the Departments of'Medicine and 2Pathology, Medical School, University ofloannina, loannina-Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical School, University of loannina, 453 32 Ioannina-Greece","institution_ids":["https://openalex.org/I194019607"]},{"raw_affiliation_string":"From the Departments of'Medicine and 2Pathology, Medical School, University ofloannina, loannina-Greece","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I194019607"],"apc_list":{"value":4870,"currency":"USD","value_usd":4870},"apc_paid":null,"fwci":3.5766,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.92584746,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"45","issue":"9","first_page":"732","last_page":"735"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/primary-sjogren-syndrome","display_name":"primary Sj\u00f6gren's syndrome","score":1.0},{"id":"https://openalex.org/keywords/xerostomia","display_name":"xerostomia","score":0.9729999899864197},{"id":"https://openalex.org/keywords/xerophthalmia","display_name":"xerophthalmia","score":0.9570000171661377},{"id":"https://openalex.org/keywords/parotid-gland-enlargement","display_name":"parotid gland enlargement","score":0.9599999785423279},{"id":"https://openalex.org/keywords/salivary-flow","display_name":"salivary flow","score":0.7630000114440918},{"id":"https://openalex.org/keywords/salivary-gland-histopathology","display_name":"salivary gland histopathology","score":0.859000027179718},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.828000009059906},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6890000104904175},{"id":"https://openalex.org/keywords/hypertrichosis","display_name":"hypertrichosis","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9377102255821228},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8519032597541809},{"id":"https://openalex.org/C2777373371","wikidata":"https://www.wikidata.org/wiki/Q1054713","display_name":"Xerophthalmia","level":5,"score":0.6633842587471008},{"id":"https://openalex.org/C2775876775","wikidata":"https://www.wikidata.org/wiki/Q595010","display_name":"Hypertrichosis","level":2,"score":0.5618051290512085},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5548807978630066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5384765267372131},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4934159815311432},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.44310876727104187},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3602997660636902},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34345293045043945},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.2216625213623047},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21900683641433716},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2779573558","wikidata":"https://www.wikidata.org/wiki/Q424976","display_name":"Retinol","level":3,"score":0.0},{"id":"https://openalex.org/C2778129702","wikidata":"https://www.wikidata.org/wiki/Q2655893","display_name":"Vitamin A deficiency","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006983","descriptor_name":"Hypertrichosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012470","descriptor_name":"Salivary Glands, Minor","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1136/ard.45.9.732","doi":"https://doi.org/10.1136/ard.45.9.732","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ard.45.9.732","pdf_url":"https://ard.bmj.com/content/annrheumdis/45/9/732.full.pdf","source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1001978","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1001978","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1001978/pdf/annrheumd00276-0028.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Rheum Dis","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:399033","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1001978","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:3532967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3532967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the rheumatic diseases","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.827.1902","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.827.1902","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ard.bmj.com/content/45/9/732.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1136/ard.45.9.732","doi":"https://doi.org/10.1136/ard.45.9.732","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ard.45.9.732","pdf_url":"https://ard.bmj.com/content/annrheumdis/45/9/732.full.pdf","source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2039924752.pdf","grobid_xml":"https://content.openalex.org/works/W2039924752.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1513402792","https://openalex.org/W1988451659","https://openalex.org/W1998327960","https://openalex.org/W2016005774","https://openalex.org/W2023406953","https://openalex.org/W2060958447","https://openalex.org/W2067962600","https://openalex.org/W2080064179","https://openalex.org/W2080894267","https://openalex.org/W2084450252","https://openalex.org/W2085894167","https://openalex.org/W2093662571","https://openalex.org/W2160250478","https://openalex.org/W2286617130","https://openalex.org/W2399494832","https://openalex.org/W2413603144","https://openalex.org/W2414408789","https://openalex.org/W2416431420","https://openalex.org/W4244697632","https://openalex.org/W4253710446"],"related_works":["https://openalex.org/W7100074841","https://openalex.org/W2466690813","https://openalex.org/W57192031","https://openalex.org/W6927562017","https://openalex.org/W7061547539","https://openalex.org/W2412190507","https://openalex.org/W2486248034","https://openalex.org/W2486225600","https://openalex.org/W2803866704","https://openalex.org/W2044723511"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}