{"id":"https://openalex.org/W2039909459","doi":"https://doi.org/10.1074/jbc.272.30.19000","title":"Differential Regulation of Phosphoinositide 3-Kinase Adapter Subunit Variants by Insulin in Human Skeletal Muscle","display_name":"Differential Regulation of Phosphoinositide 3-Kinase Adapter Subunit Variants by Insulin in Human Skeletal Muscle","publication_year":1997,"publication_date":"1997-07-01","ids":{"openalex":"https://openalex.org/W2039909459","doi":"https://doi.org/10.1074/jbc.272.30.19000","mag":"2039909459","pmid":"https://pubmed.ncbi.nlm.nih.gov/9228082"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.272.30.19000","doi":"https://doi.org/10.1074/jbc.272.30.19000","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.30.19000","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.272.30.19000","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005007188","display_name":"Peter Robin Shepherd","orcid":"https://orcid.org/0000-0001-9742-5811","observed_orcids":["https://orcid.org/0000-0001-9742-5811","https://orcid.org/0000-0001-8591-7309"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Peter R. Shepherd","raw_affiliation_strings":["Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, United Kingdom. p.shepherd@biochem.ucl.ac.uk","Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, United Kingdom. p.shepherd@biochem.ucl.ac.uk","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047132791","display_name":"BARBARA T. NAV\u00c9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Barbara T. Nav\u00e9","raw_affiliation_strings":["Department of Clinical Biochemistry, University of Cambridge, Cambridge, CB2 2QR United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, University of Cambridge, Cambridge, CB2 2QR United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113348105","display_name":"Jorge Rinc\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jorge Rincon","raw_affiliation_strings":["Department of Clinical Physiology, Karolinska Hospital, Stockholm, 10401 Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Karolinska Hospital, Stockholm, 10401 Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111734905","display_name":"Lorraine A. Nolte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lorraine A. Nolte","raw_affiliation_strings":["Department of Clinical Physiology, Karolinska Hospital, Stockholm, 10401 Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Karolinska Hospital, Stockholm, 10401 Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079249283","display_name":"A. Paul Bevan","orcid":"https://orcid.org/0000-0002-0656-9164","observed_orcids":["https://orcid.org/0000-0002-0656-9164"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Paul Bevan","raw_affiliation_strings":["Department of Clinical Biochemistry, University of Cambridge, Cambridge, CB2 2QR United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, University of Cambridge, Cambridge, CB2 2QR United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068690836","display_name":"Kenneth Siddle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kenneth Siddle","raw_affiliation_strings":["Department of Clinical Biochemistry, University of Cambridge, Cambridge, CB2 2QR United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, University of Cambridge, Cambridge, CB2 2QR United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000008605","display_name":"Juleen Rae Zierath","orcid":"https://orcid.org/0000-0001-6891-7497","observed_orcids":["https://orcid.org/0000-0001-6891-7497"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Juleen R. Zierath","raw_affiliation_strings":["Department of Clinical Physiology, Karolinska Hospital, Stockholm, 10401 Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Karolinska Hospital, Stockholm, 10401 Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001810758","display_name":"Harriet Wallberg\u2010Henriksson","orcid":"https://orcid.org/0000-0001-7681-1537","observed_orcids":["https://orcid.org/0000-0001-7681-1537"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Harriet Wallberg-Henriksson","raw_affiliation_strings":["Department of Clinical Physiology, Karolinska Hospital, Stockholm, 10401 Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Karolinska Hospital, Stockholm, 10401 Sweden","institution_ids":["https://openalex.org/I1335113835"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005007188"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.679,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.91245304,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"272","issue":"30","first_page":"19000","last_page":"19007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.5189999938011169},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.921999990940094},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9430000185966492},{"id":"https://openalex.org/keywords/p85alpha","display_name":"p85\u03b1","score":0.8840000033378601},{"id":"https://openalex.org/keywords/p85beta","display_name":"p85\u03b2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/3-o-methylglucose-transport","display_name":"3-O-methylglucose transport","score":0.9290000200271606},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6495121717453003},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6330193281173706},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6078664064407349},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.5975174903869629},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5543404221534729},{"id":"https://openalex.org/C2781322055","wikidata":"https://www.wikidata.org/wiki/Q423725","display_name":"Phosphoinositide 3-kinase","level":4,"score":0.5497997403144836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5452091097831726},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5095739364624023},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.44049158692359924},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4271845817565918},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3561317026615143},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.29080599546432495},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22116172313690186},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.14753574132919312},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0644499659538269},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06224167346954346}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010748","descriptor_name":"Phosphopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019325","descriptor_name":"3-O-Methylglucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.272.30.19000","doi":"https://doi.org/10.1074/jbc.272.30.19000","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.30.19000","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9228082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9228082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:186302","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/186302/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JOURNAL OF BIOLOGICAL CHEMISTRY , 272 (30) pp. 19000-19007. (1997)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.272.30.19000","doi":"https://doi.org/10.1074/jbc.272.30.19000","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.30.19000","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W67399661","https://openalex.org/W1525701947","https://openalex.org/W1529396499","https://openalex.org/W1531590504","https://openalex.org/W1547466369","https://openalex.org/W1551443142","https://openalex.org/W1555224377","https://openalex.org/W1572009433","https://openalex.org/W1582699368","https://openalex.org/W1588962899","https://openalex.org/W1604326532","https://openalex.org/W1689754237","https://openalex.org/W1712871378","https://openalex.org/W1838131144","https://openalex.org/W1934347187","https://openalex.org/W1947575656","https://openalex.org/W1969161473","https://openalex.org/W1979187651","https://openalex.org/W1991276398","https://openalex.org/W1994253356","https://openalex.org/W2000790515","https://openalex.org/W2004336881","https://openalex.org/W2019691564","https://openalex.org/W2020504795","https://openalex.org/W2025998518","https://openalex.org/W2033125833","https://openalex.org/W2034397029","https://openalex.org/W2041555311","https://openalex.org/W2043206871","https://openalex.org/W2058390591","https://openalex.org/W2059738943","https://openalex.org/W2081698610","https://openalex.org/W2100943227","https://openalex.org/W2108264768","https://openalex.org/W2109300167","https://openalex.org/W2131383531","https://openalex.org/W2141795340","https://openalex.org/W2143485714","https://openalex.org/W2150365979","https://openalex.org/W2152213025","https://openalex.org/W2157189324","https://openalex.org/W2161316513","https://openalex.org/W2164002753","https://openalex.org/W2171424906","https://openalex.org/W2178492210","https://openalex.org/W2340078041","https://openalex.org/W2344973376","https://openalex.org/W2395723816","https://openalex.org/W2402333849"],"related_works":["https://openalex.org/W2416283290","https://openalex.org/W2141067543","https://openalex.org/W1531590504","https://openalex.org/W2061959038","https://openalex.org/W2131383531","https://openalex.org/W2171424906","https://openalex.org/W2344973376","https://openalex.org/W2263735455","https://openalex.org/W1570629413","https://openalex.org/W2051351017"],"abstract_inverted_index":{"The":[0,50,231],"role":[1],"of":[2,35,68,75,86,104,132,164,169,193,197,209,224,233],"phosphoinositide":[3],"3-kinase":[4,21,43,52,136,155,253],"(PI":[5],"3-kinase)":[6],"in":[7,12,26,178,213,221,250],"insulin":[8],"signaling":[9,254],"was":[10,38,176],"evaluated":[11],"human":[13,158],"skeletal":[14,28],"muscle.":[15],"Insulin":[16,33,204],"stimulated":[17],"both":[18],"antiphosphotyrosine-precipitable":[19],"PI":[20,42,51,135,154,252],"activity":[22,137,156],"and":[23,90,108,147,174,200,216,227,235],"3-O-methylglucose":[24,36],"transport":[25,37],"isolated":[27],"muscle":[29,58,159],"(both":[30],"approximately":[31],"2-3-fold).":[32],"stimulation":[34],"inhibited":[39],"by":[40,139,245],"the":[41,65,69,76,80,84,111,115,133,148,165,170,194,201,207,210,222,228,251],"inhibitor":[44],"LY294002":[45],"(IC50":[46],"=":[47],"2.5":[48],"microM).":[49],"adapter":[53,92,101,150],"subunits":[54],"were":[55,126,237],"purified":[56],"from":[57,157,181],"lysates":[59],"using":[60],"phosphopeptide":[61,81],"beads":[62,82],"based":[63],"on":[64],"Tyr-751":[66],"region":[67],"platelet-derived":[70],"growth":[71],"factor":[72],"receptor.":[73],"Immunoblotting":[74],"material":[77],"adsorbed":[78],"onto":[79],"revealed":[83],"presence":[85],"p85alpha,":[87,198,225],"p85beta,":[88,145,199,226],"p55(PIK)/p55gamma,":[89,146],"p50":[91,116,149,234],"subunit":[93,102,151],"isoforms.":[94],"In":[95],"addition,":[96],"p85alpha-NSH2":[97,140],"antibodies":[98],"recognized":[99],"four":[100,124],"variants":[103],"54,":[105],"53,":[106],"48,":[107],"46":[109],"kDa,":[110],"latter":[112],"corresponding":[113],"to":[114,144],"splice":[117],"variant.":[118,203,230],"Serial":[119],"immunoprecipitations":[120],"demonstrated":[121],"that":[122],"these":[123,185],"proteins":[125],"associated":[127],"with":[128],"a":[129,189],"large":[130,162],"proportion":[131,163,192],"total":[134,166],"immunoprecipitated":[138,153],"domain":[141],"antibodies.":[142],"Antibodies":[143],"also":[152],"lysates.":[160],"A":[161],"cellular":[167,195],"pool":[168,196],"53-kDa":[171,229],"variant,":[172],"p50,":[173],"p55(PIK)":[175,236],"present":[177],"antiphosphotyrosine":[179,214],"immunoprecipitates":[180,186,215],"unstimulated":[182],"muscle,":[183],"whereas":[184],"contained":[187],"only":[188],"very":[190],"small":[191],"48-kDa":[202,211],"greatly":[205],"increased":[206],"levels":[208,223,232],"variant":[212],"caused":[217],"smaller":[218],"-fold":[219],"increases":[220],"not":[238],"significantly":[239],"changed.":[240],"These":[241],"properties":[242],"indicate":[243],"mechanisms":[244],"which":[246],"specificity":[247],"is":[248],"achieved":[249],"system.":[255]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}