{"id":"https://openalex.org/W2039874009","doi":"https://doi.org/10.1038/sj.onc.1204206","title":"Upregulation of p21WAF1/CIP1 leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1","display_name":"Upregulation of p21WAF1/CIP1 leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1","publication_year":2001,"publication_date":"2001-03-08","ids":{"openalex":"https://openalex.org/W2039874009","doi":"https://doi.org/10.1038/sj.onc.1204206","mag":"2039874009","pmid":"https://pubmed.ncbi.nlm.nih.gov/11313866"},"language":"en","primary_location":{"id":"doi:10.1038/sj.onc.1204206","doi":"https://doi.org/10.1038/sj.onc.1204206","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1204206","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004562934","display_name":"Ryo Sugibayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Sugibayashi","raw_affiliation_strings":["Department of Hygiene-Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya, Funagawara-Machi, Shinjuku-ku, Tokyo 162-0826, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene-Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya, Funagawara-Machi, Shinjuku-ku, Tokyo 162-0826, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110015560","display_name":"Takahisa Shimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahisa Shimizu","raw_affiliation_strings":["Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya-Funagawara-machi, Shinjuku-ku, Tokyo, 162-0826, Japan","Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya-Funagawara-machi, Shinjuku-ku, Tokyo, 162-0826, Japan","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100691456","display_name":"Toshihiro Suzuki","orcid":"https://orcid.org/0000-0002-7095-6556","observed_orcids":["https://orcid.org/0000-0002-7095-6556"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiro Suzuki","raw_affiliation_strings":["Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya-Funagawara-machi, Shinjuku-ku, Tokyo, 162-0826, Japan","Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya-Funagawara-machi, Shinjuku-ku, Tokyo, 162-0826, Japan","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019906266","display_name":"Naoki Yamamoto","orcid":"https://orcid.org/0000-0002-9659-3204","observed_orcids":["https://orcid.org/0000-0002-9659-3204"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Yamamoto","raw_affiliation_strings":["Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya-Funagawara-machi, Shinjuku-ku, Tokyo, 162-0826, Japan","Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya-Funagawara-machi, Shinjuku-ku, Tokyo, 162-0826, Japan","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100806826","display_name":"Hirofumi Hamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Hamada","raw_affiliation_strings":["Sapporo Medical University Department of Molecular Medicine, South-1 West-17, Chuo-ku, Sapporo, 060-8556, Japan","Sapporo Medical University Department of Molecular Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapporo Medical University Department of Molecular Medicine, South-1 West-17, Chuo-ku, Sapporo, 060-8556, Japan","institution_ids":["https://openalex.org/I141882310"]},{"raw_affiliation_string":"Sapporo Medical University Department of Molecular Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055554576","display_name":"Ken Takeda","orcid":"https://orcid.org/0000-0002-2906-5575","observed_orcids":["https://orcid.org/0000-0002-2906-5575"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Takeda","raw_affiliation_strings":["Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya-Funagawara-machi, Shinjuku-ku, Tokyo, 162-0826, Japan","Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya-Funagawara-machi, Shinjuku-ku, Tokyo, 162-0826, Japan","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":null,"fwci":0.7238,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.67315761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"10","first_page":"1220","last_page":"1228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.10909999907016754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.996999979019165},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7429999709129333},{"id":"https://openalex.org/keywords/tpa-induced-differentiation","display_name":"TPA-induced differentiation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8220000267028809},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.8420000076293945},{"id":"https://openalex.org/keywords/protein-kinase-c-alpha","display_name":"protein kinase C alpha","score":0.7179999947547913},{"id":"https://openalex.org/keywords/pkc-gamma","display_name":"PKC gamma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pkc-epsilon","display_name":"protein kinase C epsilon","score":0.9980000257492065},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.753000020980835},{"id":"https://openalex.org/keywords/alpha-naphthyl-acetate-esterase","display_name":"alpha-naphthyl acetate esterase","score":0.906000018119812},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7089260816574097},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.6795883178710938},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5358219146728516},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5356971621513367},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.533665657043457},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.46909984946250916},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4472082555294037},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.42010465264320374},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34141266345977783},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3355959951877594},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.182801753282547},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008301","descriptor_name":"Maleimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009283","descriptor_name":"Naphthol AS D Esterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.onc.1204206","doi":"https://doi.org/10.1038/sj.onc.1204206","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1204206","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:11313866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11313866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1526528713","https://openalex.org/W1576671418","https://openalex.org/W1964971369","https://openalex.org/W1969785844","https://openalex.org/W1975702359","https://openalex.org/W1976112378","https://openalex.org/W1983466646","https://openalex.org/W1991320440","https://openalex.org/W1991592196","https://openalex.org/W1991904257","https://openalex.org/W1991972636","https://openalex.org/W1994953133","https://openalex.org/W1998658648","https://openalex.org/W2001724554","https://openalex.org/W2002623358","https://openalex.org/W2010061244","https://openalex.org/W2012281199","https://openalex.org/W2015519364","https://openalex.org/W2017474714","https://openalex.org/W2018074547","https://openalex.org/W2028618614","https://openalex.org/W2029212302","https://openalex.org/W2029506276","https://openalex.org/W2034577150","https://openalex.org/W2037230449","https://openalex.org/W2038173255","https://openalex.org/W2048983596","https://openalex.org/W2050924165","https://openalex.org/W2052651806","https://openalex.org/W2054531119","https://openalex.org/W2061394487","https://openalex.org/W2062124441","https://openalex.org/W2065472541","https://openalex.org/W2068502127","https://openalex.org/W2072374837","https://openalex.org/W2076440956","https://openalex.org/W2084910239","https://openalex.org/W2087654555","https://openalex.org/W2111295274","https://openalex.org/W2111590747","https://openalex.org/W2119985976","https://openalex.org/W2124982669","https://openalex.org/W2129265687","https://openalex.org/W2162741492","https://openalex.org/W2163421864","https://openalex.org/W2235827406","https://openalex.org/W2291425766","https://openalex.org/W2313211164","https://openalex.org/W2315643721","https://openalex.org/W2329211716","https://openalex.org/W2330718429","https://openalex.org/W2411990940"],"related_works":["https://openalex.org/W2415387673","https://openalex.org/W2082010137","https://openalex.org/W2411990940","https://openalex.org/W1965943756","https://openalex.org/W2163658663","https://openalex.org/W2312785620","https://openalex.org/W2466001069","https://openalex.org/W2038452369","https://openalex.org/W2088302947","https://openalex.org/W2335588880"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}