{"id":"https://openalex.org/W2039852887","doi":"https://doi.org/10.1021/bi034384s","title":"Domain-Specific Interactions of Talin with the Membrane-Proximal Region of the Integrin \u03b23 Subunit","display_name":"Domain-Specific Interactions of Talin with the Membrane-Proximal Region of the Integrin \u03b23 Subunit","publication_year":2003,"publication_date":"2003-06-10","ids":{"openalex":"https://openalex.org/W2039852887","doi":"https://doi.org/10.1021/bi034384s","mag":"2039852887","pmid":"https://pubmed.ncbi.nlm.nih.gov/12846579"},"language":"en","primary_location":{"id":"doi:10.1021/bi034384s","doi":"https://doi.org/10.1021/bi034384s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi034384s","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028480003","display_name":"Tobias S. Ulmer","orcid":"https://orcid.org/0000-0001-7811-2131","observed_orcids":["https://orcid.org/0000-0001-7811-2131"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Tobias S. Ulmer","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088502721","display_name":"David Calderwood","orcid":"https://orcid.org/0000-0002-0791-4142","observed_orcids":["https://orcid.org/0000-0002-0791-4142"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"David A. Calderwood","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032907445","display_name":"Mark H. Ginsberg","orcid":"https://orcid.org/0000-0002-5685-5417","observed_orcids":["https://orcid.org/0000-0002-5685-5417"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Mark H. Ginsberg","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108863927","display_name":"Iain Donald Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Iain D. Campbell","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032907445","https://openalex.org/A5108863927"],"corresponding_institution_ids":["https://openalex.org/I123431417","https://openalex.org/I40120149"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.7725,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.95252226,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"42","issue":"27","first_page":"8307","last_page":"8312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/talin","display_name":"talin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.8799999952316284},{"id":"https://openalex.org/keywords/integrin-activation","display_name":"integrin activation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ferm-domain","display_name":"FERM domain","score":0.8140000104904175},{"id":"https://openalex.org/keywords/membrane-proximal-region","display_name":"membrane-proximal region","score":0.8690000176429749},{"id":"https://openalex.org/keywords/actin-filament-binding","display_name":"actin filament binding","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.9014884829521179},{"id":"https://openalex.org/C200342125","wikidata":"https://www.wikidata.org/wiki/Q24726381","display_name":"FERM domain","level":5,"score":0.8322385549545288},{"id":"https://openalex.org/C119524353","wikidata":"https://www.wikidata.org/wiki/Q5145908","display_name":"Collagen receptor","level":4,"score":0.5899498462677002},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5858941078186035},{"id":"https://openalex.org/C4894155","wikidata":"https://www.wikidata.org/wiki/Q4201950","display_name":"CD49c","level":5,"score":0.5660241842269897},{"id":"https://openalex.org/C156585808","wikidata":"https://www.wikidata.org/wiki/Q18028043","display_name":"Integrin, beta 6","level":4,"score":0.5436278581619263},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5345050096511841},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.48817068338394165},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.45967844128608704},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.4224483370780945},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4164700508117676},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3504220247268677},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.3232002556324005},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.28103065490722656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25945863127708435},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.19307750463485718},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16469255089759827},{"id":"https://openalex.org/C161200384","wikidata":"https://www.wikidata.org/wiki/Q1757382","display_name":"Integral membrane protein","level":4,"score":0.0818275511264801},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016608","descriptor_name":"Talin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039661","descriptor_name":"Integrin beta3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039661","descriptor_name":"Integrin beta3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi034384s","doi":"https://doi.org/10.1021/bi034384s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi034384s","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:12846579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12846579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G780268991","display_name":"CELL ADHESION MECHANISMS IN VASCULAR DISEASE","funder_award_id":"P01HL048728","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G882865996","display_name":"Thrombus Formation and Antithrombotic Intervention","funder_award_id":"P01HL031950","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1553624503","https://openalex.org/W1952949712","https://openalex.org/W1992733780","https://openalex.org/W2081401313","https://openalex.org/W2083965774","https://openalex.org/W2088544660","https://openalex.org/W2123122700","https://openalex.org/W2148377692","https://openalex.org/W2157330541","https://openalex.org/W2162378755","https://openalex.org/W2168918180","https://openalex.org/W2170877356","https://openalex.org/W4322095699"],"related_works":["https://openalex.org/W1981368559","https://openalex.org/W2017645968","https://openalex.org/W2157330541","https://openalex.org/W2259717485","https://openalex.org/W2171338165","https://openalex.org/W2088544660","https://openalex.org/W1974416367","https://openalex.org/W2571874603","https://openalex.org/W2008549435","https://openalex.org/W2032348507"],"abstract_inverted_index":{"Activation":[0],"(affinity":[1],"regulation)":[2],"of":[3,44,53,80,102,113,137],"integrin":[4,22,54,88,147],"adhesion":[5],"receptors":[6],"controls":[7],"cell":[8],"migration":[9],"and":[10,20,49,61,92],"extracellular":[11],"matrix":[12],"assembly.":[13],"Talin":[14],"connects":[15],"integrins":[16],"with":[17,145],"actin":[18],"filaments":[19],"influences":[21],"affinity":[23],"by":[24],"binding":[25,35],"to":[26,86,119],"the":[27,64,71,99,103,114,121,126,138],"integrins'":[28],"short":[29],"cytoplasmic":[30],"beta-tail.":[31],"The":[32],"principal":[33],"beta-tail":[34],"site":[36],"in":[37],"talin":[38],"is":[39,143],"a":[40],"FERM":[41],"domain,":[42],"comprised":[43],"three":[45],"subdomains":[46],"(F1,":[47],"F2,":[48,96],"F3).":[50],"Previous":[51],"studies":[52],"alphaIIbbeta3":[55],"have":[56],"shown":[57],"that":[58,117,135],"both":[59],"F2":[60],"F3":[62,91],"bind":[63],"beta3":[65,81,104,115,139],"tail,":[66],"but":[67,94],"only":[68],"F3,":[69],"or":[70],"F2-F3":[72],"domain":[73],"pair,":[74],"induces":[75],"activation.":[76,148],"Here,":[77],"talin-induced":[78],"perturbations":[79],"NMR":[82],"resonances":[83],"were":[84],"examined":[85],"explore":[87],"activation":[89],"mechanisms.":[90],"F2-F3,":[93],"not":[95],"distinctly":[97],"perturbed":[98,109],"membrane-proximal":[100,141],"region":[101,142],"tail.":[105],"All":[106],"domains":[107],"also":[108],"more":[110],"distal":[111],"regions":[112],"tail":[116,140],"appear":[118],"form":[120],"major":[122],"interaction":[123],"surface,":[124],"since":[125],"beta3(Y747A)":[127],"mutation":[128],"suppressed":[129],"those":[130],"effects.":[131],"These":[132],"results":[133],"suggest":[134],"perturbation":[136],"associated":[144],"talin-mediated":[146]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
