{"id":"https://openalex.org/W2039770313","doi":"https://doi.org/10.3851/imp1915","title":"Population Pharmacokinetics of Lopinavir and Ritonavir in Combination with Rifampicin-Based Antitubercular Treatment in HIV-Infected Children","display_name":"Population Pharmacokinetics of Lopinavir and Ritonavir in Combination with Rifampicin-Based Antitubercular Treatment in HIV-Infected Children","publication_year":2011,"publication_date":"2011-09-28","ids":{"openalex":"https://openalex.org/W2039770313","doi":"https://doi.org/10.3851/imp1915","mag":"2039770313","pmid":"https://pubmed.ncbi.nlm.nih.gov/22267466","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3743021"},"language":"en","primary_location":{"id":"doi:10.3851/imp1915","doi":"https://doi.org/10.3851/imp1915","is_oa":true,"landing_page_url":"https://doi.org/10.3851/imp1915","pdf_url":"https://journals.sagepub.com/doi/pdf/10.3851/IMP1915","source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.3851/IMP1915","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Chao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Chao Zhang","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025069184","display_name":"Helen McIlleron","orcid":"https://orcid.org/0000-0002-0982-6226","observed_orcids":["https://orcid.org/0000-0002-0982-6226"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Helen McIlleron","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055908487","display_name":"Yuan Ren","orcid":"https://orcid.org/0000-0001-7155-7664","observed_orcids":["https://orcid.org/0000-0001-7155-7664"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Yuan Ren","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109227136","display_name":"Jan\u2010Stefan van der Walt","orcid":"https://orcid.org/0000-0002-6790-0172","observed_orcids":["https://orcid.org/0000-0002-6790-0172"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["SE","ZA"],"is_corresponding":false,"raw_author_name":"Jan-Stefan van der Walt","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070310610","display_name":"Mats O. Karlsson","orcid":"https://orcid.org/0000-0003-1258-8297","observed_orcids":["https://orcid.org/0000-0003-1258-8297"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mats O Karlsson","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013955124","display_name":"Ulrika S. H. Simonsson","orcid":"https://orcid.org/0000-0002-3424-9686","observed_orcids":["https://orcid.org/0000-0002-3424-9686"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ulrika SH Simonsson","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056892721","display_name":"Paolo Denti","orcid":"https://orcid.org/0000-0001-7494-079X","observed_orcids":["https://orcid.org/0000-0001-7494-079X"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Paolo Denti","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025069184"],"corresponding_institution_ids":["https://openalex.org/I157614274"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":1.7261,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.83207575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"17","issue":"1","first_page":"25","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lopinavir","display_name":"lopinavir","score":0.8809999823570251},{"id":"https://openalex.org/keywords/ritonavir","display_name":"ritonavir","score":1.0},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.7239999771118164},{"id":"https://openalex.org/keywords/hiv-infected-children","display_name":"HIV-infected children","score":0.8190000057220459},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.5239999890327454},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/dose-simulation","display_name":"dose simulation","score":0.4099999964237213},{"id":"https://openalex.org/keywords/integrated-population-model","display_name":"integrated population model","score":0.5490000247955322},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.7120000123977661},{"id":"https://openalex.org/keywords/hiv-tb-co-infection","display_name":"HIV/TB coinfection","score":0.6629999876022339},{"id":"https://openalex.org/keywords/pediatric-dosing","display_name":"pediatric dosing","score":0.5770000219345093},{"id":"https://openalex.org/keywords/non-nucleoside-reverse-transcriptase-inhibitors","display_name":"non-nucleoside reverse transcriptase inhibitors","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2777182164","wikidata":"https://www.wikidata.org/wiki/Q422585","display_name":"Lopinavir","level":5,"score":0.8948057293891907},{"id":"https://openalex.org/C2781392899","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Lopinavir/ritonavir","level":5,"score":0.8790849447250366},{"id":"https://openalex.org/C2779298103","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Ritonavir","level":5,"score":0.8552958965301514},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.7307961583137512},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.697845458984375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6833618879318237},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5206117630004883},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4756816625595093},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4590946137905121},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4571618139743805},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35985851287841797},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.34005701541900635},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.28773969411849976},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.2508428990840912},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07453253865242004},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012293","descriptor_name":"Rifampin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D054796","descriptor_name":"Drug Dosage Calculations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060085","descriptor_name":"Coinfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061466","descriptor_name":"Lopinavir","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D061466","descriptor_name":"Lopinavir","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3851/imp1915","doi":"https://doi.org/10.3851/imp1915","is_oa":true,"landing_page_url":"https://doi.org/10.3851/imp1915","pdf_url":"https://journals.sagepub.com/doi/pdf/10.3851/IMP1915","source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},{"id":"pmid:22267466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22267466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral therapy","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2734807","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3743021","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3743021","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3743021","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Antivir Ther","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3851/imp1915","doi":"https://doi.org/10.3851/imp1915","is_oa":true,"landing_page_url":"https://doi.org/10.3851/imp1915","pdf_url":"https://journals.sagepub.com/doi/pdf/10.3851/IMP1915","source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4189300119","display_name":"Population pharmacokinetic-pharmacodynamic modelling to optimise treatments for HIV, TB and malaria.","funder_award_id":"083851/Z/07/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5054873001","display_name":"South Africa Tuberculosis/AIDS Training","funder_award_id":"U2RTW007373","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G727067426","display_name":"South Africa Tuberculosis AIDS Training (SATBAT)","funder_award_id":"U2RTW007370","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G924106205","display_name":"Population pharmacokinetic-pharmacodynamic modelling to optimise treatments for HIV, TB and malaria.","funder_award_id":"083851","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"},{"id":"https://openalex.org/F4320338462","display_name":"European and Developing Countries Clinical Trials Partnership","ror":"https://ror.org/031jv9v19"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2039770313.pdf"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1965479467","https://openalex.org/W1986282875","https://openalex.org/W1992857384","https://openalex.org/W2006583270","https://openalex.org/W2015441944","https://openalex.org/W2020365240","https://openalex.org/W2061790725","https://openalex.org/W2066464642","https://openalex.org/W2089510676","https://openalex.org/W2107518873","https://openalex.org/W2117116437","https://openalex.org/W2118286071","https://openalex.org/W2120416054","https://openalex.org/W2127996698","https://openalex.org/W2135816098","https://openalex.org/W2145319476","https://openalex.org/W2470303801"],"related_works":["https://openalex.org/W1584321696","https://openalex.org/W2089510676","https://openalex.org/W2470303801","https://openalex.org/W2770072870","https://openalex.org/W2902951550","https://openalex.org/W2145319476","https://openalex.org/W4385334175","https://openalex.org/W3008365138","https://openalex.org/W4281401978","https://openalex.org/W2606012441"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,74,148,226],"preferred":[2],"antiretroviral":[3],"regimen":[4],"for":[5,72],"young":[6,237],"children":[7,70,80,88,104,178,217,238],"previously":[8],"exposed":[9],"to":[10,32,60],"non-nucleoside":[11],"reverse":[12,20],"transcriptase":[13,21],"inhibitors":[14],"is":[15,42],"lopinavir/ritonavir":[16,33,62,95,107,182,244],"plus":[17],"two":[18],"nucleoside":[19],"inhibitors.":[22],"Rifampicin-based":[23],"antitubercular":[24,100,120,251],"treatment":[25,168],"reduces":[26],"lopinavir":[27,56,67,83,136,155,174,203,208,248],"concentrations.":[28],"Adding":[29],"extra":[30],"ritonavir":[31,58,146,152,186,233],"overcomes":[34],"the":[35,91,133,170,229],"effect":[36],"of":[37,94,135,151,173,202,216,243],"rifampicin,":[38],"however":[39],"this":[40],"approach":[41],"not":[43],"feasible":[44,240],"in":[45,69,177,212,236,246],"many":[46],"settings.":[47],"METHODS:":[48],"We":[49],"developed":[50],"an":[51,164],"integrated":[52],"population":[53],"model":[54,75,125,140,227],"describing":[55,228],"and":[57,86,102,115,129,137,184,197,222,234],"pharmacokinetics":[59,134],"predict":[61],"(4:1)":[63],"doses":[64,108,183,201,242],"achieving":[65],"target":[66],"exposures":[68],"treated":[71],"tuberculosis.":[73],"included":[76],"data":[77],"from":[78,103],"15":[79],"given":[81,89,105],"'super-boosted'":[82],"(lopinavir/ritonavir":[84],"=1:1)":[85],"20":[87,196],"twice":[90,180],"standard":[92,106],"dose":[93],"every":[96,109],"12":[97,110],"h":[98,111],"during":[99,250],"treatment,":[101],"(39":[112],"without":[113],"tuberculosis":[114],"11":[116],"sampled":[117],"again":[118],"after":[119],"treatment).":[121],"RESULTS:":[122],"A":[123],"one-compartment":[124,139],"with":[126,141,163],"first-order":[127],"absorption":[128,143],"elimination":[130],"best":[131],"described":[132,145],"a":[138],"transit":[142],"compartments":[144],"pharmacokinetics.":[147],"dynamic":[149],"influence":[150],"concentration":[153],"on":[154],"oral":[156,171],"clearance":[157,187],"was":[158],"modelled":[159],"as":[160],"direct":[161],"inhibition":[162],"E(max)":[165],"model.":[166],"Antitubercular":[167],"reduced":[169],"bioavailability":[172],"by":[175,188],"77%":[176],"receiving":[179],"usual":[181],"increased":[185],"50%.":[189],"Simulations":[190],"predicted":[191,239],"that":[192],"respective":[193],"27,":[194],"21,":[195],"18":[198],"mg/kg":[199],"8-hourly":[200,241],"(in":[204],"lopinavir/ritonavir,":[205],"4:1)":[206],"maintains":[207],"concentrations":[209,249],">1":[210],"mg/l":[211],"at":[213],"least":[214],"95%":[215],"weighing":[218],"3-5.9,":[219],"6-9.9,":[220],"10-13.9":[221],"14-19.9":[223],"kg.":[224],"CONCLUSIONS:":[225],"interactions":[230],"between":[231],"lopinavir,":[232],"rifampicin":[235],"resulting":[245],"therapeutic":[247],"treatment.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
