{"id":"https://openalex.org/W2039740311","doi":"https://doi.org/10.1097/00005768-200209000-00007","title":"Effects of topical analgesics on the pressor response evoked by muscle afferents","display_name":"Effects of topical analgesics on the pressor response evoked by muscle afferents","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W2039740311","doi":"https://doi.org/10.1097/00005768-200209000-00007","mag":"2039740311","pmid":"https://pubmed.ncbi.nlm.nih.gov/12218736"},"language":"en","primary_location":{"id":"doi:10.1097/00005768-200209000-00007","doi":"https://doi.org/10.1097/00005768-200209000-00007","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005768-200209000-00007","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine & Science in Sports & Exercise","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032049257","display_name":"Ronaldo M. Ichiyama","orcid":"https://orcid.org/0000-0002-7640-8032","observed_orcids":["https://orcid.org/0000-0002-7640-8032"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I2801919071","display_name":"University of Illinois System","ror":"https://ror.org/05e94g991","country_code":"US","type":"education","lineage":["https://openalex.org/I2801919071"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RONALDO M. ICHIYAMA","raw_affiliation_strings":["Department of Kinesiology, University of Illinois at Urbana-Champaign, 906 South Goodwin, Urbana, IL 61801, USA","Accepted for publication April 2002","Departments of Kinesiology, Molecular and Integrative Physiology, Athletic Training Education Program and the Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL","Submitted for publication September 2001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology, University of Illinois at Urbana-Champaign, 906 South Goodwin, Urbana, IL 61801, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Accepted for publication April 2002","institution_ids":[]},{"raw_affiliation_string":"Departments of Kinesiology, Molecular and Integrative Physiology, Athletic Training Education Program and the Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]},{"raw_affiliation_string":"Submitted for publication September 2001","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035738299","display_name":"Brian G. Ragan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I2801919071","display_name":"University of Illinois System","ror":"https://ror.org/05e94g991","country_code":"US","type":"education","lineage":["https://openalex.org/I2801919071"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BRIAN G. RAGAN","raw_affiliation_strings":["Departments of Kinesiology, Molecular and Integrative Physiology, Athletic Training Education Program and the Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL","Submitted for publication September 2001","Accepted for publication April 2002"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Kinesiology, Molecular and Integrative Physiology, Athletic Training Education Program and the Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]},{"raw_affiliation_string":"Submitted for publication September 2001","institution_ids":[]},{"raw_affiliation_string":"Accepted for publication April 2002","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035378124","display_name":"Gerald W. Bell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I2801919071","display_name":"University of Illinois System","ror":"https://ror.org/05e94g991","country_code":"US","type":"education","lineage":["https://openalex.org/I2801919071"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GERALD W. BELL","raw_affiliation_strings":["Departments of Kinesiology, Molecular and Integrative Physiology, Athletic Training Education Program and the Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL","Submitted for publication September 2001","Accepted for publication April 2002"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Kinesiology, Molecular and Integrative Physiology, Athletic Training Education Program and the Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]},{"raw_affiliation_string":"Submitted for publication September 2001","institution_ids":[]},{"raw_affiliation_string":"Accepted for publication April 2002","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022845523","display_name":"Gary A. Iwamoto","orcid":"https://orcid.org/0000-0001-5880-4843","observed_orcids":["https://orcid.org/0000-0001-5880-4843"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I2801919071","display_name":"University of Illinois System","ror":"https://ror.org/05e94g991","country_code":"US","type":"education","lineage":["https://openalex.org/I2801919071"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GARY A. IWAMOTO","raw_affiliation_strings":["Departments of Kinesiology, Molecular and Integrative Physiology, Athletic Training Education Program and the Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL","Submitted for publication September 2001","Accepted for publication April 2002"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Kinesiology, Molecular and Integrative Physiology, Athletic Training Education Program and the Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]},{"raw_affiliation_string":"Submitted for publication September 2001","institution_ids":[]},{"raw_affiliation_string":"Accepted for publication April 2002","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6054,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.67753192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"34","issue":"9","first_page":"1440","last_page":"1445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topical-analgesics","display_name":"topical analgesics","score":0.9589999914169312},{"id":"https://openalex.org/keywords/muscle-afferents","display_name":"muscle afferents","score":0.8199999928474426},{"id":"https://openalex.org/keywords/pressor-response","display_name":"pressor response","score":0.9359999895095825},{"id":"https://openalex.org/keywords/methyl-salicylate","display_name":"methyl salicylate","score":0.7350000143051147},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"muscle contraction","score":0.621999979019165},{"id":"https://openalex.org/keywords/autonomic-responses","display_name":"autonomic responses","score":0.5},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.7160000205039978},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.7860000133514404},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.7739999890327454},{"id":"https://openalex.org/keywords/decerebrate-cats","display_name":"decerebrate cats","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.7347705364227295},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.6028831601142883},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6012941002845764},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5616219639778137},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5313912630081177},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.48742011189460754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4862998425960541},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46490561962127686},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.4494629502296448},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4296698570251465},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.426910400390625},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.42022454738616943},{"id":"https://openalex.org/C2780196728","wikidata":"https://www.wikidata.org/wiki/Q1413166","display_name":"Scratching","level":2,"score":0.41274744272232056},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28715699911117554},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24131664633750916},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011311","descriptor_name":"Pressoreceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011311","descriptor_name":"Pressoreceptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012459","descriptor_name":"Salicylates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005768-200209000-00007","doi":"https://doi.org/10.1097/00005768-200209000-00007","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005768-200209000-00007","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine & Science in Sports & Exercise","raw_type":"journal-article"},{"id":"pmid:12218736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12218736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine and science in sports and exercise","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1577567207","display_name":null,"funder_award_id":"HL06296","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2026888195","display_name":null,"funder_award_id":"HL 34700","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W44438419","https://openalex.org/W1658562319","https://openalex.org/W1890739221","https://openalex.org/W1949730857","https://openalex.org/W1966592072","https://openalex.org/W1986228066","https://openalex.org/W2001846314","https://openalex.org/W2009113851","https://openalex.org/W2032972307","https://openalex.org/W2038848442","https://openalex.org/W2089412101","https://openalex.org/W2089903081","https://openalex.org/W2169923097","https://openalex.org/W2415283546","https://openalex.org/W2416302782","https://openalex.org/W2473737984"],"related_works":["https://openalex.org/W1967956285","https://openalex.org/W1982414219","https://openalex.org/W2086252123","https://openalex.org/W1993422892","https://openalex.org/W2802735672","https://openalex.org/W2000649258","https://openalex.org/W2294031787","https://openalex.org/W2095971269","https://openalex.org/W2467002755","https://openalex.org/W2290999222"],"abstract_inverted_index":{"PURPOSE:":[0],"Pressor":[1],"responses":[2,36,214],"are":[3,17],"reflexly":[4],"evoked":[5,76,110,126],"by":[6,77,127],"the":[7,27,40,50,100,104,116,146,153,156,160,175,180,184,191,198,205,238],"activation":[8],"of":[9,29,42,45,72,80,159,166,179,188,223,232],"groups":[10],"III":[11],"and":[12,59,82,137,155,227,235],"IV":[13],"muscle":[14],"afferents,":[15],"which":[16],"also":[18],"known":[19],"to":[20,99,177,183,190,197,204,215],"mediate":[21],"nociceptive":[22],"responses.":[23],"In":[24],"this":[25],"experiment,":[26],"effects":[28,48,242],"analgesic":[30,241],"balm":[31],"(AB)":[32],"application":[33,203,231],"on":[34,237,243],"these":[35],"were":[37,62,75,109,132,149,170],"investigated":[38],"without":[39],"interference":[41],"other":[43],"types":[44],"anesthesia":[46],"or":[47],"from":[49,245],"higher":[51,224],"brain.":[52],"METHODS:":[53],"Heart":[54],"rate":[55],"(HR),":[56],"blood":[57],"pressure,":[58],"end-tidal":[60],"CO(2)":[61],"monitored":[63],"in":[64,121,145,174,248],"midcollicularly":[65],"decerebrated":[66],"cats.":[67],"Static":[68],"contractions":[69,108],"(30":[70],"s)":[71],"hindlimb":[73,181],"muscles":[74,210],"electric":[78],"stimulation":[79],"L7":[81],"S1":[83],"ventral":[84],"roots.":[85],"After":[86],"control":[87],"runs,":[88],"a":[89],"commercial":[90],"AB":[91,141,167,185,189,202],"(1%":[92],"capsaicin,":[93],"12.5%":[94],"methyl":[95,233],"salicylate)":[96],"was":[97,221],"applied":[98],"skin":[101,206,239],"surface":[102,207],"over":[103,208],"contracting":[105,209],"muscles.":[106],"Muscle":[107],"every":[111],"10":[112],"min,":[113],"alternating":[114],"between":[115],"two":[117],"hindlimbs.":[118],"RESULTS:":[119],"Changes":[120],"mean":[122],"arterial":[123],"pressure":[124],"(MAP)":[125],"static":[128,216],"ipsilateral":[129,199],"muscular":[130,217],"contraction":[131,178],"significantly":[133,211],"attenuated":[134],"20":[135,164],"min":[136,139,165],"40":[138],"after":[140,163],"application.":[142,168,186],"The":[143],"decreases":[144],"pressor":[147],"response":[148,176],"significant":[150,172],"at":[151],"both":[152],"initial":[154],"last":[157],"parts":[158],"stimulus":[161],"intervention":[162],"There":[169],"no":[171],"changes":[173],"contralateral":[182,192],"Application":[187],"leg":[193],"did":[194],"not":[195],"add":[196],"effects.":[200],"CONCLUSIONS:":[201],"decreased":[212],"autonomic":[213],"contraction.":[218],"This":[219],"effect":[220],"independent":[222],"cortical":[225],"processing":[226],"strongly":[228],"suggests":[229],"that":[230],"salicylate":[234],"capsaicin":[236],"has":[240],"signals":[244],"receptors":[246],"located":[247],"muscle.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}