{"id":"https://openalex.org/W2039712873","doi":"https://doi.org/10.1016/j.mrgentox.2008.08.010","title":"Perturbation of HP1 localization and chromatin binding ability causes defects in sister-chromatid cohesion","display_name":"Perturbation of HP1 localization and chromatin binding ability causes defects in sister-chromatid cohesion","publication_year":2008,"publication_date":"2008-08-27","ids":{"openalex":"https://openalex.org/W2039712873","doi":"https://doi.org/10.1016/j.mrgentox.2008.08.010","mag":"2039712873","pmid":"https://pubmed.ncbi.nlm.nih.gov/18790078"},"language":"en","primary_location":{"id":"doi:10.1016/j.mrgentox.2008.08.010","doi":"https://doi.org/10.1016/j.mrgentox.2008.08.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mrgentox.2008.08.010","pdf_url":null,"source":{"id":"https://openalex.org/S29775604","display_name":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","issn_l":"1383-5718","issn":["1383-5718","1879-3592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045434631","display_name":"Akira Inoue","orcid":"https://orcid.org/0000-0002-1938-656X","observed_orcids":["https://orcid.org/0000-0002-1938-656X"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Akira Inoue","raw_affiliation_strings":["Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. akira.inoue@stjude.org","Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. akira.inoue@stjude.org","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, United States","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017204086","display_name":"Judith W. Hyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith Hyle","raw_affiliation_strings":["Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, United States","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026169909","display_name":"Mark S. Lechner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark S. Lechner","raw_affiliation_strings":["Department of Bioscience and Biotechnology, Drexel University, Philadelphia, PA 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Biotechnology, Drexel University, Philadelphia, PA 19104, United States","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052921260","display_name":"Jill M. Lahti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I2799495847","display_name":"University of Tennessee System","ror":"https://ror.org/00xzqjh13","country_code":"US","type":"education","lineage":["https://openalex.org/I2799495847"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jill M. Lahti","raw_affiliation_strings":["Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, United States","Department of Molecular Sciences, University of Tennessee, Memphis, TN 18163, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, United States","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Molecular Sciences, University of Tennessee, Memphis, TN 18163, United States","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I2799495847"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045434631","https://openalex.org/A5052921260"],"corresponding_institution_ids":["https://openalex.org/I1313298211","https://openalex.org/I160606119","https://openalex.org/I2799495847"],"apc_list":{"value":3350,"currency":"USD","value_usd":3350},"apc_paid":null,"fwci":1.8946,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.83025805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"657","issue":"1","first_page":"48","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.15700000524520874,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hp1","display_name":"HP1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/sister-chromatid-cohesion","display_name":"sister chromatid cohesion","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hp1alpha","display_name":"HP1\u03b1","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hp1beta","display_name":"HP1\u03b2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dominant-negative-mutant","display_name":"dominant-negative mutant","score":0.8629999756813049},{"id":"https://openalex.org/keywords/chromosome-misalignment","display_name":"chromosome misalignment","score":0.7049999833106995},{"id":"https://openalex.org/keywords/chromosome-missegregation","display_name":"chromosome missegregation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cohesin","display_name":"cohesin","score":0.7250000238418579},{"id":"https://openalex.org/keywords/kinetochore","display_name":"kinetochore","score":0.9079999923706055},{"id":"https://openalex.org/keywords/chromosome-condensation","display_name":"chromosome condensation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/condensin","display_name":"condensin","score":0.7870000004768372},{"id":"https://openalex.org/keywords/aneuploidy-prevention","display_name":"aneuploidy prevention","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C152369539","wikidata":"https://www.wikidata.org/wiki/Q5399999","display_name":"Establishment of sister chromatid cohesion","level":5,"score":0.9148852825164795},{"id":"https://openalex.org/C8502773","wikidata":"https://www.wikidata.org/wiki/Q2066168","display_name":"Sister chromatids","level":4,"score":0.8485583066940308},{"id":"https://openalex.org/C115821613","wikidata":"https://www.wikidata.org/wiki/Q21103063","display_name":"Cohesin","level":4,"score":0.8362639546394348},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.699012279510498},{"id":"https://openalex.org/C192838845","wikidata":"https://www.wikidata.org/wiki/Q908912","display_name":"Kinetochore","level":4,"score":0.6905992031097412},{"id":"https://openalex.org/C92149661","wikidata":"https://www.wikidata.org/wiki/Q1616164","display_name":"Heterochromatin protein 1","level":5,"score":0.6599847078323364},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.6294307708740234},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6185252666473389},{"id":"https://openalex.org/C73397532","wikidata":"https://www.wikidata.org/wiki/Q623749","display_name":"Chromatid","level":4,"score":0.5818751454353333},{"id":"https://openalex.org/C2778354886","wikidata":"https://www.wikidata.org/wiki/Q5113927","display_name":"Chromosome segregation","level":4,"score":0.5604516267776489},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5216377377510071},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.5105825066566467},{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.501760721206665},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.48687615990638733},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.31186938285827637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000090266","descriptor_name":"Chromobox Protein Homolog 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002842","descriptor_name":"Chromatids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020090","descriptor_name":"Chromosome Segregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.mrgentox.2008.08.010","doi":"https://doi.org/10.1016/j.mrgentox.2008.08.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mrgentox.2008.08.010","pdf_url":null,"source":{"id":"https://openalex.org/S29775604","display_name":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","issn_l":"1383-5718","issn":["1383-5718","1879-3592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","raw_type":"journal-article"},{"id":"pmid:18790078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18790078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5128352934","display_name":null,"funder_award_id":"P30CA02175","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5525103208","display_name":"A role for the CdLS gene NIPBL in HP1 gene silencing","funder_award_id":"R21HD050538","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7809563142","display_name":null,"funder_award_id":"HD050538","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1509466986","https://openalex.org/W1522400386","https://openalex.org/W1603793127","https://openalex.org/W1971537513","https://openalex.org/W1972307085","https://openalex.org/W1976842433","https://openalex.org/W1981269441","https://openalex.org/W1982783943","https://openalex.org/W1991125055","https://openalex.org/W2002954217","https://openalex.org/W2011068062","https://openalex.org/W2013687234","https://openalex.org/W2014012985","https://openalex.org/W2015735754","https://openalex.org/W2027779055","https://openalex.org/W2032187789","https://openalex.org/W2037541952","https://openalex.org/W2040234712","https://openalex.org/W2040285686","https://openalex.org/W2042812035","https://openalex.org/W2043367084","https://openalex.org/W2045006215","https://openalex.org/W2049846825","https://openalex.org/W2064297857","https://openalex.org/W2066872364","https://openalex.org/W2067724937","https://openalex.org/W2069378046","https://openalex.org/W2070122527","https://openalex.org/W2092403756","https://openalex.org/W2101092089","https://openalex.org/W2106642338","https://openalex.org/W2113774087","https://openalex.org/W2113787496","https://openalex.org/W2120917736","https://openalex.org/W2125746597","https://openalex.org/W2126531920","https://openalex.org/W2129274682","https://openalex.org/W2132200096","https://openalex.org/W2138481654","https://openalex.org/W2138884038","https://openalex.org/W2140525749","https://openalex.org/W2142308337","https://openalex.org/W2143178737","https://openalex.org/W2145593944","https://openalex.org/W2146295682","https://openalex.org/W2150374310","https://openalex.org/W2152414953","https://openalex.org/W2154595537","https://openalex.org/W2160352834","https://openalex.org/W2167951120","https://openalex.org/W2417114846","https://openalex.org/W3211005720","https://openalex.org/W6716762553"],"related_works":["https://openalex.org/W2789069321","https://openalex.org/W2155643740","https://openalex.org/W7096219350","https://openalex.org/W2012383380","https://openalex.org/W2789746416","https://openalex.org/W2038136265","https://openalex.org/W2896156764","https://openalex.org/W2025669923","https://openalex.org/W4394711201","https://openalex.org/W2806456860"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
