{"id":"https://openalex.org/W2039710093","doi":"https://doi.org/10.1097/00007890-199810270-00232","title":"NATURAL HISTORY OF HEPATITIS C RECURRENCE IN ORTHOTOPIC LIVER TRANSPLANT RECIPIENTS FOR HEPATITIS C ALONE VS HEPATITIS C AND ALCOHOLIC CIRRHOSIS","display_name":"NATURAL HISTORY OF HEPATITIS C RECURRENCE IN ORTHOTOPIC LIVER TRANSPLANT RECIPIENTS FOR HEPATITIS C ALONE VS HEPATITIS C AND ALCOHOLIC CIRRHOSIS","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2039710093","doi":"https://doi.org/10.1097/00007890-199810270-00232","mag":"2039710093"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199810270-00232","doi":"https://doi.org/10.1097/00007890-199810270-00232","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199810270-00232","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006148077","display_name":"John M. Rabkin","orcid":"https://orcid.org/0000-0001-6606-4152","observed_orcids":["https://orcid.org/0000-0001-6606-4152"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Rabkin","raw_affiliation_strings":["Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017698587","display_name":"Susan L. Orloff","orcid":"https://orcid.org/0000-0001-6737-4638","observed_orcids":["https://orcid.org/0000-0001-6737-4638"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan L. Orloff","raw_affiliation_strings":["Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026593581","display_name":"Christopher L. Corless","orcid":"https://orcid.org/0000-0003-4871-8364","observed_orcids":["https://orcid.org/0000-0003-4871-8364"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher L. Corless","raw_affiliation_strings":["Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108440323","display_name":"Kent G. Benner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kent G. Benner","raw_affiliation_strings":["Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111673172","display_name":"Ken D. Flora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken D. Flora","raw_affiliation_strings":["Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012197289","display_name":"Hugo R. Rosen","orcid":"https://orcid.org/0000-0002-1110-6914","observed_orcids":["https://orcid.org/0000-0002-1110-6914"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hugo R. Rosen","raw_affiliation_strings":["Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102735910","display_name":"Ali J. Olyaei","orcid":"https://orcid.org/0000-0002-1631-8289","observed_orcids":["https://orcid.org/0000-0002-1631-8289"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali J. Olyaei","raw_affiliation_strings":["Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, Oregon","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22252045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":"8","first_page":"S51","last_page":"S51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-hepatitis-c","display_name":"recurrent hepatitis C","score":0.8479999899864197},{"id":"https://openalex.org/keywords/orthotopic-liver-transplantation","display_name":"orthotopic liver transplantation","score":0.906000018119812},{"id":"https://openalex.org/keywords/alcoholic-cirrhosis","display_name":"alcoholic cirrhosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/post-transplant-liver-disease","display_name":"post-transplant liver disease","score":0.5070000290870667},{"id":"https://openalex.org/keywords/allograft-failure","display_name":"allograft failure","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hcv-serology","display_name":"HCV serology","score":0.4740000069141388},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.4869999885559082},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9425293207168579},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6674305200576782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6636964082717896},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.5833575129508972},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5806328058242798},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.5625323057174683},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.5265501141548157},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.4947030246257782},{"id":"https://openalex.org/C2780732942","wikidata":"https://www.wikidata.org/wiki/Q3144986","display_name":"Alcoholic hepatitis","level":4,"score":0.43646323680877686},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.4177989065647125},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.41544464230537415},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.2962864637374878},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15127041935920715},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.05604797601699829},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00007890-199810270-00232","doi":"https://doi.org/10.1097/00007890-199810270-00232","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199810270-00232","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2412190570","https://openalex.org/W2081702039","https://openalex.org/W2059531645","https://openalex.org/W7099414833","https://openalex.org/W91576351","https://openalex.org/W154922294","https://openalex.org/W1986274014","https://openalex.org/W2062320843","https://openalex.org/W2978263087","https://openalex.org/W1976091382"],"abstract_inverted_index":{"202":[0],"Background:":[1],"Hepatitis":[2],"C":[3],"(HCV)":[4],"and":[5,62,105,125,154,175,179,210,264],"alcoholic":[6,43,82,126,265],"cirrhosis":[7,44,127,266],"are":[8],"common":[9],"indications":[10],"for":[11,182,212],"adult":[12],"orthotopic":[13],"liver":[14,167,191,203,292],"transplantation":[15],"(OLTx).":[16],"Recurrence":[17,197],"of":[18,29,38,42,49,71,74,81,93,114,162,198,219,221,262,271,277,283,291,297,308,311],"HCV":[19,50,120,124,144,199,222,230,250,263,278],"in":[20,234,255,268,288,300],"the":[21,36,46,160,163,269,289,295,305],"hepatic":[22,185],"allograft":[23,186],"post-OLTx":[24,223],"is":[25,33],"common.":[26],"The":[27,110,216,246,280],"Aim":[28],"this":[30],"retrospective":[31],"study":[32,111,164],"to":[34,103,135,249],"evaluate":[35],"effect":[37],"a":[39,69,78],"pre-OLTx":[40],"diagnosis":[41,70,80,261,276],"on":[45],"natural":[47],"history":[48],"recurrence":[51,220,251],"after":[52],"OLTx.":[53],"Methods:":[54],"309":[55],"consecutive":[56],"recipients":[57,67,76,257,272],"(327":[58],"OLTx)":[59],"between":[60],"10/91":[61],"6/96":[63],"were":[64,101,108,157,169,180],"reviewed.":[65],"105":[66],"had":[68,87,95],"HCV;":[72],"58":[73],"these":[75],"carried":[77],"concomitant":[79],"cirrhosis.":[83],"19":[84],"patients":[85,206],"who":[86],"either":[88,119],"died":[89],"within":[90],"6":[91,136],"months":[92,134,241],"transplant,":[94],"additional":[96],"etiologic":[97],"diagnoses":[98],"(not":[99],"alcohol),":[100],"lost":[102],"follow-up,":[104],"any":[106],"re-transplants":[107],"excluded.":[109],"population":[112],"consisted":[113],"86":[115],"OLTx":[116,178,256],"recipients,":[117],"with":[118,258,273,285],"alone":[121],"(n=34)":[122],"or":[123,190],"(n=52).":[128],"Followed":[129],"up":[130],"ranged":[131],"from":[132,229,304],"18":[133],"yrs":[137],"(mean":[138],"2.92":[139],"yrs,":[140],"median":[141],"2.8":[142],"yrs).":[143],"was":[145,188,200,224,242,252],"diagnosed":[146],"by":[147,202],"anti-HCV":[148],"antibody":[149],"serology;":[150],"both":[151],"ELISA":[152],"I":[153],"II":[155],"assays":[156],"employed":[158],"over":[159],"duration":[161],"period.":[165],"Protocol":[166],"biopsies":[168],"performed":[170],"at":[171],"weeks":[172],"1,":[173],"2,":[174],"52":[176],"following":[177,316],"obtained":[181],"cause":[183],"whenever":[184],"rejection":[187],"suspected":[189],"function":[192],"test":[193],"abnormalities":[194],"prompted":[195],"investigation.":[196],"documented":[201],"biopsy.":[204],"All":[205],"received":[207],"CSA,":[208],"AZA,":[209],"prednisone":[211],"maintenance":[213],"immunosuppression.":[214],"Results:":[215],"overall":[217],"incidence":[218],"83%":[225],"(71/86).":[226],"Allograft":[227],"failure":[228],"requiring":[231],"re-OLTx":[232],"occurred":[233],"4":[235],"patients.":[236],"Overall":[237],"mortality":[238],"beyond":[239],"six":[240],"7%":[243],"(6/86).":[244],"TableTableConclusion:":[245],"mean":[247],"time":[248],"significantly":[253],"shorter":[254],"an":[259,274],"initial":[260,275],"than":[267],"group":[270],"alone.":[279],"known":[281],"synergism":[282],"alcohol":[284,312],"viral":[286],"hepatitis":[287],"development":[290],"disease":[293],"raises":[294],"suspicion":[296],"persistent":[298],"changes":[299],"host":[301],"immune":[302],"characteristics":[303],"pre-transplant":[306],"consumption":[307],"excessive":[309],"quantities":[310],"and/or":[313],"unrecognized":[314],"recidivism":[315],"transplantation.":[317]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}