{"id":"https://openalex.org/W2039701065","doi":"https://doi.org/10.4155/fmc.14.115","title":"Isoxazolotacrines as Non-Toxic and Selective Butyrylcholinesterase Inhibitors for Alzheimer'S Disease","display_name":"Isoxazolotacrines as Non-Toxic and Selective Butyrylcholinesterase Inhibitors for Alzheimer'S Disease","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W2039701065","doi":"https://doi.org/10.4155/fmc.14.115","mag":"2039701065","pmid":"https://pubmed.ncbi.nlm.nih.gov/25495982"},"language":"en","primary_location":{"id":"doi:10.4155/fmc.14.115","doi":"https://doi.org/10.4155/fmc.14.115","is_oa":false,"landing_page_url":"https://doi.org/10.4155/fmc.14.115","pdf_url":null,"source":{"id":"https://openalex.org/S122867665","display_name":"Future Medicinal Chemistry","issn_l":"1756-8919","issn":["1756-8919","1756-8927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071423345","display_name":"Oussama Cherif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142899784","display_name":"University of Sfax","ror":"https://ror.org/04d4sd432","country_code":"TN","type":"education","lineage":["https://openalex.org/I142899784"]},{"id":"https://openalex.org/I4405252705","display_name":"Faculty of Sciences of Sfax","ror":"https://ror.org/01thp0k37","country_code":"TN","type":"education","lineage":["https://openalex.org/I142899784","https://openalex.org/I4405252705"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Oussama Cherif","raw_affiliation_strings":["Laboratoire de Chimie Appliqu\u00e9e: H\u00e9t\u00e9rocycles, Corps Gras et Polym\u00e8res Facult\u00e9 des Sciences de Sfax, Universit\u00e9 de Sfax, 3018Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Appliqu\u00e9e: H\u00e9t\u00e9rocycles, Corps Gras et Polym\u00e8res Facult\u00e9 des Sciences de Sfax, Universit\u00e9 de Sfax, 3018Sfax, Tunisia","institution_ids":["https://openalex.org/I142899784","https://openalex.org/I4405252705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020381877","display_name":"Fatma Allouche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142899784","display_name":"University of Sfax","ror":"https://ror.org/04d4sd432","country_code":"TN","type":"education","lineage":["https://openalex.org/I142899784"]},{"id":"https://openalex.org/I4405252705","display_name":"Faculty of Sciences of Sfax","ror":"https://ror.org/01thp0k37","country_code":"TN","type":"education","lineage":["https://openalex.org/I142899784","https://openalex.org/I4405252705"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Fatma Allouche","raw_affiliation_strings":["Laboratoire de Chimie Appliqu\u00e9e: H\u00e9t\u00e9rocycles, Corps Gras et Polym\u00e8res Facult\u00e9 des Sciences de Sfax, Universit\u00e9 de Sfax, 3018Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Appliqu\u00e9e: H\u00e9t\u00e9rocycles, Corps Gras et Polym\u00e8res Facult\u00e9 des Sciences de Sfax, Universit\u00e9 de Sfax, 3018Sfax, Tunisia","institution_ids":["https://openalex.org/I142899784","https://openalex.org/I4405252705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084469840","display_name":"Fakher Chabchoub","orcid":"https://orcid.org/0000-0003-4375-0277","observed_orcids":["https://orcid.org/0000-0003-4375-0277"]},"institutions":[{"id":"https://openalex.org/I142899784","display_name":"University of Sfax","ror":"https://ror.org/04d4sd432","country_code":"TN","type":"education","lineage":["https://openalex.org/I142899784"]},{"id":"https://openalex.org/I4405252705","display_name":"Faculty of Sciences of Sfax","ror":"https://ror.org/01thp0k37","country_code":"TN","type":"education","lineage":["https://openalex.org/I142899784","https://openalex.org/I4405252705"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Fakher Chabchoub","raw_affiliation_strings":["Laboratoire de Chimie Appliqu\u00e9e: H\u00e9t\u00e9rocycles, Corps Gras et Polym\u00e8res Facult\u00e9 des Sciences de Sfax, Universit\u00e9 de Sfax, 3018Sfax, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Appliqu\u00e9e: H\u00e9t\u00e9rocycles, Corps Gras et Polym\u00e8res Facult\u00e9 des Sciences de Sfax, Universit\u00e9 de Sfax, 3018Sfax, Tunisia","institution_ids":["https://openalex.org/I142899784","https://openalex.org/I4405252705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044493452","display_name":"Mourad Chioua","orcid":"https://orcid.org/0000-0002-8016-5459","observed_orcids":["https://orcid.org/0000-0002-8016-5459"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210121842","display_name":"Instituto de Qu\u00edmica M\u00e9dica","ror":"https://ror.org/02vznxv75","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210121842"]},{"id":"https://openalex.org/I4210162082","display_name":"Instituto de Qu\u00edmica Org\u00e1nica General","ror":"https://ror.org/05e0q7s59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210162082"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mourad Chioua","raw_affiliation_strings":["Laboratorio de Qu\u00edmica M\u00e9dica (IQOG, CSIC), C/Juan de la Cierva 3, 28006-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Qu\u00edmica M\u00e9dica (IQOG, CSIC), C/Juan de la Cierva 3, 28006-Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210121842","https://openalex.org/I4210162082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052444783","display_name":"Elena Soriano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210162082","display_name":"Instituto de Qu\u00edmica Org\u00e1nica General","ror":"https://ror.org/05e0q7s59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210162082"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Soriano","raw_affiliation_strings":["SEPCO, (IQOG, CSIC), Juan de la Cierva, 3, 28006-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SEPCO, (IQOG, CSIC), Juan de la Cierva, 3, 28006-Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210162082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071785591","display_name":"Matilde Y\u00e1\u00f1ez","orcid":"https://orcid.org/0000-0003-1965-3709","observed_orcids":["https://orcid.org/0000-0003-1965-3709"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Matilde Ya\u00f1ez","raw_affiliation_strings":["Facultad de Farmacia, Departamento de Farmacolog\u00eda, Universidad de Santiago de Compostela, Campus Vida, Santiago de Compostela, La Coru\u00f1a, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Farmacia, Departamento de Farmacolog\u00eda, Universidad de Santiago de Compostela, Campus Vida, Santiago de Compostela, La Coru\u00f1a, Spain","institution_ids":["https://openalex.org/I200284239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004538565","display_name":"Ram\u00f3n Cacabelos","orcid":"https://orcid.org/0000-0002-0554-4037","observed_orcids":["https://orcid.org/0000-0002-0554-4037"]},"institutions":[{"id":"https://openalex.org/I4210118861","display_name":"EuroEspes Biomedical Research Center","ror":"https://ror.org/02er0sb79","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210118861"]},{"id":"https://openalex.org/I59946547","display_name":"Camilo Jos\u00e9 Cela University","ror":"https://ror.org/03f6h9044","country_code":"ES","type":"education","lineage":["https://openalex.org/I59946547"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ram\u00f3n Cacabelos","raw_affiliation_strings":["C\u00e1tedra de Medicina Gen\u00f3mica, Universidad Camilo Jos\u00e9 Cela, 28692-Villafranca del Castillo, Madrid, Spain","EuroEspes Biomedical Research Center, Institute for CNS Disorders and Genomic Medicine,15166-La Coru\u00f1a, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C\u00e1tedra de Medicina Gen\u00f3mica, Universidad Camilo Jos\u00e9 Cela, 28692-Villafranca del Castillo, Madrid, Spain","institution_ids":["https://openalex.org/I59946547"]},{"raw_affiliation_string":"EuroEspes Biomedical Research Center, Institute for CNS Disorders and Genomic Medicine,15166-La Coru\u00f1a, Spain","institution_ids":["https://openalex.org/I4210118861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017542552","display_name":"Alejandro Romero","orcid":"https://orcid.org/0000-0001-5483-4973","observed_orcids":["https://orcid.org/0000-0001-5483-4973"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro Romero","raw_affiliation_strings":["Departamentode Toxicolog\u00eda y Farmacolog\u00eda, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040Madrid, Spain","InstitutoTe\u00f3filo Hernando and Departamento de Farmacolog\u00eda y Terap\u00e9ut\u00edca, Facultad de Medicina, Universidad Aut\u00f3noma de Madrid, C/Arzobispo Morcillo 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamentode Toxicolog\u00eda y Farmacolog\u00eda, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"InstitutoTe\u00f3filo Hernando and Departamento de Farmacolog\u00eda y Terap\u00e9ut\u00edca, Facultad de Medicina, Universidad Aut\u00f3noma de Madrid, C/Arzobispo Morcillo 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074411698","display_name":"Manuela G. L\u00f3pez","orcid":"https://orcid.org/0000-0003-4461-8788","observed_orcids":["https://orcid.org/0000-0003-4461-8788"]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuela G L\u00f3pez","raw_affiliation_strings":["InstitutoTe\u00f3filo Hernando and Departamento de Farmacolog\u00eda y Terap\u00e9ut\u00edca, Facultad de Medicina, Universidad Aut\u00f3noma de Madrid, C/Arzobispo Morcillo 4, 28029-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"InstitutoTe\u00f3filo Hernando and Departamento de Farmacolog\u00eda y Terap\u00e9ut\u00edca, Facultad de Medicina, Universidad Aut\u00f3noma de Madrid, C/Arzobispo Morcillo 4, 28029-Madrid, Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111604795","display_name":"Jose Luis Marco","orcid":"https://orcid.org/0000-0003-0690-0328","observed_orcids":["https://orcid.org/0000-0003-0690-0328"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210121842","display_name":"Instituto de Qu\u00edmica M\u00e9dica","ror":"https://ror.org/02vznxv75","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210121842"]},{"id":"https://openalex.org/I4210162082","display_name":"Instituto de Qu\u00edmica Org\u00e1nica General","ror":"https://ror.org/05e0q7s59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210162082"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Marco-Contelles","raw_affiliation_strings":["Laboratorio de Qu\u00edmica M\u00e9dica (IQOG, CSIC), C/Juan de la Cierva 3, 28006-Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Qu\u00edmica M\u00e9dica (IQOG, CSIC), C/Juan de la Cierva 3, 28006-Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210121842","https://openalex.org/I4210162082"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8811,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.69945118,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"17","first_page":"1883","last_page":"1891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/butyrylcholinesterase-inhibitors","display_name":"butyrylcholinesterase inhibitors","score":0.9520000219345093},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/multi-target-drugs","display_name":"multi-target drugs","score":0.7609999775886536},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.6830000281333923},{"id":"https://openalex.org/keywords/drug-likeness","display_name":"drug-likeness","score":0.7129999995231628},{"id":"https://openalex.org/keywords/molecular-modeling","display_name":"molecular modeling","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2779101902","wikidata":"https://www.wikidata.org/wiki/Q22679015","display_name":"Butyrylcholinesterase","level":5,"score":0.9307410717010498},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5775314569473267},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.5444175004959106},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5056400299072266},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.45577478408813477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42598623037338257},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33051803708076477},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.2888656258583069},{"id":"https://openalex.org/C2779059548","wikidata":"https://www.wikidata.org/wiki/Q383701","display_name":"Ach\u00e9","level":4,"score":0.20942389965057373},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19677239656448364},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17297649383544922},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17027366161346436}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013619","descriptor_name":"Tacrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013619","descriptor_name":"Tacrine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013619","descriptor_name":"Tacrine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4155/fmc.14.115","doi":"https://doi.org/10.4155/fmc.14.115","is_oa":false,"landing_page_url":"https://doi.org/10.4155/fmc.14.115","pdf_url":null,"source":{"id":"https://openalex.org/S122867665","display_name":"Future Medicinal Chemistry","issn_l":"1756-8919","issn":["1756-8919","1756-8927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:25495982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25495982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/111328","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/111328","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1526325397","https://openalex.org/W1629179716","https://openalex.org/W1940331911","https://openalex.org/W1965315991","https://openalex.org/W1965910452","https://openalex.org/W1966570892","https://openalex.org/W1971048984","https://openalex.org/W1976527379","https://openalex.org/W1995042037","https://openalex.org/W1995272223","https://openalex.org/W2000837493","https://openalex.org/W2003715018","https://openalex.org/W2016991826","https://openalex.org/W2018378808","https://openalex.org/W2038003364","https://openalex.org/W2042485050","https://openalex.org/W2044632501","https://openalex.org/W2052642773","https://openalex.org/W2054662854","https://openalex.org/W2060809301","https://openalex.org/W2071593129","https://openalex.org/W2092815169","https://openalex.org/W2104156437","https://openalex.org/W2104182950","https://openalex.org/W2105668062","https://openalex.org/W2111863354","https://openalex.org/W2112006614","https://openalex.org/W2116456566","https://openalex.org/W2125200386","https://openalex.org/W2126866334","https://openalex.org/W2130748975","https://openalex.org/W2144052800","https://openalex.org/W2159866533","https://openalex.org/W2766821062","https://openalex.org/W2917868259","https://openalex.org/W4239923351"],"related_works":["https://openalex.org/W2936023333","https://openalex.org/W2613036180","https://openalex.org/W3182694033","https://openalex.org/W3173048853","https://openalex.org/W2561560438","https://openalex.org/W4400868928","https://openalex.org/W2763760575","https://openalex.org/W2044695391","https://openalex.org/W4284708252","https://openalex.org/W4323926593"],"abstract_inverted_index":{"BACKGROUND:":[0],"Owing":[1],"to":[2,27,96],"the":[3,29,34,44,59,97,121],"complex":[4],"nature":[5],"of":[6,33,53,61,108,124],"Alzheimer's":[7,62,125],"disease,":[8],"there":[9],"is":[10,67],"a":[11,68],"renewed":[12],"and":[13,31,50,78],"growing":[14],"search":[15],"for":[16,58,120],"multitarget":[17],"non-toxic":[18],"tacrines":[19],"as":[20,55],"simple,":[21],"easily":[22],"available":[23],"drugs":[24,57],"in":[25,46,75],"order":[26],"stop":[28],"progress":[30],"development":[32],"disease.":[35,63,126],"RESULTS:":[36],"This":[37],"paper":[38],"describes":[39],"our":[40],"preliminary":[41],"results":[42],"on":[43],"synthesis,":[45],"vitro":[47],"biochemical":[48],"evaluation":[49],"molecular":[51],"modeling":[52],"isoxazolotacrines":[54],"potential":[56,122],"treatment":[60,123],"Novel":[64],"3-phenyl-5,6,7,8-tetrahydroisoxazolo[5,4-b]quinolin-4-amine":[65],"(OC41)":[66],"promising,":[69],"31%":[70],"less":[71],"toxic":[72],"than":[73],"tacrine":[74,111],"HepG2":[76],"cells,":[77],"selective":[79,114],"reversible":[80],"human":[81],"butyrylcholinesterase":[82,115],"inhibitor":[83],"(IC50":[84],"=":[85],"5.08":[86],"\u00b1":[87],"1.12":[88],"\u00b5M),":[89],"also":[90],"showing":[91,113],"good":[92],"drug-like":[93],"properties":[94],"according":[95],"absorption,":[98],"Distribution,":[99],"Metabolism,":[100],"Excretion,":[101],"Toxicity":[102],"analysis.":[103],"CONCLUSION:":[104],"A":[105],"new":[106],"family":[107],"non-hepatotoxic":[109],"permeable":[110],"analogs,":[112],"inhibition,":[116],"have":[117],"been":[118],"discovered":[119]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}