{"id":"https://openalex.org/W2039675975","doi":"https://doi.org/10.1002/(sici)1097-0231(199611)10:14<1792::aid-rcm753>3.0.co;2-n","title":"Accurate Mass Measurement of Oligonucleotides Using a Time-lag Focusing Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometer","display_name":"Accurate Mass Measurement of Oligonucleotides Using a Time-lag Focusing Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometer","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W2039675975","doi":"https://doi.org/10.1002/(sici)1097-0231(199611)10:14<1792::aid-rcm753>3.0.co;2-n","mag":"2039675975","pmid":"https://pubmed.ncbi.nlm.nih.gov/8953780"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0231(199611)10:14<1792::aid-rcm753>3.0.co;2-n","doi":"https://doi.org/10.1002/(sici)1097-0231(199611)10:14<1792::aid-rcm753>3.0.co;2-n","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0231(199611)10:14<1792::aid-rcm753>3.0.co;2-n","pdf_url":null,"source":{"id":"https://openalex.org/S89689683","display_name":"Rapid Communications in Mass Spectrometry","issn_l":"0951-4198","issn":["0951-4198","1097-0231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid Communications in Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102601222","display_name":"Yuqin Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yuqin Dai","raw_affiliation_strings":["Department of Chemistry, University of Alberta, Edmonton, Canada","Department of Chemistry, University of Alberta, Edmonton, Alberta, CANADA T6G 2G2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Department of Chemistry, University of Alberta, Edmonton, Alberta, CANADA T6G 2G2","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000523710","display_name":"Randy M. Whittal","orcid":"https://orcid.org/0000-0003-1174-8172","observed_orcids":["https://orcid.org/0000-0003-1174-8172"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Randy M. Whittal","raw_affiliation_strings":["Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420700","display_name":"Liang Li","orcid":"https://orcid.org/0000-0002-9347-2108","observed_orcids":["https://orcid.org/0000-0002-9347-2108"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Liang Li","raw_affiliation_strings":["Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045689433","display_name":"Scot R. Weinberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324840837","display_name":"Hewlett-Packard (United States)","ror":"https://ror.org/059rn9488","country_code":"US","type":"company","lineage":["https://openalex.org/I1324840837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scot R. Weinberger","raw_affiliation_strings":["California Analytical Division, Chemical Analysis Group, Hewlett-Packard Co., 1601 California Ave., Palo Alto, CA 94303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Analytical Division, Chemical Analysis Group, Hewlett-Packard Co., 1601 California Ave., Palo Alto, CA 94303, USA","institution_ids":["https://openalex.org/I1324840837"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100420700"],"corresponding_institution_ids":["https://openalex.org/I154425047"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":1.2161,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.74395492,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"10","issue":"14","first_page":"1792","last_page":"1796"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oligonucleotides","display_name":"oligonucleotides","score":0.902999997138977},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.4099999964237213},{"id":"https://openalex.org/keywords/accurate-mass-measurement","display_name":"accurate mass measurement","score":0.9169999957084656},{"id":"https://openalex.org/keywords/maldi-tof-mass-spectrometry","display_name":"MALDI-TOF mass spectrometry","score":0.8939999938011169},{"id":"https://openalex.org/keywords/adduct-ions","display_name":"adduct ions","score":0.9200000166893005},{"id":"https://openalex.org/keywords/external-calibration","display_name":"external calibration","score":0.9340000152587891},{"id":"https://openalex.org/keywords/calibrants","display_name":"calibrants","score":0.7649999856948853},{"id":"https://openalex.org/keywords/matrix-assisted-laser-desorption","display_name":"matrix-assisted laser desorption","score":0.6510000228881836},{"id":"https://openalex.org/keywords/sample-preparation","display_name":"sample preparation","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8364945650100708},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.8363926410675049},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.68655925989151},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5446107387542725},{"id":"https://openalex.org/C16291436","wikidata":"https://www.wikidata.org/wiki/Q874402","display_name":"Time-of-flight mass spectrometry","level":4,"score":0.523357093334198},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.46173274517059326},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.45586657524108887},{"id":"https://openalex.org/C167050937","wikidata":"https://www.wikidata.org/wiki/Q1661644","display_name":"Sample preparation in mass spectrometry","level":4,"score":0.44468748569488525},{"id":"https://openalex.org/C139883154","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Surface-enhanced laser desorption/ionization","level":5,"score":0.4330247640609741},{"id":"https://openalex.org/C198291218","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Ionization","level":3,"score":0.4243309199810028},{"id":"https://openalex.org/C162711632","wikidata":"https://www.wikidata.org/wiki/Q905514","display_name":"Desorption","level":3,"score":0.42410731315612793},{"id":"https://openalex.org/C98960154","wikidata":"https://www.wikidata.org/wiki/Q3983322","display_name":"Time of flight","level":2,"score":0.42183417081832886},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.3862230181694031},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.33241158723831177},{"id":"https://openalex.org/C40684141","wikidata":"https://www.wikidata.org/wiki/Q902061","display_name":"Electrospray ionization","level":3,"score":0.2060239613056183},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010848","descriptor_name":"Picolinic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1097-0231(199611)10:14<1792::aid-rcm753>3.0.co;2-n","doi":"https://doi.org/10.1002/(sici)1097-0231(199611)10:14<1792::aid-rcm753>3.0.co;2-n","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0231(199611)10:14<1792::aid-rcm753>3.0.co;2-n","pdf_url":null,"source":{"id":"https://openalex.org/S89689683","display_name":"Rapid Communications in Mass Spectrometry","issn_l":"0951-4198","issn":["0951-4198","1097-0231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid Communications in Mass Spectrometry","raw_type":"journal-article"},{"id":"pmid:8953780","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8953780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid communications in mass spectrometry : RCM","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306217","display_name":"Alliance for Cancer Gene Therapy","ror":"https://ror.org/00mms0j12"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1577361326","https://openalex.org/W1593030148","https://openalex.org/W2051335940","https://openalex.org/W2088374036","https://openalex.org/W2040033652","https://openalex.org/W2026748173","https://openalex.org/W1981873207","https://openalex.org/W1981051436","https://openalex.org/W1999489881","https://openalex.org/W1976026508"],"abstract_inverted_index":{"A":[0,110],"method":[1],"for":[2,62,162],"accurate":[3],"mass":[4,19,30,37,47,102,134,160],"measurement":[5,135,161],"of":[6,49,82,89,93,101,119,165],"oligonucleotides":[7],"up":[8],"to":[9,34,39],"a":[10,26,63,71,78,116,125,163],"DNA":[11,154,166],"35-mer":[12,67],"based":[13,104],"on":[14,98,105,124],"matrix-assisted":[15],"laser":[16],"desorption/ionization":[17],"(MALDI)":[18],"spectrometry":[20],"is":[21,32,128,131,168],"described.":[22,129],"In":[23],"this":[24],"method,":[25],"time-lag":[27],"focusing":[28],"time-of-flight":[29,75],"spectrometer":[31],"used":[33,97],"achieve":[35],"high":[36],"resolution":[38],"resolve":[40],"adduct":[41],"ions":[42],"that":[43,114,133],"often":[44],"complicate":[45],"the":[46,99],"analysis":[48],"oligonucleotides.":[50],"Mass":[51],"resolutions":[52],"between":[53],"1170":[54],"and":[55,66,95,121],"1300":[56],"(full":[57],"width":[58],"at":[59],"half":[60],"maximum)":[61],"17-mer,":[64],"23-mer,":[65],"are":[68,108],"obtained":[69,149],"using":[70],"1":[72],"m":[73],"linear":[74],"instrument":[76],"with":[77,141,150],"total":[79],"sample":[80,90,111,122],"loading":[81],"less":[83,137],"than":[84,138,144],"10":[85],"pmol.":[86],"The":[87],"effects":[88],"preparation,":[91],"type":[92],"calibrant":[94],"matrix":[96,120],"accuracy":[100],"measurement,":[103],"external":[106,157],"calibration,":[107],"discussed.":[109],"preparation":[112],"protocol":[113],"forms":[115],"thin":[117],"film":[118],"crystals":[123],"MALDI":[126],"probe":[127],"It":[130],"shown":[132],"error":[136],"100":[139],"ppm":[140,146],"reproducibility":[142],"better":[143],"+/-60":[145],"can":[147],"be":[148],"either":[151],"proteins":[152],"or":[153],"fragments":[155,167],"as":[156],"calibrants.":[158],"Accurate":[159],"mixture":[164],"also":[169],"illustrated.":[170]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}