{"id":"https://openalex.org/W2039635853","doi":"https://doi.org/10.1210/en.137.5.1991","title":"Transforming growth factor-beta 1 responsiveness of the rat osteocalcin gene is mediated by an activator protein-1 binding site","display_name":"Transforming growth factor-beta 1 responsiveness of the rat osteocalcin gene is mediated by an activator protein-1 binding site","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2039635853","doi":"https://doi.org/10.1210/en.137.5.1991","mag":"2039635853","pmid":"https://pubmed.ncbi.nlm.nih.gov/8612540"},"language":"en","primary_location":{"id":"doi:10.1210/en.137.5.1991","doi":"https://doi.org/10.1210/en.137.5.1991","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.137.5.1991","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073628813","display_name":"Chaitali Banerjee","orcid":"https://orcid.org/0000-0001-7668-5112","observed_orcids":["https://orcid.org/0000-0001-7668-5112"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Banerjee","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081119848","display_name":"Janet Lee Stein","orcid":"https://orcid.org/0000-0002-2474-6822","observed_orcids":["https://orcid.org/0000-0002-2474-6822"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Stein","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008755139","display_name":"Andr\u00e9 J. van Wijnen","orcid":"https://orcid.org/0000-0002-4458-0946","observed_orcids":["https://orcid.org/0000-0002-4458-0946"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A J Van Wijnen","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054966468","display_name":"Baruch Frenkel","orcid":"https://orcid.org/0000-0001-6295-6858","observed_orcids":["https://orcid.org/0000-0001-6295-6858"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Frenkel","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031362021","display_name":"Jane B. Lian","orcid":"https://orcid.org/0000-0001-8683-9138","observed_orcids":["https://orcid.org/0000-0001-8683-9138"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J B Lian","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110642660","display_name":"Gary Stephen Stein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G S Stein","raw_affiliation_strings":["Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":3.4084,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.93467189,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"137","issue":"5","first_page":"1991","last_page":"2000"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.12770000100135803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9549999833106995},{"id":"https://openalex.org/keywords/activator-protein-1","display_name":"activator protein-1","score":0.8190000057220459},{"id":"https://openalex.org/keywords/fra-2","display_name":"Fra-2","score":0.9380000233650208},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8090000152587891},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.5180000066757202},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.824999988079071},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.6029999852180481},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.7139999866485596},{"id":"https://openalex.org/keywords/ros-17-2-8-cells","display_name":"ROS 17/2.8 cells","score":0.875}],"concepts":[{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.6073381900787354},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.5822961926460266},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5552451610565186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5418742895126343},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.5413306951522827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5199255347251892},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5170929431915283},{"id":"https://openalex.org/C2780730277","wikidata":"https://www.wikidata.org/wiki/Q24744759","display_name":"Chloramphenicol acetyltransferase","level":5,"score":0.48134860396385193},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.42579221725463867},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.38618797063827515},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3523591160774231},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.31471946835517883},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24397650361061096},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.24212795495986938},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11315402388572693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.093828946352005},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0831352174282074}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051921","descriptor_name":"Fos-Related Antigen-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1210/en.137.5.1991","doi":"https://doi.org/10.1210/en.137.5.1991","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.137.5.1991","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/endo.137.5.8612540","doi":"https://doi.org/10.1210/endo.137.5.8612540","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.137.5.8612540","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:8612540","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8612540","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:gsbs_sp-1074","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/gsbs_sp/75","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Morningside Graduate School of Biomedical Sciences Student Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2729082053","display_name":null,"funder_award_id":"AR33920","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4172909306","display_name":"SYNTHESIS OF OSTEOCALCIN IN BONE","funder_award_id":"5r01ar033920-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G57866040","display_name":null,"funder_award_id":"AR 39588","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6723465385","display_name":"Control of Osteoblast Proliferation and Differentiation","funder_award_id":"R01AR039588","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1488596745","https://openalex.org/W1489573122","https://openalex.org/W1543126301","https://openalex.org/W1584215988","https://openalex.org/W1610710421","https://openalex.org/W1811606715","https://openalex.org/W1906149319","https://openalex.org/W1980968239","https://openalex.org/W1993243592","https://openalex.org/W1994937757","https://openalex.org/W2007768242","https://openalex.org/W2013413602","https://openalex.org/W2077046161","https://openalex.org/W2077708138","https://openalex.org/W2085824396","https://openalex.org/W2097794242","https://openalex.org/W2120248091","https://openalex.org/W2130535740","https://openalex.org/W2136819827","https://openalex.org/W2144206181","https://openalex.org/W2232407802"],"related_works":["https://openalex.org/W104613051","https://openalex.org/W2145332575","https://openalex.org/W2047076201","https://openalex.org/W2080119418","https://openalex.org/W2051695848","https://openalex.org/W2289676906","https://openalex.org/W2120248091","https://openalex.org/W2008187858","https://openalex.org/W2002773456","https://openalex.org/W2052863582"],"abstract_inverted_index":{"Osteocalcin":[0],"(OC),":[1],"a":[2,154,200,252],"bone":[3,13,42],"specific":[4],"protein":[5,202],"expressed":[6],"during":[7],"differentiation":[8],"and":[9,44,92,141,146,149,174],"mineralization":[10],"of":[11,31,41,51,63,83,120,134,170,191,197,211,224,260,265],"the":[12,28,48,52,96,106,135,171,212,225,263],"extracellular":[14],"matrix,":[15],"is":[16,167,185,233],"down-regulated":[17],"upon":[18,187],"treatment":[19,73,190,196],"with":[20,199,244,251],"transforming":[21],"growth":[22],"factor":[23],"(TGF)-beta":[24],"1.":[25],"To":[26],"address":[27],"potential":[29],"role":[30,254],"OC":[32,54,65,111,172,213,266],"gene":[33,228,267],"expression":[34],"in":[35,80,114,229,262],"relation":[36],"to":[37,105,108,128,160],"TGF-beta":[38,57,71,97,102,131,175,188,207,221,256],"1":[39,58,72,98,103,132,176,189,208,222,257],"regulation":[40],"formation":[43],"resorption,":[45],"we":[46],"examined":[47],"transcriptional":[49],"activity":[50,77],"rat":[53,64,110,226],"promoter":[55,113,214],"after":[56],"treatment.":[59],"5'":[60],"deletion":[61],"analysis":[62],"promoter-chloramphenicol":[66],"acetyltransferase":[67,76],"constructs":[68],"demonstrated":[69],"that":[70,152,165,183,220,242],"repressed":[74],"chloramphenicol":[75],"by":[78],"2.4-fold":[79],"transient":[81],"transfections":[82],"ROS":[84,192,230],"17/2.8":[85,193,231],"cells.":[86,194],"A":[87],"29-bp":[88],"region":[89],"between":[90],"-162":[91],"-134":[93],"identified":[94],"as":[95],"response":[99],"domain,":[100],"conferred":[101],"responsiveness":[104,133,223],"-108":[107],"+24":[109],"basal":[112],"an":[115,121,168,236],"orientation":[116],"dependent":[117],"manner.":[118],"Mutation":[119],"activator":[122,169,237],"protein-1/cAMP-response":[123],"element-like":[124],"motif":[125],"(-":[126],"146":[127],"-139)":[129],"abolished":[130],"construct.":[136],"In":[137],"vitro":[138],"gel-mobility":[139],"shift":[140],"competition":[142],"assays":[143],"using":[144],"wild-type":[145],"mutated":[147],"oligonucleotides":[148],"antibodies":[150],"indicate":[151],"Fra-2,":[153],"Fos":[155],"related":[156],"transcription":[157],"factor,":[158],"binds":[159],"this":[161,178],"motif.":[162],"We":[163],"show":[164],"Fra-2":[166,184,261],"promoter,":[173],"inhibits":[177],"activation.":[179],"Our":[180],"results":[181,218,248],"demonstrate":[182,219],"hyperphosphorylated":[186],"Additionally,":[195],"cells":[198,232],"staurosporine":[201],"kinase":[203],"C":[204],"inhibitor":[205],"abrogates":[206],"mediated":[209,234],"down-regulation":[210],"activity.":[215],"Together,":[216],"these":[217],"osteocalcin":[227],"through":[235],"protein-1":[238],"like":[239],"cis-acting":[240],"element":[241],"interacts":[243],"Fra-2.":[245],"Furthermore,":[246],"our":[247],"are":[249],"consistent":[250],"critical":[253],"for":[255],"induced":[258],"phosphorylation":[259],"repression":[264],"transcription.":[268]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
