{"id":"https://openalex.org/W2039627167","doi":"https://doi.org/10.1371/journal.pgen.0030114","title":"Imputation-Based Analysis of Association Studies: Candidate Regions and Quantitative Traits","display_name":"Imputation-Based Analysis of Association Studies: Candidate Regions and Quantitative Traits","publication_year":2007,"publication_date":"2007-07-25","ids":{"openalex":"https://openalex.org/W2039627167","doi":"https://doi.org/10.1371/journal.pgen.0030114","mag":"2039627167","pmid":"https://pubmed.ncbi.nlm.nih.gov/17676998","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1934390"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.0030114","doi":"https://doi.org/10.1371/journal.pgen.0030114","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.0030114","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030114&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030114&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064091393","display_name":"Bertrand Servin","orcid":"https://orcid.org/0000-0001-5141-0913","observed_orcids":["https://orcid.org/0000-0001-5141-0913"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210153075","display_name":"Laboratoire de G\u00e9n\u00e9tique Cellulaire","ror":"https://ror.org/05k317v03","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210153075"]}],"countries":["FR","US"],"is_corresponding":true,"raw_author_name":"Bertrand Servin","raw_affiliation_strings":["Department of Statistics, University of Washington, Seattle, Washington, United States of America. bservin@toulouse.inra.fr","Department of Statistics (University of Washington Department of Statistics Box 354322 Seattle, WA 98195-4322 U.S.A. - \u00c9tats-Unis)","LGC - Laboratoire de G\u00e9n\u00e9tique Cellulaire (23 Chemin des Capelles BP 87614 31076 Toulouse Cedex 3 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, University of Washington, Seattle, Washington, United States of America. bservin@toulouse.inra.fr","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Statistics (University of Washington Department of Statistics Box 354322 Seattle, WA 98195-4322 U.S.A. - \u00c9tats-Unis)","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"LGC - Laboratoire de G\u00e9n\u00e9tique Cellulaire (23 Chemin des Capelles BP 87614 31076 Toulouse Cedex 3 - France)","institution_ids":["https://openalex.org/I4210153075"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036504609","display_name":"Matthew Stephens","orcid":"https://orcid.org/0000-0001-5397-9257","observed_orcids":["https://orcid.org/0000-0001-5397-9257"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Stephens","raw_affiliation_strings":["Department of Statistics, University of Washington, Seattle, Washington, United States of America","Department of Statistics (University of Washington Department of Statistics Box 354322 Seattle, WA 98195-4322 U.S.A. - \u00c9tats-Unis)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Statistics (University of Washington Department of Statistics Box 354322 Seattle, WA 98195-4322 U.S.A. - \u00c9tats-Unis)","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064091393"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210153075"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":23.0138,"has_fulltext":true,"cited_by_count":517,"citation_normalized_percentile":{"value":0.9975048,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"3","issue":"7","first_page":"e114","last_page":"e114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genotype-imputation","display_name":"genotype imputation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/association-studies","display_name":"association studies","score":0.6430000066757202},{"id":"https://openalex.org/keywords/tag-snps","display_name":"tag SNPs","score":0.7549999952316284},{"id":"https://openalex.org/keywords/candidate-genomic-regions","display_name":"candidate genomic regions","score":0.6050000190734863},{"id":"https://openalex.org/keywords/quantitative-traits","display_name":"quantitative traits","score":0.9549999833106995},{"id":"https://openalex.org/keywords/statistical-power","display_name":"statistical power","score":0.5920000076293945},{"id":"https://openalex.org/keywords/causal-variant-identification","display_name":"causal variant identification","score":0.6200000047683716},{"id":"https://openalex.org/keywords/hapmap","display_name":"HapMap","score":0.7089999914169312},{"id":"https://openalex.org/keywords/whole-genome-association-studies","display_name":"whole-genome association studies","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C177580304","wikidata":"https://www.wikidata.org/wiki/Q1147298","display_name":"International HapMap Project","level":5,"score":0.7848224639892578},{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.7325578331947327},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6964454650878906},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.6843571066856384},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6680155992507935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.660172164440155},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6391679048538208},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49762943387031555},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.4681691527366638},{"id":"https://openalex.org/C2994538360","wikidata":"https://www.wikidata.org/wiki/Q774081","display_name":"Association test","level":5,"score":0.46758174896240234},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.4658791422843933},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45446908473968506},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.4223417639732361},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3782760798931122},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.24096432328224182},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.2140529751777649},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18465808033943176},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10088253021240234}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pgen.0030114","doi":"https://doi.org/10.1371/journal.pgen.0030114","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.0030114","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030114&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1934390","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1934390","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:17676998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17676998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02662573v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-02662573","pdf_url":"https://hal.inrae.fr/hal-02662573/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.plosgenetics.org/","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.279.4452","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.279.4452","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/43/86/PLoS_Genet_2007_Jul_27_3(7)_e114.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:29a5a68b0c434f19b9226202e31c2005","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/29a5a68b0c434f19b9226202e31c2005","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 3, Iss 7, p e114 (2007)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/151905","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Imputation_Based_Analysis_of_Association_Studies_Candidate_Regions_and_Quantitative_Traits/151905","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.0030114","doi":"https://doi.org/10.1371/journal.pgen.0030114","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.0030114","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030114&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8799834844","display_name":null,"funder_award_id":"R01 HG02585-01","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000171115","display_name":null,"funder_award_id":"HG02585","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000879013","display_name":"Genome analysis:  statistical methods and applications","funder_award_id":"R01HG002585","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2039627167.pdf","grobid_xml":"https://content.openalex.org/works/W2039627167.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W171292237","https://openalex.org/W1577941315","https://openalex.org/W1962960380","https://openalex.org/W1971771243","https://openalex.org/W1982220354","https://openalex.org/W1989321129","https://openalex.org/W1990059547","https://openalex.org/W1991882349","https://openalex.org/W2002790383","https://openalex.org/W2006681603","https://openalex.org/W2015408724","https://openalex.org/W2021051417","https://openalex.org/W2024622153","https://openalex.org/W2025843662","https://openalex.org/W2031082289","https://openalex.org/W2051458787","https://openalex.org/W2064994526","https://openalex.org/W2074282020","https://openalex.org/W2086510608","https://openalex.org/W2097226958","https://openalex.org/W2107104883","https://openalex.org/W2110755408","https://openalex.org/W2115335486","https://openalex.org/W2115837368","https://openalex.org/W2157288342","https://openalex.org/W2162468038","https://openalex.org/W2171669685","https://openalex.org/W2217809488","https://openalex.org/W4211177544","https://openalex.org/W7075647632"],"related_works":["https://openalex.org/W6958469598","https://openalex.org/W6939790886","https://openalex.org/W2081221567","https://openalex.org/W6902202971","https://openalex.org/W2274194468","https://openalex.org/W7097776656","https://openalex.org/W2149791927","https://openalex.org/W2057930084","https://openalex.org/W2104742476","https://openalex.org/W2416189753"],"abstract_inverted_index":{"We":[0],"introduce":[1],"a":[2,26,50,63,156,161,182],"new":[3],"framework":[4,165],"for":[5,23,124,129,171],"the":[6,42,77,102,108,132,135,164,188],"analysis":[7],"of":[8,36,53,134],"association":[9,24,75,150,174],"studies,":[10],"designed":[11],"to":[12,16,31,67,94],"allow":[13],"untyped":[14],"variants":[15,115],"be":[17],"more":[18,121],"effectively":[19],"and":[20,72,79,155,168],"directly":[21],"tested":[22],"with":[25,55,84,107,152],"phenotype.":[27],"The":[28],"idea":[29],"is":[30,105,144,166],"combine":[32],"knowledge":[33],"on":[34,62,149],"patterns":[35],"correlation":[37],"among":[38],"SNPs":[39,60],"(e.g.,":[40,160],"from":[41,187],"International":[43],"HapMap":[44],"project":[45],"or":[46],"resequencing":[47],"data":[48,57],"in":[49,91,98,100,181],"candidate":[51,162],"region":[52,159],"interest)":[54],"genotype":[56],"at":[58],"tag":[59],"collected":[61],"phenotyped":[64],"study":[65],"sample,":[66],"estimate":[68],"(\"impute\")":[69],"unmeasured":[70],"genotypes,":[71],"then":[73],"assess":[74],"between":[76],"phenotype":[78,154],"these":[80],"estimated":[81],"genotypes.":[82],"Compared":[83],"standard":[85],"single-SNP":[86],"tests,":[87],"this":[88],"approach":[89],"results":[90],"increased":[92],"power":[93],"detect":[95],"association,":[96],"even":[97],"cases":[99],"which":[101],"causal":[103,114],"variant":[104],"typed,":[106],"greatest":[109],"gain":[110],"occurring":[111],"when":[112],"multiple":[113],"are":[116,179],"present.":[117],"It":[118],"also":[119],"provides":[120],"interpretable":[122],"explanations":[123],"observed":[125],"associations,":[126],"including":[127],"assessing,":[128],"each":[130],"SNP,":[131],"strength":[133],"evidence":[136],"that":[137],"it":[138],"(rather":[139],"than":[140],"another":[141],"correlated":[142],"SNP)":[143],"causal.":[145],"Although":[146],"we":[147],"focus":[148],"studies":[151],"quantitative":[153],"relatively":[157],"restricted":[158],"gene),":[163],"applicable":[167],"computationally":[169],"practical":[170],"whole":[172],"genome":[173],"studies.":[175],"Methods":[176],"described":[177],"here":[178],"implemented":[180],"software":[183],"package,":[184],"Bim-Bam,":[185],"available":[186],"Stephens":[189],"Lab":[190],"website":[191],"http://stephenslab.uchicago.edu/software.html.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":35},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":39},{"year":2012,"cited_by_count":34}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}