{"id":"https://openalex.org/W2039616482","doi":"https://doi.org/10.1016/0006-2952(77)90218-0","title":"Effects of disulfiram and chloral hydrate on the metabolism of catecholamines in rat liver and brain","display_name":"Effects of disulfiram and chloral hydrate on the metabolism of catecholamines in rat liver and brain","publication_year":1977,"publication_date":"1977-04-01","ids":{"openalex":"https://openalex.org/W2039616482","doi":"https://doi.org/10.1016/0006-2952(77)90218-0","mag":"2039616482","pmid":"https://pubmed.ncbi.nlm.nih.gov/856206"},"language":"en","primary_location":{"id":"doi:10.1016/0006-2952(77)90218-0","doi":"https://doi.org/10.1016/0006-2952(77)90218-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(77)90218-0","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078784159","display_name":"Denis Berger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denis Berger","raw_affiliation_strings":["Department of Biochemistry, Purdue University, West Lafayette, IN 47907, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Purdue University, West Lafayette, IN 47907, U.S.A","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012958448","display_name":"Henry Weiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry Weiner","raw_affiliation_strings":["Department of Biochemistry, Purdue University, West Lafayette, IN 47907, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Purdue University, West Lafayette, IN 47907, U.S.A","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":2.6307,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.88621964,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"26","issue":"8","first_page":"741","last_page":"747"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.062199998646974564,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disulfiram","display_name":"disulfiram","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chloral-hydrate","display_name":"chloral hydrate","score":1.0},{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase-inhibition","display_name":"aldehyde dehydrogenase inhibition","score":0.9629999995231628},{"id":"https://openalex.org/keywords/catecholamine-metabolism","display_name":"catecholamine metabolism","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dopamine-metabolism","display_name":"dopamine metabolism","score":0.7990000247955322},{"id":"https://openalex.org/keywords/noradrenaline-metabolism","display_name":"noradrenaline metabolism","score":0.9810000061988831},{"id":"https://openalex.org/keywords/dopac","display_name":"DOPAC","score":0.9760000109672546},{"id":"https://openalex.org/keywords/homovanillic-acid","display_name":"homovanillic acid","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tetrahydropapaveroline","display_name":"tetrahydropapaveroline","score":0.9120000004768372},{"id":"https://openalex.org/keywords/acetaldehyde-oxidation","display_name":"acetaldehyde oxidation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.6510000228881836},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C2777612814","wikidata":"https://www.wikidata.org/wiki/Q412340","display_name":"Chloral hydrate","level":2,"score":0.7872946262359619},{"id":"https://openalex.org/C2778523461","wikidata":"https://www.wikidata.org/wiki/Q409665","display_name":"Disulfiram","level":2,"score":0.7682228088378906},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7112197875976562},{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.6926334500312805},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6782139539718628},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6446197628974915},{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.5309996604919434},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5083405375480652},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4586276412010193},{"id":"https://openalex.org/C145782189","wikidata":"https://www.wikidata.org/wiki/Q628025","display_name":"Deamination","level":3,"score":0.43839913606643677},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43467968702316284},{"id":"https://openalex.org/C2775950743","wikidata":"https://www.wikidata.org/wiki/Q422755","display_name":"Chloral","level":2,"score":0.4157823324203491},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40846502780914307},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3745806813240051},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.28577160835266113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2010883390903473},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13671866059303284},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000445","descriptor_name":"Aldehyde Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002697","descriptor_name":"Chloral Hydrate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004221","descriptor_name":"Disulfiram","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006719","descriptor_name":"Homovanillic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015102","descriptor_name":"3,4-Dihydroxyphenylacetic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-2952(77)90218-0","doi":"https://doi.org/10.1016/0006-2952(77)90218-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(77)90218-0","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:856206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/856206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W993173766","https://openalex.org/W1526596922","https://openalex.org/W1555217358","https://openalex.org/W1589027452","https://openalex.org/W1598486575","https://openalex.org/W1982557686","https://openalex.org/W2002865586","https://openalex.org/W2006916132","https://openalex.org/W2057605956","https://openalex.org/W2059577220","https://openalex.org/W2094270126","https://openalex.org/W2121621243","https://openalex.org/W2156895606","https://openalex.org/W2260071057","https://openalex.org/W6631630573"],"related_works":["https://openalex.org/W2038319802","https://openalex.org/W2044761523","https://openalex.org/W2029155129","https://openalex.org/W2129115991","https://openalex.org/W2062083208","https://openalex.org/W2012882007","https://openalex.org/W2412326327","https://openalex.org/W7098931853","https://openalex.org/W2159385868","https://openalex.org/W1973512913"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}