{"id":"https://openalex.org/W2039476992","doi":"https://doi.org/10.1093/jac/24.5.657","title":"An increase in the antimicrobial activity in vitro of fosfomycin under anaerobic conditions","display_name":"An increase in the antimicrobial activity in vitro of fosfomycin under anaerobic conditions","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2039476992","doi":"https://doi.org/10.1093/jac/24.5.657","mag":"2039476992","pmid":"https://pubmed.ncbi.nlm.nih.gov/2599990"},"language":"en","primary_location":{"id":"doi:10.1093/jac/24.5.657","doi":"https://doi.org/10.1093/jac/24.5.657","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/24.5.657","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103638098","display_name":"Shigeharu Inouye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405275510","display_name":"Meiji Seika Pharma Co., Ltd. (Japan)","ror":"https://ror.org/03qt4xn36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275510"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeharu Inouye","raw_affiliation_strings":["Central Research Laboratories, Meiji Seika Kaisha, Ltd., Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratories, Meiji Seika Kaisha, Ltd., Yokohama, Japan","institution_ids":["https://openalex.org/I4405275510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112210748","display_name":"Tadahiro Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405275510","display_name":"Meiji Seika Pharma Co., Ltd. (Japan)","ror":"https://ror.org/03qt4xn36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275510"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadahiro Watanabe","raw_affiliation_strings":["Research & Development, Meiji Seika Kaisha Ltd Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research & Development, Meiji Seika Kaisha Ltd Tokyo, Japan","institution_ids":["https://openalex.org/I4405275510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033069282","display_name":"Tsutomu Tsuruoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405275510","display_name":"Meiji Seika Pharma Co., Ltd. (Japan)","ror":"https://ror.org/03qt4xn36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275510"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Tsuruoka","raw_affiliation_strings":["Research & Development, Meiji Seika Kaisha Ltd Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research & Development, Meiji Seika Kaisha Ltd Tokyo, Japan","institution_ids":["https://openalex.org/I4405275510"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054765847","display_name":"Ichiro Kitasato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405275510","display_name":"Meiji Seika Pharma Co., Ltd. (Japan)","ror":"https://ror.org/03qt4xn36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275510"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichiro Kitasato","raw_affiliation_strings":["Research & Development, Meiji Seika Kaisha Ltd Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research & Development, Meiji Seika Kaisha Ltd Tokyo, Japan","institution_ids":["https://openalex.org/I4405275510"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405275510"],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":0.3931,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.53468829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"24","issue":"5","first_page":"657","last_page":"666"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.6381999850273132,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.6381999850273132,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.07649999856948853,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.07569999992847443,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fosfomycin","display_name":"fosfomycin","score":1.0},{"id":"https://openalex.org/keywords/anaerobic-conditions","display_name":"anaerobic conditions","score":0.8799999952316284},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.9120000004768372},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/redox-potential","display_name":"redox potential","score":0.796999990940094},{"id":"https://openalex.org/keywords/agar-medium","display_name":"agar medium","score":0.6639999747276306},{"id":"https://openalex.org/keywords/bacteriolytic-activity","display_name":"bacteriolytic activity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/drug-uptake","display_name":"drug uptake","score":0.5680000185966492},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.6970000267028809},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C2778897966","wikidata":"https://www.wikidata.org/wiki/Q183554","display_name":"Fosfomycin","level":3,"score":0.9811795949935913},{"id":"https://openalex.org/C5140985","wikidata":"https://www.wikidata.org/wiki/Q483866","display_name":"Anaerobic exercise","level":2,"score":0.8604227304458618},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7328928709030151},{"id":"https://openalex.org/C2778660310","wikidata":"https://www.wikidata.org/wiki/Q177998","display_name":"Agar","level":3,"score":0.6060130596160889},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5932953953742981},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5925000905990601},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.46766769886016846},{"id":"https://openalex.org/C62643968","wikidata":"https://www.wikidata.org/wiki/Q574816","display_name":"Agar plate","level":3,"score":0.4333703815937042},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2864401340484619},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24474763870239258},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.06171116232872009},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000693","descriptor_name":"Anaerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005578","descriptor_name":"Fosfomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005578","descriptor_name":"Fosfomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005958","descriptor_name":"Glucosephosphates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006094","descriptor_name":"Gram-Positive Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jac/24.5.657","doi":"https://doi.org/10.1093/jac/24.5.657","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/24.5.657","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmid:2599990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2599990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W151017840","https://openalex.org/W2021127967","https://openalex.org/W2172527305","https://openalex.org/W2057332990","https://openalex.org/W2422828501","https://openalex.org/W2043847740","https://openalex.org/W7097065421","https://openalex.org/W2123039629","https://openalex.org/W3191252707","https://openalex.org/W2079671030"],"abstract_inverted_index":{"Fosfomycin":[0],"showed":[1],"lower":[2],"MIC":[3],"values":[4,126],"under":[5,11],"anaerobic":[6,74,112],"culture":[7,32,75],"conditions":[8,13],"than":[9,119],"those":[10],"aerobic":[12,121],"for":[14],"four":[15],"Gram-positive":[16],"and":[17,34],"18":[18],"Gram-negative":[19],"bacterial":[20],"isolates.":[21],"The":[22,37,66,111],"degree":[23],"of":[24,55,68,71,82,89,91,102,114],"change":[25,81,88],"in":[26,40,46,51,64,73,93,109,127],"MICs":[27,113,122],"was":[28,61,76],"dependent":[29],"on":[30],"the":[31,41,49,52,56,69,80,87,100,105,120,124],"media":[33],"strains":[35],"tested.":[36],"growth-inhibitory":[38],"diameter":[39],"paper":[42],"disc":[43],"assay":[44],"increased":[45,108],"parallel":[47],"with":[48,123],"decrease":[50],"redox":[53],"potential":[54],"agar":[57],"medium.":[58],"Bacteriolytic":[59],"activity":[60],"also":[62],"potentiated":[63],"anaerobiosis.":[65,110],"increase":[67],"bio-activity":[70],"fosfomycin":[72,103,115],"neither":[77],"due":[78],"to":[79,86],"medium":[83],"pH":[84],"nor":[85],"mobility":[90],"drug":[92],"agar.":[94],"However":[95],"it":[96],"is":[97],"possible":[98],"that":[99],"uptake":[101],"through":[104],"cell":[106],"membrane":[107],"were":[116],"better":[117],"correlated":[118],"ED50":[125],"a":[128],"mouse":[129],"systemic":[130],"infection":[131],"model.":[132]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
