{"id":"https://openalex.org/W2039450652","doi":"https://doi.org/10.1046/j.1460-9568.2003.02590.x","title":"The ability of atypical antipsychotic drugs vs. haloperidol to protect PC12 cells against MPP+\u2010induced apoptosis","display_name":"The ability of atypical antipsychotic drugs vs. haloperidol to protect PC12 cells against MPP+\u2010induced apoptosis","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W2039450652","doi":"https://doi.org/10.1046/j.1460-9568.2003.02590.x","mag":"2039450652","pmid":"https://pubmed.ncbi.nlm.nih.gov/12752374"},"language":"en","primary_location":{"id":"doi:10.1046/j.1460-9568.2003.02590.x","doi":"https://doi.org/10.1046/j.1460-9568.2003.02590.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1460-9568.2003.02590.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048869783","display_name":"Hong Qing","orcid":"https://orcid.org/0000-0003-2820-450X","observed_orcids":["https://orcid.org/0000-0003-2820-450X","https://orcid.org/0000-0003-0216-4044"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hong Qing","raw_affiliation_strings":["Neuropsychiatric Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropsychiatric Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046703379","display_name":"Haiyun Xu","orcid":"https://orcid.org/0000-0002-0752-6502","observed_orcids":["https://orcid.org/0000-0002-0752-6502","https://orcid.org/0009-0002-4778-3906"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Haiyun Xu","raw_affiliation_strings":["H.Q. and H.X. contributed equally to this work","Neuropsychiatric Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H.Q. and H.X. contributed equally to this work","institution_ids":[]},{"raw_affiliation_string":"Neuropsychiatric Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113964974","display_name":"Zelan Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Zelan Wei","raw_affiliation_strings":["Neuropsychiatric Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropsychiatric Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046374045","display_name":"Kurt Gibson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kurt Gibson","raw_affiliation_strings":["Neuropsychiatric Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropsychiatric Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001211894","display_name":"Xin\u2010Min Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Xin\u2010Min Li","raw_affiliation_strings":["Neuropsychiatric Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropsychiatric Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada","institution_ids":["https://openalex.org/I32625721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001211894"],"corresponding_institution_ids":["https://openalex.org/I32625721"],"apc_list":{"value":3560,"currency":"USD","value_usd":3560},"apc_paid":null,"fwci":8.7208,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.9832364,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"8","first_page":"1563","last_page":"1570"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.921999990940094},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mpp","display_name":"MPP+","score":0.7279999852180481},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.5879999995231628},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.7850000262260437},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9010000228881836},{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":0.7099999785423279},{"id":"https://openalex.org/keywords/olanzapine","display_name":"olanzapine","score":1.0},{"id":"https://openalex.org/keywords/quetiapine","display_name":"quetiapine","score":1.0},{"id":"https://openalex.org/keywords/risperidone","display_name":"risperidone","score":1.0},{"id":"https://openalex.org/keywords/copper-zinc-superoxide-dismutase","display_name":"copper-zinc superoxide dismutase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7020000219345093},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5509999990463257},{"id":"https://openalex.org/keywords/dna-glycosylase","display_name":"DNA glycosylase","score":0.7429999709129333},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.3869999945163727},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.7630220651626587},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6904963254928589},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.5335968136787415},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5216458439826965},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.4754502475261688},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4682168960571289},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.39027294516563416},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3649033308029175},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3434043228626251},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2862705588340759},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24695664644241333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15924367308616638},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12724089622497559},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.10307639837265015},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006220","descriptor_name":"Haloperidol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006220","descriptor_name":"Haloperidol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006220","descriptor_name":"Haloperidol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006540","descriptor_name":"Herbicides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006540","descriptor_name":"Herbicides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006540","descriptor_name":"Herbicides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015655","descriptor_name":"1-Methyl-4-phenylpyridinium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015655","descriptor_name":"1-Methyl-4-phenylpyridinium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015655","descriptor_name":"1-Methyl-4-phenylpyridinium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1460-9568.2003.02590.x","doi":"https://doi.org/10.1046/j.1460-9568.2003.02590.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1460-9568.2003.02590.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:12752374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12752374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European journal of neuroscience","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.75}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319919","display_name":"Saskatchewan Health Research Foundation","ror":"https://ror.org/00trnds81"},{"id":"https://openalex.org/F4320319934","display_name":"Canadian Psychiatric Research Foundation","ror":"https://ror.org/04n2kg767"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W948550917","https://openalex.org/W1594355831","https://openalex.org/W1891659218","https://openalex.org/W1973818091","https://openalex.org/W1973895407","https://openalex.org/W1978406998","https://openalex.org/W1980118507","https://openalex.org/W1982539986","https://openalex.org/W1984290310","https://openalex.org/W1995166208","https://openalex.org/W1998385128","https://openalex.org/W1998555371","https://openalex.org/W2002904952","https://openalex.org/W2006916686","https://openalex.org/W2014498028","https://openalex.org/W2018388019","https://openalex.org/W2020744120","https://openalex.org/W2024539177","https://openalex.org/W2025693768","https://openalex.org/W2028912128","https://openalex.org/W2033314408","https://openalex.org/W2033580906","https://openalex.org/W2042391155","https://openalex.org/W2048952420","https://openalex.org/W2051915459","https://openalex.org/W2059912456","https://openalex.org/W2062906067","https://openalex.org/W2067892235","https://openalex.org/W2071727158","https://openalex.org/W2071953515","https://openalex.org/W2072069319","https://openalex.org/W2075174032","https://openalex.org/W2077260129","https://openalex.org/W2080956259","https://openalex.org/W2083252023","https://openalex.org/W2086455336","https://openalex.org/W2091249865","https://openalex.org/W2095004303","https://openalex.org/W2109865728","https://openalex.org/W2111065594","https://openalex.org/W2121640875","https://openalex.org/W2126557788","https://openalex.org/W2127217405","https://openalex.org/W2137775389","https://openalex.org/W2139704528","https://openalex.org/W2155342545","https://openalex.org/W2157577940","https://openalex.org/W2158489115","https://openalex.org/W2168380686","https://openalex.org/W2249779816","https://openalex.org/W4294575919"],"related_works":["https://openalex.org/W4244148723","https://openalex.org/W4252940922","https://openalex.org/W2066241385","https://openalex.org/W2624635748","https://openalex.org/W2418288010","https://openalex.org/W2102012656","https://openalex.org/W2280261174","https://openalex.org/W4292352220","https://openalex.org/W2045659791","https://openalex.org/W2051499477"],"abstract_inverted_index":{"The":[0],"present":[1],"study":[2],"examined":[3],"the":[4,7,28,67,74,94,99,107,128,135,167,178,197,205,223,234,246],"effects":[5,249],"of":[6,44,61,98,157,210,225,236,253],"atypical":[8,69,108,136,179,198,256],"antipsychotic":[9,37,70,109,137,180,199,219,257],"drugs":[10,71,138,181,220,258],"clozapine,":[11],"olanzapine,":[12],"quetiapine":[13],"and":[14,20,26,104,163,250,255],"risperidone,":[15],"on":[16],"N-methyl-4-phenylpyridinium":[17,51,75,100,120,129,174,186,206],"ion-induced":[18,76,101,121,130,187,207],"apoptosis":[19],"DNA":[21,123],"damage":[22],"in":[23,57,63,215,259],"PC12":[24,45,116,216],"cells,":[25],"explored":[27],"molecular":[29],"mechanisms":[30],"underlying":[31],"these":[32],"effects.":[33],"Haloperidol,":[34],"a":[35,58,158],"typical":[36,254],"drug,":[38],"was":[39],"used":[40],"for":[41,53,245],"comparison.":[42],"Exposure":[43],"cells":[46,62,117],"to":[47],"50":[48],"micro":[49,82],"m":[50],"ion":[52],"24":[54],"h":[55],"resulted":[56],"35-45%":[59],"loss":[60],"culture.":[64],"Pretreatment":[65,133,176],"with":[66,134,177],"aforementioned":[68],"significantly":[72],"reduced":[73],"cell":[77,102],"loss,":[78],"whereas":[79,144,230],"haloperidol":[80,145,231],"(10-100":[81],"m)":[83],"did":[84,190],"not":[85,112,202],"have":[86],"this":[87,119,141,185],"protective":[88],"effect.":[89],"Hoechst":[90],"33258":[91],"staining":[92],"revealed":[93],"apoptotic":[95],"nuclear":[96,131,142],"features":[97],"death,":[103],"showed":[105,195],"that":[106,161,170,196],"drugs,":[110,200],"but":[111,201],"haloperidol,":[113,203],"effectively":[114,183],"prevented":[115,140,148],"from":[118],"apoptosis.":[122],"fragmentation":[124],"assays":[125,153],"further":[126],"confirmed":[127],"fragmentation.":[132],"completely":[139],"fragmentation,":[143],"only":[146],"partially":[147],"it.":[149],"In":[150],"vitro":[151],"oligonucleotide":[152],"indicated":[154],"an":[155],"activation":[156,188],"specific":[159],"glycosylase":[160],"recognizes":[162],"cleaves":[164],"bases":[165],"(at":[166],"8-hydroxyl-2-deoxyguanine":[168],"site)":[169],"were":[171],"damaged":[172],"by":[173],"ion.":[175],"more":[182],"attenuated":[184],"than":[189],"haloperidol.":[191],"Northern":[192],"blot":[193],"analyses":[194],"blocked":[204],"substantial":[208],"increase":[209],"copper/zinc":[211,226,237],"superoxide":[212,227,238],"dismutase":[213,228,239],"mRNA":[214],"cells.":[217],"Atypical":[218],"slightly":[221],"up-regulated":[222],"expression":[224,235],"mRNA,":[229],"strongly":[232],"increased":[233],"mRNA.":[240],"These":[241],"data":[242],"may":[243],"account":[244],"different":[247],"therapeutic":[248],"side-effect":[251],"profiles":[252],"schizophrenia.":[260]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}
