{"id":"https://openalex.org/W2039449683","doi":"https://doi.org/10.1038/325726a0","title":"Independent phosphatidylinositol synthesis in pituitary plasma membrane and endoplasmic reticulum","display_name":"Independent phosphatidylinositol synthesis in pituitary plasma membrane and endoplasmic reticulum","publication_year":1987,"publication_date":"1987-02-01","ids":{"openalex":"https://openalex.org/W2039449683","doi":"https://doi.org/10.1038/325726a0","mag":"2039449683","pmid":"https://pubmed.ncbi.nlm.nih.gov/3029593"},"language":"en","primary_location":{"id":"doi:10.1038/325726a0","doi":"https://doi.org/10.1038/325726a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/325726a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101461132","display_name":"Atsushi Imai","orcid":"https://orcid.org/0000-0001-7691-4982","observed_orcids":["https://orcid.org/0000-0001-7691-4982"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atsushi Imai","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Medicine, Cornell University Medical College and The New York Hospital, 1300 York Avenue, New York, New York, 10021, USA","Division of Endocrinology and Metabolism, Department of Medicine, Cornell University Medical College and The New York Hospital, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, Cornell University Medical College and The New York Hospital, 1300 York Avenue, New York, New York, 10021, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, Cornell University Medical College and The New York Hospital, New York, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005079343","display_name":"Marvin Carl Gershengorn","orcid":"https://orcid.org/0000-0001-6256-6470","observed_orcids":["https://orcid.org/0000-0001-6256-6470"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marvin C. Gershengorn","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Medicine, Cornell University Medical College and The New York Hospital, 1300 York Avenue, New York, New York, 10021, USA","Division of Endocrinology and Metabolism, Department of Medicine, Cornell University Medical College and The New York Hospital, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, Cornell University Medical College and The New York Hospital, 1300 York Avenue, New York, New York, 10021, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, Cornell University Medical College and The New York Hospital, New York, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":8.803,"has_fulltext":false,"cited_by_count":131,"citation_normalized_percentile":{"value":0.99360662,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"325","issue":"6106","first_page":"726","last_page":"728"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.11339999735355377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.056299999356269836,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatidylinositol-synthesis","display_name":"phosphatidylinositol synthesis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gh3-cells","display_name":"GH3 cells","score":0.9470000267028809},{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone","display_name":"thyrotropin-releasing hormone","score":0.9470000267028809},{"id":"https://openalex.org/keywords/phosphoinositide-metabolism","display_name":"phosphoinositide metabolism","score":0.9129999876022339},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-5-bisphosphate","display_name":"phosphatidylinositol 4,5-bisphosphate","score":0.890999972820282},{"id":"https://openalex.org/keywords/phosphoinositide-hydrolysis","display_name":"phosphoinositide hydrolysis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/polyphosphoinositides","display_name":"polyphosphoinositides","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8645681142807007},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.8252024054527283},{"id":"https://openalex.org/C2777853560","wikidata":"https://www.wikidata.org/wiki/Q3083814","display_name":"Phosphatidylinositol 4,5-bisphosphate","level":4,"score":0.5131624341011047},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5046447515487671},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4941084682941437},{"id":"https://openalex.org/C88020867","wikidata":"https://www.wikidata.org/wiki/Q6815123","display_name":"Membrane contact site","level":5,"score":0.4796088933944702},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.44390031695365906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41358864307403564},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3911556303501129},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3678746223449707},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.36561107635498047},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.1944969892501831},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1114591658115387},{"id":"https://openalex.org/C161200384","wikidata":"https://www.wikidata.org/wiki/Q1757382","display_name":"Integral membrane protein","level":4,"score":0.107246994972229}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017855","descriptor_name":"Transferases (Other Substituted Phosphate Groups)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019870","descriptor_name":"1-Phosphatidylinositol 4-Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051607","descriptor_name":"CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/325726a0","doi":"https://doi.org/10.1038/325726a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/325726a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:3029593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3029593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W12664899","https://openalex.org/W191377311","https://openalex.org/W1498162448","https://openalex.org/W1513905140","https://openalex.org/W1515904479","https://openalex.org/W1524430393","https://openalex.org/W1535808294","https://openalex.org/W1536992430","https://openalex.org/W1553883441","https://openalex.org/W1568167591","https://openalex.org/W1576009119","https://openalex.org/W1593740515","https://openalex.org/W1598998118","https://openalex.org/W1645044045","https://openalex.org/W1775749144","https://openalex.org/W1854021632","https://openalex.org/W1998129853","https://openalex.org/W2001692359","https://openalex.org/W2019935012","https://openalex.org/W2024479106","https://openalex.org/W2025881724","https://openalex.org/W2068877244","https://openalex.org/W2090062949","https://openalex.org/W2090276011","https://openalex.org/W2093113620","https://openalex.org/W2117206237","https://openalex.org/W2134016419","https://openalex.org/W2205094121","https://openalex.org/W2226230079"],"related_works":["https://openalex.org/W1641213085","https://openalex.org/W1554718847","https://openalex.org/W2330123777","https://openalex.org/W1536992430","https://openalex.org/W1998129853","https://openalex.org/W2042578314","https://openalex.org/W2058992886","https://openalex.org/W2205094121","https://openalex.org/W2035212952","https://openalex.org/W3008239302"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}