{"id":"https://openalex.org/W2039322158","doi":"https://doi.org/10.1016/j.bcp.2007.02.016","title":"Novel tetra-acridine derivatives as dual inhibitors of topoisomerase II and the human proteasome","display_name":"Novel tetra-acridine derivatives as dual inhibitors of topoisomerase II and the human proteasome","publication_year":2007,"publication_date":"2007-03-04","ids":{"openalex":"https://openalex.org/W2039322158","doi":"https://doi.org/10.1016/j.bcp.2007.02.016","mag":"2039322158","pmid":"https://pubmed.ncbi.nlm.nih.gov/17391647"},"language":"en","primary_location":{"id":"doi:10.1016/j.bcp.2007.02.016","doi":"https://doi.org/10.1016/j.bcp.2007.02.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcp.2007.02.016","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073745948","display_name":"St\u00e9phane Visp\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271382","display_name":"Institut de Recherche Pierre Fabre (France)","ror":"https://ror.org/02by0jk38","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405271382"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"S. Visp\u00e9","raw_affiliation_strings":["Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France. stephane.vispe@pierre-fabre.com","Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France. stephane.vispe@pierre-fabre.com","institution_ids":[]},{"raw_affiliation_string":"Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4405271382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055186435","display_name":"Isabelle Vandenberghe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271382","display_name":"Institut de Recherche Pierre Fabre (France)","ror":"https://ror.org/02by0jk38","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405271382"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"I. Vandenberghe","raw_affiliation_strings":["Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4405271382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005518592","display_name":"Maxime Robin","orcid":"https://orcid.org/0000-0001-9914-786X","observed_orcids":["https://orcid.org/0000-0001-9914-786X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405264346","display_name":"Universit\u00e9 Aix-Marseille-III","ror":"https://ror.org/01n0sdq82","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767","https://openalex.org/I4405264346"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Robin","raw_affiliation_strings":["UMR CNRS 6178 Symbio, Laboratoire de Valorisation de la Chimie Fine, Universit\u00e9 Paul C\u00e9zanne Aix-Marseille III, 13397 Marseille Cedex 3, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS 6178 Symbio, Laboratoire de Valorisation de la Chimie Fine, Universit\u00e9 Paul C\u00e9zanne Aix-Marseille III, 13397 Marseille Cedex 3, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029625785","display_name":"Jean\u2010Philippe Annereau","orcid":"https://orcid.org/0000-0003-1248-8640","observed_orcids":["https://orcid.org/0000-0003-1248-8640"]},"institutions":[{"id":"https://openalex.org/I4405271382","display_name":"Institut de Recherche Pierre Fabre (France)","ror":"https://ror.org/02by0jk38","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405271382"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.P. Annereau","raw_affiliation_strings":["Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4405271382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079889263","display_name":"Laurent Cr\u00e9ancier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271382","display_name":"Institut de Recherche Pierre Fabre (France)","ror":"https://ror.org/02by0jk38","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405271382"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L. Cr\u00e9ancier","raw_affiliation_strings":["Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4405271382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022487044","display_name":"Val\u00e9rie Pique","orcid":"https://orcid.org/0000-0001-8740-8495","observed_orcids":["https://orcid.org/0000-0001-8740-8495"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405264346","display_name":"Universit\u00e9 Aix-Marseille-III","ror":"https://ror.org/01n0sdq82","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767","https://openalex.org/I4405264346"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V. Pique","raw_affiliation_strings":["UMR CNRS 6178 Symbio, Laboratoire de Valorisation de la Chimie Fine, Universit\u00e9 Paul C\u00e9zanne Aix-Marseille III, 13397 Marseille Cedex 3, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS 6178 Symbio, Laboratoire de Valorisation de la Chimie Fine, Universit\u00e9 Paul C\u00e9zanne Aix-Marseille III, 13397 Marseille Cedex 3, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067442119","display_name":"Jean\u2010Pierre Galy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405264346","display_name":"Universit\u00e9 Aix-Marseille-III","ror":"https://ror.org/01n0sdq82","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767","https://openalex.org/I4405264346"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.P. Galy","raw_affiliation_strings":["UMR CNRS 6178 Symbio, Laboratoire de Valorisation de la Chimie Fine, Universit\u00e9 Paul C\u00e9zanne Aix-Marseille III, 13397 Marseille Cedex 3, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS 6178 Symbio, Laboratoire de Valorisation de la Chimie Fine, Universit\u00e9 Paul C\u00e9zanne Aix-Marseille III, 13397 Marseille Cedex 3, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405264346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047450286","display_name":"Anna Kruczynski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271382","display_name":"Institut de Recherche Pierre Fabre (France)","ror":"https://ror.org/02by0jk38","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405271382"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Kruczynski","raw_affiliation_strings":["Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4405271382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083741321","display_name":"Jean-Marc M. Barret","orcid":"https://orcid.org/0000-0001-8085-3422","observed_orcids":["https://orcid.org/0000-0001-8085-3422"]},"institutions":[{"id":"https://openalex.org/I4405271382","display_name":"Institut de Recherche Pierre Fabre (France)","ror":"https://ror.org/02by0jk38","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405271382"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.M. Barret","raw_affiliation_strings":["Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4405271382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073920505","display_name":"Christian Bailly","orcid":"https://orcid.org/0000-0002-2973-9357","observed_orcids":["https://orcid.org/0000-0002-2973-9357"]},"institutions":[{"id":"https://openalex.org/I4405271382","display_name":"Institut de Recherche Pierre Fabre (France)","ror":"https://ror.org/02by0jk38","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405271382"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Bailly","raw_affiliation_strings":["Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Oncologie Exp\u00e9rimentale, Institut de Recherche Pierre Fabre, Parc Technologique du Canal, 3 rue des satellites, B.P. 94244, 31432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4405271382"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073745948"],"corresponding_institution_ids":["https://openalex.org/I4405271382"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":0.8704,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.68441074,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"73","issue":"12","first_page":"1863","last_page":"1872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibition","display_name":"topoisomerase II inhibition","score":0.8450000286102295},{"id":"https://openalex.org/keywords/proteasome-inhibition","display_name":"proteasome inhibition","score":0.9409999847412109},{"id":"https://openalex.org/keywords/dual-inhibitors","display_name":"dual inhibitors","score":0.628000020980835},{"id":"https://openalex.org/keywords/amsacrine","display_name":"amsacrine","score":0.7639999985694885},{"id":"https://openalex.org/keywords/acridine-derivatives","display_name":"acridine derivatives","score":0.5889999866485596},{"id":"https://openalex.org/keywords/anticancer-drug-discovery","display_name":"anticancer drug discovery","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.8984047174453735},{"id":"https://openalex.org/C2776148510","wikidata":"https://www.wikidata.org/wiki/Q6468907","display_name":"Lactacystin","level":4,"score":0.8639711737632751},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.8425315618515015},{"id":"https://openalex.org/C2780500152","wikidata":"https://www.wikidata.org/wiki/Q2784004","display_name":"Amsacrine","level":4,"score":0.7229277491569519},{"id":"https://openalex.org/C2776924795","wikidata":"https://www.wikidata.org/wiki/Q342713","display_name":"Acridine","level":2,"score":0.5444227457046509},{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.5272007584571838},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49787211418151855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4661971628665924},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41606175899505615},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.35948801040649414},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.35928863286972046},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07344448566436768}],"mesh":[{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000166","descriptor_name":"Acridines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bcp.2007.02.016","doi":"https://doi.org/10.1016/j.bcp.2007.02.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcp.2007.02.016","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:17391647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17391647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W86385217","https://openalex.org/W1537166599","https://openalex.org/W1545792411","https://openalex.org/W1558937675","https://openalex.org/W1912775546","https://openalex.org/W1966426060","https://openalex.org/W1972489358","https://openalex.org/W1975345108","https://openalex.org/W1984558282","https://openalex.org/W1985275612","https://openalex.org/W1986621896","https://openalex.org/W1998593049","https://openalex.org/W1998733276","https://openalex.org/W2009303078","https://openalex.org/W2010962421","https://openalex.org/W2011420746","https://openalex.org/W2018466113","https://openalex.org/W2057812817","https://openalex.org/W2066284211","https://openalex.org/W2085459881","https://openalex.org/W2097790679","https://openalex.org/W2102071915","https://openalex.org/W2106909352","https://openalex.org/W2118559527","https://openalex.org/W2122837196","https://openalex.org/W2139395990","https://openalex.org/W2139474242","https://openalex.org/W2140600345","https://openalex.org/W2154324414","https://openalex.org/W2160957049","https://openalex.org/W2164296930","https://openalex.org/W2173048202","https://openalex.org/W2297718137","https://openalex.org/W2315546268","https://openalex.org/W2326740745","https://openalex.org/W2410084107","https://openalex.org/W2413011818","https://openalex.org/W2417549375","https://openalex.org/W2418074839","https://openalex.org/W2949466603","https://openalex.org/W6675233531"],"related_works":["https://openalex.org/W2038257492","https://openalex.org/W1980782542","https://openalex.org/W2949075565","https://openalex.org/W4280501410","https://openalex.org/W4410758887","https://openalex.org/W2065880323","https://openalex.org/W3200655770","https://openalex.org/W3089152250","https://openalex.org/W2560112903","https://openalex.org/W2030820821"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
