{"id":"https://openalex.org/W2039308658","doi":"https://doi.org/10.1073/pnas.79.22.6787","title":"Inhibition of formation of complex oligosaccharides by the glucosidase inhibitor bromoconduritol.","display_name":"Inhibition of formation of complex oligosaccharides by the glucosidase inhibitor bromoconduritol.","publication_year":1982,"publication_date":"1982-11-01","ids":{"openalex":"https://openalex.org/W2039308658","doi":"https://doi.org/10.1073/pnas.79.22.6787","mag":"2039308658","pmid":"https://pubmed.ncbi.nlm.nih.gov/6757922","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/347218"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.79.22.6787","doi":"https://doi.org/10.1073/pnas.79.22.6787","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.79.22.6787","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC347218","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052798986","display_name":"Roelf DATEMA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Datema","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019269257","display_name":"Pedro Romero","orcid":"https://orcid.org/0000-0002-9446-4556","observed_orcids":["https://orcid.org/0000-0002-9446-4556"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P A Romero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110237603","display_name":"G\ufffdnter Legler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Legler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018948877","display_name":"Ralph \u03a4. Schwarz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R T Schwarz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.265,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.93349007,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"79","issue":"22","first_page":"6787","last_page":"6791"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibition","display_name":"\u03b1-glucosidase inhibition","score":0.8870000243186951},{"id":"https://openalex.org/keywords/high-mannose-oligosaccharides","display_name":"high-mannose oligosaccharides","score":0.925000011920929},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/lipid-linked-oligosaccharides","display_name":"lipid-linked oligosaccharides","score":0.8399999737739563},{"id":"https://openalex.org/keywords/viral-glycoproteins","display_name":"viral glycoproteins","score":0.7450000047683716},{"id":"https://openalex.org/keywords/influenza-virus","display_name":"influenza virus","score":0.8349999785423279},{"id":"https://openalex.org/keywords/fowl-plague-virus","display_name":"fowl plague virus","score":0.8730000257492065},{"id":"https://openalex.org/keywords/chicken-embryo-cells","display_name":"chicken embryo cells","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.8156654834747314},{"id":"https://openalex.org/C2776708817","wikidata":"https://www.wikidata.org/wiki/Q4380751","display_name":"Pronase","level":4,"score":0.7801831960678101},{"id":"https://openalex.org/C2777726330","wikidata":"https://www.wikidata.org/wiki/Q320607","display_name":"Oligosaccharide","level":2,"score":0.6356587409973145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6172001361846924},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.6040875911712646},{"id":"https://openalex.org/C2776584326","wikidata":"https://www.wikidata.org/wiki/Q5572352","display_name":"Glucosidases","level":3,"score":0.5932562947273254},{"id":"https://openalex.org/C134164806","wikidata":"https://www.wikidata.org/wiki/Q409485","display_name":"Neuraminidase","level":3,"score":0.5329512357711792},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5108572840690613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4870453178882599},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.4657467305660248},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36569511890411377},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.13012480735778809}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002236","descriptor_name":"Carbohydrate Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005959","descriptor_name":"Glucosidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053138","descriptor_name":"Cyclohexenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.79.22.6787","doi":"https://doi.org/10.1073/pnas.79.22.6787","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.79.22.6787","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:61011","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC347218","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:6757922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6757922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:347218","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC347218/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:61011","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC347218","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W277110946","https://openalex.org/W1039916612","https://openalex.org/W1505467568","https://openalex.org/W1547260693","https://openalex.org/W1564443351","https://openalex.org/W1588112662","https://openalex.org/W1604355742","https://openalex.org/W1941783149","https://openalex.org/W1998253351","https://openalex.org/W2027988055","https://openalex.org/W2045840764","https://openalex.org/W2088468038","https://openalex.org/W2090568685","https://openalex.org/W2149736282","https://openalex.org/W2410483784","https://openalex.org/W4246020825"],"related_works":["https://openalex.org/W2050055676","https://openalex.org/W2054931916","https://openalex.org/W1977561121","https://openalex.org/W2410888280","https://openalex.org/W1642778195","https://openalex.org/W2407565604","https://openalex.org/W2065524283","https://openalex.org/W1522253950","https://openalex.org/W2052040763","https://openalex.org/W2072376967"],"abstract_inverted_index":{"The":[0,34,69,89,97],"alpha-glucosidase":[1],"inhibitor":[2],"bromoconduritol":[3],"(6-bromo-3,4,5-trihydroxycyclohex-1-ene)":[4],"inhibits":[5],"trimming":[6,59],"of":[7,16,36,45,47,60,67,91,99],"the":[8,13],"innermost":[9],"glucose":[10],"residue":[11],"from":[12,79,110],"Glc3Man9GlcNAc2":[14],"precursor":[15],"high-mannose":[17,48,71],"and":[18,28,75,86],"complex":[19,92],"oligosaccharides.":[20],"This":[21],"inhibition":[22],"occurs":[23],"both":[24],"in":[25,41],"intact":[26],"cells":[27],"with":[29,84],"a":[30],"microsomal":[31],"enzyme":[32],"preparation.":[33],"formation":[35,90],"lipid-linked":[37],"oligosaccharides":[38,49,72,93],"was":[39,52,94,108],"increased":[40],"glucosidase-inhibited":[42],"cells.":[43,114],"Inhibition":[44],"transfer":[46],"to":[50],"protein":[51],"not":[53],"observed.":[54],"In":[55],"bromoconduritol-treated":[56,111],"virus-infected":[57],"cells,":[58],"mannose":[61],"can":[62],"occur":[63],"despite":[64],"incomplete":[65],"removal":[66],"glucose.":[68],"glucosylated":[70],"GlcMan9GlcNAc,":[73],"GlcMan8GlcNAc,":[74],"GlcMan7GlcNAc":[76],"were":[77],"released":[78],"viral":[80],"glycoproteins":[81],"after":[82],"digestion":[83],"Pronase":[85],"endo-beta-N-acetylglucosaminidase":[87],"H.":[88],"concomitantly":[95],"inhibited.":[96],"release":[98],"infectious":[100],"fowl":[101],"plague":[102],"virus":[103],"particles":[104],"(an":[105],"influenza":[106],"virus)":[107],"inhibited":[109],"infected":[112],"chicken-embryo":[113]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}