{"id":"https://openalex.org/W2039301033","doi":"https://doi.org/10.1117/12.17661","title":"Studies on the mechanism of photodynamic-therapy-induced tumor destruction","display_name":"Studies on the mechanism of photodynamic-therapy-induced tumor destruction","publication_year":1990,"publication_date":"1990-07-01","ids":{"openalex":"https://openalex.org/W2039301033","doi":"https://doi.org/10.1117/12.17661","mag":"2039301033"},"language":"en","primary_location":{"id":"doi:10.1117/12.17661","doi":"https://doi.org/10.1117/12.17661","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.17661","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035398414","display_name":"Victor H. Fingar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor H. Fingar","raw_affiliation_strings":["Univ. of Louisville (USA)","University of Louisville, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Louisville (USA)","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"University of Louisville, United States","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108229718","display_name":"Thomas J. Wieman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Wieman","raw_affiliation_strings":["Univ. of Louisville (USA)","University of Louisville, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Louisville (USA)","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"University of Louisville, United States","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":null,"apc_paid":null,"fwci":4.7881,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.94642857,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1203","issue":null,"first_page":"168","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-destruction","display_name":"tumor destruction","score":0.8989999890327454},{"id":"https://openalex.org/keywords/singlet-oxygen","display_name":"singlet oxygen","score":0.8320000171661377},{"id":"https://openalex.org/keywords/thromboxane","display_name":"thromboxane","score":0.8619999885559082},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolites","display_name":"arachidonic acid metabolites","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tumor-microvasculature","display_name":"tumor microvasculature","score":0.7390000224113464},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.8840000033378601},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/porphyrins","display_name":"porphyrins","score":0.6480000019073486},{"id":"https://openalex.org/keywords/photofrin","display_name":"Photofrin","score":0.8149999976158142},{"id":"https://openalex.org/keywords/chondrosarcoma","display_name":"chondrosarcoma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.972000002861023},{"id":"https://openalex.org/keywords/vascular-injury","display_name":"vascular injury","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.6157466769218445},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.5990669131278992},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.5793167352676392},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5666282176971436},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.515412449836731},{"id":"https://openalex.org/C2781080829","wikidata":"https://www.wikidata.org/wiki/Q3009646","display_name":"Thromboxane B2","level":3,"score":0.49393540620803833},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48533502221107483},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.46346205472946167},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.4568316638469696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4452574551105499},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.43646252155303955},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4001297950744629},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30114123225212097},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23415309190750122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1406404972076416},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.17661","doi":"https://doi.org/10.1117/12.17661","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.17661","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2170752460","https://openalex.org/W2067037885","https://openalex.org/W2017075189","https://openalex.org/W1985935476","https://openalex.org/W2095209996","https://openalex.org/W2095805115","https://openalex.org/W2143054540","https://openalex.org/W2003968416","https://openalex.org/W136746920","https://openalex.org/W2034842373"],"abstract_inverted_index":{"There":[0],"exists":[1],"little":[2],"doubt":[3],"that":[4,19,32],"profound":[5],"changes":[6,21],"occur":[7],"to":[8,61,124,161,174,192],"both":[9],"tumor":[10,28,182,190],"and":[11,18,45,65,85,119,136,157,163,183,186,189],"normal":[12,184],"tissue":[13],"microvasculature":[14],"during":[15,36,209],"photodynamic":[16],"therapy,":[17],"these":[20],"are":[22],"important":[23,199],"in":[24,89,96,112,147,205],"the":[25,47,56,74,97,113,120,154,177,198],"process":[26],"of":[27,39,49,76,83,168,179,201],"destruction.":[29],"We":[30,143],"hypothesize":[31],"singlet":[33],"oxygen,":[34],"produced":[35],"light":[37,86,158,164],"activation":[38],"photosensitizer,":[40],"interacts":[41],"with":[42,103],"cellular":[43],"membranes":[44],"induces":[46],"release":[48,75,178],"arachidonic":[50,202],"acid":[51,203],"metabolites,":[52],"notably":[53],"thromboxane,":[54],"into":[55,78],"intravascular":[57],"environment.":[58],"This":[59],"leads":[60],"vasoconstriction,":[62],"platelet":[63],"aggregation,":[64],"hemostasis.":[66],"To":[67],"test":[68],"this":[69],"hypothesis,":[70],"we":[71],"have":[72,196],"measured":[73,140],"thromboxane":[77,137,149,180],"serum":[79,133],"as":[80],"a":[81],"function":[82],"porphyrin":[84,156],"doses":[87],"used":[88],"phototherapy.":[90,193,210],"Sprague":[91],"Dawley":[92],"rats":[93],"bearing":[94],"chondrosarcoma":[95],"right":[98],"hind":[99,121],"limb":[100,122],"were":[101,139],"injected":[102],"0-25":[104],"mg/kg":[105,171],"Photofrin":[106],"IP'.":[107],"A":[108],"catheter":[109],"was":[110,134],"implanted":[111],"carotid":[114],"artery":[115],"24":[116],"h":[117],"later,":[118],"exposed":[123],"0-135":[125],"J/cm2":[126],"630":[127],"nm":[128],"light.":[129],"Immediately":[130],"after":[131],"treatment,":[132],"collected":[135],"levels":[138],"by":[141],"radioimmunoassay.":[142],"found":[144],"significant":[145],"increases":[146],"systemic":[148],"concentrations":[150],"following":[151],"phototherapy":[152],"at":[153],"highest":[155],"doses,":[159],"compared":[160],"drug":[162],"controls.":[165],"The":[166],"administration":[167],"indomethacin":[169],"(10":[170],"i.p.)":[172],"prior":[173],"treatment":[175],"suppressed":[176],"from":[181],"tissues":[185],"inhibited":[187],"hemostasis":[188],"response":[191],"These":[194],"studies":[195],"reinforced":[197],"role":[200],"metabolites":[204],"producing":[206],"vascular":[207],"damage":[208]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2016-06-24T00:00:00"}
