{"id":"https://openalex.org/W2039290751","doi":"https://doi.org/10.1002/wnan.100","title":"Tissue scaffolds for skin wound healing and dermal reconstruction","display_name":"Tissue scaffolds for skin wound healing and dermal reconstruction","publication_year":2010,"publication_date":"2010-07-06","ids":{"openalex":"https://openalex.org/W2039290751","doi":"https://doi.org/10.1002/wnan.100","mag":"2039290751","pmid":"https://pubmed.ncbi.nlm.nih.gov/20607703"},"language":"en","primary_location":{"id":"doi:10.1002/wnan.100","doi":"https://doi.org/10.1002/wnan.100","is_oa":false,"landing_page_url":"https://doi.org/10.1002/wnan.100","pdf_url":null,"source":{"id":"https://openalex.org/S132212666","display_name":"Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology","issn_l":"1939-0041","issn":["1939-0041","1939-5116"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"WIREs Nanomedicine and Nanobiotechnology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S. P. Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"S. P. Zhong","raw_affiliation_strings":["Division of Bioengineering, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bioengineering, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002821280","display_name":"Yanzhong Zhang","orcid":"https://orcid.org/0000-0002-2663-1279","observed_orcids":["https://orcid.org/0000-0002-2663-1279","https://orcid.org/0009-0001-3444-4879"]},"institutions":[{"id":"https://openalex.org/I181326427","display_name":"Donghua University","ror":"https://ror.org/035psfh38","country_code":"CN","type":"education","lineage":["https://openalex.org/I181326427"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Z. Zhang","raw_affiliation_strings":["Department of Bioengineering, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China","institution_ids":["https://openalex.org/I181326427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031498697","display_name":"Chwee Teck Lim","orcid":"https://orcid.org/0000-0003-4019-9782","observed_orcids":["https://orcid.org/0000-0003-4019-9782","https://orcid.org/0000-0002-9841-1603"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"C. T. Lim","raw_affiliation_strings":["Department of Mechanical Engineering, National University of Singapore, Singapore","Division of Bioengineering, National University of Singapore, Singapore","Research Centre of Excellence in Mechanobiology, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Division of Bioengineering, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Research Centre of Excellence in Mechanobiology, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031498697"],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":4.6621,"has_fulltext":false,"cited_by_count":702,"citation_normalized_percentile":{"value":0.98216508,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"2","issue":"5","first_page":"510","last_page":"525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.7148000001907349,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.2712000012397766,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-engineering-scaffolds","display_name":"tissue engineering scaffolds","score":0.984000027179718},{"id":"https://openalex.org/keywords/cutaneous-wound-healing","display_name":"skin wound healing","score":0.859000027179718},{"id":"https://openalex.org/keywords/tissue-engineered-skin-substitutes","display_name":"bioengineered skin substitutes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/electrospinning","display_name":"electrospinning","score":0.8379999995231628},{"id":"https://openalex.org/keywords/biomimetic-scaffolds","display_name":"biomimetic scaffolds","score":0.968999981880188},{"id":"https://openalex.org/keywords/wound-contraction","display_name":"wound contraction","score":0.5759999752044678},{"id":"https://openalex.org/keywords/scar-formation","display_name":"scar formation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.9399999976158142},{"id":"https://openalex.org/keywords/scaffold-fabrication-techniques","display_name":"scaffold fabrication techniques","score":0.906000018119812},{"id":"https://openalex.org/keywords/scaffold-mechanical-properties","display_name":"scaffold mechanical properties","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7844619154930115},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.7003467082977295},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.587748110294342},{"id":"https://openalex.org/C175933922","wikidata":"https://www.wikidata.org/wiki/Q3344895","display_name":"Artificial skin","level":2,"score":0.5790275931358337},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.569351851940155},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.5402836799621582},{"id":"https://openalex.org/C2993269979","wikidata":"https://www.wikidata.org/wiki/Q523536","display_name":"Wound dressing","level":2,"score":0.47779709100723267},{"id":"https://openalex.org/C190567982","wikidata":"https://www.wikidata.org/wiki/Q7535422","display_name":"Skin repair","level":3,"score":0.42254072427749634},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.40323036909103394},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.38003990054130554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2796023488044739},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1801842749118805},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12751418352127075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10217338800430298},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017768","descriptor_name":"Skin, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019651","descriptor_name":"Plastic Surgery Procedures","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062109","descriptor_name":"Dermatologic Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/wnan.100","doi":"https://doi.org/10.1002/wnan.100","is_oa":false,"landing_page_url":"https://doi.org/10.1002/wnan.100","pdf_url":null,"source":{"id":"https://openalex.org/S132212666","display_name":"Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology","issn_l":"1939-0041","issn":["1939-0041","1939-5116"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"WIREs Nanomedicine and Nanobiotechnology","raw_type":"journal-article"},{"id":"pmid:20607703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20607703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/68450","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/68450","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Review"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":134,"referenced_works":["https://openalex.org/W10872701","https://openalex.org/W163325168","https://openalex.org/W944567389","https://openalex.org/W1016534219","https://openalex.org/W1273743834","https://openalex.org/W1516867179","https://openalex.org/W1570625406","https://openalex.org/W1590178434","https://openalex.org/W1963534084","https://openalex.org/W1964236004","https://openalex.org/W1964842639","https://openalex.org/W1965244808","https://openalex.org/W1965402473","https://openalex.org/W1967354534","https://openalex.org/W1968484490","https://openalex.org/W1968658917","https://openalex.org/W1971340125","https://openalex.org/W1972229031","https://openalex.org/W1974959164","https://openalex.org/W1975784203","https://openalex.org/W1976913986","https://openalex.org/W1977353636","https://openalex.org/W1978351659","https://openalex.org/W1978607268","https://openalex.org/W1978862186","https://openalex.org/W1979948054","https://openalex.org/W1980091438","https://openalex.org/W1982439886","https://openalex.org/W1984277999","https://openalex.org/W1984734563","https://openalex.org/W1985767462","https://openalex.org/W1987154895","https://openalex.org/W1987407408","https://openalex.org/W1987460373","https://openalex.org/W1990384757","https://openalex.org/W1992104579","https://openalex.org/W1993306582","https://openalex.org/W1995276955","https://openalex.org/W1996482787","https://openalex.org/W1997006958","https://openalex.org/W1997509414","https://openalex.org/W1998868529","https://openalex.org/W1999363713","https://openalex.org/W1999948840","https://openalex.org/W2006875835","https://openalex.org/W2007233095","https://openalex.org/W2009399707","https://openalex.org/W2013501439","https://openalex.org/W2014973713","https://openalex.org/W2015726845","https://openalex.org/W2017372315","https://openalex.org/W2019167552","https://openalex.org/W2025426356","https://openalex.org/W2026569399","https://openalex.org/W2027268415","https://openalex.org/W2028424840","https://openalex.org/W2029259783","https://openalex.org/W2031436335","https://openalex.org/W2031957301","https://openalex.org/W2034617875","https://openalex.org/W2034884320","https://openalex.org/W2036362576","https://openalex.org/W2036901246","https://openalex.org/W2038213213","https://openalex.org/W2041000069","https://openalex.org/W2041558541","https://openalex.org/W2042864468","https://openalex.org/W2043310171","https://openalex.org/W2043442238","https://openalex.org/W2044913356","https://openalex.org/W2045312132","https://openalex.org/W2047646146","https://openalex.org/W2050088971","https://openalex.org/W2052031414","https://openalex.org/W2052378238","https://openalex.org/W2054067471","https://openalex.org/W2054475237","https://openalex.org/W2055022924","https://openalex.org/W2056478815","https://openalex.org/W2058921865","https://openalex.org/W2062211713","https://openalex.org/W2062962443","https://openalex.org/W2065942568","https://openalex.org/W2066371575","https://openalex.org/W2066620625","https://openalex.org/W2067034911","https://openalex.org/W2067396886","https://openalex.org/W2068867114","https://openalex.org/W2069851964","https://openalex.org/W2078919314","https://openalex.org/W2079661003","https://openalex.org/W2080207900","https://openalex.org/W2080547323","https://openalex.org/W2080795285","https://openalex.org/W2081025989","https://openalex.org/W2083774544","https://openalex.org/W2084105601","https://openalex.org/W2084197859","https://openalex.org/W2084914882","https://openalex.org/W2084999384","https://openalex.org/W2085339354","https://openalex.org/W2086206243","https://openalex.org/W2086904922","https://openalex.org/W2087172810","https://openalex.org/W2087436263","https://openalex.org/W2092154501","https://openalex.org/W2094451978","https://openalex.org/W2095457189","https://openalex.org/W2096855516","https://openalex.org/W2097922637","https://openalex.org/W2103630920","https://openalex.org/W2106016315","https://openalex.org/W2112604656","https://openalex.org/W2115987316","https://openalex.org/W2119560400","https://openalex.org/W2127803605","https://openalex.org/W2129014707","https://openalex.org/W2134150152","https://openalex.org/W2137721915","https://openalex.org/W2139162721","https://openalex.org/W2139586508","https://openalex.org/W2143564590","https://openalex.org/W2143691028","https://openalex.org/W2147158757","https://openalex.org/W2147834652","https://openalex.org/W2158363156","https://openalex.org/W2160354693","https://openalex.org/W2169378628","https://openalex.org/W2178633787","https://openalex.org/W2211569981","https://openalex.org/W2496206786","https://openalex.org/W2504551893","https://openalex.org/W3022034520","https://openalex.org/W3023791346"],"related_works":["https://openalex.org/W7171424905","https://openalex.org/W2733849149","https://openalex.org/W4402520798","https://openalex.org/W2150275873","https://openalex.org/W6996122032","https://openalex.org/W2023072189","https://openalex.org/W3180130614","https://openalex.org/W4327653263","https://openalex.org/W4385686991","https://openalex.org/W334057674"],"abstract_inverted_index":{"One":[0,206],"of":[1,5,17,47,72,159,181,220,231],"the":[2,15,31,70,122,192,195,216],"major":[3],"applications":[4,227],"tissue-engineered":[6],"skin":[7,37,61,126,185],"substitutes":[8,38,62,186],"for":[9,39,118,125,187],"wound":[10,40,50,100,110,188,204,229],"healing":[11,16,41,230],"is":[12,212],"to":[13,80,87,150,172,191],"promote":[14],"cutaneous":[18],"wounds.":[19],"In":[20],"this":[21],"respect,":[22],"many":[23],"important":[24],"clinical":[25],"milestones":[26],"have":[27,161],"been":[28,162],"reached":[29],"in":[30,228],"past":[32],"decades.":[33],"However,":[34],"currently":[35],"available":[36],"often":[42],"suffer":[43],"from":[44,168],"a":[45,103,179],"range":[46],"problems":[48],"including":[49],"contraction,":[51],"scar":[52],"formation,":[53],"and":[54,85,90,101,121,137,140,146,148,155,199,218],"poor":[55],"integration":[56],"with":[57,203],"host":[58],"tissue.":[59,92],"Engineering":[60],"by":[63],"tissue":[64,127,131],"engineering":[65],"approach":[66],"has":[67],"relied":[68],"upon":[69],"creation":[71],"three-dimensional":[73,94],"scaffolds":[74,95,160,222],"as":[75,109],"extracellular":[76],"matrix":[77],"(ECM)":[78],"analog":[79],"guide":[81],"cell":[82],"adhesion,":[83],"growth,":[84],"differentiation":[86],"form":[88],"skin-functional":[89],"structural":[91],"The":[93],"can":[96,114],"not":[97],"only":[98],"cover":[99],"give":[102],"physical":[104,136],"barrier":[105],"against":[106],"external":[107],"infection":[108],"dressing,":[111],"but":[112],"also":[113],"provide":[115,141],"support":[116],"both":[117],"dermal":[119],"fibroblasts":[120],"overlying":[123],"keratinocytes":[124],"engineering.":[128],"A":[129,157],"successful":[130],"scaffold":[132],"should":[133],"exhibit":[134],"appropriate":[135,143],"mechanical":[138],"characteristics":[139,201],"an":[142],"surface":[144],"chemistry":[145],"nano":[147],"microstructures":[149],"facilitate":[151],"cellular":[152],"attachment,":[153],"proliferation,":[154],"differentiation.":[156],"variety":[158,180],"fabricated":[163],"based":[164],"on":[165],"materials":[166],"ranging":[167],"naturally":[169],"occurring":[170],"ones":[171],"those":[173],"manufactured":[174],"synthetically.":[175],"This":[176],"review":[177],"discusses":[178],"commercial":[182],"or":[183],"laboratory-engineered":[184],"healing.":[189,205],"Central":[190],"discussion":[193],"are":[194],"scaffolds/materials,":[196],"fabrication":[197,210,219],"techniques,":[198],"their":[200],"associated":[202],"specifically":[207],"highlighted":[208],"emerging":[209],"technique":[211],"electrospinning":[213],"that":[214,223],"allows":[215],"design":[217],"biomimetic":[221],"offer":[224],"tremendous":[225],"potential":[226],"skin.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":44},{"year":2024,"cited_by_count":51},{"year":2023,"cited_by_count":54},{"year":2022,"cited_by_count":66},{"year":2021,"cited_by_count":56},{"year":2020,"cited_by_count":59},{"year":2019,"cited_by_count":72},{"year":2018,"cited_by_count":59},{"year":2017,"cited_by_count":44},{"year":2016,"cited_by_count":40},{"year":2015,"cited_by_count":29},{"year":2014,"cited_by_count":32},{"year":2013,"cited_by_count":31},{"year":2012,"cited_by_count":33}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}