{"id":"https://openalex.org/W2039205641","doi":"https://doi.org/10.1111/bju.13096","title":"Clinical efficacy of collagenase Clostridium histolyticum in the treatment of Peyronie's disease by subgroup: results from two large, double\u2010blind, randomized, placebo\u2010controlled, phase III studies","display_name":"Clinical efficacy of collagenase Clostridium histolyticum in the treatment of Peyronie's disease by subgroup: results from two large, double\u2010blind, randomized, placebo\u2010controlled, phase III studies","publication_year":2015,"publication_date":"2015-02-24","ids":{"openalex":"https://openalex.org/W2039205641","doi":"https://doi.org/10.1111/bju.13096","mag":"2039205641","pmid":"https://pubmed.ncbi.nlm.nih.gov/25711400"},"language":"en","primary_location":{"id":"doi:10.1111/bju.13096","doi":"https://doi.org/10.1111/bju.13096","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bju.13096","pdf_url":null,"source":{"id":"https://openalex.org/S191188855","display_name":"British Journal of Urology","issn_l":"1464-4096","issn":["1464-4096","1464-410X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087500960","display_name":"Larry I. Lipshultz","orcid":"https://orcid.org/0000-0001-8676-7285","observed_orcids":["https://orcid.org/0000-0001-8676-7285"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Larry I. Lipshultz","raw_affiliation_strings":["Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014078830","display_name":"Irwin Goldstein","orcid":"https://orcid.org/0000-0002-4117-8361","observed_orcids":["https://orcid.org/0000-0002-4117-8361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irwin Goldstein","raw_affiliation_strings":["San Diego Sexual Medicine Alvarado Hospital San Diego CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego Sexual Medicine Alvarado Hospital San Diego CA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111758117","display_name":"Allen D. Seftel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800704349","display_name":"Cooper University Hospital","ror":"https://ror.org/049wjac82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800704349","https://openalex.org/I4210157085"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen D. Seftel","raw_affiliation_strings":["Cooper University Hospital Camden, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooper University Hospital Camden, NJ, USA","institution_ids":["https://openalex.org/I2800704349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020840591","display_name":"Gregory J. Kaufman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory J. Kaufman","raw_affiliation_strings":["Auxilium Pharmaceuticals, Inc. Chesterbrook PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auxilium Pharmaceuticals, Inc. Chesterbrook PA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103573817","display_name":"Ted M. Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ted M. Smith","raw_affiliation_strings":["Auxilium Pharmaceuticals, Inc. Chesterbrook PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auxilium Pharmaceuticals, Inc. Chesterbrook PA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008871581","display_name":"James P. Tursi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James P. Tursi","raw_affiliation_strings":["Auxilium Pharmaceuticals, Inc. Chesterbrook PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auxilium Pharmaceuticals, Inc. Chesterbrook PA USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037019692","display_name":"Arthur L. \u201cBud\u201d Burnett","orcid":"https://orcid.org/0000-0001-6560-8605","observed_orcids":["https://orcid.org/0000-0001-6560-8605"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur L. Burnett","raw_affiliation_strings":["Johns Hopkins Medicine, Baltimore, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Medicine, Baltimore, MD USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087500960"],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":4770,"currency":"USD","value_usd":4770},"apc_paid":null,"fwci":11.5445,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.99156538,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"116","issue":"4","first_page":"650","last_page":"656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13313","display_name":"Dupuytren's Contracture and Treatments","score":0.6714000105857849,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13313","display_name":"Dupuytren's Contracture and Treatments","score":0.6714000105857849,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.15710000693798065,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.14399999380111694,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peyronie-s-disease","display_name":"Peyronie's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/collagenase-clostridium-histolyticum","display_name":"collagenase clostridium histolyticum","score":0.9860000014305115},{"id":"https://openalex.org/keywords/intralesional-injection","display_name":"intralesional injection","score":0.9739999771118164},{"id":"https://openalex.org/keywords/plaque-calcification","display_name":"plaque calcification","score":0.7870000004768372},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.8460000157356262},{"id":"https://openalex.org/keywords/erectile-function","display_name":"erectile function","score":0.9850000143051147},{"id":"https://openalex.org/keywords/subgroup-analysis","display_name":"subgroup analysis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.6340000033378601},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8669999837875366},{"id":"https://openalex.org/keywords/symptom-bother","display_name":"symptom bother","score":0.47099998593330383},{"id":"https://openalex.org/keywords/sexual-performance","display_name":"sexual performance","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C2779145901","wikidata":"https://www.wikidata.org/wiki/Q874586","display_name":"Peyronie's disease","level":3,"score":0.9606069326400757},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.6983153820037842},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6889225244522095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6341690421104431},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5116260647773743},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.45646655559539795},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.44149380922317505},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.44025373458862305},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.42154043912887573},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3505762219429016},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16618981957435608},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.14584335684776306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12191012501716614},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.056805163621902466},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003012","descriptor_name":"Microbial Collagenase","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003012","descriptor_name":"Microbial Collagenase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010411","descriptor_name":"Penile Induration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010411","descriptor_name":"Penile Induration","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010411","descriptor_name":"Penile Induration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/bju.13096","doi":"https://doi.org/10.1111/bju.13096","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bju.13096","pdf_url":null,"source":{"id":"https://openalex.org/S191188855","display_name":"British Journal of Urology","issn_l":"1464-4096","issn":["1464-4096","1464-410X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU International","raw_type":"journal-article"},{"id":"pmid:25711400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25711400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU international","raw_type":"Clinical Trial, Phase III"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1277718165","https://openalex.org/W1550092261","https://openalex.org/W1604434236","https://openalex.org/W1924137210","https://openalex.org/W1975895485","https://openalex.org/W2003470763","https://openalex.org/W2025237264","https://openalex.org/W2032500729","https://openalex.org/W2042622855","https://openalex.org/W2062052817","https://openalex.org/W2066488908","https://openalex.org/W2085933203","https://openalex.org/W2086685692","https://openalex.org/W2092171649","https://openalex.org/W2112858138","https://openalex.org/W2114222033","https://openalex.org/W2153633032","https://openalex.org/W2159961919","https://openalex.org/W2162323812","https://openalex.org/W2163234213","https://openalex.org/W2328267095"],"related_works":["https://openalex.org/W2129327761","https://openalex.org/W2156906840","https://openalex.org/W2159171635","https://openalex.org/W2316703390","https://openalex.org/W2120255651","https://openalex.org/W2407146658","https://openalex.org/W2032500729","https://openalex.org/W1495606016","https://openalex.org/W2152434517","https://openalex.org/W2396232949"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"examine":[2],"the":[3,43,179,220,270,303,317],"efficacy":[4,24,252,304],"of":[5,14,25,40,64,100,122,133,253,307,313,319,322],"intralesional":[6],"collagenase":[7],"Clostridium":[8],"histolyticum":[9],"(CCH)":[10],"in":[11,38,153,163,219,310],"defined":[12,60,311],"subgroups":[13,39,58,312],"patients":[15],"with":[16,28,120,173,176,316],"Peyronie's":[17,47],"disease":[18,188,227],"(PD).":[19],"PATIENTS":[20],"AND":[21],"METHODS:":[22],"The":[23,57],"CCH":[26,123,174,221,254,308],"compared":[27],"placebo,":[29],"assessed":[30],"from":[31,42],"baseline":[32,69,128,182],"to":[33,82,88,191,300],"week":[34],"52,":[35],"was":[36,265],"examined":[37],"participants":[41],"Investigation":[44],"for":[45,178,210,245,256],"Maximal":[46],"Reduction":[48],"Efficacy":[49],"and":[50,55,74,93,113,127,146,157,186,194,199,233,240,261,273,305],"Safety":[51],"Studies":[52],"(IMPRESS)":[53],"I":[54,272],"II.":[56],"were":[59,161,170,216,279],"according":[61],"to:":[62],"severity":[63],"penile":[65,154,183,224,258,292],"curvature":[66,155,167,184,225,259],"deformity":[67,156,168,260],"at":[68],"(30-60\u00b0":[70],"[n":[71,76,84,90,96,105,110,124,139,143,148],"=":[72,77,85,91,97,106,111,125,140,144,149],"492]":[73],"61-90\u00b0":[75],"120]);":[78],"PD":[79,158,212,262,314],"duration":[80,189,228],"(1":[81],"\u22642":[83],"201],":[86],">2":[87,190],"\u22644":[89,192],"212]":[92],">4":[94,195,229],"years":[95,193],"199]);":[98],"degree":[99],"plaque":[101],"calcification":[102,104,115],"(no":[103,237],"447],":[107],"non-contiguous":[108],"stippling":[109],"103]":[112],"contiguous":[114],"that":[116],"did":[117],"not":[118],"interfere":[119],"injection":[121],"62]);":[126],"erectile":[129],"function":[130,205],"(International":[131],"Index":[132],"Erectile":[134],"Function":[135],"[IIEF]":[136],"scores":[137],"1-5":[138,236],"22],":[141],"6-16":[142],"106]":[145],"\u226517":[147,202,241],"480]).":[150],"RESULTS:":[151],"Reductions":[152],"symptom":[159,213,263],"bother":[160,214,264],"observed":[162],"all":[164],"subgroups.":[165,268],"Penile":[166],"reductions":[169,215],"significantly":[171,217],"greater":[172,218],"than":[175],"placebo":[177],"following":[180],"subgroups:":[181],"30-60\u00b0":[185],"61-90\u00b0;":[187],"years;":[196,230],"no":[197,231],"calcification;":[198,232],"IIEF":[200,234],"score":[201,235],"(high":[203],"IIEF-erectile":[204],"score;":[206],"P":[207],"<":[208,243],"0.05":[209,244],"all).":[211,246],"group":[222],"for:":[223],"30-60\u00b0;":[226],"sexual":[238],"activity)":[239],"(P":[242],"CONCLUSIONS:":[247],"In":[248,269],"this":[249],"analysis,":[250],"clinical":[251],"treatment":[255,309,324],"reducing":[257],"found":[266],"across":[267],"IMPRESS":[271],"II":[274],"overall,":[275],"adverse":[276],"events":[277],"(AEs)":[278],"typically":[280],"mild":[281],"or":[282,291],"moderate,":[283],"although":[284],"treatment-related":[285],"serious":[286],"AEs,":[287],"including":[288],"corporal":[289],"rupture":[290],"haematoma,":[293],"occurred.":[294],"Future":[295],"studies":[296],"could":[297],"be":[298],"considered":[299],"directly":[301],"assess":[302],"safety":[306],"patients,":[315],"goal":[318],"identifying":[320],"predictors":[321],"optimum":[323],"success.":[325]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}