{"id":"https://openalex.org/W2039197754","doi":"https://doi.org/10.1385/ep:16:4:253","title":"Cyclooxygenase-2 and Thromboxane Synthase in Non-Endocrine and Endocrine Tumors: A Review","display_name":"Cyclooxygenase-2 and Thromboxane Synthase in Non-Endocrine and Endocrine Tumors: A Review","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2039197754","doi":"https://doi.org/10.1385/ep:16:4:253","mag":"2039197754","pmid":"https://pubmed.ncbi.nlm.nih.gov/16627914"},"language":"en","primary_location":{"id":"doi:10.1385/ep:16:4:253","doi":"https://doi.org/10.1385/ep:16:4:253","is_oa":false,"landing_page_url":"https://doi.org/10.1385/ep:16:4:253","pdf_url":null,"source":{"id":"https://openalex.org/S53004546","display_name":"Endocrine Pathology","issn_l":"1046-3976","issn":["1046-3976","1559-0097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107391387","display_name":"\u00d6nder \u00d6ng\u00fcr\u00fc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Onder Onguru","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA","Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 55905, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 55905, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033125571","display_name":"Mary B. Casey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary B. Casey","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 55905, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 55905, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016027728","display_name":"Sabine Kajita","orcid":"https://orcid.org/0000-0003-0010-4275","observed_orcids":["https://orcid.org/0000-0003-0010-4275"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabine Kajita","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 55905, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 55905, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089864120","display_name":"Nobuki Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nobuki Nakamura","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 55905, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 55905, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110331817","display_name":"Ricardo V. Lloyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ricardo V. Lloyd","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 55905, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 55905, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110331817"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":null,"fwci":1.0042,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.75582763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"16","issue":"4","first_page":"253","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":1.0},{"id":"https://openalex.org/keywords/thromboxane-synthase","display_name":"thromboxane synthase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/thromboxane-a2","display_name":"thromboxane A2","score":0.9079999923706055},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.9390000104904175},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5870000123977661},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.925000011920929},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.871999979019165},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":1.0},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.9769999980926514},{"id":"https://openalex.org/keywords/endocrine-tumors","display_name":"endocrine tumors","score":0.9509999752044678},{"id":"https://openalex.org/keywords/pituitary-tumors","display_name":"pituitary tumors","score":0.8159999847412109},{"id":"https://openalex.org/keywords/thyroid-tumors","display_name":"thyroid tumors","score":0.9089999794960022}],"concepts":[{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.7016317844390869},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6094973683357239},{"id":"https://openalex.org/C2780978440","wikidata":"https://www.wikidata.org/wiki/Q416567","display_name":"Prostaglandin H2","level":4,"score":0.6057043075561523},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.5914393663406372},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5826536417007446},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.5626696348190308},{"id":"https://openalex.org/C173202427","wikidata":"https://www.wikidata.org/wiki/Q408575","display_name":"Thromboxane-A synthase","level":4,"score":0.540963888168335},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5149372220039368},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4803006052970886},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44039851427078247},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.4346180856227875},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.4245510697364807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34578001499176025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32453763484954834},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.25731682777404785},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.198053240776062},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1771281659603119},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.07915744185447693}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004701","descriptor_name":"Endocrine Gland Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013930","descriptor_name":"Thromboxane-A Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1385/ep:16:4:253","doi":"https://doi.org/10.1385/ep:16:4:253","is_oa":false,"landing_page_url":"https://doi.org/10.1385/ep:16:4:253","pdf_url":null,"source":{"id":"https://openalex.org/S53004546","display_name":"Endocrine Pathology","issn_l":"1046-3976","issn":["1046-3976","1559-0097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Pathology","raw_type":"journal-article"},{"id":"pmid:16627914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16627914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":156,"referenced_works":["https://openalex.org/W24602962","https://openalex.org/W77440476","https://openalex.org/W134937540","https://openalex.org/W152093935","https://openalex.org/W203226604","https://openalex.org/W297430692","https://openalex.org/W1485442945","https://openalex.org/W1487226962","https://openalex.org/W1510472405","https://openalex.org/W1520864002","https://openalex.org/W1521161473","https://openalex.org/W1533240983","https://openalex.org/W1576582769","https://openalex.org/W1579616493","https://openalex.org/W1588167055","https://openalex.org/W1598952686","https://openalex.org/W1606022491","https://openalex.org/W1647648618","https://openalex.org/W1648593433","https://openalex.org/W1666619344","https://openalex.org/W1754585763","https://openalex.org/W1783009344","https://openalex.org/W1783022590","https://openalex.org/W1837402230","https://openalex.org/W1865550052","https://openalex.org/W1907972050","https://openalex.org/W1928411162","https://openalex.org/W1964246992","https://openalex.org/W1968890157","https://openalex.org/W1968907630","https://openalex.org/W1970050679","https://openalex.org/W1970836524","https://openalex.org/W1972602319","https://openalex.org/W1981436577","https://openalex.org/W1982448318","https://openalex.org/W1985950453","https://openalex.org/W1986085130","https://openalex.org/W1992189334","https://openalex.org/W1993592556","https://openalex.org/W1995469282","https://openalex.org/W1995568029","https://openalex.org/W1999593839","https://openalex.org/W2002060305","https://openalex.org/W2006276633","https://openalex.org/W2007187686","https://openalex.org/W2010404222","https://openalex.org/W2010561174","https://openalex.org/W2010973568","https://openalex.org/W2011611199","https://openalex.org/W2011698701","https://openalex.org/W2013551103","https://openalex.org/W2016778410","https://openalex.org/W2018350475","https://openalex.org/W2020973773","https://openalex.org/W2021304625","https://openalex.org/W2023212677","https://openalex.org/W2023353312","https://openalex.org/W2024087814","https://openalex.org/W2024425168","https://openalex.org/W2025544563","https://openalex.org/W2026307857","https://openalex.org/W2028236892","https://openalex.org/W2029445418","https://openalex.org/W2029535021","https://openalex.org/W2030109883","https://openalex.org/W2030213691","https://openalex.org/W2031984107","https://openalex.org/W2032855340","https://openalex.org/W2035810647","https://openalex.org/W2037033245","https://openalex.org/W2037666720","https://openalex.org/W2041140906","https://openalex.org/W2041623586","https://openalex.org/W2042033090","https://openalex.org/W2043152596","https://openalex.org/W2043707891","https://openalex.org/W2044761146","https://openalex.org/W2046345325","https://openalex.org/W2048009051","https://openalex.org/W2049821512","https://openalex.org/W2050310941","https://openalex.org/W2050888137","https://openalex.org/W2051279880","https://openalex.org/W2051686420","https://openalex.org/W2052720577","https://openalex.org/W2053070624","https://openalex.org/W2055951936","https://openalex.org/W2060692647","https://openalex.org/W2061463913","https://openalex.org/W2062813587","https://openalex.org/W2063014011","https://openalex.org/W2065777603","https://openalex.org/W2067290049","https://openalex.org/W2071112954","https://openalex.org/W2075039358","https://openalex.org/W2078386196","https://openalex.org/W2081761148","https://openalex.org/W2082990300","https://openalex.org/W2084613153","https://openalex.org/W2085316933","https://openalex.org/W2086176357","https://openalex.org/W2088905899","https://openalex.org/W2089920319","https://openalex.org/W2089923844","https://openalex.org/W2090018438","https://openalex.org/W2090902301","https://openalex.org/W2095495874","https://openalex.org/W2096410299","https://openalex.org/W2097522414","https://openalex.org/W2097997344","https://openalex.org/W2098510054","https://openalex.org/W2099019590","https://openalex.org/W2108346917","https://openalex.org/W2114867730","https://openalex.org/W2115424486","https://openalex.org/W2118333771","https://openalex.org/W2118450502","https://openalex.org/W2120404354","https://openalex.org/W2125471714","https://openalex.org/W2126853519","https://openalex.org/W2127558096","https://openalex.org/W2128699196","https://openalex.org/W2130544027","https://openalex.org/W2134818882","https://openalex.org/W2136621342","https://openalex.org/W2138397971","https://openalex.org/W2138925671","https://openalex.org/W2140631527","https://openalex.org/W2142849884","https://openalex.org/W2145149010","https://openalex.org/W2145925849","https://openalex.org/W2148122132","https://openalex.org/W2148907720","https://openalex.org/W2150818154","https://openalex.org/W2153154305","https://openalex.org/W2153979571","https://openalex.org/W2157905092","https://openalex.org/W2158805501","https://openalex.org/W2159767540","https://openalex.org/W2162230360","https://openalex.org/W2163462883","https://openalex.org/W2165191737","https://openalex.org/W2165663767","https://openalex.org/W2167686417","https://openalex.org/W2170271978","https://openalex.org/W2170720478","https://openalex.org/W2171794152","https://openalex.org/W2203291581","https://openalex.org/W2264682931","https://openalex.org/W2318925269","https://openalex.org/W2330709704","https://openalex.org/W2336169581","https://openalex.org/W2336215030","https://openalex.org/W2394914270","https://openalex.org/W4242442904","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2073455500","https://openalex.org/W2097522414","https://openalex.org/W2028001386","https://openalex.org/W2021185028","https://openalex.org/W1992634781","https://openalex.org/W2002354023","https://openalex.org/W2376493863","https://openalex.org/W2352442179","https://openalex.org/W2032303549","https://openalex.org/W2138397971"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}