{"id":"https://openalex.org/W2039097119","doi":"https://doi.org/10.1056/nejm198010023031403","title":"Development of a Scleroderma-like Illness during Therapy with L-5-Hydroxytryptophan and Carbidopa","display_name":"Development of a Scleroderma-like Illness during Therapy with L-5-Hydroxytryptophan and Carbidopa","publication_year":1980,"publication_date":"1980-10-02","ids":{"openalex":"https://openalex.org/W2039097119","doi":"https://doi.org/10.1056/nejm198010023031403","mag":"2039097119","pmid":"https://pubmed.ncbi.nlm.nih.gov/6997735"},"language":"en","primary_location":{"id":"doi:10.1056/nejm198010023031403","doi":"https://doi.org/10.1056/nejm198010023031403","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm198010023031403","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111764619","display_name":"Esther M. Sternberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esther M. Sternberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111722977","display_name":"Melvtn H. Van Woert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melvtn H. Van Woert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077418824","display_name":"Simon N. Young","orcid":"https://orcid.org/0000-0001-9666-8096","observed_orcids":["https://orcid.org/0000-0001-9666-8096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon N. Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090383676","display_name":"Ib Magnussen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ib Magnussen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111442287","display_name":"Herman Baker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herman Baker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004968642","display_name":"Serge G. Gauthier","orcid":"https://orcid.org/0000-0003-4272-3330","observed_orcids":["https://orcid.org/0000-0003-4272-3330"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Serge Gauthier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109039697","display_name":"C. Kirk Osterland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Kirk Osterland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1774,"has_fulltext":false,"cited_by_count":155,"citation_normalized_percentile":{"value":0.87313433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"303","issue":"14","first_page":"782","last_page":"787"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.6577000021934509,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.16110000014305115,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.07069999724626541,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-hydroxy-l-tryptophan","display_name":"L-5-hydroxytryptophan","score":0.9430000185966492},{"id":"https://openalex.org/keywords/carbidopa","display_name":"carbidopa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kynurenine","display_name":"kynurenine","score":0.8510000109672546},{"id":"https://openalex.org/keywords/drug-induced-scleroderma","display_name":"drug-induced scleroderma","score":0.7670000195503235},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.5320000052452087},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8550000190734863},{"id":"https://openalex.org/keywords/l-dopa","display_name":"L-DOPA","score":0.8880000114440918},{"id":"https://openalex.org/keywords/rechallenge","display_name":"drug rechallenge","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2776754145","wikidata":"https://www.wikidata.org/wiki/Q71133637","display_name":"Carbidopa","level":5,"score":0.9558473825454712},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8104010820388794},{"id":"https://openalex.org/C2779967694","wikidata":"https://www.wikidata.org/wiki/Q1383511","display_name":"Scleroderma (fungus)","level":3,"score":0.7536506652832031},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.6122288107872009},{"id":"https://openalex.org/C2776538686","wikidata":"https://www.wikidata.org/wiki/Q116275","display_name":"Myoclonus","level":2,"score":0.5714840292930603},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4555644989013672},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.4283443093299866},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.42703476548194885},{"id":"https://openalex.org/C2777503454","wikidata":"https://www.wikidata.org/wiki/Q415768","display_name":"Kynurenine","level":4,"score":0.41263070702552795},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.31559425592422485},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.3056967258453369},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27663135528564453},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.15158316493034363},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.12467718124389648},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.10368594527244568},{"id":"https://openalex.org/C180032290","wikidata":"https://www.wikidata.org/wiki/Q1664296","display_name":"Inoculation","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002230","descriptor_name":"Carbidopa","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002230","descriptor_name":"Carbidopa","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006916","descriptor_name":"5-Hydroxytryptophan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006916","descriptor_name":"5-Hydroxytryptophan","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009207","descriptor_name":"Myoclonus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1056/nejm198010023031403","doi":"https://doi.org/10.1056/nejm198010023031403","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm198010023031403","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:6997735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6997735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Case Reports"},{"id":"mag:2904622985","doi":null,"is_oa":false,"landing_page_url":"https://dissem.in/p/40108945/development-of-a-scleroderma-like-illness-during-l-5htp-carbidopa-therapy","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W265183046","https://openalex.org/W1816386271","https://openalex.org/W1966137607","https://openalex.org/W1973815983","https://openalex.org/W1980472324","https://openalex.org/W1990784490","https://openalex.org/W2005881176","https://openalex.org/W2010118589","https://openalex.org/W2013699833","https://openalex.org/W2018634523","https://openalex.org/W2019288474","https://openalex.org/W2020373599","https://openalex.org/W2029843646","https://openalex.org/W2034064424","https://openalex.org/W2043094224","https://openalex.org/W2072479208","https://openalex.org/W2086549079","https://openalex.org/W2087965792","https://openalex.org/W2090964430","https://openalex.org/W2136320861","https://openalex.org/W2165998673","https://openalex.org/W2196566018","https://openalex.org/W2274148752","https://openalex.org/W2294535173","https://openalex.org/W2324563126","https://openalex.org/W2326519870","https://openalex.org/W2405619413","https://openalex.org/W4233573171"],"related_works":["https://openalex.org/W2904622985","https://openalex.org/W2078450974","https://openalex.org/W2010118589","https://openalex.org/W2410778189","https://openalex.org/W2416217945","https://openalex.org/W4242314391","https://openalex.org/W2073440386","https://openalex.org/W1964450692","https://openalex.org/W2686627377","https://openalex.org/W2417592044"],"abstract_inverted_index":{"A":[0],"scleroderma-like":[1,124],"illness":[2],"developed":[3],"in":[4,47,63,73,87,94,109,119],"a":[5,83],"patient":[6,18],"treated":[7,79,100],"with":[8,76,80,97,133],"L-5":[9],"hydroxytryptophan":[10],"(L-5HTP)":[11],"and":[12,82,86,103,107,129],"carbidopa":[13],"for":[14],"intention":[15,77],"myoclonus.":[16],"The":[17],"had":[19],"high":[20,26,62,126],"plasma":[21,127],"kynurenine":[22,56],"levels":[23,34],"that":[24,41,52,113],"remained":[25],"when":[27],"the":[28,42,50,110,120,130],"L-5HTP-carbidopa":[29],"combination":[30],"was":[31,57],"discontinued,":[32],"However,":[33],"rose":[35],"futher":[36],"on":[37],"drug":[38,43],"rechallenge,":[39],"suggesting":[40],"unmasked":[44],"an":[45],"abnormality":[46,131],"one":[48],"of":[49,65,122],"enzymes":[51],"catabolize":[53],"kynurenine.":[54,135],"Plasma":[55],"also":[58],"determined":[59],"to":[60],"be":[61,117],"seven":[64],"15":[66],"patients":[67,75,96],"wth":[68,101],"idiopathic":[69],"scleroderma,":[70],"but":[71],"not":[72,91],"eight":[74],"myoclonus":[78],"L-5HTP":[81],"decarboxylase":[84],"inhibitor":[85],"whom":[88],"scleroderma":[89],"did":[90],"develop":[92],"or":[93],"10":[95],"Parkinson's":[98],"disease":[99],"L-dopa":[102],"carbidopa.":[104],"Our":[105],"data":[106],"studies":[108],"literature":[111],"suggest":[112],"two":[114],"factors":[115],"may":[116],"important":[118],"pathogenesis":[121],"some":[123],"illness:":[125],"serotonin":[128],"associated":[132],"elevated":[134]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
