{"id":"https://openalex.org/W203898233","doi":"https://doi.org/10.33588/rn.5405.2011675","title":"Estudio comparativo de grupos independientes de pacientes con migra\u00f1a epis\u00f3dica tratados preventivamente con flunaricina o nadolol","display_name":"Estudio comparativo de grupos independientes de pacientes con migra\u00f1a epis\u00f3dica tratados preventivamente con flunaricina o nadolol","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W203898233","doi":"https://doi.org/10.33588/rn.5405.2011675","mag":"203898233","pmid":"https://pubmed.ncbi.nlm.nih.gov/22362476"},"language":"es","primary_location":{"id":"doi:10.33588/rn.5405.2011675","doi":"https://doi.org/10.33588/rn.5405.2011675","is_oa":false,"landing_page_url":"https://doi.org/10.33588/rn.5405.2011675","pdf_url":null,"source":{"id":"https://openalex.org/S184263677","display_name":"Revista de Neurolog\u00eda","issn_l":"0210-0010","issn":["0210-0010","1576-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4322632785","host_organization_name":"Viguera Publishers","host_organization_lineage":["https://openalex.org/P4322632785"],"host_organization_lineage_names":["Viguera Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de Neurolog\u00eda","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111390405","display_name":"Manuel Gracia Naya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114530","display_name":"Hospital Universitario Miguel Servet","ror":"https://ror.org/01r13mt55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210114530"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Gracia Naya","raw_affiliation_strings":["HUMS. Hospital Universitario Miguel Servet, Zaragoza, Espana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HUMS. Hospital Universitario Miguel Servet, Zaragoza, Espana","institution_ids":["https://openalex.org/I4210114530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019018871","display_name":"Mariano Huerta Villanueva","orcid":"https://orcid.org/0000-0003-0181-5335","observed_orcids":["https://orcid.org/0000-0003-0181-5335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariano Huerta Villanueva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044946194","display_name":"Consuelo R\u00edos G\u00f3mez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Consuelo R\u00edos G\u00f3mez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072958995","display_name":"Mar\u00eda Jos\u00e9 Garc\u00eda Gomara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda Jos\u00e9 Garc\u00eda Gomara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111383625","display_name":"Jorge Artal Roy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge Artal Roy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113470454","display_name":"Sara S\u00e1nchez Valiente","orcid":"https://orcid.org/0009-0005-2210-2838","observed_orcids":["https://orcid.org/0009-0005-2210-2838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara S\u00e1nchez Valiente","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005262099","display_name":"Sonia Santos Lasaosa","orcid":"https://orcid.org/0000-0002-4141-7705","observed_orcids":["https://orcid.org/0000-0002-4141-7705","https://orcid.org/0000-0001-5139-6031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sonia Santos Lasaosa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044954071","display_name":"J.\u00c1. Mauri Llerda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 \u00c1ngel Mauri Llerda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110072976","display_name":"Ana Mar\u00eda Latorre Jim\u00e9nez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Mar\u00eda Latorre Jim\u00e9nez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01996483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"05","first_page":"277","last_page":"277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/episodic-migraine","display_name":"episodic migraine","score":0.8180000185966492},{"id":"https://openalex.org/keywords/migraine-prevention","display_name":"migraine prophylaxis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/flunarizine","display_name":"flunarizine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nadolol","display_name":"nadolol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.6790000200271606},{"id":"https://openalex.org/keywords/drug-comparison","display_name":"drug comparison","score":0.5210000276565552},{"id":"https://openalex.org/keywords/responder-rate","display_name":"responder rate","score":0.7749999761581421},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.7319999933242798},{"id":"https://openalex.org/keywords/patient-satisfaction","display_name":"patient satisfaction","score":0.9020000100135803},{"id":"https://openalex.org/keywords/treatment-effectiveness","display_name":"treatment effectiveness","score":0.35499998927116394},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.8289999961853027},{"id":"https://openalex.org/keywords/beta-2-adrenergic-agonists","display_name":"beta2-adrenergic agonists","score":0.5400000214576721},{"id":"https://openalex.org/keywords/migraine-frequency-reduction","display_name":"migraine frequency reduction","score":0.3240000009536743},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C2777286116","wikidata":"https://www.wikidata.org/wiki/Q416237","display_name":"Flunarizine","level":3,"score":0.9853981733322144},{"id":"https://openalex.org/C2776256041","wikidata":"https://www.wikidata.org/wiki/Q424952","display_name":"Nadolol","level":3,"score":0.9787262082099915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7674872279167175},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.5346258282661438},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5089626312255859},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2401466965675354},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005444","descriptor_name":"Flunarizine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009248","descriptor_name":"Nadolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.33588/rn.5405.2011675","doi":"https://doi.org/10.33588/rn.5405.2011675","is_oa":false,"landing_page_url":"https://doi.org/10.33588/rn.5405.2011675","pdf_url":null,"source":{"id":"https://openalex.org/S184263677","display_name":"Revista de Neurolog\u00eda","issn_l":"0210-0010","issn":["0210-0010","1576-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4322632785","host_organization_name":"Viguera Publishers","host_organization_lineage":["https://openalex.org/P4322632785"],"host_organization_lineage_names":["Viguera Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de Neurolog\u00eda","raw_type":"journal-article"},{"id":"pmid:22362476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22362476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de neurologia","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W9255039","https://openalex.org/W78610309","https://openalex.org/W1510107467","https://openalex.org/W2287974693","https://openalex.org/W2123467413","https://openalex.org/W2050349834","https://openalex.org/W2414596118","https://openalex.org/W4408079732","https://openalex.org/W2116530528","https://openalex.org/W2348421757"],"abstract_inverted_index":{"INTRODUCTION.":[0],"Flunarizine,":[1],"with":[2,9,49,76,95,135,147,215,219,229,233,254,258,269,273],"level":[3,11],"of":[4,19,32,45,51,111,116,160,187,210,212,246,264,300],"evidence":[5,10],"A,":[6],"and":[7,118,145,173,198,217,231,256,271,290,311],"nadolol,":[8],"C,":[12],"would":[13],"be":[14,294],"indicated":[15],"as":[16],"preventive":[17,89,298],"treatment":[18,90,117,164,188,299],"migraine.":[20,302],"Yet,":[21],"no":[22],"previous":[23],"studies":[24],"have":[25],"been":[26],"conducted":[27],"to":[28,80,131,163,293],"compare":[29,38],"the":[30,33,39,52,55,57,72,92,109,170,178,195,203,244,297],"effectiveness":[31,40,105],"two":[34],"drugs.":[35],"AIM.":[36],"To":[37],"parameters":[41],"in":[42,62,108,169,177,194,202,243,283,296,308],"independent":[43],"groups":[44],"patients":[46,75,128],"treated":[47],"preventively":[48],"one":[50],"pharmaceuticals":[53],"from":[54],"study,":[56],"same":[58],"protocol":[59],"being":[60],"applied":[61],"both":[63,284],"cases.":[64],"PATIENTS":[65],"AND":[66],"METHODS.":[67],"The":[68,103,124,157,224,238,278],"subjects":[69],"selected":[70],"for":[71,91],"study":[73,125],"were":[74,121],"episodic":[77,301],"migraine":[78],"(according":[79],"2004":[81],"International":[82],"Headache":[83],"Society":[84],"criteria)":[85],"who":[86,129],"had":[87],"undergone":[88],"first":[93],"time,":[94],"flunarizine":[96,136,171,196,216,230,255,270,289],"(5":[97],"mg/day)":[98],"or":[99,250],"nadolol":[100,148,179,204,220,234,259,274,291],"(20-40":[101],"mg/day).":[102],"main":[104],"variables":[106],"(reduction":[107,242],"number":[110,159,245],"seizures":[112,161,247],"at":[113,184],"four":[114,185],"months":[115,186],"responder":[119,225],"rates)":[120],"analysed.":[122],"RESULTS.":[123],"included":[126],"227":[127],"intended":[130],"receive":[132],"treatment:":[133],"155":[134],"(80.5%":[137],"females;":[138,150],"mean":[139,151,158],"age:":[140,152],"38.3":[141],"\u00b1":[142,154,167,175,192,200],"12.1":[143],"years)":[144],"72":[146],"(63.8%":[149],"37.1":[153],"12.0":[155],"years).":[156],"prior":[162],"was":[165,190,227,252,281,312],"6.09":[166],"2.6":[168],"group":[172,180,197,205],"5.1":[174],"1.7":[176],"(p":[181,206,221,235,260,275],"=":[182,207,222,236,261,276],"0.0079);":[183],"it":[189],"2.61":[191],"2.4":[193,201],"2.77":[199],"NS).":[208,223,237],"Percentage":[209,263],"reduction":[211],"migraines:":[213],"55.2%":[214],"50.4%":[218],"rate":[226,241,280],"69%":[228],"67%":[232],"excellent":[239],"response":[240],"by":[248],"75%":[249],"more)":[251],"52.2%":[253],"36.1%":[257],"0.0077).":[262],"adverse":[265],"side":[266],"effects:":[267],"48.3%":[268],"25%":[272],"0.0009).":[277],"satisfaction":[279],"similar":[282],"groups,":[285],"68%.":[286],"CONCLUSIONS.":[287],"Both":[288],"proved":[292],"effective":[295],"Flunarizine":[303],"is":[304],"used":[305],"more":[306],"often":[307],"our":[309],"milieu":[310],"less":[313],"well":[314],"tolerated.":[315]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}