{"id":"https://openalex.org/W2038968673","doi":"https://doi.org/10.1158/1538-7445.am2012-4656","title":"Abstract 4656: Targeting Sp1 and survivin for potential ovarian cancer therapy: Comparative assessment of anti-cancer NSAID tolfenamic acid and cisplatin","display_name":"Abstract 4656: Targeting Sp1 and survivin for potential ovarian cancer therapy: Comparative assessment of anti-cancer NSAID tolfenamic acid and cisplatin","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2038968673","doi":"https://doi.org/10.1158/1538-7445.am2012-4656","mag":"2038968673"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-4656","doi":"https://doi.org/10.1158/1538-7445.am2012-4656","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-4656","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041786738","display_name":"Umesh T. Sankpal","orcid":"https://orcid.org/0000-0001-6696-2315","observed_orcids":["https://orcid.org/0000-0001-6696-2315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Umesh T. Sankpal","raw_affiliation_strings":["1MD Anderson Cancer Center Orlando, Orlando, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center Orlando, Orlando, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111749671","display_name":"Susan Blaydes Ingersoll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210085997","display_name":"Florida Hospital Cancer Institute","ror":"https://ror.org/00aqz8k66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210085997"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan B. Ingersoll","raw_affiliation_strings":["2Florida Hospital Cancer Institute, Orlando, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Florida Hospital Cancer Institute, Orlando, FL","institution_ids":["https://openalex.org/I4210085997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023889890","display_name":"Chris M. Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris M. Lee","raw_affiliation_strings":["1MD Anderson Cancer Center Orlando, Orlando, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center Orlando, Orlando, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086445708","display_name":"Hasina C. McGann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210085997","display_name":"Florida Hospital Cancer Institute","ror":"https://ror.org/00aqz8k66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210085997"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hasina C. McGann","raw_affiliation_strings":["2Florida Hospital Cancer Institute, Orlando, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Florida Hospital Cancer Institute, Orlando, FL","institution_ids":["https://openalex.org/I4210085997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110567138","display_name":"Vadiraja B. Bhat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vadiraja B. Bhat","raw_affiliation_strings":["3Agilent Technologies, Wilmington, DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Agilent Technologies, Wilmington, DE","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030675074","display_name":"Mooez Khan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mooez Khan","raw_affiliation_strings":["1MD Anderson Cancer Center Orlando, Orlando, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center Orlando, Orlando, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040010155","display_name":"Sarfraz Ahmad","orcid":"https://orcid.org/0000-0002-5180-0409","observed_orcids":["https://orcid.org/0000-0002-5180-0409"]},"institutions":[{"id":"https://openalex.org/I4210085997","display_name":"Florida Hospital Cancer Institute","ror":"https://ror.org/00aqz8k66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210085997"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarfraz Ahmad","raw_affiliation_strings":["2Florida Hospital Cancer Institute, Orlando, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Florida Hospital Cancer Institute, Orlando, FL","institution_ids":["https://openalex.org/I4210085997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032881252","display_name":"Robert W. Holloway","orcid":"https://orcid.org/0000-0002-3121-4605","observed_orcids":["https://orcid.org/0000-0002-3121-4605"]},"institutions":[{"id":"https://openalex.org/I4210085997","display_name":"Florida Hospital Cancer Institute","ror":"https://ror.org/00aqz8k66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210085997"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Holloway","raw_affiliation_strings":["2Florida Hospital Cancer Institute, Orlando, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Florida Hospital Cancer Institute, Orlando, FL","institution_ids":["https://openalex.org/I4210085997"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007695569","display_name":"Riyaz M. Basha","orcid":"https://orcid.org/0000-0002-4071-0993","observed_orcids":["https://orcid.org/0000-0002-4071-0993","https://orcid.org/0000-0002-6955-5448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Riyaz Basha","raw_affiliation_strings":["1MD Anderson Cancer Center Orlando, Orlando, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MD Anderson Cancer Center Orlando, Orlando, FL","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"4656","last_page":"4656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":1.0},{"id":"https://openalex.org/keywords/tolfenamic-acid","display_name":"tolfenamic acid","score":0.9700000286102295},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/caspase-3-7-activity","display_name":"caspase 3/7 activity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.39899998903274536},{"id":"https://openalex.org/keywords/cancer-cell-viability","display_name":"tumor cell viability","score":0.46299999952316284},{"id":"https://openalex.org/keywords/gene-expression-in-tumor-tissue","display_name":"gene expression in tumor tissue","score":0.45500001311302185},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.6800000071525574},{"id":"https://openalex.org/keywords/inhibitor-of-apoptosis-proteins","display_name":"inhibitor of apoptosis proteins","score":0.6489999890327454},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6000000238418579},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.9793621301651001},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.810188889503479},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6688494086265564},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5716733932495117},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5492845773696899},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49369940161705017},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.4765263795852661},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4680442810058594},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43966323137283325},{"id":"https://openalex.org/C2777408456","wikidata":"https://www.wikidata.org/wiki/Q174299","display_name":"Inhibitor of apoptosis","level":4,"score":0.4386722445487976},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.43032971024513245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37125837802886963},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36851444840431213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3361814618110657},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2244141399860382},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.17391401529312134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15134486556053162},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12283623218536377},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-4656","doi":"https://doi.org/10.1158/1538-7445.am2012-4656","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-4656","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2329719540","https://openalex.org/W2019033215","https://openalex.org/W2515067541","https://openalex.org/W2314961361","https://openalex.org/W2264619158","https://openalex.org/W2014635556","https://openalex.org/W2039320366","https://openalex.org/W2072059383","https://openalex.org/W2061515040","https://openalex.org/W2144320478"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Expression":[2],"of":[3,22,24,57,73,125,167,211,251,266,316,334,371,427,432],"specificity":[4],"protein":[5,99],"1":[6],"(Sp1)":[7,250],"transcription":[8],"factor":[9],"is":[10,340,393],"negatively":[11],"associated":[12],"with":[13,141,164,238,342,384],"survival":[14],"in":[15,46,61,69,79,120,283,293,326,355,375],"some":[16,47],"cancer":[17,48,63],"patients.":[18],"Survivin,":[19],"a":[20,38,261,301,323],"member":[21],"Inhibitor":[23],"Apoptosis":[25],"Protein":[26],"family,":[27],"causes":[28,399],"resistance":[29],"to":[30,53,94,407],"chemo-":[31],"and":[32,42,59,66,75,78,97,102,109,127,134,151,186,189,201,208,213,228,258,263,273,289,312,329,346,352,381,413],"radiation":[33],"therapy.":[34],"Tolfenamic":[35],"acid":[36],"(TA),":[37],"NSAID,":[39],"targets":[40],"Sp1":[41,58,101,199,233,348,351,377],"inhibits":[43],"survivin":[44,60,103,224,353,379,383],"expression":[45,56,104,191,225,234,255,354,380],"models.":[49],"Our":[50],"aims":[51],"were":[52,92,117,139,162,204],"examine":[54],"the":[55,68,229,239,369,388,409,428,433],"ovarian":[62],"(OC)":[64],"specimens":[65,85,252,357],"compare":[67],"vitro":[70,121],"anticancer":[71,401],"response":[72,124,370],"cisplatin":[74,126,148,172,259,279,290,372,397],"TA":[76,128,144,168,212,257,269,288,321,367,385,392],"alone":[77],"combination.":[80,376],"Methods:":[81],"Tissues":[82],"from":[83],"clinical":[84],"(16":[86],"advanced":[87],"stage":[88],"tumors,":[89],"3":[90],"normal)":[91],"used":[93,118,374],"isolate":[95],"RNA":[96],"prepare":[98],"extracts.":[100],"was":[105,129,154,180,192],"measured":[106,130,181],"using":[107,156,182,411],"qPCR":[108,216,240],"Western":[110,195,242],"blots.":[111,196],"OC":[112,356,389],"cell":[113,152,267,285,335],"lines":[114],"(ES-2,":[115],"SKOV3-AF2)":[116],"for":[119,175,436],"assays.":[122],"Anti-proliferative":[123],"at":[131],"24,":[132],"48":[133,176],"72":[135],"h,":[136],"post-treatment.":[137],"Cells":[138],"treated":[140,163],"DMSO":[142],"(vehicle),":[143],"(25/50/100":[145],"\u00b5M)":[146,170],"or":[147,171,248],"(5/10/20/50":[149],"nM),":[150],"viability":[153],"assayed":[155],"CellTiter":[157],"Glo":[158,184],"kit.":[159],"Subsequently,":[160],"cells":[161,390],"optimized":[165],"doses":[166],"(50":[169],"(20":[173],"nM)":[174],"h.":[177],"Caspase-3/7":[178,183],"activity":[179,203,345,402],"kit":[185],"Sp1,":[187,327],"survivin,":[188,328],"c-PARP":[190,311],"determined":[193],"by":[194],"Cell":[197],"viability,":[198],"expression,":[200],"caspase-3/7":[202,313,344],"assessed":[205],"following":[206,337],"individual":[207],"combination":[209,338],"treatment":[210,291,339],"cisplatin.":[214,404],"Results:":[215],"revealed":[217],"that":[218,245,307,359],"all":[219,246],"tumor":[220],"samples":[221],"have":[222,253],"increased":[223,232,343],"(>5":[226],"fold)":[227],"majority":[230,249],"showed":[231,260],"(2-3":[235],"fold).":[236],"Consistent":[237],"data,":[241],"blot":[243],"confirmed":[244,306,358],"(survivin)":[247],"high":[254],"levels.":[256],"dose-":[262],"time-dependent":[264],"inhibition":[265,277,282,295,333],"viability.":[268],"caused":[270,280,322],"75%":[271],"(ES-2)":[272],"25%":[274],"(SKOV3-AF2)":[275],"growth":[276,336],"while":[278],"\u223c20%":[281],"both":[284,308],"lines.":[286],"Combination":[287],"resulted":[292],"maximum":[294],"(ES2:":[296],">90%;":[297],"SKOV3-AF2:":[298],"75%),":[299],"showing":[300],"synergistic":[302],"effect.":[303],"These":[304],"data":[305],"agents":[309],"up-regulated":[310],"indicating":[314],"activation":[315],"apoptotic":[317],"pathways.":[318],"However,":[319],"only":[320],"significant":[324],"decrease":[325],"c-Met":[330],"expression.":[331,349],"Increased":[332],"consistent":[341],"decreased":[347],"Conclusions:":[350],"targeting":[360,382],"these":[361],"molecules/pathways":[362],"would":[363],"be":[364],"therapeutically":[365],"relevant.":[366],"enhanced":[368],"when":[373],"regulates":[378],"might":[386],"render":[387],"radiation-sensitive.":[391],"less":[394],"toxic":[395],"than":[396],"but":[398],"greater":[400],"over":[403],"Further":[405],"studies":[406],"evaluate":[408],"mechanism(s)":[410],"proteomic":[412],"molecular":[414],"profiling":[415],"approach":[416],"are":[417],"underway.":[418],"Citation":[419],"Format:":[420],"{Authors}.":[421],"{Abstract":[422],"title}":[423],"[abstract].":[424],"In:":[425],"Proceedings":[426],"103rd":[429],"Annual":[430],"Meeting":[431],"American":[434],"Association":[435],"Cancer":[437,448],"Research;":[438],"2012":[439],"Mar":[440],"31-Apr":[441],"4;":[442],"Chicago,":[443],"IL.":[444],"Philadelphia":[445],"(PA):":[446],"AACR;":[447],"Res":[449],"2012;72(8":[450],"Suppl):Abstract":[451],"nr":[452],"4656.":[453],"doi:1538-7445.AM2012-4656":[454]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
