{"id":"https://openalex.org/W2038803232","doi":"https://doi.org/10.1055/s-0029-1191592","title":"Single shot ATG induction followed by postoperative CNI holiday: A renal sparing and safe strategy after heart transplantation!","display_name":"Single shot ATG induction followed by postoperative CNI holiday: A renal sparing and safe strategy after heart transplantation!","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2038803232","doi":"https://doi.org/10.1055/s-0029-1191592","mag":"2038803232"},"language":"en","primary_location":{"id":"doi:10.1055/s-0029-1191592","doi":"https://doi.org/10.1055/s-0029-1191592","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0029-1191592","pdf_url":null,"source":{"id":"https://openalex.org/S81394012","display_name":"The Thoracic and Cardiovascular Surgeon","issn_l":"0171-6425","issn":["0171-6425","1439-1902"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Thoracic and Cardiovascular Surgeon","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055462466","display_name":"Florian Wagner","orcid":"https://orcid.org/0000-0001-7407-9741","observed_orcids":["https://orcid.org/0000-0001-7407-9741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FM Wagner","raw_affiliation_strings":["Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050047175","display_name":"Johannes M. Schirmer","orcid":"https://orcid.org/0000-0003-2203-1353","observed_orcids":["https://orcid.org/0000-0003-2203-1353"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Schirmer","raw_affiliation_strings":["Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006861368","display_name":"Hendrik Treede","orcid":"https://orcid.org/0000-0002-8458-7667","observed_orcids":["https://orcid.org/0000-0002-8458-7667"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Treede","raw_affiliation_strings":["Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037262377","display_name":"Marcin Kubik","orcid":"https://orcid.org/0000-0001-6968-8913","observed_orcids":["https://orcid.org/0000-0001-6968-8913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kubik","raw_affiliation_strings":["Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108598606","display_name":"S. Meyer","orcid":"https://orcid.org/0000-0002-3098-9038","observed_orcids":["https://orcid.org/0000-0002-3098-9038"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Meyer","raw_affiliation_strings":["Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032232677","display_name":"Loant Baholli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Baholli","raw_affiliation_strings":["Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003044687","display_name":"Angelika Costard\u2010J\u00e4ckle","orcid":"https://orcid.org/0000-0003-1464-239X","observed_orcids":["https://orcid.org/0000-0003-1464-239X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J\u00e4ckle","raw_affiliation_strings":["Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076167190","display_name":"Hermann C. Reichenspurner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Reichenspurner","raw_affiliation_strings":["Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4res Herzzentrum Hamburg, Herz- und Gef\u00e4\u00dfchirurgie, Hamburg, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18375302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"56","issue":"S 01","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/antithymocyte-globulin-induction","display_name":"antithymocyte globulin induction","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.8220000267028809},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/postoperative-renal-function","display_name":"postoperative renal function","score":0.6140000224113464},{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.6769999861717224},{"id":"https://openalex.org/keywords/viremia","display_name":"viremia","score":0.7670000195503235},{"id":"https://openalex.org/keywords/post-transplant-malignancy","display_name":"post-transplant malignancy","score":0.7070000171661377},{"id":"https://openalex.org/keywords/immunosuppression-timing","display_name":"immunosuppression timing","score":0.5590000152587891},{"id":"https://openalex.org/keywords/cyclosporine-trough-levels","display_name":"cyclosporine trough levels","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7374265193939209},{"id":"https://openalex.org/C3019835501","wikidata":"https://www.wikidata.org/wiki/Q1310130","display_name":"Single shot","level":2,"score":0.6359114050865173},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.5635712742805481},{"id":"https://openalex.org/C2778344882","wikidata":"https://www.wikidata.org/wiki/Q278938","display_name":"Shot (pellet)","level":2,"score":0.48336905241012573},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4298827648162842},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4119143486022949},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.41000932455062866},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3328121304512024},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.05493718385696411},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.042435914278030396},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0029-1191592","doi":"https://doi.org/10.1055/s-0029-1191592","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0029-1191592","pdf_url":null,"source":{"id":"https://openalex.org/S81394012","display_name":"The Thoracic and Cardiovascular Surgeon","issn_l":"0171-6425","issn":["0171-6425","1439-1902"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Thoracic and Cardiovascular Surgeon","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2330336240","https://openalex.org/W2341101595","https://openalex.org/W2015878807","https://openalex.org/W2123420160","https://openalex.org/W2775785761","https://openalex.org/W2051269675","https://openalex.org/W2053738410","https://openalex.org/W2588367596","https://openalex.org/W4412852718","https://openalex.org/W2921923838"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"evaluate":[2],"safety":[3],"and":[4,36,60,121,135,164,200,205,233,240],"efficacy":[5],"of":[6,9,58,127,180,231,237],"significant":[7],"delay":[8,219],"postoperative":[10],"CNI":[11,220],"administration":[12,221],"after":[13],"single":[14,48],"shot":[15,210],"ATG":[16,50,213],"induction.":[17],"Methods:":[18],"63":[19],"patients":[20,174],"(ICM":[21],"23,":[22],"DCM":[23],"36,":[24],"other":[25],"4,":[26],"age":[27],"54\u00b114yrs)":[28],"underwent":[29],"orthotopic":[30],"heart":[31],"transplantation":[32],"between":[33],"Jan.":[34],"2004":[35],"Aug.":[37],"2007.":[38],"Preop.":[39],"creatinine":[40,160],"was":[41,44,74,107,131,185],"2.1\u00b10.8mg/dl.":[42],"Immunosuppression":[43],"induced":[45],"by":[46],"a":[47],"dosis":[49],"(Thymoglobulin":[51],"1.5mg/kg)":[52],"with":[53,212,228],"concommittant":[54],"MMF":[55],"(fixed":[56],"dose":[57],"2g/day)":[59],"steroids":[61],"(taper":[62],"from":[63],"1":[64,146,199],"to":[65,82,111,116,166,217],"0.1mg/kg/day)":[66],"starting":[67],"day":[68,90,133,137,157],"one.":[69],"Oral":[70],"CyA":[71,128],"or":[72,101,129],"Tac":[73,130],"started":[75],"only":[76,87,145,172],"at":[77,88,156,162,168,198],"48\u201372":[78],"hours":[79],"post":[80],"HTx":[81],"reach":[83],"target":[84],"through":[85],"levels":[86],"postop.":[89,143],"7\u201310.":[91],"Postoperative":[92],"monitoring":[93],"included":[94],"daily":[95],"echocardiography,":[96],"endomyocardial":[97],"biopsy":[98],"when":[99],"indicated":[100],"before":[102],"discharge.":[103],"Results:":[104],"Perioperative":[105],"mortality":[106],"7/63":[108],"(11.1%)":[109],"due":[110],"primary":[112],"graft":[113],"failure":[114],"unrelated":[115],"rejection":[117,153],"(n=3),":[118],"sepsis/MOF":[119],"(n=3)":[120],"mediastinitis":[122],"(n=1).":[123],"C0":[124],"level":[125],"(HPLC)":[126],"147\u00b164/6.8\u00b11.4at":[132],"7":[134],"189\u00b123/8.9\u00b11.9at":[136],"10":[138],"respectively.":[139,207],"During":[140],"the":[141],"first":[142,189],"month":[144],"patient":[147,193],"required":[148,176],"treatment":[149],"for":[150],"moderate":[151],"acute":[152],"(ISHLT":[154],"II)":[155],"10.":[158],"Postop.":[159],"peaked":[161],"2.9\u00b11.5,":[163],"decreased":[165],"1.5\u00b10.3mg/dl":[167],"discharge":[169],"(day":[170],"28\u00b125);":[171],"3":[173,201],"(4.8%)":[175],"temporary":[177],"hemofiltration.":[178],"Incidence":[179],"viremia":[181],"requiring":[182],"preemptive":[183],"therapy":[184],"39.3%":[186],"(22/56)":[187],"during":[188],"year":[190],"follow-up.":[191],"No":[192],"developed":[194],"malignoma.":[195,241],"Actuarial":[196],"survival":[197],"years":[202],"is":[203,214],"83.6%":[204],"81.8%":[206],"Conclusion:":[208],"Single":[209],"induction":[211],"potent":[215],"enough":[216],"safely":[218],"translating":[222],"into":[223],"excellent":[224],"perioperative":[225],"renal":[226],"function":[227],"<5%":[229],"use":[230],"hemofiltration":[232],"avoids":[234],"increased":[235],"incidence":[236],"viral":[238],"infection":[239]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
