{"id":"https://openalex.org/W2038734404","doi":"https://doi.org/10.1016/0092-8674(83)90179-4","title":"Developmental activation of the H-2K gene is correlated with an increase in DNA methylation","display_name":"Developmental activation of the H-2K gene is correlated with an increase in DNA methylation","publication_year":1983,"publication_date":"1983-12-01","ids":{"openalex":"https://openalex.org/W2038734404","doi":"https://doi.org/10.1016/0092-8674(83)90179-4","mag":"2038734404","pmid":"https://pubmed.ncbi.nlm.nih.gov/6197180"},"language":"en","primary_location":{"id":"doi:10.1016/0092-8674(83)90179-4","doi":"https://doi.org/10.1016/0092-8674(83)90179-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0092-8674(83)90179-4","pdf_url":null,"source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101508358","display_name":"Kenichi Tanaka","orcid":"https://orcid.org/0000-0003-3538-3163","observed_orcids":["https://orcid.org/0000-0003-3538-3163"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenichi Tanaka","raw_affiliation_strings":["Laboratories of Cell Biology and Molecular Virology National Cancer Institute Bethesda, Maryland 20205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories of Cell Biology and Molecular Virology National Cancer Institute Bethesda, Maryland 20205 USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036354240","display_name":"Ettore Appella","orcid":"https://orcid.org/0000-0003-0569-9722","observed_orcids":["https://orcid.org/0000-0003-0569-9722"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ettore Appella","raw_affiliation_strings":["Laboratories of Cell Biology and Molecular Virology National Cancer Institute Bethesda, Maryland 20205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories of Cell Biology and Molecular Virology National Cancer Institute Bethesda, Maryland 20205 USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":null,"display_name":"Gilbert Jay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilbert Jay","raw_affiliation_strings":["Laboratories of Cell Biology and Molecular Virology National Cancer Institute Bethesda, Maryland 20205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories of Cell Biology and Molecular Virology National Cancer Institute Bethesda, Maryland 20205 USA","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":6.9211,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.98096268,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"35","issue":"2","first_page":"457","last_page":"465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gene-activation","display_name":"gene activation","score":0.703000009059906},{"id":"https://openalex.org/keywords/f9-teratocarcinoma-cells","display_name":"F9 teratocarcinoma cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/embryonal-carcinoma","display_name":"embryonal carcinoma","score":0.6690000295639038},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.8579999804496765},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.8529999852180481},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5529999732971191},{"id":"https://openalex.org/keywords/histocompatibility-antigens","display_name":"histocompatibility antigens","score":0.7009999752044678},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8812936544418335},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8259730339050293},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6802510023117065},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6439501047134399},{"id":"https://openalex.org/C2908788973","wikidata":"https://www.wikidata.org/wiki/Q1737977","display_name":"Teratocarcinoma","level":4,"score":0.6144956350326538},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.591881513595581},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5762094259262085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5609830021858215},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5109981298446655},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4858400523662567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2589636445045471}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004262","descriptor_name":"DNA Restriction Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011061","descriptor_name":"Poly A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013724","descriptor_name":"Teratoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013724","descriptor_name":"Teratoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0092-8674(83)90179-4","doi":"https://doi.org/10.1016/0092-8674(83)90179-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0092-8674(83)90179-4","pdf_url":null,"source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},{"id":"pmid:6197180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6197180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W99625710","https://openalex.org/W1486084384","https://openalex.org/W1521909328","https://openalex.org/W1579587268","https://openalex.org/W1845717996","https://openalex.org/W1974747095","https://openalex.org/W1978783239","https://openalex.org/W1981206726","https://openalex.org/W1981435309","https://openalex.org/W1984924023","https://openalex.org/W2000874837","https://openalex.org/W2001656603","https://openalex.org/W2003932465","https://openalex.org/W2011275780","https://openalex.org/W2015155519","https://openalex.org/W2020555116","https://openalex.org/W2027132605","https://openalex.org/W2029987769","https://openalex.org/W2032799016","https://openalex.org/W2033413127","https://openalex.org/W2034994122","https://openalex.org/W2036853135","https://openalex.org/W2042678076","https://openalex.org/W2050746444","https://openalex.org/W2050862898","https://openalex.org/W2063450941","https://openalex.org/W2068867045","https://openalex.org/W2070547356","https://openalex.org/W2073848823","https://openalex.org/W2077077811","https://openalex.org/W2084984946","https://openalex.org/W2085579924","https://openalex.org/W2087030435","https://openalex.org/W2087688021","https://openalex.org/W2091602444","https://openalex.org/W2122385641","https://openalex.org/W2145750252","https://openalex.org/W2149753612","https://openalex.org/W2153090288","https://openalex.org/W2158343596","https://openalex.org/W6645025326","https://openalex.org/W6683275416"],"related_works":["https://openalex.org/W1541595061","https://openalex.org/W2418224947","https://openalex.org/W7214204456","https://openalex.org/W7097299614","https://openalex.org/W1990374273","https://openalex.org/W4299600481","https://openalex.org/W4229794869","https://openalex.org/W2021895505","https://openalex.org/W2011761102","https://openalex.org/W1786292396"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
