{"id":"https://openalex.org/W2038720696","doi":"https://doi.org/10.1371/journal.pone.0048072","title":"Artepillin C, a Major Ingredient of Brazilian Propolis, Induces a Pungent Taste by Activating TRPA1 Channels","display_name":"Artepillin C, a Major Ingredient of Brazilian Propolis, Induces a Pungent Taste by Activating TRPA1 Channels","publication_year":2012,"publication_date":"2012-11-02","ids":{"openalex":"https://openalex.org/W2038720696","doi":"https://doi.org/10.1371/journal.pone.0048072","mag":"2038720696","pmid":"https://pubmed.ncbi.nlm.nih.gov/23133611","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3487895"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0048072","doi":"https://doi.org/10.1371/journal.pone.0048072","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048072","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048072&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048072&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047334626","display_name":"Taketoshi Hata","orcid":"https://orcid.org/0000-0002-0344-0306","observed_orcids":["https://orcid.org/0000-0002-0344-0306"]},"institutions":[{"id":"https://openalex.org/I4210132388","display_name":"API (Japan)","ror":"https://ror.org/03a9hgn46","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210132388"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taketoshi Hata","raw_affiliation_strings":["Nagaragawa Research Center, API Co., Ltd., Nagara, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagaragawa Research Center, API Co., Ltd., Nagara, Gifu, Japan","institution_ids":["https://openalex.org/I4210132388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018954591","display_name":"Shigemi Tazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132388","display_name":"API (Japan)","ror":"https://ror.org/03a9hgn46","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210132388"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigemi Tazawa","raw_affiliation_strings":["Nagaragawa Research Center, API Co., Ltd., Nagara, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagaragawa Research Center, API Co., Ltd., Nagara, Gifu, Japan","institution_ids":["https://openalex.org/I4210132388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110214137","display_name":"Shozo Ohta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132388","display_name":"API (Japan)","ror":"https://ror.org/03a9hgn46","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210132388"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shozo Ohta","raw_affiliation_strings":["Nagaragawa Research Center, API Co., Ltd., Nagara, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagaragawa Research Center, API Co., Ltd., Nagara, Gifu, Japan","institution_ids":["https://openalex.org/I4210132388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003447522","display_name":"Mee\u2010Ra Rhyu","orcid":"https://orcid.org/0000-0002-1693-8330","observed_orcids":["https://orcid.org/0000-0002-1693-8330","https://orcid.org/0009-0000-5506-1925"]},"institutions":[{"id":"https://openalex.org/I4210114577","display_name":"Korea Food Research Institute","ror":"https://ror.org/028jp5z02","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210114577","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mee-Ra Rhyu","raw_affiliation_strings":["Functional Food Technology Research Group, Korea Food Research Institute, Bundang-gu, Sungnam-si, Gyeonggi-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Food Technology Research Group, Korea Food Research Institute, Bundang-gu, Sungnam-si, Gyeonggi-do, Republic of Korea","institution_ids":["https://openalex.org/I4210114577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076541058","display_name":"Takumi Misaka","orcid":"https://orcid.org/0000-0002-9547-5767","observed_orcids":["https://orcid.org/0000-0002-9547-5767"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takumi Misaka","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072651764","display_name":"Kenji Ichihara","orcid":"https://orcid.org/0000-0001-7925-4561","observed_orcids":["https://orcid.org/0000-0001-7925-4561"]},"institutions":[{"id":"https://openalex.org/I4210132388","display_name":"API (Japan)","ror":"https://ror.org/03a9hgn46","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210132388"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kenji Ichihara","raw_affiliation_strings":["Nagaragawa Research Center, API Co., Ltd., Nagara, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagaragawa Research Center, API Co., Ltd., Nagara, Gifu, Japan","institution_ids":["https://openalex.org/I4210132388"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072651764"],"corresponding_institution_ids":["https://openalex.org/I4210132388"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.7758,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.949625,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"7","issue":"11","first_page":"e48072","last_page":"e48072"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.15800000727176666,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.04960000142455101,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artepillin-c","display_name":"artepillin C","score":0.9950000047683716},{"id":"https://openalex.org/keywords/brazilian-green-propolis","display_name":"Brazilian green propolis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/p-coumaric-acid","display_name":"p-coumaric acid","score":0.9089999794960022},{"id":"https://openalex.org/keywords/allyl-isothiocyanate","display_name":"allyl isothiocyanate","score":0.9430000185966492},{"id":"https://openalex.org/keywords/ethanol-extract-of-propolis","display_name":"ethanol extract of propolis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/sensory-evaluation","display_name":"sensory evaluation","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C2780589914","wikidata":"https://www.wikidata.org/wiki/Q10675206","display_name":"Ingredient","level":2,"score":0.8024308681488037},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.6793937087059021},{"id":"https://openalex.org/C2780488879","wikidata":"https://www.wikidata.org/wiki/Q184398","display_name":"Propolis","level":2,"score":0.6529483795166016},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6417927145957947},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5220513343811035},{"id":"https://openalex.org/C3020017864","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Bitter taste","level":3,"score":0.4886498749256134},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47965410351753235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28198951482772827}],"mesh":[{"descriptor_ui":"D000074025","descriptor_name":"TRPA1 Cation Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002934","descriptor_name":"Cinnamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003373","descriptor_name":"Coumaric Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010666","descriptor_name":"Phenylpropionates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010666","descriptor_name":"Phenylpropionates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011429","descriptor_name":"Propolis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014255","descriptor_name":"Trichothecenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017879","descriptor_name":"Isothiocyanates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050051","descriptor_name":"Transient Receptor Potential Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0048072","doi":"https://doi.org/10.1371/journal.pone.0048072","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048072","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048072&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2488315","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3487895","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3487895","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3487895","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23133611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23133611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4d27e5bd0ffd4a6b9d795b0660d0b37a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4d27e5bd0ffd4a6b9d795b0660d0b37a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 11, p e48072 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0048072","doi":"https://doi.org/10.1371/journal.pone.0048072","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048072","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048072&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322832","display_name":"University of Tokyo","ror":"https://ror.org/057zh3y96"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2038720696.pdf","grobid_xml":"https://content.openalex.org/works/W2038720696.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W104487360","https://openalex.org/W1499810030","https://openalex.org/W1511198581","https://openalex.org/W1963618232","https://openalex.org/W1974714973","https://openalex.org/W1995390205","https://openalex.org/W1996634599","https://openalex.org/W1997566046","https://openalex.org/W2009967312","https://openalex.org/W2010165261","https://openalex.org/W2016157515","https://openalex.org/W2018430708","https://openalex.org/W2020833052","https://openalex.org/W2035257142","https://openalex.org/W2037279263","https://openalex.org/W2045742765","https://openalex.org/W2048659234","https://openalex.org/W2050992572","https://openalex.org/W2056162142","https://openalex.org/W2062978707","https://openalex.org/W2078696617","https://openalex.org/W2081120437","https://openalex.org/W2088822646","https://openalex.org/W2111195206","https://openalex.org/W2113529594","https://openalex.org/W2120229762","https://openalex.org/W2129326126","https://openalex.org/W2137137814","https://openalex.org/W2151532445","https://openalex.org/W2152809882","https://openalex.org/W2156291426","https://openalex.org/W2235330923","https://openalex.org/W2462118941"],"related_works":["https://openalex.org/W2024412544","https://openalex.org/W2091257978","https://openalex.org/W162361059","https://openalex.org/W2601050918","https://openalex.org/W2070068066","https://openalex.org/W2096773815","https://openalex.org/W2278402723","https://openalex.org/W4293126616","https://openalex.org/W2051036402","https://openalex.org/W2106097986"],"abstract_inverted_index":{"Brazilian":[0,18],"green":[1,19],"propolis":[2,20],"is":[3,22,53,231],"a":[4,80,113,183,240],"popular":[5],"health":[6],"supplement":[7],"because":[8],"of":[9,17,84,110,116,128,136,196],"its":[10,25,37],"various":[11],"biological":[12],"properties.":[13],"The":[14],"ethanol":[15],"extract":[16],"(EEBP)":[21],"characteristic":[23],"for":[24,36],"herb-like":[26],"smell":[27],"and":[28,60,88,139,154,173,186,200,208,238],"unique":[29],"pungent":[30,56,93,105,126,169,234,241],"taste.":[31],"However,":[32],"the":[33,47,54,89,92,104,125,134,164,176,193,218,232],"ingredients":[34],"responsible":[35],"pungency":[38],"have":[39],"not":[40],"yet":[41],"been":[42],"identified.":[43],"This":[44],"study":[45],"provides":[46],"first":[48],"evidence":[49],"that":[50,61,103,228],"artepillin":[51,111,137,197,212,229],"C":[52,120,138,172,213,230],"main":[55,233],"ingredient":[57,235],"in":[58,144,158,236],"EEBP":[59,73,129,145,237],"it":[62],"potently":[63],"activates":[64],"human":[65,159],"transient":[66],"receptor":[67],"potential":[68],"ankyrin":[69],"1":[70],"(TRPA1)":[71],"channels.":[72,246],"was":[74,107,121,214],"fractionated":[75],"using":[76],"column":[77],"chromatography":[78],"with":[79],"step":[81],"gradient":[82],"elution":[83],"an":[85],"ethanol-water":[86],"solution,":[87],"fractions":[90],"having":[91],"taste":[94,242],"were":[95,149,203],"determined":[96],"by":[97,130,151,243],"sensory":[98],"tests.":[99],"HPLC":[100],"analysis":[101],"revealed":[102],"fraction":[106],"composed":[108],"primarily":[109],"C,":[112,198],"prenylated":[114],"derivative":[115],"cinnamic":[117,141],"acid.":[118],"Artepillin":[119,171],"also":[122],"identified":[123],"as":[124],"compound":[127],"organoleptic":[131],"examiners.":[132],"Furthermore,":[133],"effects":[135],"other":[140],"acids":[142],"found":[143],"on":[146],"TRPA1":[147,177,220,245],"channels":[148],"examined":[150],"calcium":[152],"imaging":[153],"plate":[155],"reader-based":[156],"assays":[157],"TRPA1-expressing":[160],"cells":[161],"to":[162],"investigate":[163],"molecular":[165],"mechanisms":[166],"underlying":[167],"their":[168],"tastes.":[170],"baccharin":[174],"activated":[175],"channel":[178],"strongly,":[179],"whereas":[180],"drupanin":[181],"caused":[182],"slight":[184],"activation":[185],"p-coumaric":[187],"acid":[188],"showed":[189],"no":[190],"activation.":[191],"Because":[192],"EC(50)":[194],"values":[195],"baccharin,":[199],"allyl":[201,222],"isothiocyanate":[202],"1.8":[204],"\u00b5M,":[205,207,210],"15.5":[206],"6.2":[209],"respectively,":[211],"more":[215],"potent":[216],"than":[217],"typical":[219],"agonist":[221],"isothiocyanate.":[223],"These":[224],"findings":[225],"strongly":[226],"indicate":[227],"stimulates":[239],"activating":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
