{"id":"https://openalex.org/W2038677281","doi":"https://doi.org/10.1074/jbc.m109.078592","title":"Role for the Proapoptotic Factor BIM in Mediating Imatinib-induced Apoptosis in a c-KIT-dependent Gastrointestinal Stromal Tumor Cell Line","display_name":"Role for the Proapoptotic Factor BIM in Mediating Imatinib-induced Apoptosis in a c-KIT-dependent Gastrointestinal Stromal Tumor Cell Line","publication_year":2010,"publication_date":"2010-03-16","ids":{"openalex":"https://openalex.org/W2038677281","doi":"https://doi.org/10.1074/jbc.m109.078592","mag":"2038677281","pmid":"https://pubmed.ncbi.nlm.nih.gov/20231287","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2863214"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109.078592","doi":"https://doi.org/10.1074/jbc.m109.078592","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.078592","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m109.078592","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000082261","display_name":"Peter M. Gordon","orcid":"https://orcid.org/0000-0002-3159-1881","observed_orcids":["https://orcid.org/0000-0002-3159-1881"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter M. Gordon","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA","Children's Hospital Boston, Boston, Massachusetts 02115","Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114","Dana-Farber Cancer Institute, Boston, Massachusetts 02115","Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Children's Hospital Boston, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078874539","display_name":"David E. Fisher","orcid":"https://orcid.org/0000-0002-5506-0575","observed_orcids":["https://orcid.org/0000-0002-5506-0575"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David E. Fisher","raw_affiliation_strings":["Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114","Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5078874539"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.5993,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.94319033,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"285","issue":"19","first_page":"14109","last_page":"14114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/building-information-modeling","display_name":"building information modeling","score":0.9850000143051147},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9919999837875366},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.8619999885559082},{"id":"https://openalex.org/keywords/gastrointestinal-stromal-tumor","display_name":"gastrointestinal stromal tumor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/foxo3","display_name":"FOXO3","score":0.8870000243186951},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6299999952316284},{"id":"https://openalex.org/keywords/deubiquitination","display_name":"deubiquitination","score":0.8479999899864197},{"id":"https://openalex.org/keywords/protein-dephosphorylation","display_name":"protein dephosphorylation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7789999842643738},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-inhibition","display_name":"receptor tyrosine kinase inhibition","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.8407875895500183},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7489690780639648},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7139408588409424},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.5970793962478638},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.5765866637229919},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5583189725875854},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.5175303816795349},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.4852614104747772},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4759937524795532},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4637027382850647},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4063875079154968},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3867166340351105},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.360909104347229},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3595532178878784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18547821044921875},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1546926200389862},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15153533220291138},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071316","descriptor_name":"Forkhead Box Protein O3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072224","descriptor_name":"Bcl-2-Like Protein 11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002070","descriptor_name":"Butadienes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046152","descriptor_name":"Gastrointestinal Stromal Tumors","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D046152","descriptor_name":"Gastrointestinal Stromal Tumors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046152","descriptor_name":"Gastrointestinal Stromal Tumors","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m109.078592","doi":"https://doi.org/10.1074/jbc.m109.078592","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.078592","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2099136","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2863214","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2863214","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2863214","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:20231287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20231287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m109.078592","doi":"https://doi.org/10.1074/jbc.m109.078592","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.078592","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8272206519","display_name":null,"funder_award_id":"AR043369-14","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000877509","display_name":"MITF from control of pigmentation to melanoma risk","funder_award_id":"R01AR043369","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1821265034","https://openalex.org/W1977914780","https://openalex.org/W1979274840","https://openalex.org/W1984169187","https://openalex.org/W1985182434","https://openalex.org/W1990408342","https://openalex.org/W1996735342","https://openalex.org/W2009307226","https://openalex.org/W2011785467","https://openalex.org/W2034201098","https://openalex.org/W2045515200","https://openalex.org/W2047253022","https://openalex.org/W2058170540","https://openalex.org/W2063956512","https://openalex.org/W2076448066","https://openalex.org/W2078229640","https://openalex.org/W2079420659","https://openalex.org/W2084016417","https://openalex.org/W2087942829","https://openalex.org/W2091567220","https://openalex.org/W2097115069","https://openalex.org/W2100626226","https://openalex.org/W2101214437","https://openalex.org/W2102088611","https://openalex.org/W2104602638","https://openalex.org/W2114734999","https://openalex.org/W2127933711","https://openalex.org/W2132279911","https://openalex.org/W2140594007","https://openalex.org/W2141332502","https://openalex.org/W2143295396","https://openalex.org/W2152636515","https://openalex.org/W2162574319","https://openalex.org/W2167334545","https://openalex.org/W2168466568","https://openalex.org/W2169363650"],"related_works":["https://openalex.org/W1527544331","https://openalex.org/W2048288692","https://openalex.org/W2141332502","https://openalex.org/W2132279911","https://openalex.org/W2156578460","https://openalex.org/W2114734999","https://openalex.org/W2002060029","https://openalex.org/W2560440105","https://openalex.org/W2055763832","https://openalex.org/W2009307226"],"abstract_inverted_index":{"The":[0,17,114,178],"c-KIT":[1,77,92,117],"receptor":[2],"tyrosine":[3],"kinase":[4],"is":[5],"constitutively":[6],"activated":[7],"and":[8,49,72,111,125,180,200],"oncogenic":[9],"in":[10,33,69,95,176,190],"the":[11,34,43,50,73,101,104,123,134,137,142,164,183,203],"majority":[12],"of":[13,19,22,36,46,91,103,116,122,128,136,148,166,182,197,205],"gastrointestinal":[14,96],"stromal":[15,97],"tumors.":[16],"identification":[18,179],"selective":[20],"inhibitors":[21],"c-KIT,":[23],"such":[24],"as":[25,54,130,132],"imatinib,":[26,167],"has":[27,64],"provided":[28],"a":[29,55,194],"novel":[30],"therapeutic":[31,207],"approach":[32,63],"treatment":[35],"this":[37,62],"chemotherapy":[38],"refractory":[39],"tumor.":[40],"However,":[41],"despite":[42],"clinical":[44],"importance":[45],"these":[47,212],"findings":[48],"potential":[51],"it":[52],"provides":[53],"model":[56],"system":[57],"for":[58,193],"understanding":[59,196],"targeted":[60,198],"therapy,":[61],"not":[65,83],"yielded":[66],"curative":[67],"outcomes":[68],"most":[70],"patients,":[71],"biochemical":[74],"pathways":[75,184],"connecting":[76],"inhibition":[78,90,115],"to":[79,145,173,209],"cell":[80,188],"death":[81,189],"are":[82],"completely":[84],"understood.":[85],"Here,":[86],"we":[87,158],"show":[88],"that":[89,160,169,185],"with":[93],"imatinib":[94,119],"tumors":[98],"(GISTs)":[99],"triggered":[100,133],"up-regulation":[102],"proapoptotic":[105],"protein":[106],"BIM":[107,129,143,149,161,170],"via":[108],"both":[109],"transcriptional":[110],"post-translational":[112],"mechanisms.":[113],"by":[118],"increased":[120],"levels":[121],"dephosphorylated":[124],"deubiquitinated":[126],"form":[127],"well":[131],"accumulation":[135],"transcription":[138,147],"factor":[139],"FOXO3a":[140],"on":[141],"promoter":[144],"activate":[146],"mRNA.":[150],"Furthermore,":[151],"using":[152],"RNA":[153],"interference":[154],"directed":[155],"against":[156],"BIM,":[157],"demonstrated":[159],"knockdown":[162],"attenuated":[163],"effects":[165],"suggesting":[168],"functionally":[171],"contributes":[172],"imatinib-induced":[174,187],"apoptosis":[175],"GIST.":[177],"characterization":[181],"mediate":[186],"GIST":[191],"provide":[192],"better":[195],"therapy":[199],"may":[201],"facilitate":[202],"development":[204],"new":[206],"approaches":[208],"further":[210],"exploit":[211],"pathways.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
