{"id":"https://openalex.org/W2038670745","doi":"https://doi.org/10.1073/pnas.1220050110","title":"Mechanism for activation of mutated epidermal growth factor receptors in lung cancer","display_name":"Mechanism for activation of mutated epidermal growth factor receptors in lung cancer","publication_year":2013,"publication_date":"2013-09-09","ids":{"openalex":"https://openalex.org/W2038670745","doi":"https://doi.org/10.1073/pnas.1220050110","mag":"2038670745","pmid":"https://pubmed.ncbi.nlm.nih.gov/24019492","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3780914"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1220050110","doi":"https://doi.org/10.1073/pnas.1220050110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1220050110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3780914","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086276533","display_name":"Monica Red Brewer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Red Brewer","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, TN 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, TN 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006840181","display_name":"Cai\u2010Hong Yun","orcid":"https://orcid.org/0000-0002-5880-8307","observed_orcids":["https://orcid.org/0000-0002-5880-8307"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cai-Hong Yun","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA 02215; and","Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Boston, MA 02115;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA 02215; and","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070061145","display_name":"Darson Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darson Lai","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, TN 37232;","aDivision of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, TN 37232;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, TN 37232;","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"aDivision of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, TN 37232;","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073959537","display_name":"Mark A. Lemmon","orcid":"https://orcid.org/0000-0002-3379-5319","observed_orcids":["https://orcid.org/0000-0002-3379-5319"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Lemmon","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104","dDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"dDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041782093","display_name":"Michael J. Eck","orcid":"https://orcid.org/0000-0003-4247-9403","observed_orcids":["https://orcid.org/0000-0003-4247-9403"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Eck","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA 02215; and","Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Boston, MA 02115;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA 02215; and","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062616992","display_name":"William J. Pao","orcid":"https://orcid.org/0000-0002-9888-0733","observed_orcids":["https://orcid.org/0000-0002-9888-0733"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Pao","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, TN 37232;","aDivision of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, TN 37232;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, TN 37232;","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"aDivision of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, TN 37232;","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.5413,"has_fulltext":false,"cited_by_count":148,"citation_normalized_percentile":{"value":0.97788468,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"110","issue":"38","first_page":"E3595","last_page":"604"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tyrosine-kinase-activation","display_name":"tyrosine kinase activation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.8429999947547913},{"id":"https://openalex.org/keywords/allosteric-conformational-change","display_name":"allosteric conformational change","score":0.8259999752044678},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6909999847412109},{"id":"https://openalex.org/keywords/erbb-family","display_name":"ErbB family","score":0.5440000295639038},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.7814500331878662},{"id":"https://openalex.org/C2777930144","wikidata":"https://www.wikidata.org/wiki/Q25100112","display_name":"T790M","level":5,"score":0.6944926977157593},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5913402438163757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5689608454704285},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5371928811073303},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5296152830123901},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5269131064414978},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.4619811475276947},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.44244593381881714},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.42055243253707886},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.4191807210445404},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.41672712564468384},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.4114392399787903},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37643373012542725},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3762929439544678},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36955416202545166},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3166946470737457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3051367402076721},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2995206117630005},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.16498339176177979},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14051949977874756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12971967458724976},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12251713871955872},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09016001224517822}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1220050110","doi":"https://doi.org/10.1073/pnas.1220050110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1220050110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2790710","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3780914","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3780914","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3780914","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:24019492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24019492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2790710","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3780914","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1347075831","display_name":"ErbB receptor homo- and hetero-dimerization","funder_award_id":"R01CA079992","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1948227108","display_name":"Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma","funder_award_id":"R01CA116020","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3680935081","display_name":"Overcoming acquired resistance to EGFR inhibitors in lung cancer","funder_award_id":"R01CA121210","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3690077713","display_name":"Targets for Therapy for Carcinomas of the Lung","funder_award_id":"P01CA129243","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6906191313","display_name":"Protein Kinase Therapeutic Targets for Non-Small Cell Lung Carcinoma","funder_award_id":"P01CA154303","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7243535510","display_name":"Evolutionary Dynamics of Brain, Lung, and Hematopoietic Tumors","funder_award_id":"U54CA143798","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7769827287","display_name":"SPORE in Lung Cancer","funder_award_id":"P50CA090949","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000880732","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1539796472","https://openalex.org/W1967394241","https://openalex.org/W1968324646","https://openalex.org/W1971944335","https://openalex.org/W1978343870","https://openalex.org/W1980323101","https://openalex.org/W1981981363","https://openalex.org/W1996804310","https://openalex.org/W2002937040","https://openalex.org/W2010030578","https://openalex.org/W2016710415","https://openalex.org/W2020405262","https://openalex.org/W2020833679","https://openalex.org/W2028415754","https://openalex.org/W2032490375","https://openalex.org/W2036785342","https://openalex.org/W2043911313","https://openalex.org/W2045709340","https://openalex.org/W2048396830","https://openalex.org/W2057166163","https://openalex.org/W2063391304","https://openalex.org/W2086339389","https://openalex.org/W2090029719","https://openalex.org/W2099805317","https://openalex.org/W2100794900","https://openalex.org/W2106186049","https://openalex.org/W2106856557","https://openalex.org/W2111109297","https://openalex.org/W2123185010","https://openalex.org/W2124026197","https://openalex.org/W2127732584","https://openalex.org/W2128307445","https://openalex.org/W2129360604","https://openalex.org/W2133963438","https://openalex.org/W2139236349","https://openalex.org/W2143651667","https://openalex.org/W2143913849","https://openalex.org/W2145497412","https://openalex.org/W2159013299","https://openalex.org/W2166084034","https://openalex.org/W2184278156"],"related_works":["https://openalex.org/W2319574654","https://openalex.org/W2169290666","https://openalex.org/W2048396830","https://openalex.org/W7100742311","https://openalex.org/W7204467514","https://openalex.org/W7116060564","https://openalex.org/W2136343696","https://openalex.org/W2395138697","https://openalex.org/W2279058190","https://openalex.org/W2122706875"],"abstract_inverted_index":{"The":[0],"initiation":[1],"of":[2,35,92,130,198,209,217],"epidermal":[3],"growth":[4],"factor":[5],"receptor":[6],"(EGFR)":[7],"kinase":[8,21],"activity":[9,166],"proceeds":[10],"via":[11],"an":[12,25,138,156],"asymmetric":[13,139],"dimerization":[14],"mechanism":[15],"in":[16,52,68,110,121,133,149,160,180],"which":[17,218],"a":[18,36,53,111,171,205],"\"donor\"":[19],"tyrosine":[20],"domain":[22],"(TKD)":[23],"contacts":[24],"\"acceptor\"":[26],"TKD,":[27],"leading":[28,89],"to":[29,45,90],"its":[30],"activation.":[31],"In":[32],"the":[33,47,73,93,100,122,134,145,161,181,195,199],"context":[34],"ligand-induced":[37],"dimer,":[38],"identical":[39],"wild-type":[40],"EGFR":[41,65,183],"TKDs":[42],"are":[43],"thought":[44],"assume":[46,72],"donor":[48,196],"or":[49],"acceptor":[50,74,162],"roles":[51],"random":[54],"manner.":[55,113],"Here,":[56],"we":[57],"present":[58],"biochemical":[59],"reconstitution":[60],"data":[61],"demonstrating":[62],"that":[63,142,148,193],"activated":[64],"mutants":[66],"found":[67],"lung":[69],"cancer":[70],"preferentially":[71],"role":[75,197],"when":[76],"coexpressed":[77],"with":[78,86,176,185],"WT":[79,87,94,150],"EGFR.":[80,151],"Mutated":[81,96],"EGFRs":[82,97],"show":[83],"enhanced":[84],"association":[85],"EGFR,":[88],"hyperphosphorylation":[91],"counterpart.":[95],"also":[98],"hyperphosphorylate":[99],"related":[101],"erythroblastic":[102],"leukemia":[103],"viral":[104],"oncogene":[105],"(ErbB)":[106],"family":[107],"member,":[108],"ErbB-2,":[109],"similar":[112],"This":[114],"directional":[115],"\"superacceptor":[116],"activity\"":[117],"is":[118,143],"particularly":[119],"pronounced":[120],"drug-resistant":[123],"L834R/T766M":[124],"mutant.":[125,200],"A":[126],"4-\u00c5":[127],"crystal":[128],"structure":[129],"this":[131,177],"mutant":[132,182],"active":[135],"conformation":[136],"reveals":[137],"dimer":[140,153],"interface":[141],"essentially":[144],"same":[146],"as":[147],"Asymmetric":[152],"formation":[154],"induces":[155],"allosteric":[157],"conformational":[158,178],"change":[159,179],"subunit.":[163],"Thus,":[164],"superacceptor":[165],"likely":[167],"arises":[168],"simply":[169],"from":[170,189],"lower":[172],"energetic":[173],"cost":[174],"associated":[175],"compared":[184],"WT,":[186],"rather":[187],"than":[188],"any":[190],"structural":[191],"alteration":[192],"impairs":[194],"Collectively,":[201],"these":[202],"findings":[203],"define":[204],"previously":[206],"unrecognized":[207],"mode":[208],"mutant-specific":[210],"intermolecular":[211],"regulation":[212],"for":[213,223],"ErbB":[214],"receptors,":[215],"knowledge":[216],"could":[219],"potentially":[220],"be":[221],"exploited":[222],"therapeutic":[224],"benefit.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}