{"id":"https://openalex.org/W2038599271","doi":"https://doi.org/10.1074/jbc.m513587200","title":"PUMA Dissociates Bax and Bcl-XL to Induce Apoptosis in Colon Cancer Cells","display_name":"PUMA Dissociates Bax and Bcl-XL to Induce Apoptosis in Colon Cancer Cells","publication_year":2006,"publication_date":"2006-04-12","ids":{"openalex":"https://openalex.org/W2038599271","doi":"https://doi.org/10.1074/jbc.m513587200","mag":"2038599271","pmid":"https://pubmed.ncbi.nlm.nih.gov/16608847"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m513587200","doi":"https://doi.org/10.1074/jbc.m513587200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m513587200","pdf_url":"http://www.jbc.org/article/S0021925820559231/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820559231/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019759735","display_name":"Lihua Ming","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihua Ming","raw_affiliation_strings":["Department of Pathology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA","Department of Pathology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"raw_affiliation_string":"Department of Pathology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Wang","raw_affiliation_strings":["Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047895331","display_name":"Alexander Bank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Bank","raw_affiliation_strings":["Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086910766","display_name":"Jian Yu","orcid":"https://orcid.org/0000-0002-4021-1000","observed_orcids":["https://orcid.org/0000-0002-4021-1000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Yu","raw_affiliation_strings":["Department of Pathology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100351902","display_name":"Lin Zhang","orcid":"https://orcid.org/0000-0003-0018-3903","observed_orcids":["https://orcid.org/0000-0003-0018-3903"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100351902"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.5181,"has_fulltext":true,"cited_by_count":185,"citation_normalized_percentile":{"value":0.97825137,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"281","issue":"23","first_page":"16034","last_page":"16042"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/puma","display_name":"PUMA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9679999947547913},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":1.0},{"id":"https://openalex.org/keywords/bh3-only-proteins","display_name":"BH3-only proteins","score":0.871999979019165},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.9039999842643738},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dna-damage-induced-apoptosis","display_name":"DNA damage-induced apoptosis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/mitochondrial-translocation","display_name":"mitochondrial translocation","score":0.9750000238418579}],"concepts":[{"id":"https://openalex.org/C2777417711","wikidata":"https://www.wikidata.org/wiki/Q270748","display_name":"Puma","level":3,"score":0.9985190629959106},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.848288893699646},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6610314846038818},{"id":"https://openalex.org/C2780362710","wikidata":"https://www.wikidata.org/wiki/Q408476","display_name":"Bcl-2-associated X protein","level":5,"score":0.5897451639175415},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5003681182861328},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48135048151016235},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4289303421974182},{"id":"https://openalex.org/C2776789625","wikidata":"https://www.wikidata.org/wiki/Q4875408","display_name":"Bcl-xL","level":4,"score":0.4259302616119385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4106300473213196},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4073617458343506},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4039844870567322},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3932739794254303},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.23046448826789856},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15277892351150513},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15059104561805725},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.1391770839691162}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m513587200","doi":"https://doi.org/10.1074/jbc.m513587200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m513587200","pdf_url":"http://www.jbc.org/article/S0021925820559231/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16608847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16608847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m513587200","doi":"https://doi.org/10.1074/jbc.m513587200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m513587200","pdf_url":"http://www.jbc.org/article/S0021925820559231/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1686557677","display_name":"PUMA-mediated apoptosis in human cancer cells","funder_award_id":"R01CA106348","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2744668261","display_name":null,"funder_award_id":"CA106348","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3337023614","display_name":null,"funder_award_id":"HCT116","funder_id":"https://openalex.org/F4320310145","funder_display_name":"Johns Hopkins University"}],"funders":[{"id":"https://openalex.org/F4320306470","display_name":"Elsa U. Pardee Foundation","ror":"https://ror.org/05sjnvv07"},{"id":"https://openalex.org/F4320306536","display_name":"V Foundation for Cancer Research","ror":"https://ror.org/00kbbk236"},{"id":"https://openalex.org/F4320308625","display_name":"Flight Attendant Medical Research Institute","ror":"https://ror.org/00ybhm522"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320313698","display_name":"Edward Mallinckrodt, Jr. Foundation","ror":"https://ror.org/035yf7a66"},{"id":"https://openalex.org/F4320316030","display_name":"Hillman Foundation","ror":"https://ror.org/02sxfy669"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2038599271.pdf","grobid_xml":"https://content.openalex.org/works/W2038599271.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1532194993","https://openalex.org/W1607777232","https://openalex.org/W1825915710","https://openalex.org/W1965071591","https://openalex.org/W1970817319","https://openalex.org/W1970941018","https://openalex.org/W1976720365","https://openalex.org/W1978259246","https://openalex.org/W1978554125","https://openalex.org/W2008715871","https://openalex.org/W2024996523","https://openalex.org/W2032603938","https://openalex.org/W2047160541","https://openalex.org/W2056418403","https://openalex.org/W2062547838","https://openalex.org/W2065333640","https://openalex.org/W2068025977","https://openalex.org/W2072252062","https://openalex.org/W2087877138","https://openalex.org/W2089082314","https://openalex.org/W2094052642","https://openalex.org/W2102597691","https://openalex.org/W2108163896","https://openalex.org/W2112906120","https://openalex.org/W2112968535","https://openalex.org/W2113999599","https://openalex.org/W2114001234","https://openalex.org/W2118001641","https://openalex.org/W2122400112","https://openalex.org/W2125963106","https://openalex.org/W2126376871","https://openalex.org/W2140372706","https://openalex.org/W2147318282","https://openalex.org/W2151238743","https://openalex.org/W2152247516","https://openalex.org/W2164786703","https://openalex.org/W2166601968","https://openalex.org/W2169495754","https://openalex.org/W2186790240","https://openalex.org/W4249877820"],"related_works":["https://openalex.org/W7095426849","https://openalex.org/W2171322822","https://openalex.org/W7036084263","https://openalex.org/W7097523473","https://openalex.org/W2029845173","https://openalex.org/W2049426872","https://openalex.org/W2054937822","https://openalex.org/W2032603938","https://openalex.org/W2112968535","https://openalex.org/W4412731193"],"abstract_inverted_index":{"PUMA":[0,16,40,135,140,191],"is":[1,24],"a":[2],"BH3-only":[3],"Bcl-2":[4,20],"family":[5],"protein":[6],"that":[7,58,82,162,190],"plays":[8],"an":[9],"essential":[10],"role":[11],"in":[12,51,67,105,110,123,128,132,148,170,182,194],"DNA":[13],"damage-induced":[14],"apoptosis.":[15,30,94],"interacts":[17],"with":[18,41,46,85],"anti-apoptotic":[19],"and":[21,23,71,137,146,199,205],"Bcl-X(L)":[22,59,81,97,122,147,154],"dependent":[25],"on":[26],"Bax":[27,47,86,114,145,168,198,203],"to":[28,48,89,117,134,153,178],"induce":[29],"In":[31],"this":[32],"study,":[33],"we":[34,160],"investigated":[35],"how":[36],"the":[37,42,76,129,142,183],"interactions":[38],"of":[39,96,144],"antiapoptotic":[43,65],"proteins":[44,66],"coordinate":[45],"initiate":[49],"apoptosis":[50,70,73,104,181,193],"HCT116":[52,106,124],"colon":[53],"cancer":[54],"cells.":[55,112,185],"We":[56],"found":[57,116,161],"was":[60,87,115,176],"most":[61],"effective":[62],"among":[63],"several":[64],"suppressing":[68],"PUMA-induced":[69,180],"PUMA-dependent":[72],"induced":[74],"by":[75,98,150,196],"DNA-damaging":[77],"agent":[78],"adriamycin.":[79],"Mutant":[80],"cannot":[83],"interact":[84],"unable":[88],"protect":[90],"cells":[91,107,125],"from":[92,121],"PUMA-mediated":[93,103],"Knockdown":[95],"RNA":[99],"interference":[100],"significantly":[101],"enhanced":[102],"but":[108,126,165],"not":[109,127,166],"PUMA-knockout":[111,130],"Furthermore,":[113],"be":[118],"dissociated":[119],"preferentially":[120],"cells,":[131],"response":[133],"induction":[136],"adriamycin":[138],"treatment.":[139],"inhibited":[141],"association":[143],"vitro":[149],"directly":[151],"binding":[152],"through":[155],"its":[156],"BH3":[157],"domain.":[158],"Finally,":[159],"wild-type":[163],"Bax,":[164],"mutant":[167],"deficient":[169],"either":[171],"multimerization":[172,204],"or":[173],"mitochondrial":[174,206],"localization,":[175],"able":[177],"restore":[179],"BAX-knockout":[184],"Together,":[186],"these":[187],"results":[188],"indicate":[189],"initiates":[192],"part":[195],"dissociating":[197],"Bcl-X(L),":[200],"thereby":[201],"promoting":[202],"translocation.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
