{"id":"https://openalex.org/W2038596108","doi":"https://doi.org/10.1200/jco.20.6.1692","title":"Inhibition of KIT Tyrosine Kinase Activity: A Novel Molecular Approach to the Treatment of KIT-Positive Malignancies","display_name":"Inhibition of KIT Tyrosine Kinase Activity: A Novel Molecular Approach to the Treatment of KIT-Positive Malignancies","publication_year":2002,"publication_date":"2002-03-15","ids":{"openalex":"https://openalex.org/W2038596108","doi":"https://doi.org/10.1200/jco.20.6.1692","mag":"2038596108","pmid":"https://pubmed.ncbi.nlm.nih.gov/11896121"},"language":"en","primary_location":{"id":"doi:10.1200/jco.20.6.1692","doi":"https://doi.org/10.1200/jco.20.6.1692","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.20.6.1692","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091057405","display_name":"Michael Charles Heinrich","orcid":"https://orcid.org/0000-0003-3790-0478","observed_orcids":["https://orcid.org/0000-0003-3790-0478"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael C. Heinrich","raw_affiliation_strings":["From the Department of Medicine, Division of Hematology/Oncology and Department of Pathology and Laboratory Medicine, Oregon Health and Science University; and Portland Veterans Affairs Medical Center, Portland, OR","Department of Medicine, Division of Hematology/Oncology, Oregon Health and Science University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Division of Hematology/Oncology and Department of Pathology and Laboratory Medicine, Oregon Health and Science University; and Portland Veterans Affairs Medical Center, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"]},{"raw_affiliation_string":"Department of Medicine, Division of Hematology/Oncology, Oregon Health and Science University, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Charles D. Blanke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles D. Blanke","raw_affiliation_strings":["From the Department of Medicine, Division of Hematology/Oncology and Department of Pathology and Laboratory Medicine, Oregon Health and Science University; and Portland Veterans Affairs Medical Center, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Division of Hematology/Oncology and Department of Pathology and Laboratory Medicine, Oregon Health and Science University; and Portland Veterans Affairs Medical Center, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125591963","display_name":"Brian J. Druker","orcid":"https://orcid.org/0000-0001-8331-8206","observed_orcids":["https://orcid.org/0000-0001-8331-8206"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J. Druker","raw_affiliation_strings":["From the Department of Medicine, Division of Hematology/Oncology and Department of Pathology and Laboratory Medicine, Oregon Health and Science University; and Portland Veterans Affairs Medical Center, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Division of Hematology/Oncology and Department of Pathology and Laboratory Medicine, Oregon Health and Science University; and Portland Veterans Affairs Medical Center, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"last","author":{"id":null,"display_name":"Christopher L. Corless","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher L. Corless","raw_affiliation_strings":["From the Department of Medicine, Division of Hematology/Oncology and Department of Pathology and Laboratory Medicine, Oregon Health and Science University; and Portland Veterans Affairs Medical Center, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Division of Hematology/Oncology and Department of Pathology and Laboratory Medicine, Oregon Health and Science University; and Portland Veterans Affairs Medical Center, Portland, OR","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091057405"],"corresponding_institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"],"apc_list":null,"apc_paid":null,"fwci":50.7525,"has_fulltext":false,"cited_by_count":630,"citation_normalized_percentile":{"value":0.99945165,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"20","issue":"6","first_page":"1692","last_page":"1703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kit-tyrosine-kinase-inhibitors","display_name":"KIT tyrosine kinase inhibitors","score":0.9100000262260437},{"id":"https://openalex.org/keywords/gastrointestinal-stromal-tumor","display_name":"gastrointestinal stromal tumor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mastocytosis","display_name":"mastocytosis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/seminoma","display_name":"seminoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.8569999933242798},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9290000200271606},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8199712038040161},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.6660898923873901},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.6577986478805542},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5855457782745361},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5581461191177368},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5246819853782654},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.5115543007850647},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.47245314717292786},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.4630812108516693},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4556844234466553},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.44163796305656433},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.41032862663269043},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.37359726428985596},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2755669951438904},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.23590010404586792},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.08720517158508301},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078183","descriptor_name":"Oxindoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1200/jco.20.6.1692","doi":"https://doi.org/10.1200/jco.20.6.1692","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.20.6.1692","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"doi:10.1200/jco.2002.20.6.1692","doi":"https://doi.org/10.1200/jco.2002.20.6.1692","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2002.20.6.1692","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:11896121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11896121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W11751756","https://openalex.org/W69990049","https://openalex.org/W79630512","https://openalex.org/W80427156","https://openalex.org/W137971093","https://openalex.org/W141980956","https://openalex.org/W169768324","https://openalex.org/W200097423","https://openalex.org/W209719701","https://openalex.org/W337375082","https://openalex.org/W1480076252","https://openalex.org/W1484947470","https://openalex.org/W1490860457","https://openalex.org/W1496385581","https://openalex.org/W1549034776","https://openalex.org/W1564365085","https://openalex.org/W1592402132","https://openalex.org/W1734860714","https://openalex.org/W1752312133","https://openalex.org/W1782493106","https://openalex.org/W1864184149","https://openalex.org/W1868766650","https://openalex.org/W1896134422","https://openalex.org/W1933084689","https://openalex.org/W1963858437","https://openalex.org/W1966822439","https://openalex.org/W1969914921","https://openalex.org/W1978095082","https://openalex.org/W1981320930","https://openalex.org/W1981734032","https://openalex.org/W1984578995","https://openalex.org/W1992085819","https://openalex.org/W1992632909","https://openalex.org/W2000998080","https://openalex.org/W2002564923","https://openalex.org/W2003213723","https://openalex.org/W2003544192","https://openalex.org/W2008033006","https://openalex.org/W2010684388","https://openalex.org/W2013562919","https://openalex.org/W2014082408","https://openalex.org/W2016086822","https://openalex.org/W2016433042","https://openalex.org/W2017028833","https://openalex.org/W2018171716","https://openalex.org/W2022249868","https://openalex.org/W2031209812","https://openalex.org/W2032164085","https://openalex.org/W2032235066","https://openalex.org/W2033922704","https://openalex.org/W2035858586","https://openalex.org/W2037695813","https://openalex.org/W2037751628","https://openalex.org/W2037957809","https://openalex.org/W2039037540","https://openalex.org/W2045593483","https://openalex.org/W2046283103","https://openalex.org/W2053314612","https://openalex.org/W2055702130","https://openalex.org/W2056175166","https://openalex.org/W2056203481","https://openalex.org/W2057470956","https://openalex.org/W2058070604","https://openalex.org/W2061150131","https://openalex.org/W2061807131","https://openalex.org/W2071859574","https://openalex.org/W2074479874","https://openalex.org/W2078325902","https://openalex.org/W2079420659","https://openalex.org/W2079648469","https://openalex.org/W2080411938","https://openalex.org/W2081007495","https://openalex.org/W2083348402","https://openalex.org/W2083864497","https://openalex.org/W2085000900","https://openalex.org/W2089542617","https://openalex.org/W2093216846","https://openalex.org/W2099226150","https://openalex.org/W2101808949","https://openalex.org/W2102763487","https://openalex.org/W2105396280","https://openalex.org/W2106341560","https://openalex.org/W2109399667","https://openalex.org/W2109508638","https://openalex.org/W2118857049","https://openalex.org/W2119455657","https://openalex.org/W2129095768","https://openalex.org/W2131174104","https://openalex.org/W2133146038","https://openalex.org/W2134094496","https://openalex.org/W2140814882","https://openalex.org/W2151493026","https://openalex.org/W2151504205","https://openalex.org/W2151527507","https://openalex.org/W2156160133","https://openalex.org/W2161717556","https://openalex.org/W2163654110","https://openalex.org/W2170285778","https://openalex.org/W2171620774","https://openalex.org/W2243180814","https://openalex.org/W2263807834","https://openalex.org/W2264714702","https://openalex.org/W2277373027","https://openalex.org/W2284118197","https://openalex.org/W2321213005","https://openalex.org/W2324215039","https://openalex.org/W2324850882","https://openalex.org/W2329648702","https://openalex.org/W2409253641","https://openalex.org/W2409260403","https://openalex.org/W2412593438","https://openalex.org/W2413864184","https://openalex.org/W2416204046","https://openalex.org/W2417106273","https://openalex.org/W2418168510","https://openalex.org/W2419248416","https://openalex.org/W2437811962","https://openalex.org/W2590767421","https://openalex.org/W3110952719","https://openalex.org/W3198337823","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2136536867","https://openalex.org/W2134094496","https://openalex.org/W2047381692","https://openalex.org/W7097372909","https://openalex.org/W2112844283","https://openalex.org/W2079420659","https://openalex.org/W7097653166","https://openalex.org/W1979269934","https://openalex.org/W2130710121","https://openalex.org/W4300873667"],"abstract_inverted_index":{"PURPOSE:":[0],"Activation":[1],"of":[2,16,37,64,72,86,88,93,139,156,165,174,182,188,195,218],"the":[3,59,70,123,153,163,172,179,186,189,201],"KIT":[4,65,107,140,157,183,196,208,221,237],"tyrosine":[5,66,100],"kinase":[6,39,67,101,154],"by":[7,122],"somatic":[8],"mutation":[9],"has":[10,40,118],"been":[11,41,120],"documented":[12],"in":[13,43,112,142,198,228,235],"a":[14,82,159,175],"number":[15],"human":[17,73,199],"malignancies,":[18,46],"including":[19,47],"gastrointestinal":[20],"stromal":[21],"tumor":[22],"(GIST),":[23],"seminoma,":[24],"acute":[25],"myelogenous":[26,135],"leukemia":[27],"(AML),":[28],"and":[29,51,62,91,115,127,178,214],"mastocytosis.":[30],"In":[31,54],"addition,":[32],"paracrine":[33],"or":[34],"autocrine":[35],"activation":[36,184,238],"this":[38,55],"postulated":[42],"numerous":[44],"other":[45],"small-cell":[48,232],"lung":[49,233],"cancer":[50],"ovarian":[52],"cancer.":[53],"review,":[56],"we":[57],"discuss":[58],"rationale":[60],"for":[61,69,130,205],"development":[63],"inhibitors":[68,102,141,209,222],"treatment":[71,164,206],"malignancies.":[74,167],"MATERIALS":[75],"AND":[76],"METHODS:":[77],"Studies":[78],"were":[79],"identified":[80],"through":[81],"MEDLINE":[83],"search,":[84],"review":[85,92],"bibliographies":[87],"relevant":[89],"articles,":[90],"abstracts":[94],"from":[95],"national":[96],"meetings.":[97],"RESULTS:":[98],"Four":[99],"that":[103],"have":[104],"activity":[105,155,197],"against":[106],"are":[108,171,210],"currently":[109],"being":[110],"used":[111],"clinical":[113],"trials,":[114],"one,":[116],"STI571,":[117],"recently":[119],"approved":[121],"United":[124],"States":[125],"Food":[126],"Drug":[128],"Administration":[129],"treating":[131,143],"patients":[132],"with":[133,207],"chronic":[134],"leukemia.":[136],"The":[137],"role":[138,227],"KIT-positive":[144,166],"malignancies":[145],"is":[146,158,239],"reviewed.":[147],"CONCLUSION:":[148],"Targeted":[149],"therapy":[150],"to":[151,162,185,241],"inhibit":[152],"rational":[160],"approach":[161],"Two":[168],"key":[169],"factors":[170],"potency":[173],"given":[176],"inhibitor":[177],"relative":[180],"contribution":[181],"growth":[187],"tumor.":[190],"Given":[191],"our":[192],"current":[193],"understanding":[194],"malignancy,":[200],"best":[202],"candidate":[203],"diseases":[204,229],"GIST,":[211],"mastocytosis,":[212],"seminoma":[213],"possibly":[215],"some":[216],"cases":[217],"AML.":[219],"Additionally,":[220],"may":[223],"play":[224],"an":[225,246],"adjunctive":[226],"such":[230],"as":[231],"cancer,":[234],"which":[236],"secondary":[240],"ligand":[242],"binding":[243],"rather":[244],"than":[245],"acquired":[247],"mutation.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}