{"id":"https://openalex.org/W2038529477","doi":"https://doi.org/10.1007/s12192-009-0142-9","title":"Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response","display_name":"Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response","publication_year":2009,"publication_date":"2009-11-06","ids":{"openalex":"https://openalex.org/W2038529477","doi":"https://doi.org/10.1007/s12192-009-0142-9","mag":"2038529477","pmid":"https://pubmed.ncbi.nlm.nih.gov/19898960","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2866998"},"language":"en","primary_location":{"id":"doi:10.1007/s12192-009-0142-9","doi":"https://doi.org/10.1007/s12192-009-0142-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12192-009-0142-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12192-009-0142-9.pdf","source":{"id":"https://openalex.org/S5415759","display_name":"Cell Stress and Chaperones","issn_l":"1355-8145","issn":["1355-8145","1466-1268"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stress and Chaperones","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12192-009-0142-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102198536","display_name":"Yanjun Ma","orcid":"https://orcid.org/0009-0001-9091-0555","observed_orcids":["https://orcid.org/0009-0001-9091-0555"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanjun Ma","raw_affiliation_strings":["Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069199599","display_name":"Yuichiro Shimizu","orcid":"https://orcid.org/0000-0002-1329-7259","observed_orcids":["https://orcid.org/0000-0002-1329-7259"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuichiro Shimizu","raw_affiliation_strings":["Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, USA","St. Jude Children's Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"St. Jude Children's Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079779137","display_name":"Melissa J. Mann","orcid":"https://orcid.org/0000-0001-8543-9714","observed_orcids":["https://orcid.org/0000-0001-8543-9714"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa J. Mann","raw_affiliation_strings":["Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, USA","St. Jude Children's Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"St. Jude Children's Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100754834","display_name":"Yi Jin","orcid":"https://orcid.org/0000-0001-8094-6899","observed_orcids":["https://orcid.org/0000-0001-8094-6899"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Jin","raw_affiliation_strings":["Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, USA","Department of Molecular Science, University of Tennessee Health Science Center, Memphis, USA","St Jude Children\u2019s Research Hospital","University of Tennessee, Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Molecular Science, University of Tennessee Health Science Center, Memphis, USA","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"St Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"University of Tennessee, Health Science Center","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068769982","display_name":"Linda M. Hendershot","orcid":"https://orcid.org/0000-0002-5473-0274","observed_orcids":["https://orcid.org/0000-0002-5473-0274"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Linda M. Hendershot","raw_affiliation_strings":["Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, USA","Department of Molecular Science, University of Tennessee Health Science Center, Memphis, USA","St Jude Children\u2019s Research Hospital","University of Tennessee, Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Molecular Science, University of Tennessee Health Science Center, Memphis, USA","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"St Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"University of Tennessee, Health Science Center","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068769982"],"corresponding_institution_ids":["https://openalex.org/I1313298211","https://openalex.org/I160606119"],"apc_list":{"value":2850,"currency":"USD","value_usd":2850},"apc_paid":{"value":2850,"currency":"USD","value_usd":2850},"fwci":2.0864,"has_fulltext":true,"cited_by_count":164,"citation_normalized_percentile":{"value":0.85248714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"15","issue":"3","first_page":"281","last_page":"293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-cell-differentiation","display_name":"plasma cell differentiation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9559999704360962},{"id":"https://openalex.org/keywords/perk","display_name":"PERK","score":0.5400000214576721},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9039999842643738},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.7720000147819519},{"id":"https://openalex.org/keywords/antibody-production","display_name":"antibody production","score":0.7599999904632568},{"id":"https://openalex.org/keywords/xbp1-splicing","display_name":"XBP1 splicing","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ire1","display_name":"IRE1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/atf6","display_name":"ATF6","score":0.9610000252723694},{"id":"https://openalex.org/keywords/eif2alpha","display_name":"eIF2\u03b1","score":0.8659999966621399},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8870000243186951},{"id":"https://openalex.org/keywords/secretory-pathway","display_name":"secretory pathway","score":0.7160000205039978},{"id":"https://openalex.org/keywords/translational-arrest","display_name":"translational arrest","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.93243008852005},{"id":"https://openalex.org/C2778997996","wikidata":"https://www.wikidata.org/wiki/Q18036598","display_name":"ATF6","level":4,"score":0.9247444868087769},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7209079265594482},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7042821049690247},{"id":"https://openalex.org/C2777479484","wikidata":"https://www.wikidata.org/wiki/Q5323131","display_name":"EIF-2 kinase","level":5,"score":0.5380876064300537},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5235183835029602},{"id":"https://openalex.org/C2780900454","wikidata":"https://www.wikidata.org/wiki/Q21102119","display_name":"ATF4","level":4,"score":0.4423544108867645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4381949007511139},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.43439334630966187},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4315151870250702},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4309002459049225},{"id":"https://openalex.org/C2781331208","wikidata":"https://www.wikidata.org/wiki/Q18032378","display_name":"XBP1","level":5,"score":0.43034327030181885},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4119695723056793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32391035556793213},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.2570663392543793},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17550510168075562},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.11934104561805725},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071701","descriptor_name":"Regulatory Factor X Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071717","descriptor_name":"X-Box Binding Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010950","descriptor_name":"Plasma Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010950","descriptor_name":"Plasma Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010950","descriptor_name":"Plasma Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051702","descriptor_name":"Activating Transcription Factor 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051702","descriptor_name":"Activating Transcription Factor 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051742","descriptor_name":"Transcription Factor CHOP","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051742","descriptor_name":"Transcription Factor CHOP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056811","descriptor_name":"Unfolded Protein Response","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s12192-009-0142-9","doi":"https://doi.org/10.1007/s12192-009-0142-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12192-009-0142-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12192-009-0142-9.pdf","source":{"id":"https://openalex.org/S5415759","display_name":"Cell Stress and Chaperones","issn_l":"1355-8145","issn":["1355-8145","1466-1268"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stress and Chaperones","raw_type":"journal-article"},{"id":"pmid:19898960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19898960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell stress & chaperones","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2866998","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2866998/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stress Chaperones","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s12192-009-0142-9","doi":"https://doi.org/10.1007/s12192-009-0142-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12192-009-0142-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12192-009-0142-9.pdf","source":{"id":"https://openalex.org/S5415759","display_name":"Cell Stress and Chaperones","issn_l":"1355-8145","issn":["1355-8145","1466-1268"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stress and Chaperones","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3123888779","display_name":"Role of Molecular Chaperones in Ig Biosynthesis","funder_award_id":"R01GM054068","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G751896108","display_name":null,"funder_award_id":"CA21765","funder_id":"https://openalex.org/F4320310040","funder_display_name":"St. Jude Children's Research Hospital"},{"id":"https://openalex.org/G865138149","display_name":null,"funder_award_id":"CA 21765","funder_id":"https://openalex.org/F4320313598","funder_display_name":"American Lebanese Syrian Associated Charities"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310040","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967"},{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2038529477.pdf","grobid_xml":"https://content.openalex.org/works/W2038529477.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W43967522","https://openalex.org/W1125909067","https://openalex.org/W1510624100","https://openalex.org/W1546139069","https://openalex.org/W1672219033","https://openalex.org/W1970090817","https://openalex.org/W1972141375","https://openalex.org/W1979733074","https://openalex.org/W1980268334","https://openalex.org/W1986737010","https://openalex.org/W1988482079","https://openalex.org/W1991999080","https://openalex.org/W2002439304","https://openalex.org/W2005691528","https://openalex.org/W2010494349","https://openalex.org/W2010668098","https://openalex.org/W2020437934","https://openalex.org/W2025434551","https://openalex.org/W2025846979","https://openalex.org/W2028279477","https://openalex.org/W2028453264","https://openalex.org/W2028866472","https://openalex.org/W2028878583","https://openalex.org/W2034505413","https://openalex.org/W2036677133","https://openalex.org/W2038481055","https://openalex.org/W2041802997","https://openalex.org/W2071273959","https://openalex.org/W2077784911","https://openalex.org/W2100472948","https://openalex.org/W2105409819","https://openalex.org/W2111480476","https://openalex.org/W2113142075","https://openalex.org/W2114360920","https://openalex.org/W2120350845","https://openalex.org/W2120736516","https://openalex.org/W2127639686","https://openalex.org/W2127848114","https://openalex.org/W2143952529","https://openalex.org/W2145271775","https://openalex.org/W2147336345","https://openalex.org/W2154372386","https://openalex.org/W2161083011","https://openalex.org/W2161257332","https://openalex.org/W2162797237","https://openalex.org/W2170504875"],"related_works":["https://openalex.org/W2025434551","https://openalex.org/W2010494349","https://openalex.org/W4206368013","https://openalex.org/W176944624","https://openalex.org/W2007313599","https://openalex.org/W3187986921","https://openalex.org/W2025846979","https://openalex.org/W2048480826","https://openalex.org/W1986045624","https://openalex.org/W2029900089"],"abstract_inverted_index":{"In":[0],"response":[1,48,77,121],"to":[2,10,78,108,122,139,155,166,241,252],"terminal":[3],"differentiation":[4,86,125],"signals":[5,233],"that":[6,34,44,119,205,231],"enable":[7],"B":[8,67,130,250],"cells":[9,68,251],"produce":[11],"vast":[12],"quantities":[13],"of":[14,19,73,81,95,126,141,175,194,220,227,246],"antibodies,":[15],"a":[16,24,60,89,212],"dramatic":[17],"expansion":[18],"the":[20,28,45,74,82,96,127,186,206,221,228,247,257],"secretory":[21],"pathway":[22],"and":[23,31,36],"corresponding":[25],"increase":[26],"in":[27,63,76,92,120],"molecular":[29],"chaperones":[30],"folding":[32],"enzymes":[33],"aid":[35],"monitor":[37],"immunoglobulin":[38],"synthesis":[39],"occurs.":[40],"Recent":[41],"studies":[42],"reveal":[43],"unfolded":[46],"protein":[47],"(UPR),":[49],"which":[50,93,137,161],"is":[51,184,209],"normally":[52],"activated":[53,135,210],"by":[54,211,224],"endoplasmic":[55],"reticulum":[56],"(ER)":[57],"stress,":[58],"plays":[59],"critical":[61],"role":[62],"this":[64,151,183,236],"process.":[65],"Although":[66],"activate":[69,156],"all":[70],"three":[71],"branches":[72,245],"UPR":[75,91,111,248,259],"pharmacological":[79,225],"inducers":[80,226],"pathway,":[83],"plasma":[84,114],"cell":[85,115,131],"elicits":[87],"only":[88],"partial":[90],"components":[94],"PKR-like":[97],"ER":[98],"kinase":[99],"(PERK)":[100],"branch":[101,208,223],"are":[102],"not":[103,153,185],"expressed.":[104],"This":[105,238],"prompted":[106],"us":[107],"further":[109],"characterize":[110],"activation":[112,219],"during":[113],"differentiation.":[116],"We":[117],"found":[118],"lipopolysaccharides":[123],"(LPS)-induced":[124],"I.29":[128],"micro(+)":[129],"line,":[132],"Ire1":[133],"was":[134,144,152],"early,":[136],"led":[138],"splicing":[140],"XBP-1.":[142],"PERK":[143,222],"partially":[145],"phosphorylated":[146],"with":[147,216],"similar":[148],"kinetics,":[149],"but":[150],"sufficient":[154],"its":[157],"downstream":[158],"target":[159],"eIF-2alpha,":[160],"initiates":[162],"translation":[163],"arrest,":[164],"or":[165,172],"induce":[167],"other":[168],"targets":[169],"like":[170],"CHOP":[171],"GADD34.":[173],"Both":[174],"these":[176,190],"events":[177],"preceded":[178],"increased":[179],"Ig":[180],"synthesis,":[181],"arguing":[182,204],"signal":[187],"for":[188],"activating":[189,195],"two":[191],"transducers.":[192],"Targets":[193],"transcription":[196],"factor":[197],"6":[198],"(ATF6)":[199],"were":[200],"up-regulated":[201],"considerably":[202],"later,":[203],"ATF6":[207],"distinct":[213,254],"signal.":[214],"Pretreatment":[215],"LPS":[217],"inhibited":[218],"UPR,":[229],"suggesting":[230],"differentiation-induced":[232],"specifically":[234],"silence":[235],"branch.":[237],"unique":[239],"ability":[240],"differentially":[242],"regulate":[243],"various":[244],"allows":[249],"accomplish":[253],"outcomes":[255],"via":[256],"same":[258],"machinery.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}