{"id":"https://openalex.org/W2038313633","doi":"https://doi.org/10.1080/15569520500371792","title":"Ocular Irritation Following Frequent Applications of Cyclosporinea","display_name":"Ocular Irritation Following Frequent Applications of Cyclosporinea","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2038313633","doi":"https://doi.org/10.1080/15569520500371792","mag":"2038313633"},"language":"en","primary_location":{"id":"doi:10.1080/15569520500371792","doi":"https://doi.org/10.1080/15569520500371792","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15569520500371792","pdf_url":null,"source":{"id":"https://openalex.org/S52317855","display_name":"Cutaneous and Ocular Toxicology","issn_l":"1556-9527","issn":["1556-9527","1556-9535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cutaneous and Ocular Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017615033","display_name":"Hiroshi Toshida","orcid":"https://orcid.org/0000-0003-4260-6687","observed_orcids":["https://orcid.org/0000-0003-4260-6687"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hiroshi Toshida","raw_affiliation_strings":["Juntendo University School of Medicine, Department of Ophthalmology, Tokyo, Japan","Louisiana State University Health Sciences Center, LSU Eye Center, New Orleans, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Juntendo University School of Medicine, Department of Ophthalmology, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"Louisiana State University Health Sciences Center, LSU Eye Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007551999","display_name":"Roger Wilmer Beuerman","orcid":"https://orcid.org/0000-0002-0725-9336","observed_orcids":["https://orcid.org/0000-0002-0725-9336"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger W. Beuerman","raw_affiliation_strings":["Louisiana State University Health Sciences Center, LSU Eye Center, New Orleans, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University Health Sciences Center, LSU Eye Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038710773","display_name":"Akira Murakami","orcid":"https://orcid.org/0000-0002-0022-2514","observed_orcids":["https://orcid.org/0000-0002-0022-2514"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Murakami","raw_affiliation_strings":["Juntendo University School of Medicine, Department of Ophthalmology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Juntendo University School of Medicine, Department of Ophthalmology, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070119726","display_name":"Kiyoo Nakayasu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoo Nakayasu","raw_affiliation_strings":["Juntendo University School of Medicine, Department of Ophthalmology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Juntendo University School of Medicine, Department of Ophthalmology, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113866482","display_name":"Atsushi Kanai","orcid":"https://orcid.org/0009-0007-1357-2381","observed_orcids":["https://orcid.org/0009-0007-1357-2381"]},"institutions":[{"id":"https://openalex.org/I4405283298","display_name":"Juntendo Tokyo Koto Geriatric Medical Center","ror":"https://ror.org/01d6kr923","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405283298"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Kanai","raw_affiliation_strings":["Juntendo Tokyo Koto Geriatric Medical Center, Department of Opthalmology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Juntendo Tokyo Koto Geriatric Medical Center, Department of Opthalmology, Tokyo, Japan","institution_ids":["https://openalex.org/I4405283298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109290388","display_name":"Shigekuni Okisaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigekuni Okisaka","raw_affiliation_strings":["National Defense Medical School, Department of Ophthalmology, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Defense Medical School, Department of Ophthalmology, Saitama, Japan","institution_ids":["https://openalex.org/I53888640"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23643969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"4","first_page":"257","last_page":"272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.4480000138282776,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.4480000138282776,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.35670000314712524,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.10189999639987946,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9760000109672546},{"id":"https://openalex.org/keywords/eye-irritation","display_name":"eye irritation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/miosis","display_name":"miosis","score":0.6809999942779541},{"id":"https://openalex.org/keywords/conjunctival-hyperemia","display_name":"conjunctival hyperemia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/calcitonin-gene-related-peptide","display_name":"calcitonin gene-related peptide","score":0.9049999713897705},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ciliary-epithelium","display_name":"ciliary epithelium","score":0.6600000262260437},{"id":"https://openalex.org/keywords/iris-vessels","display_name":"iris vessels","score":0.7200000286102295},{"id":"https://openalex.org/keywords/rabbit-eye","display_name":"rabbit eye","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2777724181","wikidata":"https://www.wikidata.org/wiki/Q596899","display_name":"Miosis","level":2,"score":0.7295043468475342},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.667499303817749},{"id":"https://openalex.org/C2993390227","wikidata":"https://www.wikidata.org/wiki/Q827681","display_name":"Aqueous humor","level":2,"score":0.6014330983161926},{"id":"https://openalex.org/C2778434524","wikidata":"https://www.wikidata.org/wiki/Q1048080","display_name":"Ciliary body","level":2,"score":0.5772184133529663},{"id":"https://openalex.org/C2777625524","wikidata":"https://www.wikidata.org/wiki/Q552308","display_name":"Eye drop","level":2,"score":0.5305199027061462},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5294862389564514},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.4932991564273834},{"id":"https://openalex.org/C2779105803","wikidata":"https://www.wikidata.org/wiki/Q2620085","display_name":"Ciliary processes","level":3,"score":0.45251843333244324},{"id":"https://openalex.org/C2778113962","wikidata":"https://www.wikidata.org/wiki/Q965041","display_name":"Slit lamp","level":2,"score":0.4467683732509613},{"id":"https://openalex.org/C2778275304","wikidata":"https://www.wikidata.org/wiki/Q76469","display_name":"Tears","level":2,"score":0.4384787380695343},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40285593271255493},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2410171926021576},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.23315975069999695}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/15569520500371792","doi":"https://doi.org/10.1080/15569520500371792","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15569520500371792","pdf_url":null,"source":{"id":"https://openalex.org/S52317855","display_name":"Cutaneous and Ocular Toxicology","issn_l":"1556-9527","issn":["1556-9527","1556-9535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cutaneous and Ocular Toxicology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W143184129","https://openalex.org/W149220717","https://openalex.org/W196511189","https://openalex.org/W1479973836","https://openalex.org/W1873750670","https://openalex.org/W1966149677","https://openalex.org/W1966421361","https://openalex.org/W1972657414","https://openalex.org/W1980106287","https://openalex.org/W1981801952","https://openalex.org/W1998810752","https://openalex.org/W2000095395","https://openalex.org/W2000131872","https://openalex.org/W2027274341","https://openalex.org/W2027796183","https://openalex.org/W2034136287","https://openalex.org/W2045689556","https://openalex.org/W2050635513","https://openalex.org/W2055122134","https://openalex.org/W2063407404","https://openalex.org/W2069252221","https://openalex.org/W2072027086","https://openalex.org/W2077530094","https://openalex.org/W2078579740","https://openalex.org/W2081175739","https://openalex.org/W2081762911","https://openalex.org/W2087854358","https://openalex.org/W2131720094","https://openalex.org/W2132208680","https://openalex.org/W2146342266","https://openalex.org/W2152927996","https://openalex.org/W2209867202","https://openalex.org/W2261585932","https://openalex.org/W2269818016","https://openalex.org/W2279736514","https://openalex.org/W2289345514","https://openalex.org/W2413920738","https://openalex.org/W2418628532","https://openalex.org/W2430351434","https://openalex.org/W2615725917","https://openalex.org/W4213142924","https://openalex.org/W4322697921"],"related_works":["https://openalex.org/W2002302351","https://openalex.org/W3099653087","https://openalex.org/W2070951459","https://openalex.org/W187131593","https://openalex.org/W2331730064","https://openalex.org/W2054254207","https://openalex.org/W2089434971","https://openalex.org/W2023015514","https://openalex.org/W1980996522","https://openalex.org/W2389199650"],"abstract_inverted_index":{"Purpose.":[0],"Previous":[1],"studies":[2,88],"have":[3],"shown":[4,158],"that":[5,228],"repetitive":[6],"administrations":[7],"of":[8,38,47,53,101,117,126,172,179,192,233,253],"Cyclosporine":[9],"A":[10],"(CsA)":[11],"eye":[12,17,56,119],"drops":[13,57],"to":[14,43,86],"the":[15,33,39,45,87,118,130,154,168,189,193,197,221,234,242,246,254],"rabbit":[16],"caused":[18],"a":[19],"long-lasting":[20],"miosis,":[21],"accompanied":[22],"by":[23,74,135,177],"conjunctival":[24],"hyperemia,":[25,142],"anterior":[26,34,80,106,115,143,155,218],"humor":[27,81,113,132,144],"flare,":[28],"and":[29,77,79,89,96,114,122,146,150,196,210,245],"fibrin":[30,151],"formation":[31,152],"in":[32,153,217,241],"chamber.":[35],"The":[36,70,124],"aim":[37],"present":[40],"study":[41],"was":[42,58,110,133,183,204],"clarify":[44],"mechanism":[46],"these":[48,173],"findings.":[49],"Methods.":[50],"One":[51],"drop":[52],"0.1%":[54],"CsA":[55,102,161,211,229],"applied":[59],"once":[60],"or":[61,103],"six":[62,160],"times":[63],"every":[64],"30":[65],"minutes":[66],"for":[67],"2.5":[68],"hours.":[69],"eyes":[71],"were":[72,83,120,157,175],"examined":[73],"slit-lamp":[75],"microscope,":[76],"IOP":[78,147],"flare":[82,109,145],"measured":[84],"prior":[85],"at":[90],"0,":[91],"1,":[92],"3,":[93],"6,":[94],"12,":[95],"24":[97],"hours":[98,166],"after":[99,159,167],"administration":[100,162],"vehicle.":[104],"While":[105,181],"chamber":[107,156],"aqueous":[108,112,131],"increasing,":[111],"segment":[116],"taken":[121],"analyzed.":[123],"entry":[125],"plasma":[127],"proteins":[128],"into":[129],"studied":[134],"using":[136],"Evans":[137,185],"blue":[138,186],"dye.":[139],"Result.":[140],"Conjunctival":[141],"rise":[148],"miosis":[149,182],"ipsilaterally":[163],"during":[164],"1\u201312":[165],"final":[169],"administration.":[170],"All":[171],"observations":[174],"inhibited":[176],"pretreatment":[178],"indomethacin.":[180],"appearing,":[184],"dye":[187],"penetrated":[188],"nonpigmented":[190],"layer":[191],"ciliary":[194,243],"epithelium":[195],"iris":[198],"vessels.":[199],"Calcitonin":[200],"gene-related":[201],"peptide":[202],"(CGRP)":[203],"detected":[205],"(184.1":[206],"\u00b1":[207,214],"84.6":[208],"pg/mL),":[209],"levels":[212],"(891.6":[213],"153.0":[215],"ng/mL)":[216],"uvea":[219],"exceeded":[220],"trough":[222],"level.":[223],"Conclusions.":[224],"These":[225],"results":[226],"suggest":[227],"can":[230],"cause":[231],"disruption":[232],"blood-aqueous":[235],"barrier":[236],"with":[237],"leaking":[238],"from":[239],"vessels":[240],"processes":[244],"iris,":[247],"which":[248],"are":[249],"probably":[250],"secondary":[251],"effects":[252],"irritation":[255],"response":[256],"releasing":[257],"CGRP.":[258]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}