{"id":"https://openalex.org/W2038144993","doi":"https://doi.org/10.1128/jvi.75.23.11565-11572.2001","title":"A Short N-Proximal Region in the Large Envelope Protein Harbors a Determinant That Contributes to the Species Specificity of Human Hepatitis B Virus","display_name":"A Short N-Proximal Region in the Large Envelope Protein Harbors a Determinant That Contributes to the Species Specificity of Human Hepatitis B Virus","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2038144993","doi":"https://doi.org/10.1128/jvi.75.23.11565-11572.2001","mag":"2038144993","pmid":"https://pubmed.ncbi.nlm.nih.gov/11689638","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/114743"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.75.23.11565-11572.2001","doi":"https://doi.org/10.1128/jvi.75.23.11565-11572.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.75.23.11565-11572.2001","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/114743","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090409671","display_name":"Philippe Chouteau","orcid":"https://orcid.org/0000-0002-2140-2506","observed_orcids":["https://orcid.org/0000-0002-2140-2506"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210124872","display_name":"H\u00f4pital Pontchaillou","ror":"https://ror.org/02r25sw81","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124872","https://openalex.org/I4210155724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Chouteau","raw_affiliation_strings":["<!--label omitted: 1-->Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210124872"]},{"raw_affiliation_string":"Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210124872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043287478","display_name":"Jacques Le Seyec","orcid":"https://orcid.org/0000-0002-1118-3311","observed_orcids":["https://orcid.org/0000-0002-1118-3311"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210124872","display_name":"H\u00f4pital Pontchaillou","ror":"https://ror.org/02r25sw81","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124872","https://openalex.org/I4210155724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Le Seyec","raw_affiliation_strings":["<!--label omitted: 1-->Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210124872"]},{"raw_affiliation_string":"Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210124872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053444843","display_name":"Isabelle Cannie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210124872","display_name":"H\u00f4pital Pontchaillou","ror":"https://ror.org/02r25sw81","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124872","https://openalex.org/I4210155724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"I. Cannie","raw_affiliation_strings":["<!--label omitted: 1-->Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210124872"]},{"raw_affiliation_string":"Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210124872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030576100","display_name":"Michael Nassal","orcid":"https://orcid.org/0000-0003-2204-9158","observed_orcids":["https://orcid.org/0000-0003-2204-9158"]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Nassal","raw_affiliation_strings":["<!--label omitted: 2-->Department of Internal Medicine II, Molecular Biology, University Hospital Freiburg, D-79107 Freiburg, Germany2","Department of Internal Medicine II, Molecular Biology, University Hospital Freiburg, D-79107 Freiburg, Germany2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Department of Internal Medicine II, Molecular Biology, University Hospital Freiburg, D-79107 Freiburg, Germany2","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Department of Internal Medicine II, Molecular Biology, University Hospital Freiburg, D-79107 Freiburg, Germany2","institution_ids":["https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004029396","display_name":"Christiane Guguen\u2010Guillouzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210124872","display_name":"H\u00f4pital Pontchaillou","ror":"https://ror.org/02r25sw81","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124872","https://openalex.org/I4210155724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Guguen-Guillouzo","raw_affiliation_strings":["<!--label omitted: 1-->Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210124872"]},{"raw_affiliation_string":"Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210124872"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089619421","display_name":"Philippe Gripon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210124872","display_name":"H\u00f4pital Pontchaillou","ror":"https://ror.org/02r25sw81","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124872","https://openalex.org/I4210155724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Gripon","raw_affiliation_strings":["<!--label omitted: 1-->Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210124872"]},{"raw_affiliation_string":"Re\u0301gulation des E\u0301quilibres Fonctionnels du Foie Normal et Pathologique U 522, Ho\u0302pital de Pontchaillou, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, 35033 Rennes Cedex, France,1 and","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210124872"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1686,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.91220806,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"75","issue":"23","first_page":"11565","last_page":"11572"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/species-specificity","display_name":"species specificity","score":0.859000027179718},{"id":"https://openalex.org/keywords/host-range","display_name":"host range","score":0.8930000066757202},{"id":"https://openalex.org/keywords/chimeric-envelope-proteins","display_name":"chimeric envelope proteins","score":0.7839999794960022},{"id":"https://openalex.org/keywords/infectivity","display_name":"infectivity","score":0.722000002861023},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8990683555603027},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.8870468139648438},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7637152671813965},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.67131108045578},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5515364408493042},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.45929187536239624},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.45246952772140503},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4173473119735718},{"id":"https://openalex.org/C25897203","wikidata":"https://www.wikidata.org/wiki/Q3241872","display_name":"Viral life cycle","level":4,"score":0.41672155261039734},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.3487631678581238},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.320831298828125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2189701497554779},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16676774621009827}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1128/jvi.75.23.11565-11572.2001","doi":"https://doi.org/10.1128/jvi.75.23.11565-11572.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.75.23.11565-11572.2001","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:175623","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/114743","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:114743","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/114743","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:11689638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11689638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05670852v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05670852","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology, 2001, 75 (23), pp.11565-11572. &#x27E8;10.1128/JVI.75.23.11565-11572.2001&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-05784475v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05784475","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology, 2001, 75 (23), pp.11565-11572. &#x27E8;10.1128/JVI.75.23.11565-11572.2001&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:175623","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/114743","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W19219484","https://openalex.org/W71504123","https://openalex.org/W1269890246","https://openalex.org/W1492423760","https://openalex.org/W1544473294","https://openalex.org/W1557805105","https://openalex.org/W1563075736","https://openalex.org/W1745359060","https://openalex.org/W1748541083","https://openalex.org/W1885980745","https://openalex.org/W1952400847","https://openalex.org/W1955933769","https://openalex.org/W1966689362","https://openalex.org/W1967446284","https://openalex.org/W1973998250","https://openalex.org/W1992202363","https://openalex.org/W2007026967","https://openalex.org/W2008933169","https://openalex.org/W2009883759","https://openalex.org/W2011257176","https://openalex.org/W2015884002","https://openalex.org/W2018143218","https://openalex.org/W2024550435","https://openalex.org/W2036298444","https://openalex.org/W2036462409","https://openalex.org/W2038475476","https://openalex.org/W2040425361","https://openalex.org/W2060913542","https://openalex.org/W2072224901","https://openalex.org/W2083703476","https://openalex.org/W2084000424","https://openalex.org/W2089921389","https://openalex.org/W2090542340","https://openalex.org/W2101273158","https://openalex.org/W2102525174","https://openalex.org/W2107513701","https://openalex.org/W2119328471","https://openalex.org/W2121406162","https://openalex.org/W2134653235"],"related_works":["https://openalex.org/W2010370103","https://openalex.org/W2038475476","https://openalex.org/W7099540170","https://openalex.org/W2748069523","https://openalex.org/W219954641","https://openalex.org/W2140038670","https://openalex.org/W7167566708","https://openalex.org/W2171299742","https://openalex.org/W1955933769","https://openalex.org/W60886217"],"abstract_inverted_index":{"Infection":[0],"by":[1,117,211],"hepatitis":[2],"B":[3],"virus":[4,64],"(HBV)":[5],"is":[6,14],"mainly":[7],"restricted":[8],"to":[9,35,66,126,198,236],"humans.":[10],"This":[11],"species":[12],"specificity":[13],"likely":[15],"determined":[16],"at":[17],"the":[18,22,27,31,38,46,58,67,71,82,95,128,133,175,180,194,215,218,232,237],"early":[19],"phase":[20],"of":[21,57,61,84,94,135,166,179,187,201,208,217,225,231,240],"viral":[23,33,137],"life":[24],"cycle.":[25],"Since":[26],"envelope":[28,87,98,160],"proteins":[29,113,131,161],"are":[30],"first":[32,176],"factors":[34],"interact":[36],"with":[37,157],"cell,":[39],"they":[40,123],"represent":[41],"attractive":[42],"candidates":[43],"for":[44,81,102,132,145],"controlling":[45],"HBV":[47,74,105,130,219],"host":[48,238],"range.":[49],"To":[50],"investigate":[51],"this":[52,191,209,228],"assumption,":[53],"we":[54],"took":[55],"advantage":[56],"recent":[59],"discovery":[60],"a":[62,163,199],"second":[63],"belonging":[65],"primate":[68],"Orthohepadnavirus":[69],"genus,":[70],"woolly":[72],"monkey":[73],"(WMHBV).":[75],"A":[76],"recombinant":[77],"plasmid":[78],"was":[79,171],"constructed":[80],"expression":[83],"all":[85],"WMHBV":[86,96,111,159,212],"proteins.":[88],"In":[89],"additional":[90],"constructs,":[91],"N-terminal":[92],"sequences":[93],"large":[97,181],"protein":[99,182,221,234],"were":[100,114,124,143],"substituted":[101],"their":[103,146],"homologous":[104],"counterparts.":[106],"All":[107],"wild-type":[108,158],"and":[109,122],"chimeric":[110],"surface":[112],"properly":[115],"synthesized":[116],"transfected":[118],"human":[119,150],"hepatoma":[120],"cells,":[121],"competent":[125],"replace":[127],"original":[129],"production":[134],"complete":[136],"particles.":[138],"The":[139],"resulting":[140],"pseudotyped":[141,156],"virions":[142],"evaluated":[144],"infectious":[147],"capacity":[148],"on":[149],"hepatocytes":[151],"in":[152,214],"primary":[153],"culture.":[154],"Virions":[155],"showed":[162],"significant":[164],"loss":[165],"infectivity.":[167],"By":[168],"contrast,":[169],"infectivity":[170,224],"completely":[172],"restored":[173],"when":[174],"30":[177],"residues":[178,213],"originated":[183],"from":[184],"HBV.":[185,226,241],"Analysis":[186],"smaller":[188],"substitutions":[189],"within":[190],"domain":[192],"limited":[193],"most":[195],"important":[196],"region":[197,230],"stretch":[200],"only":[202],"nine":[203],"amino":[204],"acids.":[205],"Reciprocally,":[206],"replacement":[207],"motif":[210],"context":[216],"L":[220,233],"significantly":[222],"reduced":[223],"Hence":[227],"short":[229],"contributes":[235],"range":[239]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}