{"id":"https://openalex.org/W2038110554","doi":"https://doi.org/10.2146/ajhp070005","title":"Elevated serum creatinine levels associated with fenofibrate therapy","display_name":"Elevated serum creatinine levels associated with fenofibrate therapy","publication_year":2008,"publication_date":"2008-01-11","ids":{"openalex":"https://openalex.org/W2038110554","doi":"https://doi.org/10.2146/ajhp070005","mag":"2038110554","pmid":"https://pubmed.ncbi.nlm.nih.gov/18192258"},"language":"en","primary_location":{"id":"doi:10.2146/ajhp070005","doi":"https://doi.org/10.2146/ajhp070005","is_oa":false,"landing_page_url":"https://doi.org/10.2146/ajhp070005","pdf_url":null,"source":{"id":"https://openalex.org/S105051383","display_name":"American Journal of Health-System Pharmacy","issn_l":"1079-2082","issn":["1079-2082","1535-2900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Health-System Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073189096","display_name":"Charles R. McQuade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles R. McQuade","raw_affiliation_strings":["University of New Mexico, College of Pharmacy, Albuquerque, NM 87131, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New Mexico, College of Pharmacy, Albuquerque, NM 87131, USA","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040992914","display_name":"Jennifer E. Griego","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Griego","raw_affiliation_strings":["University of New Mexico College of Pharmacy, Albuquerque","University of New Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New Mexico College of Pharmacy, Albuquerque","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"University of New Mexico;","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090921787","display_name":"J.E. Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe Anderson","raw_affiliation_strings":["University of New Mexico College of Pharmacy, Albuquerque","University of New Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New Mexico College of Pharmacy, Albuquerque","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"University of New Mexico;","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047374751","display_name":"Amy Barton Pai","orcid":"https://orcid.org/0000-0002-7131-5267","observed_orcids":["https://orcid.org/0000-0002-7131-5267"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amy Barton Pai","raw_affiliation_strings":["University of New Mexico College of Pharmacy, Albuquerque"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New Mexico College of Pharmacy, Albuquerque","institution_ids":["https://openalex.org/I169521973"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047374751"],"corresponding_institution_ids":["https://openalex.org/I169521973"],"apc_list":{"value":4448,"currency":"USD","value_usd":4448},"apc_paid":null,"fwci":1.0819,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.78949643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"65","issue":"2","first_page":"138","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.6118000149726868,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.6118000149726868,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.3407999873161316,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fenofibrate","display_name":"fenofibrate","score":1.0},{"id":"https://openalex.org/keywords/drug-induced-nephrotoxicity","display_name":"drug-induced nephrotoxicity","score":0.902999997138977},{"id":"https://openalex.org/keywords/creatinine-elevation","display_name":"creatinine elevation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate-decline","display_name":"estimated glomerular filtration rate decline","score":0.8650000095367432},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.5609999895095825},{"id":"https://openalex.org/keywords/naranjo-probability-scale","display_name":"Naranjo probability scale","score":0.6800000071525574},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2778110834","wikidata":"https://www.wikidata.org/wiki/Q419724","display_name":"Fenofibrate","level":2,"score":0.9566068649291992},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.7864078283309937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5441100001335144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5130399465560913},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37701234221458435},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37562328577041626},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3646233379840851}],"mesh":[{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011345","descriptor_name":"Fenofibrate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015228","descriptor_name":"Hypertriglyceridemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015228","descriptor_name":"Hypertriglyceridemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2146/ajhp070005","doi":"https://doi.org/10.2146/ajhp070005","is_oa":false,"landing_page_url":"https://doi.org/10.2146/ajhp070005","pdf_url":null,"source":{"id":"https://openalex.org/S105051383","display_name":"American Journal of Health-System Pharmacy","issn_l":"1079-2082","issn":["1079-2082","1535-2900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Health-System Pharmacy","raw_type":"journal-article"},{"id":"pmid:18192258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18192258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W65486890","https://openalex.org/W158980592","https://openalex.org/W1998811243","https://openalex.org/W2003602721","https://openalex.org/W2008263647","https://openalex.org/W2032210000","https://openalex.org/W2053358292","https://openalex.org/W2067978628","https://openalex.org/W2082236694","https://openalex.org/W2091399496","https://openalex.org/W2099822840","https://openalex.org/W2111483825","https://openalex.org/W2120259334","https://openalex.org/W2133136977","https://openalex.org/W2155023659","https://openalex.org/W2167744816","https://openalex.org/W2198678228","https://openalex.org/W2326572183","https://openalex.org/W2487377689","https://openalex.org/W4238251256","https://openalex.org/W4249825849"],"related_works":["https://openalex.org/W2103257941","https://openalex.org/W2092666385","https://openalex.org/W2155524015","https://openalex.org/W2116348090","https://openalex.org/W152448817","https://openalex.org/W2003602721","https://openalex.org/W4398756127","https://openalex.org/W2026850783","https://openalex.org/W4282940394","https://openalex.org/W1980316499"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,125,147],"case":[2],"of":[3,43,51,108,166,187,215,252],"a":[4,28,102,228],"patient":[5,148,242],"who":[6],"developed":[7,243],"clinically":[8],"relevant":[9],"increases":[10],"in":[11,158,236],"serum":[12],"creatinine":[13],"(SCr)":[14],"levels":[15],"while":[16],"receiving":[17,247],"fenofibrate":[18,52,117,211,232,248],"therapy":[19,24],"is":[20],"reported.":[21],"SUMMARY:":[22],"Fenofibrate":[23],"was":[25,119,141,149,194,227],"initiated":[26],"for":[27,40,155,160,192,206,249],"60-year":[29],"old":[30],"Hispanic":[31],"man":[32],"with":[33,184],"stage":[34],"4":[35,216],"chronic":[36],"kidney":[37],"disease":[38],"(CKD)":[39],"the":[41,54,116,152,168,197,207,218,250],"treatment":[42,251],"hypertriglyceridemia.":[44,253],"Two":[45],"weeks":[46,182],"after":[47,91,164,210,246],"taking":[48],"48":[49],"mg":[50,123],"daily,":[53],"patient's":[55,126,169,198],"SCr":[56,95,127,170],"and":[57,65,71,138,176,196,233],"blood":[58],"urea":[59],"nitrogen":[60],"concentrations":[61,112],"increased":[62,98,120],"from":[63,83,105,136],"3.0":[64],"25":[66],"mg/dL,":[67,73,101],"respectively,":[68],"to":[69,85,99,121,130,173,178],"3.5":[70],"30":[72],"respectively.":[74],"His":[75],"estimated":[76],"glomerular":[77],"filtration":[78],"rate":[79],"(eGFR)":[80],"had":[81,97],"decreased":[82],"24.8":[84],"17.9":[86],"mL/min/1.73":[87,145,189,204],"m(2).":[88,146,190],"One":[89],"month":[90],"initiating":[92],"fenofibrate,":[93,167],"his":[94,139],"concentration":[96,128,171],"3.7":[100],"32%":[103],"increase":[104,135],"baseline.":[106],"Because":[107],"persistently":[109],"high":[110],"triglyceride":[111],"(e.g.,":[113],"402":[114],"mg/dL),":[115],"dosage":[118],"145":[122],"daily.":[124],"rose":[129],"4.7":[131],"mg/dL":[132,175],"(a":[133],"62%":[134],"baseline),":[137],"eGFR":[140,186,199],"calculated":[142],"as":[143],"13":[144],"referred":[150],"by":[151],"nephrology":[153],"service":[154],"vascular-access":[156],"placement":[157],"preparation":[159],"hemodialysis.":[161],"Four":[162],"days":[163],"discontinuation":[165],"dropped":[172],"3.3":[174],"returned":[177],"baseline":[179],"approximately":[180],"six":[181],"later,":[183],"an":[185],"20.5":[188],"Preparation":[191],"hemodialysis":[193],"terminated,":[195],"remained":[200],"stable":[201],"at":[202],"20.2":[203],"m(2)":[205],"12":[208],"months":[209],"discontinuation.":[212],"A":[213,240],"score":[214],"on":[217],"Naranjo":[219],"et":[220],"al.":[221],"probability":[222],"scale":[223],"indicated":[224],"that":[225],"there":[226],"possible":[229],"association":[230],"between":[231],"renal":[234,244],"dysfunction":[235],"this":[237],"patient.":[238],"CONCLUSION:":[239],"60-year-old":[241],"impairment":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}