{"id":"https://openalex.org/W2038099508","doi":"https://doi.org/10.1021/jm00054a015","title":"3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors","display_name":"3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2038099508","doi":"https://doi.org/10.1021/jm00054a015","mag":"2038099508","pmid":"https://pubmed.ncbi.nlm.nih.gov/8423600"},"language":"en","primary_location":{"id":"doi:10.1021/jm00054a015","doi":"https://doi.org/10.1021/jm00054a015","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00054a015","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041773055","display_name":"Arun Kumar Ghosh","orcid":"https://orcid.org/0000-0003-2472-1841","observed_orcids":["https://orcid.org/0000-0003-2472-1841"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arun K. Ghosh","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043405937","display_name":"Wayne J. Thompson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wayne J. Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041852182","display_name":"Sean P. McKee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean P. McKee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114237732","display_name":"Tien T. Duong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tien T. Duong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112104312","display_name":"Terry A. Lyle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terry A. Lyle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089676012","display_name":"J. Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jenny C. Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035072487","display_name":"Paul L. Darke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul L. Darke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084996174","display_name":"Joan A. Zugay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joan A. Zugay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020211730","display_name":"Emilio A. Emini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emilio A. Emini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":8.4915,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.97853546,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"36","issue":"2","first_page":"292","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-protease-inhibitors","display_name":"HIV-1 protease inhibitors","score":0.9070000052452087},{"id":"https://openalex.org/keywords/p2-ligands","display_name":"P2 ligands","score":0.8479999899864197},{"id":"https://openalex.org/keywords/antiretroviral-drug-design","display_name":"antiretroviral drug design","score":0.7120000123977661},{"id":"https://openalex.org/keywords/tetrahydrofuran-derivatives","display_name":"tetrahydrofuran derivatives","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9536012411117554},{"id":"https://openalex.org/C2776701986","wikidata":"https://www.wikidata.org/wiki/Q278332","display_name":"Tetrahydrofuran","level":3,"score":0.8619814515113831},{"id":"https://openalex.org/C2777505907","wikidata":"https://www.wikidata.org/wiki/Q217356","display_name":"Pyran","level":2,"score":0.8468707799911499},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.6929740309715271},{"id":"https://openalex.org/C2777583353","wikidata":"https://www.wikidata.org/wiki/Q410261","display_name":"HIV-1 protease","level":4,"score":0.6020211577415466},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5053210854530334},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.418676495552063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3519822955131531},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3455919027328491},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.26978564262390137},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.15875768661499023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011714","descriptor_name":"Pyrans","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011714","descriptor_name":"Pyrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011714","descriptor_name":"Pyrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014520","descriptor_name":"Urethane","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm00054a015","doi":"https://doi.org/10.1021/jm00054a015","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00054a015","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:8423600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8423600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2949730222","https://openalex.org/W2054456535","https://openalex.org/W2613177877","https://openalex.org/W2077472737","https://openalex.org/W1797694255","https://openalex.org/W1977249481","https://openalex.org/W2027629534","https://openalex.org/W2023819168","https://openalex.org/W4400424056","https://openalex.org/W2929316536"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVArticleNEXT3-Tetrahydrofuran":[3],"and":[4,40,85,90,119,163,180,196,198],"pyran":[5],"urethanes":[6],"as":[7],"high-affinity":[8],"P2-ligands":[9],"for":[10,168],"HIV-1":[11],"protease":[12],"inhibitorsArun":[13],"K.":[14],"Ghosh,":[15],"Wayne":[16],"J.":[17,43],"Thompson,":[18],"Sean":[19],"P.":[20],"McKee,":[21],"Tien":[22],"T.":[23],"Duong,":[24],"Terry":[25],"A.":[26,35,38],"Lyle,":[27],"Jenny":[28],"C.":[29],"Chen,":[30],"Paul":[31],"L.":[32],"Darke,":[33],"Joan":[34],"Zugay,":[36],"Emilio":[37],"Emini,":[39],"Cite":[41],"this:":[42],"Med.":[44],"Chem.":[45],"1993,":[46],"36,":[47],"2,":[48],"292\u2013294Publication":[49],"Date":[50],"(Print):January":[51],"1,":[52],"1993Publication":[53],"History":[54],"Published":[55],"online1":[56],"May":[57],"2002Published":[58],"inissue":[59],"1":[60],"January":[61],"1993https://pubs.acs.org/doi/10.1021/jm00054a015https://doi.org/10.1021/jm00054a015research-articleACS":[62],"PublicationsRequest":[63],"reuse":[64],"permissionsArticle":[65],"Views351Altmetric-Citations73LEARN":[66],"ABOUT":[67],"THESE":[68],"METRICSArticle":[69],"Views":[70],"are":[71,94,107],"the":[72,103,108,137,148,161,164,169,176,182],"COUNTER-compliant":[73],"sum":[74],"of":[75,110,136],"full":[76],"text":[77],"article":[78,142],"downloads":[79],"since":[80],"November":[81],"2008":[82],"(both":[83],"PDF":[84],"HTML)":[86],"across":[87],"all":[88],"institutions":[89],"individuals.":[91],"These":[92],"metrics":[93],"regularly":[95],"updated":[96,120],"to":[97,102],"reflect":[98],"usage":[99],"leading":[100],"up":[101],"last":[104],"few":[105],"days.Citations":[106],"number":[109],"other":[111],"articles":[112],"citing":[113],"this":[114],"article,":[115],"calculated":[116],"by":[117],"Crossref":[118,126],"daily.":[121],"Find":[122,172],"more":[123,173],"information":[124,174],"about":[125,160],"citation":[127],"counts.The":[128],"Altmetric":[129,177],"Attention":[130,178],"Score":[131,179],"is":[132,184],"a":[133,140,153],"quantitative":[134],"measure":[135],"attention":[138],"that":[139],"research":[141],"has":[143],"received":[144],"online.":[145],"Clicking":[146],"on":[147,175],"donut":[149],"icon":[150],"will":[151],"load":[152],"page":[154],"at":[155],"altmetric.com":[156],"with":[157,192],"additional":[158],"details":[159],"score":[162,183],"social":[165],"media":[166],"presence":[167],"given":[170],"article.":[171],"how":[181],"calculated.":[185],"Share":[186,201],"Add":[187],"toView":[188],"InAdd":[189],"Full":[190],"Text":[191],"ReferenceAdd":[193],"Description":[194],"ExportRISCitationCitation":[195],"abstractCitation":[197],"referencesMore":[199],"Options":[200],"onFacebookTwitterWechatLinked":[202],"InRedditEmail":[203],"Other":[204],"access":[205],"optionsGet":[206],"e-AlertscloseSupporting":[207],"Info":[208],"(1)\u00bbSupporting":[209],"Information":[210,212],"Supporting":[211],"Get":[213],"e-Alerts":[214]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
