{"id":"https://openalex.org/W2038093397","doi":"https://doi.org/10.1161/circulationaha.104.491456","title":"Development of Occlusive Neointimal Lesions in Distal Pulmonary Arteries of Endothelin B Receptor\u2013Deficient Rats","display_name":"Development of Occlusive Neointimal Lesions in Distal Pulmonary Arteries of Endothelin B Receptor\u2013Deficient Rats","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2038093397","doi":"https://doi.org/10.1161/circulationaha.104.491456","mag":"2038093397","pmid":"https://pubmed.ncbi.nlm.nih.gov/15927975","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1934986"},"language":"en","primary_location":{"id":"doi:10.1161/circulationaha.104.491456","doi":"https://doi.org/10.1161/circulationaha.104.491456","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circulationaha.104.491456","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1934986","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023923057","display_name":"D. Dunbar Ivy","orcid":"https://orcid.org/0000-0003-2541-3402","observed_orcids":["https://orcid.org/0000-0003-2541-3402"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Dunbar Ivy","raw_affiliation_strings":["From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011168502","display_name":"Ivan F. McMurtry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan F. McMurtry","raw_affiliation_strings":["From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006435516","display_name":"Kelley L. Colvin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelley Colvin","raw_affiliation_strings":["From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masatoshi Imamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masatoshi Imamura","raw_affiliation_strings":["From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050459313","display_name":"Masahiko Oka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masahiko Oka","raw_affiliation_strings":["From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026903916","display_name":"Dong\u2010Seok Lee","orcid":"https://orcid.org/0000-0001-6348-8937","observed_orcids":["https://orcid.org/0000-0001-6348-8937"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong-Seok Lee","raw_affiliation_strings":["From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085381875","display_name":"Sarah A. Gebb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Gebb","raw_affiliation_strings":["From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103226928","display_name":"Peter Lloyd Jones","orcid":"https://orcid.org/0000-0003-1445-4081","observed_orcids":["https://orcid.org/0000-0003-1445-4081"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Lloyd Jones","raw_affiliation_strings":["From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Sections of Pediatric Cardiology (D.D.I., K.C., D.L.), Cardiovascular Pulmonary Research Laboratory (I.F.M., M.I., M.O., S.G.), and Critical Care and Developmental Lung Biology (P.L.J.), University of Colorado School of Medicine and Children\u2019s Hospital, Denver","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.0606,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.9515828,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"111","issue":"22","first_page":"2988","last_page":"2996"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.9620000123977661},{"id":"https://openalex.org/keywords/endothelin-b-receptor","display_name":"endothelin B receptor","score":0.8360000252723694},{"id":"https://openalex.org/keywords/neointimal-lesion","display_name":"neointimal lesion","score":0.8339999914169312},{"id":"https://openalex.org/keywords/monocrotaline","display_name":"monocrotaline","score":0.9350000023841858},{"id":"https://openalex.org/keywords/endothelin-system","display_name":"endothelin system","score":0.6819999814033508},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-proliferation","display_name":"vascular smooth muscle cell proliferation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/pulmonary-vascular-remodeling","display_name":"pulmonary vascular remodeling","score":0.5830000042915344},{"id":"https://openalex.org/keywords/right-ventricular-hypertrophy","display_name":"right ventricular hypertrophy","score":0.8510000109672546},{"id":"https://openalex.org/keywords/endothelial-growth-factor","display_name":"endothelial growth factor","score":0.5429999828338623},{"id":"https://openalex.org/keywords/tenascin-c","display_name":"tenascin-C","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endothelin-a-receptor","display_name":"ETA receptor","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8631976842880249},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.5493679642677307},{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.5459831953048706},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49974584579467773},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4821174144744873},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.4725351631641388},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.4598136842250824},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.4417400360107422},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4339636564254761},{"id":"https://openalex.org/C2779376020","wikidata":"https://www.wikidata.org/wiki/Q2014808","display_name":"Right ventricular hypertrophy","level":3,"score":0.4111579656600952},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.393303781747818},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36861899495124817},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3560575842857361},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.15766680240631104},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.11379867792129517}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001157","descriptor_name":"Arterial Occlusive Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016686","descriptor_name":"Monocrotaline","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017380","descriptor_name":"Hypertrophy, Right Ventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044023","descriptor_name":"Receptor, Endothelin B","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D044023","descriptor_name":"Receptor, Endothelin B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/circulationaha.104.491456","doi":"https://doi.org/10.1161/circulationaha.104.491456","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circulationaha.104.491456","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:15927975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15927975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1934986","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1934986","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circulation","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1934986","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1934986","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circulation","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1129487112","display_name":"ROLE OF ENDOTHELIN IN PERINATAL PULMONARY VASOREGULATION","funder_award_id":"K08HL003823","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2049348602","display_name":null,"funder_award_id":"HL-14985","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4558651458","display_name":null,"funder_award_id":"HL-68798","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5934708849","display_name":null,"funder_award_id":"2 P50 HL57144","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7063068489","display_name":"Adaptation to Hypoxia","funder_award_id":"P01HL014985","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G811973743","display_name":null,"funder_award_id":"HL03823","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G843349408","display_name":"SCOR: Impact of Injury on the Immature Pulmonary Circul*","funder_award_id":"P50HL057144","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G896926903","display_name":"Prx homebox genes in pulmonary vascular homeostasis","funder_award_id":"R01HL068798","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W14872226","https://openalex.org/W156930526","https://openalex.org/W204164459","https://openalex.org/W1571553794","https://openalex.org/W1712585805","https://openalex.org/W1794373707","https://openalex.org/W1919041450","https://openalex.org/W1940371341","https://openalex.org/W1966882053","https://openalex.org/W1974579801","https://openalex.org/W1977343715","https://openalex.org/W1978564785","https://openalex.org/W1999718652","https://openalex.org/W2000983409","https://openalex.org/W2012818083","https://openalex.org/W2022879525","https://openalex.org/W2041382537","https://openalex.org/W2042274135","https://openalex.org/W2043826113","https://openalex.org/W2048443661","https://openalex.org/W2059694924","https://openalex.org/W2067115616","https://openalex.org/W2082570154","https://openalex.org/W2089304754","https://openalex.org/W2097382561","https://openalex.org/W2097485120","https://openalex.org/W2100198529","https://openalex.org/W2103464580","https://openalex.org/W2105570450","https://openalex.org/W2122302939","https://openalex.org/W2122600153","https://openalex.org/W2139552462","https://openalex.org/W2146234408","https://openalex.org/W2147011107","https://openalex.org/W2154783093","https://openalex.org/W2156557619","https://openalex.org/W2164325843","https://openalex.org/W2188647398","https://openalex.org/W2385448239","https://openalex.org/W2395293792","https://openalex.org/W2414047451","https://openalex.org/W2765610915"],"related_works":["https://openalex.org/W2941839480","https://openalex.org/W4406411294","https://openalex.org/W2074248400","https://openalex.org/W2115605234","https://openalex.org/W2189363576","https://openalex.org/W2087442019","https://openalex.org/W2571331043","https://openalex.org/W2089273856","https://openalex.org/W3049454825","https://openalex.org/W2003425669"],"abstract_inverted_index":{"BACKGROUND:":[0],"Human":[1],"pulmonary":[2,32,112,145,169,188,307],"arterial":[3],"hypertension":[4],"(PAH)":[5],"is":[6],"characterized":[7,142],"by":[8,20,143],"proliferation":[9,34,214],"of":[10,23,31,41,44,48,56,85,99,105,117,132,163,190,213,241,249,264,272,283,292,302],"vascular":[11,224,308],"smooth":[12,199],"muscle":[13,200],"and,":[14],"in":[15,121,218,236,254,274,306],"its":[16],"more":[17,139],"severe":[18,140],"form,":[19],"the":[21,42,49,57,90,97,161,265,270,281,290,303],"development":[22,98],"occlusive":[24],"neointimal":[25,33,75,100,164,196,208],"lesions.":[26,76],"However,":[27],"few":[28],"animal":[29],"models":[30],"exist,":[35],"thereby":[36],"limiting":[37],"a":[38,219],"complete":[39],"understanding":[40],"pathobiology":[43,291],"PAH.":[45,107,238,293],"Recent":[46],"studies":[47],"endothelin":[50],"(ET)":[51],"system":[52],"demonstrate":[53],"that":[54,83,102,246],"deficiency":[55],"ET(B)":[58,86,125,250,266,304],"receptor":[59,259,267,305],"predisposes":[60],"adult":[61],"rats":[62,88,128,137,275],"to":[63,73,89,96],"acute":[64],"and":[65,80,114,124,151,175,201,215,229,279,285],"chronic":[66],"hypoxic":[67],"PAH,":[68,141],"yet":[69],"these":[70,295],"animals":[71],"fail":[72],"develop":[74],"Herein,":[77],"we":[78],"determined":[79],"thereafter":[81],"showed":[82,245],"exposure":[84],"receptor-deficient":[87,126],"endothelial":[91,202,225],"toxin":[92],"monocrotaline":[93],"(MCT)":[94],"leads":[95],"lesions":[101,165,197,209],"share":[103],"hallmarks":[104],"human":[106,237],"METHODS":[108],"AND":[109],"RESULTS:":[110],"The":[111],"hemodynamic":[113],"morphometric":[115,158],"effects":[116],"60":[118],"mg/kg":[119],"MCT":[120,278],"control":[122],"(MCT(+/+))":[123],"(MCT(sl/sl))":[127],"at":[129],"6":[130],"weeks":[131],"age":[133],"were":[134,216],"assessed.":[135],"MCT(sl/sl)":[136,156,191,255],"developed":[138],"elevated":[144],"artery":[146],"pressure,":[147],"diminished":[148,186],"cardiac":[149],"output,":[150],"right":[152],"ventricular":[153],"hypertrophy.":[154],"In":[155,179],"rats,":[157],"evaluation":[159],"revealed":[160,185],"presence":[162],"within":[166,195,207],"small":[167],"distal":[168,187],"arteries,":[170],"increased":[171,211],"medial":[172],"wall":[173],"thickness,":[174],"decreased":[176,253],"arterial-to-alveolar":[177],"ratio.":[178],"keeping":[180],"with":[181,223,277,289],"this,":[182],"barium":[183],"angiography":[184],"vasculature":[189],"rat":[192,256],"lungs.":[193],"Cells":[194],"expressed":[198],"cell":[203],"markers.":[204],"Moreover,":[205],"cells":[206],"exhibited":[210],"levels":[212],"located":[217],"tissue":[220],"microenvironment":[221],"enriched":[222],"growth":[226],"factor,":[227],"tenascin-C,":[228],"activated":[230],"matrix":[231],"metalloproteinase-9,":[232],"factors":[233],"already":[234],"implicated":[235],"Finally,":[239],"assessment":[240],"steady":[242],"state":[243],"mRNA":[244],"whereas":[247],"expression":[248,260],"receptors":[251],"was":[252],"lungs,":[257],"ET(A)":[258],"increased.":[261],"CONCLUSIONS:":[262],"Deficiency":[263],"markedly":[268],"accelerates":[269],"progression":[271],"PAH":[273],"treated":[276],"enhances":[280],"appearance":[282],"cellular":[284],"molecular":[286],"markers":[287],"associated":[288],"Collectively,":[294],"results":[296],"suggest":[297],"an":[298],"overall":[299],"antiproliferative":[300],"effect":[301],"homeostasis.":[309]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
