{"id":"https://openalex.org/W2038028237","doi":"https://doi.org/10.1111/j.1749-6632.1978.tb16807.x","title":"TRANSFORMATION\u2010SENSITIVE CELL SURFACE PROTEIN: ISOLATION, CHARACTERIZATION, AND ROLE IN CELLULAR MORPHOLOGY AND ADHESION","display_name":"TRANSFORMATION\u2010SENSITIVE CELL SURFACE PROTEIN: ISOLATION, CHARACTERIZATION, AND ROLE IN CELLULAR MORPHOLOGY AND ADHESION","publication_year":1978,"publication_date":"1978-06-01","ids":{"openalex":"https://openalex.org/W2038028237","doi":"https://doi.org/10.1111/j.1749-6632.1978.tb16807.x","mag":"2038028237","pmid":"https://pubmed.ncbi.nlm.nih.gov/291364"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.1978.tb16807.x","doi":"https://doi.org/10.1111/j.1749-6632.1978.tb16807.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1978.tb16807.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052453881","display_name":"Kenneth M. Yamada","orcid":"https://orcid.org/0000-0003-1512-6805","observed_orcids":["https://orcid.org/0000-0003-1512-6805"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth M. Yamada","raw_affiliation_strings":["Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040833722","display_name":"Kenneth Olden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Olden","raw_affiliation_strings":["Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056573254","display_name":"Ira H Pastan","orcid":"https://orcid.org/0000-0002-9223-0270","observed_orcids":["https://orcid.org/0000-0002-9223-0270"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira Pastan","raw_affiliation_strings":["Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":14.2067,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.98742857,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"312","issue":"1","first_page":"256","last_page":"277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-surface-proteins","display_name":"cell surface proteins","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cell-surface-glycoproteins","display_name":"cell surface glycoproteins","score":0.8109999895095825},{"id":"https://openalex.org/keywords/chicken-embryo-fibroblasts","display_name":"chicken embryo fibroblasts","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.5989999771118164},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cell-substrate-adhesion","display_name":"cell-substrate adhesion","score":0.925000011920929},{"id":"https://openalex.org/keywords/disulfide-linked-dimer","display_name":"disulfide-linked dimer","score":0.734000027179718},{"id":"https://openalex.org/keywords/oligosaccharides","display_name":"oligosaccharides","score":0.7630000114440918},{"id":"https://openalex.org/keywords/glycosylation","display_name":"glycosylation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/concanavalin-a-receptors","display_name":"concanavalin A receptors","score":0.8930000066757202},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.5450000166893005},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.5830000042915344},{"id":"https://openalex.org/keywords/microfilament-organization","display_name":"microfilament organization","score":0.5820000171661377},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cold-insoluble-globulin","display_name":"cold-insoluble globulin","score":0.8050000071525574},{"id":"https://openalex.org/keywords/tunicamycin","display_name":"tunicamycin","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.6163936257362366},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.615828812122345},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.552303671836853},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.530254065990448},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.5042017698287964},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47771382331848145},{"id":"https://openalex.org/C189040839","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Microfilament","level":4,"score":0.47232550382614136},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.44553542137145996},{"id":"https://openalex.org/C183521119","wikidata":"https://www.wikidata.org/wiki/Q5058397","display_name":"Cell\u2013cell interaction","level":3,"score":0.4243411719799042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3942699730396271},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.388374924659729},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37311822175979614},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3239492177963257},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.23715057969093323},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002449","descriptor_name":"Cell Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.1978.tb16807.x","doi":"https://doi.org/10.1111/j.1749-6632.1978.tb16807.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1978.tb16807.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:291364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/291364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W899117167","https://openalex.org/W1516971089","https://openalex.org/W1586370846","https://openalex.org/W1972963543","https://openalex.org/W1973056000","https://openalex.org/W1977134028","https://openalex.org/W1999010056","https://openalex.org/W1999776410","https://openalex.org/W2003805365","https://openalex.org/W2004699574","https://openalex.org/W2011915218","https://openalex.org/W2014172562","https://openalex.org/W2017813247","https://openalex.org/W2024373128","https://openalex.org/W2025521193","https://openalex.org/W2027873881","https://openalex.org/W2029523024","https://openalex.org/W2030533124","https://openalex.org/W2031110854","https://openalex.org/W2045380811","https://openalex.org/W2047395071","https://openalex.org/W2058271141","https://openalex.org/W2058435714","https://openalex.org/W2059745049","https://openalex.org/W2066888336","https://openalex.org/W2067231547","https://openalex.org/W2075740646","https://openalex.org/W2076292920","https://openalex.org/W2077057155","https://openalex.org/W2079422646","https://openalex.org/W2081255141","https://openalex.org/W2081926680","https://openalex.org/W2082961543","https://openalex.org/W2086392694","https://openalex.org/W2090107903","https://openalex.org/W2091947629","https://openalex.org/W2093241965","https://openalex.org/W2104497320","https://openalex.org/W2111567750","https://openalex.org/W2121558492","https://openalex.org/W2145453639","https://openalex.org/W2151591460","https://openalex.org/W2341721811","https://openalex.org/W2413026302"],"related_works":["https://openalex.org/W2004699574","https://openalex.org/W2045380811","https://openalex.org/W2090107903","https://openalex.org/W2014172562","https://openalex.org/W2081926680","https://openalex.org/W2029523024","https://openalex.org/W134241316","https://openalex.org/W2104497320","https://openalex.org/W2151591460","https://openalex.org/W1999776410"],"abstract_inverted_index":{"Cell":[0,120,173,241,257],"surface":[1,7,68,110,121,174,201,242,258,306],"protein":[2,27,122,175,243,259,333],"is":[3,24,74,176,236],"the":[4,66,158,183,196,312,328],"major":[5,304],"cell":[6,67,94,109,184,200,305],"glycoprotein":[8,19,307],"of":[9,41,48,87,130,162,198,217,276,297,302,315,332],"chick":[10,42,149],"embryo":[11],"fibroblasts.":[12],"We":[13],"have":[14,247,308],"isolated":[15,88],"and":[16,20,31,63,116,192,222,244,254,319,322,330,337],"purified":[17,89],"this":[18,303],"find":[21],"that":[22,28,166,235,264],"it":[23],"an":[25,324],"adhesive":[26],"increases":[29,290],"cell-cell":[30,146],"cell-substratum":[32,142],"adhesiveness":[33],"in":[34,45,56,81,100,169,179,252,284,291],"a":[35,53,78,103,231],"variety":[36],"cellular":[37,316],"adhesion":[38,143],"assays.":[39],"Transformation":[40],"fibroblasts":[43],"results":[44,99,283],"decreased":[46,72,285],"quantities":[47],"CSP":[49,57,90,131,156,170,187,204,215,286],"due":[50,76,135,287],"primarily":[51,178,261],"to":[52,77,102,133,136,155,209,230,266,288,326],"fivefold":[54,79],"reduction":[55,80],"biosynthesis,":[58],"although":[59],"increased":[60,141],"proteolytic":[61],"degradation":[62,293],"shedding":[64],"from":[65,96],"also":[69],"contribute.":[70],"The":[71,128,224],"biosynthesis":[73],"apparently":[75],"translatable":[82],"mRNA":[83],"for":[84,269],"CSP.":[85],"Reconstitution":[86],"on":[91,182],"14":[92],"transformed":[93,164],"lines":[95],"several":[97],"species":[98],"reversion":[101],"more":[104],"normal":[105],"fibroblastic":[106],"morphology,":[107,318],"adhesiveness,":[108],"architecture,":[111],"microfilament":[112],"bundle":[113],"organization,":[114],"motility,":[115],"alignment":[117],"at":[118,137],"confluence.":[119],"does":[123],"not":[124,194],"restore":[125],"growth":[126],"control.":[127],"effects":[129],"appear":[132,265],"be":[134,206,267],"least":[138],"two":[139],"actions,":[140],"plus":[144],"altered":[145],"interactions.":[147],"Untransformed":[148],"cells":[150,165],"treated":[151],"with":[152,212,281],"affinity-purified":[153],"antibodies":[154],"develop":[157],"rounded":[159],"morphology":[160],"characteristic":[161],"many":[163],"are":[167,189,228],"deficient":[168],"(LETS":[171],"protein).":[172],"found":[177],"fibrillar":[180],"aggregates":[181],"surface.":[185],"These":[186],"fibrils":[188],"relatively":[190],"immobile":[191],"do":[193],"affect":[195],"mobility":[197],"other":[199],"components.":[202],"However,":[203],"can":[205],"eventually":[207],"redistributed":[208],"caplike":[210],"structures":[211],"anti-CSP.":[213],"Isolated":[214],"consists":[216],"highly":[218],"asymmetric":[219],"disulfide-linked":[220],"dimers":[221],"multimers.":[223],"interchain":[225],"disulfide":[226],"bridges":[227],"confined":[229],"short":[232],"terminal":[233],"fragment":[234],"readily":[237],"removed":[238],"by":[239,279],"trypsin.":[240],"cold-insoluble":[245],"globulin":[246],"similar":[248],"compositions":[249],"but":[250],"differ":[251],"solubility":[253],"amino":[255],"termini.":[256],"contains":[260],"asparagine-linked":[262],"oligosaccharides":[263],"responsible":[268],"CSP's":[270,277],"concanavalin":[271],"A":[272],"receptor":[273],"activity.":[274],"Inhibition":[275],"glycosylation":[278],"treatment":[280],"tunicamycin":[282],"marked":[289],"its":[292],"rate,":[294],"without":[295],"inhibition":[296],"synthesis":[298],"or":[299],"secretion.":[300],"Studies":[301],"provided":[309],"insight":[310],"into":[311],"biochemical":[313],"mechanisms":[314],"adhesion,":[317],"social":[320],"interaction":[321],"provide":[323],"approach":[325],"analyze":[327],"dynamics":[329],"regulation":[331],"synthesis,":[334],"glycosylation,":[335],"secretion,":[336],"turnover.":[338]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}