{"id":"https://openalex.org/W2038023628","doi":"https://doi.org/10.1371/journal.pone.0035700","title":"Analysis of Regulatory Network Involved in Mechanical Induction of Embryonic Stem Cell Differentiation","display_name":"Analysis of Regulatory Network Involved in Mechanical Induction of Embryonic Stem Cell Differentiation","publication_year":2012,"publication_date":"2012-04-27","ids":{"openalex":"https://openalex.org/W2038023628","doi":"https://doi.org/10.1371/journal.pone.0035700","mag":"2038023628","pmid":"https://pubmed.ncbi.nlm.nih.gov/22558203","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3338716"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0035700","doi":"https://doi.org/10.1371/journal.pone.0035700","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0035700","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035700&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035700&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058742858","display_name":"Xinan Zhang","orcid":"https://orcid.org/0000-0001-8614-7975","observed_orcids":["https://orcid.org/0000-0001-8614-7975","https://orcid.org/0009-0006-8975-1792"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xinan Zhang","raw_affiliation_strings":["School of Mathematics and Statistics, Central China Normal University, Wuhan, China","Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101487684","display_name":"Mar\u00eda Jaramillo","orcid":"https://orcid.org/0000-0002-7038-720X","observed_orcids":["https://orcid.org/0000-0002-7038-720X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Jaramillo","raw_affiliation_strings":["Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109920736","display_name":"Satish S. Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satish Singh","raw_affiliation_strings":["Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090003388","display_name":"Prashant Nagesh Kumta","orcid":"https://orcid.org/0000-0003-1227-1249","observed_orcids":["https://orcid.org/0000-0003-1227-1249"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prashant Kumta","raw_affiliation_strings":["Center for Complex Engineered Multifunctional Materials, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Complex Engineered Multifunctional Materials, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087175427","display_name":"Ipsita Banerjee","orcid":"https://orcid.org/0000-0001-6791-3646","observed_orcids":["https://orcid.org/0000-0001-6791-3646"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ipsita Banerjee","raw_affiliation_strings":["Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087175427"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.899,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.71119904,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"4","first_page":"e35700","last_page":"e35700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.478300005197525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.478300005197525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.2619999945163727,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.10620000213384628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/embryonic-stem-cell-differentiation","display_name":"embryonic stem cell differentiation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mechanical-microenvironment","display_name":"mechanical microenvironment","score":0.6700000166893005},{"id":"https://openalex.org/keywords/substrate-stiffness","display_name":"substrate stiffness","score":0.7940000295639038},{"id":"https://openalex.org/keywords/endoderm-differentiation","display_name":"endoderm differentiation","score":0.875},{"id":"https://openalex.org/keywords/transcriptional-co-regulation","display_name":"transcriptional co-regulation","score":0.781000018119812},{"id":"https://openalex.org/keywords/biclustering","display_name":"biclustering","score":0.8059999942779541},{"id":"https://openalex.org/keywords/bootstrap-method","display_name":"bootstrapping","score":0.7910000085830688},{"id":"https://openalex.org/keywords/2d-vs-3d-culture","display_name":"2D vs 3D culture","score":0.800000011920929},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.675000011920929},{"id":"https://openalex.org/keywords/evolutionary-algorithms","display_name":"evolutionary algorithms","score":0.5419999957084656},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.8126194477081299},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.631145715713501},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6172720193862915},{"id":"https://openalex.org/C2777164004","wikidata":"https://www.wikidata.org/wiki/Q331858","display_name":"Endoderm","level":4,"score":0.6090630292892456},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5729246139526367},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5343351364135742},{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.4577021598815918},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38466042280197144},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29243069887161255},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.18078121542930603},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12596744298934937}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004707","descriptor_name":"Endoderm","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004707","descriptor_name":"Endoderm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004707","descriptor_name":"Endoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006244","descriptor_name":"Hardness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0035700","doi":"https://doi.org/10.1371/journal.pone.0035700","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0035700","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035700&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3338716","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3338716","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22558203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22558203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:d-scholarship.pitt.edu:14176","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/14176/8/licence.txt","pdf_url":null,"source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:19c67040538e46ee8412268a76f97e31","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/19c67040538e46ee8412268a76f97e31","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 4, p e35700 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0035700","doi":"https://doi.org/10.1371/journal.pone.0035700","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0035700","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035700&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3745236714","display_name":"University of Pittsburgh Clinical and Translational Science Institute","funder_award_id":"UL1RR024153","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4974882718","display_name":null,"funder_award_id":"DP2-116520","funder_id":"https://openalex.org/F4320337383","funder_display_name":"National Center for Chronic Disease Prevention and Health Promotion"},{"id":"https://openalex.org/G5664278136","display_name":"University of Pittsburgh Clinical and Translational Science Institute","funder_award_id":"UL1TR000005","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8888332230","display_name":null,"funder_award_id":"DP2 116520","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308963","display_name":"Oak Ridge Associated Universities","ror":"https://ror.org/0526p1y61"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337383","display_name":"National Center for Chronic Disease Prevention and Health Promotion","ror":"https://ror.org/021rths28"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2038023628.pdf","grobid_xml":"https://content.openalex.org/works/W2038023628.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1484427784","https://openalex.org/W1493217831","https://openalex.org/W1799405090","https://openalex.org/W1980724740","https://openalex.org/W1983524036","https://openalex.org/W1985192768","https://openalex.org/W1993506358","https://openalex.org/W1995945562","https://openalex.org/W2005143737","https://openalex.org/W2008494615","https://openalex.org/W2009904108","https://openalex.org/W2021858888","https://openalex.org/W2025345105","https://openalex.org/W2025982106","https://openalex.org/W2036328877","https://openalex.org/W2050059289","https://openalex.org/W2072813466","https://openalex.org/W2073808856","https://openalex.org/W2076396344","https://openalex.org/W2076409035","https://openalex.org/W2099244374","https://openalex.org/W2103588034","https://openalex.org/W2109464129","https://openalex.org/W2113547540","https://openalex.org/W2117730787","https://openalex.org/W2123584272","https://openalex.org/W2125138557","https://openalex.org/W2126580392","https://openalex.org/W2130410032","https://openalex.org/W2134208433","https://openalex.org/W2142648190","https://openalex.org/W2144544802","https://openalex.org/W2144792853","https://openalex.org/W2150930396","https://openalex.org/W2152150600","https://openalex.org/W2153685871","https://openalex.org/W2155542876","https://openalex.org/W2161732139","https://openalex.org/W2168967248","https://openalex.org/W2408360520","https://openalex.org/W2904250082","https://openalex.org/W3023540311","https://openalex.org/W3106889297","https://openalex.org/W4252191625","https://openalex.org/W4256515882"],"related_works":["https://openalex.org/W7096106325","https://openalex.org/W1484427784","https://openalex.org/W1992029307","https://openalex.org/W7161257985","https://openalex.org/W2169755701","https://openalex.org/W2203231459","https://openalex.org/W2792515237","https://openalex.org/W2465474717","https://openalex.org/W1995535951","https://openalex.org/W2501380663"],"abstract_inverted_index":{"Embryonic":[0],"stem":[1,44,78,153,233],"cells":[2,45,79],"are":[3,80,121],"conventionally":[4],"differentiated":[5,81],"by":[6,41],"modulating":[7],"specific":[8,26,50],"growth":[9],"factors":[10,109],"in":[11,23,59,218],"the":[12,17,35,43,55,115,141,150,157,171,190,230,237,240],"cell":[13,154,234],"culture":[14,242],"media.":[15],"Recently":[16],"effect":[18],"of":[19,37,49,70,85,87,106,117,144,152,162,177,195,232,239],"cellular":[20],"mechanical":[21,89],"microenvironment":[22],"inducing":[24,38],"phenotype":[25],"differentiation":[27,40,64,235],"has":[28,205],"attracted":[29],"considerable":[30],"attention.":[31],"We":[32],"have":[33],"shown":[34],"possibility":[36],"endoderm":[39,63,95,211],"culturing":[42],"on":[46,82,159,229],"fibrin":[47],"substrates":[48,86],"stiffness.":[51],"Here,":[52],"we":[53],"analyze":[54],"regulatory":[56],"network":[57,202],"involved":[58],"such":[60,136,160],"mechanically":[61],"induced":[62,210],"under":[65],"two":[66,241],"different":[67,111],"experimental":[68,98,148],"configurations":[69,243],"2-dimensional":[71,221],"and":[72,91,222],"3-dimensional":[73,223],"culture,":[74],"respectively.":[75],"Mouse":[76],"embryonic":[77],"an":[83,124,131,199],"array":[84],"varying":[88],"properties":[90],"analyzed":[92,103],"for":[93,104,208,244],"relevant":[94],"markers.":[96],"The":[97],"data":[99,146,192],"set":[100],"is":[101,128,138,167,181],"further":[102,245],"identification":[105],"co-regulated":[107],"transcription":[108],"across":[110,147],"substrate":[112],"conditions":[113],"using":[114,130],"technique":[116,166],"bi-clustering.":[118],"Overlapped":[119],"bi-clusters":[120,188,197],"identified":[122],"following":[123],"optimization":[125],"formulation,":[126],"which":[127,180],"solved":[129],"evolutionary":[132],"algorithm.":[133],"While":[134],"typically":[135],"analysis":[137,161,226],"performed":[139],"at":[140,189],"mean":[142,163,191],"value":[143],"expression":[145],"repeats,":[149],"variability":[151],"systems":[155],"reduces":[156],"confidence":[158],"data.":[164],"Bootstrapping":[165],"thus":[168],"integrated":[169],"with":[170,216],"bi-clustering":[172],"algorithm":[173],"to":[174,183],"determine":[175],"sets":[176],"robust":[178,196],"bi-clusters,":[179],"found":[182],"differ":[184],"significantly":[185],"from":[186],"corresponding":[187],"value.":[193],"Analysis":[194],"reveals":[198],"overall":[200],"similar":[201],"interaction":[203],"as":[204],"been":[206],"reported":[207],"chemically":[209],"or":[212],"endodermal":[213],"organs":[214],"but":[215],"differences":[217],"patterning":[219],"between":[220],"culture.":[224],"Such":[225],"sheds":[227],"light":[228],"pathway":[231],"indicating":[236],"prospect":[238],"maturation.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
