{"id":"https://openalex.org/W2037972726","doi":"https://doi.org/10.1002/wrna.68","title":"An active role for splicing in 3\u2032\u2010end formation","display_name":"An active role for splicing in 3\u2032\u2010end formation","publication_year":2010,"publication_date":"2010-12-16","ids":{"openalex":"https://openalex.org/W2037972726","doi":"https://doi.org/10.1002/wrna.68","mag":"2037972726","pmid":"https://pubmed.ncbi.nlm.nih.gov/21957037"},"language":"en","primary_location":{"id":"doi:10.1002/wrna.68","doi":"https://doi.org/10.1002/wrna.68","is_oa":false,"landing_page_url":"https://doi.org/10.1002/wrna.68","pdf_url":null,"source":{"id":"https://openalex.org/S122939334","display_name":"Wiley Interdisciplinary Reviews - RNA","issn_l":"1757-7004","issn":["1757-7004","1757-7012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"WIREs RNA","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072578902","display_name":"Harold G. Martinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Harold G. Martinson","raw_affiliation_strings":["Department of Chemistry & Biochemistry, Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA, USA. hgm@chem.ucla.edu","Department of Chemistry & Biochemistry, Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA, USA. hgm@chem.ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Chemistry & Biochemistry, Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072578902"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.226,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.16993785,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2","issue":"4","first_page":"459","last_page":"470"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.6830000281333923},{"id":"https://openalex.org/keywords/3-end-formation","display_name":"3' end formation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/exon-definition","display_name":"exon definition","score":0.6320000290870667},{"id":"https://openalex.org/keywords/polyadenylation-signal","display_name":"polyadenylation signal","score":0.8339999914169312},{"id":"https://openalex.org/keywords/3-splice-site","display_name":"3' splice site","score":0.8650000095367432},{"id":"https://openalex.org/keywords/5-splice-site","display_name":"5' splice site","score":0.8740000128746033},{"id":"https://openalex.org/keywords/u2af65","display_name":"U2AF65","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cleavage-and-polyadenylation-specificity-factor","display_name":"cleavage and polyadenylation specificity factor","score":0.7580000162124634},{"id":"https://openalex.org/keywords/u2-snrnp","display_name":"U2 snRNP","score":0.8709999918937683},{"id":"https://openalex.org/keywords/u1-snrnp","display_name":"U1 snRNP","score":0.9980000257492065},{"id":"https://openalex.org/keywords/poly-a-polymerase","display_name":"poly(A) polymerase","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C68483431","wikidata":"https://www.wikidata.org/wiki/Q2076770","display_name":"snRNP","level":5,"score":0.9234859943389893},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.8903768062591553},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.8044192790985107},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.710695743560791},{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.6652810573577881},{"id":"https://openalex.org/C166342232","wikidata":"https://www.wikidata.org/wiki/Q11936831","display_name":"Minigene","level":5,"score":0.5370992422103882},{"id":"https://openalex.org/C40000846","wikidata":"https://www.wikidata.org/wiki/Q915868","display_name":"Spliceosome","level":5,"score":0.5321195721626282},{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.5311058163642883},{"id":"https://openalex.org/C42576000","wikidata":"https://www.wikidata.org/wiki/Q5420618","display_name":"Exonic splicing enhancer","level":5,"score":0.49903225898742676},{"id":"https://openalex.org/C102063271","wikidata":"https://www.wikidata.org/wiki/Q7243183","display_name":"Precursor mRNA","level":5,"score":0.4712039828300476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4150405526161194},{"id":"https://openalex.org/C73758832","wikidata":"https://www.wikidata.org/wiki/Q7578564","display_name":"Splicing factor","level":5,"score":0.41111963987350464},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3847929537296295},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3775278925895691},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.36249369382858276},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.18079888820648193},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.17370185256004333},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1517925262451172}],"mesh":[{"descriptor_ui":"D000072668","descriptor_name":"Splicing Factor U2AF","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017413","descriptor_name":"Ribonucleoprotein, U2 Small Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022821","descriptor_name":"RNA Splice Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026723","descriptor_name":"Polyadenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039221","descriptor_name":"mRNA Cleavage and Polyadenylation Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059367","descriptor_name":"RNA Cleavage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/wrna.68","doi":"https://doi.org/10.1002/wrna.68","is_oa":false,"landing_page_url":"https://doi.org/10.1002/wrna.68","pdf_url":null,"source":{"id":"https://openalex.org/S122939334","display_name":"Wiley Interdisciplinary Reviews - RNA","issn_l":"1757-7004","issn":["1757-7004","1757-7012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"WIREs RNA","raw_type":"journal-article"},{"id":"pmid:21957037","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21957037","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiley interdisciplinary reviews. RNA","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W91137656","https://openalex.org/W1771001171","https://openalex.org/W1795122982","https://openalex.org/W1815939386","https://openalex.org/W1965252714","https://openalex.org/W1965435878","https://openalex.org/W1974293813","https://openalex.org/W1976560173","https://openalex.org/W1980392692","https://openalex.org/W1994563059","https://openalex.org/W2006931677","https://openalex.org/W2010589833","https://openalex.org/W2015415328","https://openalex.org/W2020077886","https://openalex.org/W2021735978","https://openalex.org/W2023542289","https://openalex.org/W2026657651","https://openalex.org/W2027403969","https://openalex.org/W2027699344","https://openalex.org/W2027784918","https://openalex.org/W2030011185","https://openalex.org/W2031491283","https://openalex.org/W2031536925","https://openalex.org/W2032033331","https://openalex.org/W2032446389","https://openalex.org/W2034941538","https://openalex.org/W2036893159","https://openalex.org/W2038424676","https://openalex.org/W2040481343","https://openalex.org/W2042212253","https://openalex.org/W2043276968","https://openalex.org/W2045936988","https://openalex.org/W2047758509","https://openalex.org/W2049847998","https://openalex.org/W2051887414","https://openalex.org/W2052494348","https://openalex.org/W2061992493","https://openalex.org/W2062420521","https://openalex.org/W2062862623","https://openalex.org/W2063151549","https://openalex.org/W2064128877","https://openalex.org/W2075988374","https://openalex.org/W2078031011","https://openalex.org/W2079304176","https://openalex.org/W2083833254","https://openalex.org/W2089029993","https://openalex.org/W2093295511","https://openalex.org/W2096746380","https://openalex.org/W2096882911","https://openalex.org/W2099294083","https://openalex.org/W2099927467","https://openalex.org/W2104844714","https://openalex.org/W2106774938","https://openalex.org/W2107657206","https://openalex.org/W2108978314","https://openalex.org/W2111624324","https://openalex.org/W2112309317","https://openalex.org/W2114512817","https://openalex.org/W2115122534","https://openalex.org/W2116741012","https://openalex.org/W2117383597","https://openalex.org/W2118150714","https://openalex.org/W2119786110","https://openalex.org/W2119931220","https://openalex.org/W2121114391","https://openalex.org/W2125165191","https://openalex.org/W2125323012","https://openalex.org/W2126510253","https://openalex.org/W2126740870","https://openalex.org/W2127017989","https://openalex.org/W2133932782","https://openalex.org/W2135743020","https://openalex.org/W2135916235","https://openalex.org/W2138717326","https://openalex.org/W2140382833","https://openalex.org/W2140894105","https://openalex.org/W2142279396","https://openalex.org/W2142574026","https://openalex.org/W2143350291","https://openalex.org/W2144214695","https://openalex.org/W2147702713","https://openalex.org/W2153074755","https://openalex.org/W2153553765","https://openalex.org/W2153722106","https://openalex.org/W2157035190","https://openalex.org/W2157279213","https://openalex.org/W2159666069","https://openalex.org/W2163485052","https://openalex.org/W2163661088","https://openalex.org/W2165477701","https://openalex.org/W2166437079","https://openalex.org/W2277483343","https://openalex.org/W4254469900","https://openalex.org/W7096644567"],"related_works":["https://openalex.org/W1771001171","https://openalex.org/W2169610660","https://openalex.org/W2081007054","https://openalex.org/W2566697726","https://openalex.org/W2479003569","https://openalex.org/W2042212253","https://openalex.org/W2000713154","https://openalex.org/W1838953070","https://openalex.org/W2104844714","https://openalex.org/W7062589632"],"abstract_inverted_index":{"When":[0],"intron-defined":[1],"splicing":[2,7,15,40,73,117],"was":[3],"replaced":[4],"by":[5,88,131,194,243],"exon-defined":[6],"in":[8,27,103,146,215,221,233],"the":[9,14,21,29,43,54,72,78,89,97,121,126,152,159,165,169,173,182,188,201,205,226,234,247],"evolution":[10],"of":[11,39,63,115],"higher":[12],"eukaryotes,":[13],"apparatus":[16,24],"had":[17],"to":[18,240],"rely":[19],"on":[20,42,53],"cleavage/polyadenylation":[22],"(CP)":[23],"for":[25,61,120,156],"help":[26],"defining":[28,187],"3'-terminal":[30,33],"exon.":[31,122,167],"The":[32,110,210],"exon-definition":[34],"complex":[35,66],"that":[36],"resulted":[37],"consists":[38],"factors":[41,52],"upstream":[44,153,189],"3'":[45,137,160,198],"splice":[46,222,238],"site":[47,145,171,207,223],"(ss)":[48],"interacting":[49],"with":[50,77,101,151,158,196,246],"CP":[51,79,119,242,248],"downstream":[55,202],"poly(A)":[56,90,127,144,170,206],"signal.":[57],"A":[58],"speculative":[59],"model":[60],"assembly":[62],"this":[64,216],"processing":[65],"proposes":[67],"several":[68],"discrete":[69],"steps.":[70],"First,":[71],"factor,":[74,80],"U2AF65,":[75],"interacts":[76,100],"CFI(m).":[81],"Then,":[82],"CFI(m)":[83],"is":[84,112,129,178,208],"displaced":[85],"from":[86,237],"U2AF65":[87],"polymerase":[91],"during":[92],"a":[93,104,132,136,143,175,197],"remodeling":[94],"step.":[95],"Finally,":[96],"U2":[98],"snRNP":[99,212,228],"CPSF":[102],"step":[105],"resembling":[106],"spliceosomal":[107],"A-complex":[108],"formation.":[109],"result":[111],"mutual":[113],"enhancement":[114],"both":[116],"and":[118],"In":[123],"contrast,":[124],"when":[125],"signal":[128],"preceded":[130],"5'":[133,154,183],"rather":[134],"than":[135],"ss,":[138],"competition":[139,217],"replaces":[140],"cooperation.":[141],"Thus,":[142],"an":[147],"intron":[148],"must":[149],"compete":[150],"ss":[155,161,184,199],"pairing":[157,195],"further":[162],"upstream,":[163],"across":[164,200],"presumptive":[166],"If":[168],"wins":[172,185],"competition,":[174],"terminal":[176],"exon":[177,190],"defined.":[179],"But":[180],"if":[181],"(by":[186],"as":[191],"internal,":[192],"followed":[193],"intron),":[203],"then":[204],"suppressed.":[209],"U1":[211,227],"obviously":[213],"participates":[214],"through":[218],"its":[219],"role":[220],"pairing.":[224],"However,":[225],"can":[229],"also":[230],"bind":[231],"elsewhere":[232],"transcript,":[235],"apart":[236],"sites,":[239],"regulate":[241],"direct":[244],"interaction":[245],"factors.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
