{"id":"https://openalex.org/W2037969252","doi":"https://doi.org/10.1073/pnas.1406847111","title":"Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae","display_name":"Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae","publication_year":2014,"publication_date":"2014-05-05","ids":{"openalex":"https://openalex.org/W2037969252","doi":"https://doi.org/10.1073/pnas.1406847111","mag":"2037969252","pmid":"https://pubmed.ncbi.nlm.nih.gov/24799712","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4040566"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1406847111","doi":"https://doi.org/10.1073/pnas.1406847111","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1406847111","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4040566","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111843371","display_name":"Wei Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Song","raw_affiliation_strings":["Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018066131","display_name":"Margaret Dominska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Dominska","raw_affiliation_strings":["Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025853909","display_name":"Patricia W. Greenwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia W. Greenwell","raw_affiliation_strings":["Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087254791","display_name":"Thomas D. Petes","orcid":"https://orcid.org/0000-0003-4890-8002","observed_orcids":["https://orcid.org/0000-0003-4890-8002"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Petes","raw_affiliation_strings":["Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":null,"apc_paid":null,"fwci":3.7213,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.94909774,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"111","issue":"21","first_page":"E2210","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fragile-sites","display_name":"fragile sites","score":0.9520000219345093},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8870000243186951},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.5830000042915344},{"id":"https://openalex.org/keywords/dna-polymerase-alpha","display_name":"DNA polymerase alpha","score":0.777999997138977},{"id":"https://openalex.org/keywords/replication-fork-stalling","display_name":"replication fork stalling","score":0.6460000276565552},{"id":"https://openalex.org/keywords/gene-conversion","display_name":"gene conversion","score":0.7419999837875366},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.859000027179718},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.8939999938011169},{"id":"https://openalex.org/keywords/chromosomal-deletion","display_name":"chromosomal deletion","score":0.8270000219345093},{"id":"https://openalex.org/keywords/chromosome-duplication","display_name":"chromosome duplication","score":0.953000009059906},{"id":"https://openalex.org/keywords/ty-retrotransposon","display_name":"Ty retrotransposon","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.7099999785423279},{"id":"https://openalex.org/keywords/chromosomal-rearrangements","display_name":"chromosomal rearrangements","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7112223505973816},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6026710271835327},{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.5391151905059814},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.5024070739746094},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.4974422752857208},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.48913127183914185},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4831766188144684},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4345627725124359},{"id":"https://openalex.org/C88354546","wikidata":"https://www.wikidata.org/wiki/Q3502973","display_name":"DNA polymerase II","level":5,"score":0.4270389676094055},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4215683341026306},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3964400887489319},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3243798017501831},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.1935727894306183},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D043283","descriptor_name":"Chromosome Fragile Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1406847111","doi":"https://doi.org/10.1073/pnas.1406847111","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1406847111","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3023145","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4040566","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4040566","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4040566","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:24799712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24799712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3023145","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4040566","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G251412040","display_name":"Recombination in yeast","funder_award_id":"R01GM024110","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6661908424","display_name":"Genetic regulation of genome stability in yeast","funder_award_id":"R01GM052319","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000911350","display_name":"Tri-Institutional Molecular Mycology and Pathogenesis Training Program","funder_award_id":"T32AI052080","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W58523881","https://openalex.org/W1758844431","https://openalex.org/W1963791180","https://openalex.org/W1965525371","https://openalex.org/W1967743500","https://openalex.org/W1973857401","https://openalex.org/W1979015046","https://openalex.org/W1980356512","https://openalex.org/W1986641560","https://openalex.org/W1991754576","https://openalex.org/W2005136252","https://openalex.org/W2006057892","https://openalex.org/W2021703784","https://openalex.org/W2023191824","https://openalex.org/W2028120529","https://openalex.org/W2033172386","https://openalex.org/W2042969047","https://openalex.org/W2043347159","https://openalex.org/W2044723896","https://openalex.org/W2049576185","https://openalex.org/W2055869110","https://openalex.org/W2058761693","https://openalex.org/W2062471193","https://openalex.org/W2069157381","https://openalex.org/W2072740439","https://openalex.org/W2075998452","https://openalex.org/W2079296555","https://openalex.org/W2080335349","https://openalex.org/W2098903937","https://openalex.org/W2103941628","https://openalex.org/W2106298969","https://openalex.org/W2109879947","https://openalex.org/W2110336860","https://openalex.org/W2111599310","https://openalex.org/W2112340727","https://openalex.org/W2122881747","https://openalex.org/W2123313645","https://openalex.org/W2123830992","https://openalex.org/W2130115977","https://openalex.org/W2133728431","https://openalex.org/W2139180337","https://openalex.org/W2142125232","https://openalex.org/W2144550200","https://openalex.org/W2146267178","https://openalex.org/W2147162465","https://openalex.org/W2156709395","https://openalex.org/W2158049003","https://openalex.org/W2158737337","https://openalex.org/W2162561014","https://openalex.org/W2163464517","https://openalex.org/W2166020754","https://openalex.org/W2167350898","https://openalex.org/W2322282894","https://openalex.org/W2474520925","https://openalex.org/W2797597138"],"related_works":["https://openalex.org/W1965525371","https://openalex.org/W2157194138","https://openalex.org/W2075998452","https://openalex.org/W2027969165","https://openalex.org/W2024002114","https://openalex.org/W2134658642","https://openalex.org/W1972703973","https://openalex.org/W2072740439","https://openalex.org/W170463023","https://openalex.org/W96944632"],"abstract_inverted_index":{"In":[0],"mammalian":[1],"cells,":[2],"perturbations":[3],"in":[4,8,11,35,107],"DNA":[5,17,33,59,87,96,118,127],"replication":[6,60],"result":[7],"chromosome":[9,24,139],"breaks":[10,97,119],"regions":[12],"termed":[13],"\"fragile":[14],"sites.\"":[15],"Using":[16],"microarrays,":[18],"we":[19],"mapped":[20],"recombination":[21,44,91,111],"events":[22,45,78,112],"and":[23,67,141,147],"rearrangements":[25],"induced":[26,98,130],"by":[27,116],"reduced":[28],"levels":[29,125],"of":[30,52,76,85,103,126,134,144],"the":[31,36,43,71,86,104,145],"replicative":[32],"polymerase-\u03b1":[34,128],"yeast":[37],"Saccharomyces":[38],"cerevisiae.":[39],"We":[40],"found":[41],"that":[42,55,83,89,113],"were":[46],"nonrandomly":[47],"associated":[48,79],"with":[49,57,80],"a":[50],"number":[51],"structural/sequence":[53],"motifs":[54],"correlate":[56],"paused":[58],"forks,":[61],"including":[62],"replication-termination":[63],"sites":[64,69],"(TER":[65],"sites)":[66],"binding":[68],"for":[70],"helicase":[72],"Rrm3p.":[73],"The":[74],"pattern":[75],"gene-conversion":[77],"cross-overs":[81],"suggests":[82],"most":[84],"lesions":[88],"initiate":[90],"between":[92],"homologs":[93],"are":[94,114],"double-stranded":[95,117],"during":[99],"S":[100],"or":[101],"G2":[102],"cell":[105],"cycle,":[106],"contrast":[108],"to":[109,122],"spontaneous":[110],"initiated":[115],"formed":[120],"prior":[121],"replication.":[123],"Low":[124],"also":[129],"very":[131],"high":[132],"rates":[133],"aneuploidy,":[135],"as":[136,138],"well":[137],"deletions":[140,146],"duplications.":[142],"Most":[143],"duplications":[148],"had":[149],"Ty":[150],"retrotransposons":[151],"at":[152],"their":[153],"breakpoints.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
