{"id":"https://openalex.org/W2037726485","doi":"https://doi.org/10.1016/s1047-8477(02)00027-8","title":"Cryoelectron microscopy and cryoelectron tomography of the nuclear pre-mRNA processing machine","display_name":"Cryoelectron microscopy and cryoelectron tomography of the nuclear pre-mRNA processing machine","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2037726485","doi":"https://doi.org/10.1016/s1047-8477(02)00027-8","mag":"2037726485","pmid":"https://pubmed.ncbi.nlm.nih.gov/12160703"},"language":"en","primary_location":{"id":"doi:10.1016/s1047-8477(02)00027-8","doi":"https://doi.org/10.1016/s1047-8477(02)00027-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1047-8477(02)00027-8","pdf_url":null,"source":{"id":"https://openalex.org/S89954039","display_name":"Journal of Structural Biology","issn_l":"1047-8477","issn":["1047-8477","1095-8657"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Structural Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068160772","display_name":"Ohad Medalia","orcid":"https://orcid.org/0000-0003-0994-2937","observed_orcids":["https://orcid.org/0000-0003-0994-2937"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ohad Medalia","raw_affiliation_strings":["Department of Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061624330","display_name":"Dieter Typke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dieter Typke","raw_affiliation_strings":["Max-Planck-Institute for Biochemistry, 82152 Martinsried, Germany","Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institute for Biochemistry, 82152 Martinsried, Germany","institution_ids":["https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001042638","display_name":"Reiner Hegerl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Reiner Hegerl","raw_affiliation_strings":["Max-Planck-Institute for Biochemistry, 82152 Martinsried, Germany","Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institute for Biochemistry, 82152 Martinsried, Germany","institution_ids":["https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064990285","display_name":"Mina Angenitzki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Mina Angenitzki","raw_affiliation_strings":["Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047459030","display_name":"Joseph M. Sperling","orcid":"https://orcid.org/0000-0003-1916-5633","observed_orcids":["https://orcid.org/0000-0003-1916-5633"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Joseph Sperling","raw_affiliation_strings":["Department of Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045761416","display_name":"Ruth Sperling","orcid":"https://orcid.org/0000-0002-8950-4584","observed_orcids":["https://orcid.org/0000-0002-8950-4584"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ruth Sperling","raw_affiliation_strings":["Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045761416"],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":{"value":4350,"currency":"USD","value_usd":4350},"apc_paid":null,"fwci":1.0427,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.73693304,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"138","issue":"1-2","first_page":"74","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.538100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.538100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.44749999046325684,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-ribonucleoprotein-particles","display_name":"nuclear ribonucleoprotein particles","score":0.8069999814033508},{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.8820000290870667},{"id":"https://openalex.org/keywords/spliceosome","display_name":"spliceosome","score":0.949999988079071},{"id":"https://openalex.org/keywords/cryo-electron-tomography","display_name":"cryo-electron tomography","score":0.7049999833106995},{"id":"https://openalex.org/keywords/3d-reconstruction","display_name":"3D reconstruction","score":0.6389999985694885},{"id":"https://openalex.org/keywords/particle-concentration","display_name":"particle concentration","score":0.5640000104904175},{"id":"https://openalex.org/keywords/intron-splicing","display_name":"intron splicing","score":0.6359999775886536},{"id":"https://openalex.org/keywords/particle-structure","display_name":"particle structure","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5997427105903625},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.5879743099212646},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5598924160003662},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4525824785232544},{"id":"https://openalex.org/C40000846","wikidata":"https://www.wikidata.org/wiki/Q915868","display_name":"Spliceosome","level":5,"score":0.4137570261955261},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4108760952949524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3887646496295929},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3770058751106262},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32948654890060425},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3273121118545532},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2720409631729126},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.1387319564819336},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12655895948410034},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.10317537188529968},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09403744339942932}],"mesh":[{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017381","descriptor_name":"Spliceosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D022003","descriptor_name":"Cell Nucleus Structures","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/s1047-8477(02)00027-8","doi":"https://doi.org/10.1016/s1047-8477(02)00027-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1047-8477(02)00027-8","pdf_url":null,"source":{"id":"https://openalex.org/S89954039","display_name":"Journal of Structural Biology","issn_l":"1047-8477","issn":["1047-8477","1095-8657"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Structural Biology","raw_type":"journal-article"},{"id":"pmid:12160703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12160703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of structural biology","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mpg.de:41768","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/41768","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Structural Biology, v.138, 74-84 (2002)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320946","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W184528742","https://openalex.org/W200073292","https://openalex.org/W214518591","https://openalex.org/W333593814","https://openalex.org/W594930176","https://openalex.org/W1416247861","https://openalex.org/W1467606010","https://openalex.org/W1605245492","https://openalex.org/W1706843564","https://openalex.org/W1977233639","https://openalex.org/W1988191681","https://openalex.org/W1989492758","https://openalex.org/W1997426724","https://openalex.org/W2000999993","https://openalex.org/W2002364672","https://openalex.org/W2007173784","https://openalex.org/W2009040652","https://openalex.org/W2010075913","https://openalex.org/W2013200053","https://openalex.org/W2016093990","https://openalex.org/W2024267851","https://openalex.org/W2037744310","https://openalex.org/W2038182020","https://openalex.org/W2039537118","https://openalex.org/W2041562931","https://openalex.org/W2051631967","https://openalex.org/W2065785815","https://openalex.org/W2074025494","https://openalex.org/W2078706180","https://openalex.org/W2081300168","https://openalex.org/W2082491111","https://openalex.org/W2083019919","https://openalex.org/W2083260388","https://openalex.org/W2086386721","https://openalex.org/W2093828809","https://openalex.org/W2103972113","https://openalex.org/W2112429094","https://openalex.org/W2116884417","https://openalex.org/W2119916003","https://openalex.org/W2125798809","https://openalex.org/W2139302318","https://openalex.org/W2141158534","https://openalex.org/W2142122497","https://openalex.org/W2143889483","https://openalex.org/W2153165650","https://openalex.org/W2155103924","https://openalex.org/W2155223361","https://openalex.org/W2166158040","https://openalex.org/W2171439317","https://openalex.org/W2178756744","https://openalex.org/W3041019241","https://openalex.org/W6682982147"],"related_works":["https://openalex.org/W7140268126","https://openalex.org/W2065785815","https://openalex.org/W7074076566","https://openalex.org/W2061434726","https://openalex.org/W1985880320","https://openalex.org/W561845034","https://openalex.org/W2041519101","https://openalex.org/W2789338130","https://openalex.org/W2043472165","https://openalex.org/W2415536083"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}