{"id":"https://openalex.org/W2037706376","doi":"https://doi.org/10.1227/01.neu.0000172172.51818.51","title":"Neurobiological Background for Performing Surgical Intervention in the Inferior Thalamic Peduncle for Treatment of Major Depression Disorders","display_name":"Neurobiological Background for Performing Surgical Intervention in the Inferior Thalamic Peduncle for Treatment of Major Depression Disorders","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W2037706376","doi":"https://doi.org/10.1227/01.neu.0000172172.51818.51","mag":"2037706376","pmid":"https://pubmed.ncbi.nlm.nih.gov/16145522"},"language":"en","primary_location":{"id":"doi:10.1227/01.neu.0000172172.51818.51","doi":"https://doi.org/10.1227/01.neu.0000172172.51818.51","is_oa":false,"landing_page_url":"https://doi.org/10.1227/01.neu.0000172172.51818.51","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109932966","display_name":"Francisco Velasco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802421035","display_name":"Hospital General de M\u00e9xico","ror":"https://ror.org/01php1d31","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I2802421035","https://openalex.org/I4210095685"]},{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Francisco Velasco","raw_affiliation_strings":["Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico","Psychiatry Department, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico (Velasco, Salin-Pascual)","Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico (F. Velasco, M. Velasco)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico","institution_ids":["https://openalex.org/I2802421035"]},{"raw_affiliation_string":"Psychiatry Department, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico (Velasco, Salin-Pascual)","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico (F. Velasco, M. Velasco)","institution_ids":["https://openalex.org/I2802421035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113588399","display_name":"Marcos Velasco","orcid":"https://orcid.org/0000-0002-8871-8046","observed_orcids":["https://orcid.org/0000-0002-8871-8046"]},"institutions":[{"id":"https://openalex.org/I2802421035","display_name":"Hospital General de M\u00e9xico","ror":"https://ror.org/01php1d31","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I2802421035","https://openalex.org/I4210095685"]},{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Marcos Velasco","raw_affiliation_strings":["Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico","Psychiatry Department, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico (Velasco, Salin-Pascual)","Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico (F. Velasco, M. Velasco)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico","institution_ids":["https://openalex.org/I2802421035"]},{"raw_affiliation_string":"Psychiatry Department, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico (Velasco, Salin-Pascual)","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico (F. Velasco, M. Velasco)","institution_ids":["https://openalex.org/I2802421035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108925155","display_name":"Fiacro Jim\u00e9nez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]},{"id":"https://openalex.org/I2802421035","display_name":"Hospital General de M\u00e9xico","ror":"https://ror.org/01php1d31","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I2802421035","https://openalex.org/I4210095685"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Fiacro Jim\u00e9nez","raw_affiliation_strings":["Unit for Medical Research in Neurophysiology, National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, Mexico","Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico (F. Velasco, M. Velasco)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit for Medical Research in Neurophysiology, National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, Mexico","institution_ids":["https://openalex.org/I164915025"]},{"raw_affiliation_string":"Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico (F. Velasco, M. Velasco)","institution_ids":["https://openalex.org/I2802421035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019648634","display_name":"Ana Luisa Velasco","orcid":"https://orcid.org/0000-0002-4091-8081","observed_orcids":["https://orcid.org/0000-0002-4091-8081"]},"institutions":[{"id":"https://openalex.org/I2802421035","display_name":"Hospital General de M\u00e9xico","ror":"https://ror.org/01php1d31","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I2802421035","https://openalex.org/I4210095685"]},{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ana Luisa Velasco","raw_affiliation_strings":["Psychiatry Department, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico","Psychiatry Department, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico (Velasco, Salin-Pascual)","Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico (F. Velasco, M. Velasco)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry Department, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Psychiatry Department, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico (Velasco, Salin-Pascual)","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico (F. Velasco, M. Velasco)","institution_ids":["https://openalex.org/I2802421035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011112510","display_name":"Rafael J. Sal\u00edn-Pascual","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802421035","display_name":"Hospital General de M\u00e9xico","ror":"https://ror.org/01php1d31","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I2802421035","https://openalex.org/I4210095685"]},{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Rafael Salin-Pascual","raw_affiliation_strings":["Psychiatry Department, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico","Psychiatry Department, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico (Velasco, Salin-Pascual)","Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico (F. Velasco, M. Velasco)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry Department, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Psychiatry Department, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico (Velasco, Salin-Pascual)","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Unit for Stereotactic, Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, Mexico City, Mexico (F. Velasco, M. Velasco)","institution_ids":["https://openalex.org/I2802421035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9268,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.65839537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"57","issue":"3","first_page":"439","last_page":"448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.06560000032186508,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.8370000123977661},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"deep brain stimulation","score":0.703000009059906},{"id":"https://openalex.org/keywords/frontal-lobe","display_name":"frontal lobe","score":0.5239999890327454},{"id":"https://openalex.org/keywords/cortical-desynchronization","display_name":"cortical desynchronization","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2776559556","wikidata":"https://www.wikidata.org/wiki/Q18717","display_name":"Orbitofrontal cortex","level":4,"score":0.8380932807922363},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7030841708183289},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.6836436986923218},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.580399215221405},{"id":"https://openalex.org/C2777127467","wikidata":"https://www.wikidata.org/wiki/Q749520","display_name":"Frontal lobe","level":2,"score":0.5286949872970581},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.4664881229400635},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.42124396562576294},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.23443952202796936},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2249939739704132},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.22176319360733032},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1803480088710785},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.17545858025550842},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.102985680103302},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.09018081426620483},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.08338657021522522},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D009446","descriptor_name":"Neurobiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019635","descriptor_name":"Neurosurgical Procedures","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1227/01.neu.0000172172.51818.51","doi":"https://doi.org/10.1227/01.neu.0000172172.51818.51","is_oa":false,"landing_page_url":"https://doi.org/10.1227/01.neu.0000172172.51818.51","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:16145522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16145522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W27854836","https://openalex.org/W158490097","https://openalex.org/W390239598","https://openalex.org/W616578618","https://openalex.org/W1498546291","https://openalex.org/W1543276710","https://openalex.org/W1784845060","https://openalex.org/W1819823821","https://openalex.org/W1938313559","https://openalex.org/W1965121287","https://openalex.org/W1968986034","https://openalex.org/W1970250618","https://openalex.org/W1972268296","https://openalex.org/W1973125755","https://openalex.org/W1977503585","https://openalex.org/W1978341871","https://openalex.org/W1980837432","https://openalex.org/W1985496076","https://openalex.org/W1986533198","https://openalex.org/W1993492541","https://openalex.org/W2011284219","https://openalex.org/W2019879838","https://openalex.org/W2020062723","https://openalex.org/W2021492964","https://openalex.org/W2023073794","https://openalex.org/W2023433791","https://openalex.org/W2030217338","https://openalex.org/W2034450065","https://openalex.org/W2037494158","https://openalex.org/W2039042355","https://openalex.org/W2048595403","https://openalex.org/W2055517112","https://openalex.org/W2056034378","https://openalex.org/W2056674018","https://openalex.org/W2058316304","https://openalex.org/W2058529178","https://openalex.org/W2058724489","https://openalex.org/W2058739412","https://openalex.org/W2069272322","https://openalex.org/W2070950603","https://openalex.org/W2072219714","https://openalex.org/W2079801723","https://openalex.org/W2079863887","https://openalex.org/W2085923628","https://openalex.org/W2087173188","https://openalex.org/W2092387077","https://openalex.org/W2092633875","https://openalex.org/W2094526136","https://openalex.org/W2095072384","https://openalex.org/W2108875303","https://openalex.org/W2114092300","https://openalex.org/W2121648229","https://openalex.org/W2122963913","https://openalex.org/W2123354702","https://openalex.org/W2124698022","https://openalex.org/W2141493047","https://openalex.org/W2144463055","https://openalex.org/W2144538553","https://openalex.org/W2151041365","https://openalex.org/W2153672274","https://openalex.org/W2171132221","https://openalex.org/W2196196104","https://openalex.org/W2326289652","https://openalex.org/W2333116600","https://openalex.org/W2345595328","https://openalex.org/W2405597125","https://openalex.org/W2411796927","https://openalex.org/W2413125141","https://openalex.org/W2438462896","https://openalex.org/W2490569883","https://openalex.org/W2501930684","https://openalex.org/W2621989522","https://openalex.org/W4241889241"],"related_works":["https://openalex.org/W55327208","https://openalex.org/W1993492541","https://openalex.org/W4378906567","https://openalex.org/W2052645752","https://openalex.org/W4281388793","https://openalex.org/W2895810033","https://openalex.org/W7093631246","https://openalex.org/W7125193391","https://openalex.org/W2608281209","https://openalex.org/W4386779411"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"present":[2],"a":[3,128,333],"review":[4],"of":[5,15,27,33,38,67,86,98,106,111,121,130,140,144,187,195,229,287,290,295,313,330,350],"evidence":[6],"for":[7,269],"an":[8,51],"inhibitory":[9],"thalamo-orbitofrontal":[10,29,60],"system":[11,30,61,78],"related":[12,209],"to":[13,21,210,282,357],"physiopathology":[14],"major":[16],"depression":[17,270],"disorders":[18],"(MDDs)":[19],"and":[20,134,147,170,181,204,216,274,317,354],"postulate":[22],"that":[23,89,201,272,304],"interfering":[24],"with":[25,55,124,192,322],"hyperactivity":[26,176,190],"the":[28,43,59,68,75,84,104,112,122,141,155,178,211,220,227,236,259,266,277,288,331,348],"by":[31,197,338],"means":[32],"chronic":[34],"high-frequency":[35],"electrical":[36,311,328],"stimulation":[37,312,329,345],"its":[39],"main":[40],"fiber":[41],"connection,":[42],"inferior":[44],"thalamic":[45,70,77,183,206],"peduncle":[46],"(ITP),":[47],"may":[48,157,341,346],"result":[49,158],"in":[50,53,83,127,159,162,177,219,226,235,242,258,263,276,299,307,320],"improvement":[52,161],"patients":[54,244,321],"MDD.":[56,163,188,230,264,323,343],"METHODS:":[57],"Experimentally,":[58],"has":[62],"been":[63,224],"proposed":[64],"as":[65],"part":[66,143],"nonspecific":[69,76],"system.":[71],"Under":[72],"normal":[73],"conditions,":[74],"induces":[79],"characteristic":[80],"electrocortical":[81],"synchronization":[82],"form":[85],"recruiting":[87],"responses":[88],"mimic":[90],"some":[91],"sleep":[92],"stages.":[93],"It":[94,301],"also":[95],"inhibits":[96],"input":[97],"irrelevant":[99],"sensory":[100],"stimuli,":[101],"thus":[102],"facilitating":[103],"process":[105],"selective":[107],"attention.":[108],"Permanent":[109],"disruption":[110],"system,":[113],"via":[114],"lesioning":[115,139],"or":[116,327],"temporary":[117],"inactivation":[118],"through":[119],"cooling":[120],"ITP":[123],"cryoprobes,":[125],"results":[126],"state":[129],"hyperkinesia,":[131],"increased":[132,241],"attention,":[133],"cortical":[135],"desynchronization.":[136],"RESULTS:":[137],"Surgical":[138],"medial":[142],"orbitofrontal":[145,179,202,296],"cortex":[146,180,203,262],"white":[148],"matter":[149],"overlying":[150],"area":[151],"13,":[152],"which":[153,251],"includes":[154],"ITP,":[156,314,332],"significant":[160],"Imaging":[164],"studies":[165],"(functional":[166],"magnetic":[167],"resonance":[168],"imaging":[169],"positron":[171],"emission":[172],"tomography)":[173],"consistently":[174,240],"demonstrate":[175],"midline":[182,205],"regions":[184],"during":[185],"episodes":[186],"This":[189],"decreases":[191],"efficient":[193],"control":[194],"MDD":[196],"medical":[198],"treatment,":[199],"indicating":[200],"overactivity":[207,294],"are":[208,252,280],"depressive":[212],"condition.":[213],"Conversely,":[214],"noradrenergic":[215,232],"serotoninergic":[217,318],"systems":[218],"frontal":[221,237,261,278],"lobes":[222,279],"have":[223,347],"implicated":[225],"pathophysiology":[228],"Although":[231],"receptor":[233],"density":[234],"lobe":[238],"is":[239,302],"depressed":[243],"who":[245],"commit":[246],"suicide,":[247],"5-hydroxytryptamine":[248],"reuptake":[249],"blockers,":[250],"potent":[253],"antidepressive":[254,284],"drugs,":[255],"decrease":[256],"hypermetabolism":[257],"orbital":[260],"Therefore,":[265],"serotonin":[267,275],"hypothesis":[268],"postulates":[271],"norepinephrine":[273],"required":[281],"maintain":[283],"responsiveness.":[285],"Dysregulation":[286],"secretion":[289],"both":[291],"neurotransmitters":[292],"initiates":[293],"cortex,":[297],"resulting":[298],"depression.":[300],"possible":[303],"surgical":[305],"interventions":[306],"this":[308],"region,":[309],"including":[310],"disrupt":[315],"adrenergic":[316],"dysregulation":[319],"CONCLUSION:":[324],"Circumscribed":[325],"lesions":[326],"discrete":[334],"target":[335],"easily":[336],"identified":[337],"electrophysiological":[339],"studies,":[340],"improve":[342],"Electrical":[344],"advantage":[349],"being":[351],"less":[352],"invasive":[353],"more":[355],"adjustable":[356],"patient":[358],"needs.":[359]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
