{"id":"https://openalex.org/W2037702107","doi":"https://doi.org/10.1371/journal.pone.0046900","title":"c-Fms Signaling Mediates Neurofibromatosis Type-1 Osteoclast Gain-In-Functions","display_name":"c-Fms Signaling Mediates Neurofibromatosis Type-1 Osteoclast Gain-In-Functions","publication_year":2012,"publication_date":"2012-11-07","ids":{"openalex":"https://openalex.org/W2037702107","doi":"https://doi.org/10.1371/journal.pone.0046900","mag":"2037702107","pmid":"https://pubmed.ncbi.nlm.nih.gov/23144792","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3492362"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0046900","doi":"https://doi.org/10.1371/journal.pone.0046900","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0046900","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046900&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046900&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077546136","display_name":"Yongzheng He","orcid":"https://orcid.org/0000-0001-8491-3103","observed_orcids":["https://orcid.org/0000-0001-8491-3103"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongzheng He","raw_affiliation_strings":["Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062014907","display_name":"Steven D. Rhodes","orcid":"https://orcid.org/0000-0002-6551-8631","observed_orcids":["https://orcid.org/0000-0002-6551-8631"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven D. Rhodes","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America","Dept. of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Dept. of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362188","display_name":"Chen Shi","orcid":"https://orcid.org/0000-0001-5500-8622","observed_orcids":["https://orcid.org/0000-0001-5500-8622","https://orcid.org/0000-0002-4018-601X"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shi Chen","raw_affiliation_strings":["Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108432910","display_name":"Xiaohua Wu","orcid":"https://orcid.org/0000-0003-4655-9136","observed_orcids":["https://orcid.org/0000-0003-4655-9136"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohua Wu","raw_affiliation_strings":["Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101788926","display_name":"Jin Yuan","orcid":"https://orcid.org/0000-0001-6807-1815","observed_orcids":["https://orcid.org/0000-0001-6807-1815"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Yuan","raw_affiliation_strings":["Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108106470","display_name":"Xianlin Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianlin Yang","raw_affiliation_strings":["Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049617151","display_name":"Li Jiang","orcid":"https://orcid.org/0009-0003-6488-1927","observed_orcids":["https://orcid.org/0009-0003-6488-1927"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Jiang","raw_affiliation_strings":["Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007939470","display_name":"Xianqi Li","orcid":"https://orcid.org/0000-0002-2122-0518","observed_orcids":["https://orcid.org/0000-0002-2122-0518"]},"institutions":[{"id":"https://openalex.org/I90960554","display_name":"Matsumoto Dental University","ror":"https://ror.org/041jyt122","country_code":"JP","type":"education","lineage":["https://openalex.org/I90960554"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Xianqi Li","raw_affiliation_strings":["Division of Hard Tissue Research, Matsumoto Dental University, Shiojiri, Nagano, Japan","Matsumoto Dental University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hard Tissue Research, Matsumoto Dental University, Shiojiri, Nagano, Japan","institution_ids":["https://openalex.org/I90960554"]},{"raw_affiliation_string":"Matsumoto Dental University","institution_ids":["https://openalex.org/I90960554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110106120","display_name":"Naoyuki Takahashi","orcid":"https://orcid.org/0009-0007-6711-4917","observed_orcids":["https://orcid.org/0009-0007-6711-4917"]},"institutions":[{"id":"https://openalex.org/I90960554","display_name":"Matsumoto Dental University","ror":"https://ror.org/041jyt122","country_code":"JP","type":"education","lineage":["https://openalex.org/I90960554"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoyuki Takahashi","raw_affiliation_strings":["Division of Hard Tissue Research, Matsumoto Dental University, Shiojiri, Nagano, Japan","Matsumoto Dental University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hard Tissue Research, Matsumoto Dental University, Shiojiri, Nagano, Japan","institution_ids":["https://openalex.org/I90960554"]},{"raw_affiliation_string":"Matsumoto Dental University","institution_ids":["https://openalex.org/I90960554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033704013","display_name":"Mingjiang Xu","orcid":"https://orcid.org/0000-0002-7063-6253","observed_orcids":["https://orcid.org/0000-0002-7063-6253"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingjiang Xu","raw_affiliation_strings":["Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046168946","display_name":"Khalid Said Mohammad","orcid":"https://orcid.org/0009-0006-9708-2111","observed_orcids":["https://orcid.org/0009-0006-9708-2111"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khalid S. Mohammad","raw_affiliation_strings":["Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067966389","display_name":"Theresa A. Guise","orcid":"https://orcid.org/0009-0006-7026-402X","observed_orcids":["https://orcid.org/0009-0006-7026-402X","https://orcid.org/0000-0003-1775-0628"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa A. Guise","raw_affiliation_strings":["Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101503698","display_name":"Feng\u2010Chun Yang","orcid":"https://orcid.org/0000-0001-8524-4095","observed_orcids":["https://orcid.org/0000-0001-8524-4095"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Feng-Chun Yang","raw_affiliation_strings":["Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101503698"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.9634,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.71251123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"11","first_page":"e46900","last_page":"e46900"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/c-fms","display_name":"c-fms","score":0.878000020980835},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/osteoclast-migration","display_name":"osteoclast migration","score":0.8019999861717224},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/osteopenia","display_name":"osteopenia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/plx3397","display_name":"PLX3397","score":0.906000018119812},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.8740000128746033},{"id":"https://openalex.org/keywords/p90rsk","display_name":"p90RSK","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ovariectomy-induced-bone-loss","display_name":"ovariectomy-induced bone loss","score":0.9020000100135803},{"id":"https://openalex.org/keywords/skeletal-abnormalities","display_name":"skeletal abnormalities","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.8923549652099609},{"id":"https://openalex.org/C2777083390","wikidata":"https://www.wikidata.org/wiki/Q1367706","display_name":"Osteopenia","level":4,"score":0.7543331384658813},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.603370726108551},{"id":"https://openalex.org/C170932241","wikidata":"https://www.wikidata.org/wiki/Q411610","display_name":"Neurofibromin 1","level":3,"score":0.5952370762825012},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5651534199714661},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5269642472267151},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49753788113594055},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.48001614212989807},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.4765208959579468},{"id":"https://openalex.org/C2778984943","wikidata":"https://www.wikidata.org/wiki/Q847605","display_name":"Neurofibromatosis","level":2,"score":0.4522550106048584},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.43426308035850525},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.43235430121421814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42260146141052246},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36642125248908997},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33385351300239563},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.2502560615539551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.231851726770401},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19885817170143127},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.14787262678146362},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14439940452575684},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1150885820388794},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0692441463470459}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016173","descriptor_name":"Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016186","descriptor_name":"Receptor, Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016186","descriptor_name":"Receptor, Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025542","descriptor_name":"Neurofibromin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025542","descriptor_name":"Neurofibromin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D038744","descriptor_name":"Ribosomal Protein S6 Kinases, 90-kDa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0046900","doi":"https://doi.org/10.1371/journal.pone.0046900","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0046900","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046900&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2492406","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3492362","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3492362","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3492362","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23144792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23144792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.785.2177","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.785.2177","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1c/ce/pone.0046900.PMC3492362.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:bd61e8d650c04223832df345f54a51a8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bd61e8d650c04223832df345f54a51a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 11, p e46900 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/117670","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/c_Fms_Signaling_Mediates_Neurofibromatosis_Type_1_Osteoclast_Gain_In_Functions__/117670","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/48574","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/48574","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0046900","doi":"https://doi.org/10.1371/journal.pone.0046900","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0046900","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046900&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3308772588","display_name":"Indiana Clinical and Translational Science Institute-T32 Program TL1","funder_award_id":"TL1RR025759","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G509571782","display_name":"Neurofibromatosis type 1 Gene Regulates Myelopoiesis","funder_award_id":"R01CA074177","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5936746164","display_name":"Do carbon nanotubes control bone remodeling?","funder_award_id":"24659833","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320330502","display_name":"Plexxikon","ror":"https://ror.org/00qk1xk35"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2037702107.pdf","grobid_xml":"https://content.openalex.org/works/W2037702107.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1966677577","https://openalex.org/W1969142291","https://openalex.org/W1983991575","https://openalex.org/W1985302646","https://openalex.org/W1987956240","https://openalex.org/W1993815111","https://openalex.org/W1998347190","https://openalex.org/W2002266390","https://openalex.org/W2007012469","https://openalex.org/W2017444651","https://openalex.org/W2018691087","https://openalex.org/W2021308032","https://openalex.org/W2033165622","https://openalex.org/W2034700718","https://openalex.org/W2036179014","https://openalex.org/W2037609465","https://openalex.org/W2041138285","https://openalex.org/W2048299560","https://openalex.org/W2052672099","https://openalex.org/W2056064252","https://openalex.org/W2058942784","https://openalex.org/W2067897112","https://openalex.org/W2069811152","https://openalex.org/W2075030252","https://openalex.org/W2075878390","https://openalex.org/W2079027396","https://openalex.org/W2080401999","https://openalex.org/W2083178141","https://openalex.org/W2085663788","https://openalex.org/W2100465512","https://openalex.org/W2119344254","https://openalex.org/W2139996507","https://openalex.org/W2142991339","https://openalex.org/W2146326641","https://openalex.org/W2154348064","https://openalex.org/W2155223320","https://openalex.org/W2158875946","https://openalex.org/W2163035374","https://openalex.org/W2169627668","https://openalex.org/W2591386831","https://openalex.org/W2602514972"],"related_works":["https://openalex.org/W2571124296","https://openalex.org/W2021308032","https://openalex.org/W1997036108","https://openalex.org/W2588186387","https://openalex.org/W2090210600","https://openalex.org/W2991722920","https://openalex.org/W2009029265","https://openalex.org/W2167393092","https://openalex.org/W2588178113","https://openalex.org/W111695404"],"abstract_inverted_index":{"Skeletal":[0],"abnormalities":[1],"including":[2],"osteoporosis":[3,184],"and":[4,11,22,30,37,86,91,106,124,130,147,173,185],"osteopenia":[5],"occur":[6],"frequently":[7],"in":[8,41,48,69,73,127,140,151],"both":[9,27],"pediatric":[10],"adult":[12],"neurofibromatosis":[13],"type":[14],"1":[15],"(NF1)":[16],"patients.":[17],"NF1":[18,28,182],"(Nf1)":[19],"haploinsufficient":[20,171],"osteoclasts":[21,172],"osteoclast":[23,76,99,145],"progenitors":[24],"derived":[25],"from":[26],"patients":[29],"Nf1(+/-)":[31,98,117],"mice":[32,119,142],"exhibit":[33],"increased":[34,70],"differentiation,":[35],"migration,":[36],"bone":[38,128,138,148],"resorptive":[39,149],"capacity":[40],"vitro,":[42],"mediated":[43,97],"by":[44,101,104,109,121,143],"hyperactivation":[45],"of":[46,53,169],"p21(Ras)":[47],"response":[49],"to":[50,64,116],"limiting":[51],"concentrations":[52],"macrophage-colony":[54],"stimulating":[55],"factor":[56],"(M-CSF).":[57],"Here,":[58],"we":[59,113],"show":[60],"that":[61,135],"M-CSF":[62,96],"binding":[63],"its":[65],"receptor,":[66],"c-Fms,":[67],"results":[68,155],"c-Fms":[71,93],"activation":[72],"Nf1(+/)":[74],"(-)":[75],"progenitors,":[77],"mediating":[78],"multiple":[79],"gain-in-functions":[80],"through":[81],"the":[82,157,166],"downstream":[83],"effectors":[84],"Erk1/2":[85],"p90RSK.":[87],"PLX3397,":[88],"a":[89,162,176],"potent":[90],"selective":[92],"inhibitor,":[94],"attenuated":[95],"migration":[100],"50%,":[102],"adhesion":[103],"70%,":[105],"pit":[107],"formation":[108],"60%.":[110],"In":[111],"vivo,":[112],"administered":[114],"PLX3397":[115,136],"osteoporotic":[118],"induced":[120],"ovariectomy":[122],"(OVX)":[123],"evaluated":[125],"changes":[126],"mass":[129],"skeletal":[131],"architecture.":[132],"We":[133],"found":[134],"prevented":[137],"loss":[139],"Nf1(+/-)-OVX":[141],"reducing":[144],"differentiation":[146],"activity":[150],"vivo.":[152],"Collectively,":[153],"these":[154],"implicate":[156],"M-CSF/c-Fms":[158],"signaling":[159],"axis":[160],"as":[161],"critical":[163],"pathway":[164],"underlying":[165],"aberrant":[167],"functioning":[168],"Nf1":[170],"may":[174],"provide":[175],"potential":[177],"therapeutic":[178],"target":[179],"for":[180],"treating":[181],"associated":[183],"osteopenia.":[186]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
