{"id":"https://openalex.org/W2037650640","doi":"https://doi.org/10.1038/sj.bjc.6603253","title":"Frequent gain of the human telomerase gene TERC at 3q26 in cervical adenocarcinomas","display_name":"Frequent gain of the human telomerase gene TERC at 3q26 in cervical adenocarcinomas","publication_year":2006,"publication_date":"2006-07-18","ids":{"openalex":"https://openalex.org/W2037650640","doi":"https://doi.org/10.1038/sj.bjc.6603253","mag":"2037650640","pmid":"https://pubmed.ncbi.nlm.nih.gov/16847471","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2360637"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6603253","doi":"https://doi.org/10.1038/sj.bjc.6603253","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603253","pdf_url":"https://www.nature.com/articles/6603253.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6603253.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010639244","display_name":"Sonia Andersson","orcid":"https://orcid.org/0000-0003-2120-7222","observed_orcids":["https://orcid.org/0000-0003-2120-7222"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"S Andersson","raw_affiliation_strings":["Department for Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, Karolinska University Hospital-Huddinge, Karolinska Institutet, Stockholm SE-141 86, Sweden","Department for Clinical Science, Division of Obstetrics and Gynecology, Intervention and Technology, Karolinska University Hospital-Huddinge, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, Karolinska University Hospital-Huddinge, Karolinska Institutet, Stockholm SE-141 86, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department for Clinical Science, Division of Obstetrics and Gynecology, Intervention and Technology, Karolinska University Hospital-Huddinge, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108471527","display_name":"K-L Wallin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"K-L Wallin","raw_affiliation_strings":["Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital-Solna, CMM L8:0, Stockholm, SE-171 76, Sweden","Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital-Solna, CMM L8:0, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital-Solna, CMM L8:0, Stockholm, SE-171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital-Solna, CMM L8:0, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111953018","display_name":"A-C Hellstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A-C Hellstr\u00f6m","raw_affiliation_strings":["Department of Gynecologic Oncology, Radiumhemmet, Karolinska University Hospital-Solna, Stockholm, SE-171 76, Sweden","Department of Gynecologic Oncology, Radiumhemmet, Karolinska University Hospital-Solna, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecologic Oncology, Radiumhemmet, Karolinska University Hospital-Solna, Stockholm, SE-171 76, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Gynecologic Oncology, Radiumhemmet, Karolinska University Hospital-Solna, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090688930","display_name":"Larry E. Morrison","orcid":"https://orcid.org/0000-0002-5813-0110","observed_orcids":["https://orcid.org/0000-0002-5813-0110"]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L E Morrison","raw_affiliation_strings":["Abbott Molecular, 1300 East Touhy Avenue, Des Plaines, 60018, IL, USA","Abbott Molecular, 1300 East Touhy Avenue, Des Plaines, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbott Molecular, 1300 East Touhy Avenue, Des Plaines, 60018, IL, USA","institution_ids":["https://openalex.org/I4210088555"]},{"raw_affiliation_string":"Abbott Molecular, 1300 East Touhy Avenue, Des Plaines, USA","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108449038","display_name":"Anders Hjerpe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A Hjerpe","raw_affiliation_strings":["Department of Oncology-Pathology, Karolinska University Hospital Solna, CCK, Stockholm, SE-171 76, Sweden","Department of Oncology-Pathology, Karolinska University Hospital Solna, CCK, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Karolinska University Hospital Solna, CCK, Stockholm, SE-171 76, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Oncology-Pathology, Karolinska University Hospital Solna, CCK, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066704814","display_name":"Gert Auer","orcid":"https://orcid.org/0000-0003-3911-0285","observed_orcids":["https://orcid.org/0000-0003-3911-0285"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"G Auer","raw_affiliation_strings":["Department of Oncology-Pathology, Karolinska University Hospital Solna, CCK, Stockholm, SE-171 76, Sweden","Department of Oncology-Pathology, Karolinska University Hospital Solna, CCK, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Karolinska University Hospital Solna, CCK, Stockholm, SE-171 76, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Oncology-Pathology, Karolinska University Hospital Solna, CCK, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031392514","display_name":"Thomas Ried","orcid":"https://orcid.org/0000-0002-0767-6009","observed_orcids":["https://orcid.org/0000-0002-0767-6009"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Ried","raw_affiliation_strings":["Genetics Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 50, Room 1408, 50 South Drive, Bethesda, 20892-8010, MD, USA","Genetics Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 50, Room 1408, 50 South Drive, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 50, Room 1408, 50 South Drive, Bethesda, 20892-8010, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Genetics Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 50, Room 1408, 50 South Drive, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060264240","display_name":"Catharina Larsson","orcid":"https://orcid.org/0000-0003-4813-3657","observed_orcids":["https://orcid.org/0000-0003-4813-3657"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"C Larsson","raw_affiliation_strings":["Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital-Solna, CMM L8:0, Stockholm, SE-171 76, Sweden","Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital-Solna, CMM L8:0, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital-Solna, CMM L8:0, Stockholm, SE-171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital-Solna, CMM L8:0, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068597889","display_name":"Kerstin Heselmeyer\u2010Haddad","orcid":"https://orcid.org/0000-0001-7349-7407","observed_orcids":["https://orcid.org/0000-0001-7349-7407"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Heselmeyer-Haddad","raw_affiliation_strings":["Genetics Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 50, Room 1408, 50 South Drive, Bethesda, 20892-8010, MD, USA","Genetics Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 50, Room 1408, 50 South Drive, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 50, Room 1408, 50 South Drive, Bethesda, 20892-8010, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Genetics Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 50, Room 1408, 50 South Drive, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5060264240"],"corresponding_institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":2.4398,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.88474402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"95","issue":"3","first_page":"331","last_page":"338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/terc","display_name":"TERC","score":0.6000000238418579},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.8100000023841858},{"id":"https://openalex.org/keywords/chromosome-3q26","display_name":"chromosome 3q26","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cervical-adenocarcinoma","display_name":"cervical adenocarcinoma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9539999961853027},{"id":"https://openalex.org/keywords/copy-number","display_name":"copy number","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.7203701734542847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6008133888244629},{"id":"https://openalex.org/C34558173","wikidata":"https://www.wikidata.org/wiki/Q18031947","display_name":"Telomerase RNA component","level":5,"score":0.5019104480743408},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.46999630331993103},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.46299606561660767},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43829280138015747},{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.4180492162704468},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4069664776325226},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3747290372848511},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3470044732093811},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3429466485977173},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23616665601730347},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2230793833732605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18210157752037048},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.167938232421875}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002893","descriptor_name":"Chromosomes, Human, Pair 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016612","descriptor_name":"Paraffin Embedding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjc.6603253","doi":"https://doi.org/10.1038/sj.bjc.6603253","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603253","pdf_url":"https://www.nature.com/articles/6603253.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2360637","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2360637","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:16847471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16847471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6603253","doi":"https://doi.org/10.1038/sj.bjc.6603253","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603253","pdf_url":"https://www.nature.com/articles/6603253.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.47999998927116394}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320313607","display_name":"Swedish Cancer Foundation","ror":null},{"id":"https://openalex.org/F4320322570","display_name":"Stockholms L\u00e4ns Landsting","ror":"https://ror.org/02zrae794"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320324250","display_name":"Cancerf\u00f6reningen i Stockholm","ror":"https://ror.org/00m8d6786"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2037650640.pdf","grobid_xml":"https://content.openalex.org/works/W2037650640.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W108835801","https://openalex.org/W1968892125","https://openalex.org/W1977998315","https://openalex.org/W1978306466","https://openalex.org/W1987350137","https://openalex.org/W1992310030","https://openalex.org/W1996196009","https://openalex.org/W1999207866","https://openalex.org/W2003268750","https://openalex.org/W2004674700","https://openalex.org/W2006272640","https://openalex.org/W2007719019","https://openalex.org/W2017352677","https://openalex.org/W2022267654","https://openalex.org/W2023957386","https://openalex.org/W2027715074","https://openalex.org/W2028967730","https://openalex.org/W2036244944","https://openalex.org/W2037413443","https://openalex.org/W2037491887","https://openalex.org/W2044547692","https://openalex.org/W2044938790","https://openalex.org/W2066860562","https://openalex.org/W2073806787","https://openalex.org/W2091219353","https://openalex.org/W2092242685","https://openalex.org/W2097981379","https://openalex.org/W2123725304","https://openalex.org/W2136111158","https://openalex.org/W2139401177","https://openalex.org/W2143581103","https://openalex.org/W2160491887","https://openalex.org/W2277108370","https://openalex.org/W2330028980","https://openalex.org/W4212909581","https://openalex.org/W4255462147","https://openalex.org/W4319308442","https://openalex.org/W6884298529"],"related_works":["https://openalex.org/W3030028527","https://openalex.org/W2097981379","https://openalex.org/W2018429811","https://openalex.org/W2359078999","https://openalex.org/W2109503720","https://openalex.org/W2186347639","https://openalex.org/W2373555065","https://openalex.org/W2009933633","https://openalex.org/W2340236813","https://openalex.org/W2358945979"],"abstract_inverted_index":{"The":[0],"level":[1],"of":[2,5,29,35,52,65,82,97,110,121],"genomic":[3],"amplification":[4],"the":[6,58,83,108,119],"human":[7,38,84],"telomerase":[8,85],"gene":[9,86],"TERC,":[10],"which":[11,36],"maps":[12],"to":[13],"chromosome":[14],"band":[15],"3q26,":[16],"was":[17],"determined":[18],"in":[19,74,92,113],"primary":[20,31],"cervical":[21,32,93,122],"adenocarcinomas.":[22,94,123],"Interphase":[23],"nuclei":[24,66],"prepared":[25],"from":[26],"archival":[27],"material":[28],"12":[30],"adenocarcinomas,":[33],"eight":[34],"were":[37,41],"papillomavirus":[39],"positive,":[40],"hybridised":[42],"with":[43,67],"a":[44,89],"triple":[45],"colour":[46],"probe":[47,99],"set":[48,100],"specific":[49],"for":[50,72,107,118],"centromeres":[51],"chromosomes":[53],"3":[54],"and":[55,57,116],"7":[56],"TERC":[59,73,87],"gene.":[60],"We":[61],"observed":[62],"high":[63],"proportions":[64],"increased":[68],"absolute":[69],"copy":[70],"numbers":[71],"all":[75],"tumours":[76],"(mean":[77],"3.3;":[78],"range":[79],"2.3-5.2).":[80],"Amplification":[81],"is":[88],"consistent":[90],"aberration":[91],"Therefore,":[95],"application":[96],"our":[98],"may":[101],"provide":[102],"an":[103],"objective":[104],"genetic":[105],"test":[106],"assessment":[109],"glandular":[111],"cells":[112],"Pap":[114],"smears":[115],"hence":[117],"diagnosis":[120]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}