{"id":"https://openalex.org/W2037598579","doi":"https://doi.org/10.1159/000253591","title":"Sustained Expression of GRAIL during Hematopoiesis Results in Dysregulated Differentiation","display_name":"Sustained Expression of GRAIL during Hematopoiesis Results in Dysregulated Differentiation","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2037598579","doi":"https://doi.org/10.1159/000253591","mag":"2037598579","pmid":"https://pubmed.ncbi.nlm.nih.gov/19887782"},"language":"en","primary_location":{"id":"doi:10.1159/000253591","doi":"https://doi.org/10.1159/000253591","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000253591","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072175911","display_name":"Debra A. MacKenzie","orcid":"https://orcid.org/0000-0003-4243-6286","observed_orcids":["https://orcid.org/0000-0003-4243-6286"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra A. MacKenzie","raw_affiliation_strings":["Division of Allergy/Immunology/Rheumatology, Department of Pediatrics, University of Wisconsin, Madison, WI., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy/Immunology/Rheumatology, Department of Pediatrics, University of Wisconsin, Madison, WI., USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035480593","display_name":"Christine M. Seroogy","orcid":"https://orcid.org/0000-0002-0532-3701","observed_orcids":["https://orcid.org/0000-0002-0532-3701"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine M. Seroogy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2213,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61598963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"122","issue":"4","first_page":"230","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.04969999939203262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grail","display_name":"GRAIL","score":0.9940000176429749},{"id":"https://openalex.org/keywords/rnf128","display_name":"RNF128","score":0.9980000257492065},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hematopoietic-differentiation","display_name":"hematopoietic differentiation","score":0.953000009059906},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/bone-marrow-reconstitution","display_name":"bone marrow reconstitution","score":0.9380000233650208},{"id":"https://openalex.org/keywords/post-translational-regulation","display_name":"post-translational regulation","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.8301982879638672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7255455255508423},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6587057113647461},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5976429581642151},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5775176882743835},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.48956379294395447},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4797990620136261},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.437975138425827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12040013074874878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08886522054672241},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011828","descriptor_name":"Radiation Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034061","descriptor_name":"Thrombopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039902","descriptor_name":"Multipotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D039902","descriptor_name":"Multipotent Stem Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000253591","doi":"https://doi.org/10.1159/000253591","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000253591","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},{"id":"pmid:19887782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19887782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta haematologica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4302907636","display_name":"Role of GRAIL in CD25+ T Regulatory Cells","funder_award_id":"R21AI064234","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1490175179","https://openalex.org/W1529360504","https://openalex.org/W1617267715","https://openalex.org/W1885288630","https://openalex.org/W1968214151","https://openalex.org/W1975347092","https://openalex.org/W1977058089","https://openalex.org/W1993517451","https://openalex.org/W1994734856","https://openalex.org/W1999783263","https://openalex.org/W2022376508","https://openalex.org/W2057299385","https://openalex.org/W2070509529","https://openalex.org/W2077438288","https://openalex.org/W2088583545","https://openalex.org/W2090786449","https://openalex.org/W2124346088","https://openalex.org/W2124560610","https://openalex.org/W2125743475","https://openalex.org/W2129971199","https://openalex.org/W2134650242","https://openalex.org/W2146660124"],"related_works":["https://openalex.org/W2148381523","https://openalex.org/W2026731083","https://openalex.org/W2484147043","https://openalex.org/W3036981293","https://openalex.org/W2059258393","https://openalex.org/W4366547346","https://openalex.org/W2130239016","https://openalex.org/W2467785211","https://openalex.org/W2979843045","https://openalex.org/W2991868191"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Despite":[1],"a":[2,128],"sophisticated":[3],"understanding":[4,15,146],"of":[5,16,19,51,65,83,90,108,138,147,151],"the":[6,11,17,34,49,136,148],"hematopoietic":[7,55,66,91],"developmental":[8],"program":[9],"at":[10],"transcriptional":[12,149],"level,":[13],"our":[14,144],"role":[18,39,129],"E3":[20,26],"ubiquitin":[21,27],"ligases":[22],"remains":[23],"underdeveloped.":[24],"The":[25],"ligase,":[28],"GRAIL":[29,52,84,109,116,131],"(RNF128),":[30],"is":[31,40,120],"expressed":[32],"in":[33,57,60,85],"bone":[35,77],"marrow,":[36],"but":[37],"its":[38],"as":[41],"yet":[42],"undefined.":[43],"In":[44],"this":[45],"study,":[46],"we":[47],"evaluate":[48],"effect":[50],"expression":[53,82],"during":[54,132],"differentiation":[56],"vitro":[58],"and":[59,76,113,134],"vivo.":[61],"METHODS:":[62],"Retroviral":[63],"transduction":[64],"multipotent":[67],"progenitor":[68,102],"cells":[69,103],"was":[70],"used":[71],"for":[72,130],"methylcellulose":[73],"colony":[74,86],"assays":[75,87],"marrow":[78,98],"reconstitution.":[79],"RESULTS:":[80],"Enforced":[81],"demonstrated":[88,110],"skewing":[89],"lineage":[92],"development":[93],"toward":[94],"granulocytic/monocytic":[95],"cells.":[96],"Bone":[97],"reconstitution":[99],"experiments":[100],"with":[101],"expressing":[104],"biologically":[105],"varied":[106],"levels":[107],"diminished":[111],"erythropoiesis":[112],"megakaryopoiesis":[114],"if":[115],"(endogenous":[117],"or":[118],"forced)":[119],"maintained":[121],"throughout":[122],"hematopoiesis.":[123,152],"CONCLUSION:":[124],"These":[125],"data":[126],"highlight":[127],"hematopoiesis":[133],"emphasize":[135],"importance":[137],"studying":[139],"posttranslational":[140],"effects":[141],"to":[142],"complement":[143],"current":[145],"regulation":[150]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
