{"id":"https://openalex.org/W2037574265","doi":"https://doi.org/10.1371/journal.pone.0028583","title":"Substrate Adhesion Regulates Sealing Zone Architecture and Dynamics in Cultured Osteoclasts","display_name":"Substrate Adhesion Regulates Sealing Zone Architecture and Dynamics in Cultured Osteoclasts","publication_year":2011,"publication_date":"2011-12-05","ids":{"openalex":"https://openalex.org/W2037574265","doi":"https://doi.org/10.1371/journal.pone.0028583","mag":"2037574265","pmid":"https://pubmed.ncbi.nlm.nih.gov/22162778","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3230604"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0028583","doi":"https://doi.org/10.1371/journal.pone.0028583","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0028583","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028583&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028583&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054161642","display_name":"Fabian Anderegg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["CH","IL"],"is_corresponding":false,"raw_author_name":"Fabian Anderegg","raw_affiliation_strings":["Laboratory for Surface Science and Technology, Department of Materials, ETH Zurich, Zurich, Switzerland","Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Surface Science and Technology, Department of Materials, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056902615","display_name":"Dafna Geblinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dafna Geblinger","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056154163","display_name":"P\u00e9ter Horv\u00e1th","orcid":"https://orcid.org/0000-0002-4492-1798","observed_orcids":["https://orcid.org/0000-0002-4492-1798","https://orcid.org/0000-0002-7355-2936","https://orcid.org/0000-0002-6017-5385"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter Horvath","raw_affiliation_strings":["Department of Biology, Light Microscopy Center, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Light Microscopy Center, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064005141","display_name":"Mirren Charnley","orcid":"https://orcid.org/0000-0003-3845-9290","observed_orcids":["https://orcid.org/0000-0003-3845-9290"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mirren Charnley","raw_affiliation_strings":["Laboratory for Surface Science and Technology, Department of Materials, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Surface Science and Technology, Department of Materials, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059573007","display_name":"Marcus Textor","orcid":"https://orcid.org/0000-0002-0178-1801","observed_orcids":["https://orcid.org/0000-0002-0178-1801"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marcus Textor","raw_affiliation_strings":["Laboratory for Surface Science and Technology, Department of Materials, ETH Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Surface Science and Technology, Department of Materials, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052255439","display_name":"Lia Addadi","orcid":"https://orcid.org/0000-0003-1693-648X","observed_orcids":["https://orcid.org/0000-0003-1693-648X"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Lia Addadi","raw_affiliation_strings":["Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046264807","display_name":"Benjamin Geiger","orcid":"https://orcid.org/0000-0001-8559-6373","observed_orcids":["https://orcid.org/0000-0001-8559-6373"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Benjamin Geiger","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046264807"],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.4682,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.78399692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"12","first_page":"e28583","last_page":"e28583"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7354000210762024,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7354000210762024,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.24549999833106995,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9760000109672546},{"id":"https://openalex.org/keywords/sealing-zone","display_name":"sealing zone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/podosomes","display_name":"podosomes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/substrate-adhesion","display_name":"substrate adhesion","score":0.9419999718666077},{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.6790000200271606},{"id":"https://openalex.org/keywords/micropatterned-surfaces","display_name":"micropatterned surfaces","score":0.6970000267028809},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.6029999852180481},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cytoskeletal-dynamics","display_name":"cytoskeletal dynamics","score":0.5879999995231628},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C141073059","wikidata":"https://www.wikidata.org/wiki/Q7207063","display_name":"Podosome","level":4,"score":0.7984508872032166},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.6886367201805115},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5995206236839294},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5399868488311768},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.5254658460617065},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5173920392990112},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.49334636330604553},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.48791810870170593},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4801308810710907},{"id":"https://openalex.org/C68928338","wikidata":"https://www.wikidata.org/wiki/Q131790","display_name":"Adhesive","level":3,"score":0.45270392298698425},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.44911491870880127},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4107625186443329},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.398465633392334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.374300092458725},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33154696226119995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18793988227844238},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1527661681175232},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09378919005393982},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08187782764434814},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.07599034905433655},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005898","descriptor_name":"Glass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011107","descriptor_name":"Polylysine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D011107","descriptor_name":"Polylysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016596","descriptor_name":"Vinculin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018715","descriptor_name":"Microscopy, Video","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1371/journal.pone.0028583","doi":"https://doi.org/10.1371/journal.pone.0028583","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0028583","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028583&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2241251","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3230604","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3230604","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3230604","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22162778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22162778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.811.527","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.811.527","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/18/d3/pone.0028583.PMC3230604.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:7d6ef39fd5894be8811f7cc7548e4567","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7d6ef39fd5894be8811f7cc7548e4567","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 12, p e28583 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/130830","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Substrate_Adhesion_Regulates_Sealing_Zone_Architecture_and_Dynamics_in_Cultured_Osteoclasts/130830","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:figshare.com:article/26215937","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Substrate_adhesion_regulates_sealing_zone_architecture_and_dynamics_in_cultured_osteoclasts/26215937","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:researchbank.swinburne.edu.au:60bb62ce-e7b0-4555-bae7-cbfbaad54f35/1","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1959.3/230928","pdf_url":null,"source":{"id":"https://openalex.org/S4306401157","display_name":"Swinburne figshare (Swinburne University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57093077","host_organization_name":"Swinburne University of Technology","host_organization_lineage":["https://openalex.org/I57093077"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol. 6, no. 12 (2011), article no. e28583","raw_type":"publishedVersion"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/46204","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/46204","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 6 (12)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.25916/sut.26215937.v1","doi":"https://doi.org/10.25916/sut.26215937.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25916/sut.26215937.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401157","display_name":"Swinburne figshare (Swinburne University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57093077","host_organization_name":"Swinburne University of Technology","host_organization_lineage":["https://openalex.org/I57093077"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.3929/ethz-b-000046204","doi":"https://doi.org/10.3929/ethz-b-000046204","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000046204","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0028583","doi":"https://doi.org/10.1371/journal.pone.0028583","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0028583","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028583&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2488755638","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G393177772","display_name":null,"funder_award_id":"FP7 2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6139839801","display_name":"Tissue Transmigration Training Network","funder_award_id":"237946","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320946","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306"},{"id":"https://openalex.org/F4320321652","display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","ror":"https://ror.org/05a28rw58"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320336422","display_name":"Irving and Cherna Moskowitz Center for Nano and Bio-nano Imaging, Weizmann Institute of Science","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2037574265.pdf","grobid_xml":"https://content.openalex.org/works/W2037574265.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1590619267","https://openalex.org/W1597787921","https://openalex.org/W1964413664","https://openalex.org/W1968850740","https://openalex.org/W1969894990","https://openalex.org/W1971058266","https://openalex.org/W1973514306","https://openalex.org/W1986225001","https://openalex.org/W1986411839","https://openalex.org/W1991227464","https://openalex.org/W1993006648","https://openalex.org/W2000647744","https://openalex.org/W2002453791","https://openalex.org/W2005716633","https://openalex.org/W2006950202","https://openalex.org/W2017330811","https://openalex.org/W2018190245","https://openalex.org/W2026266643","https://openalex.org/W2026632078","https://openalex.org/W2030828986","https://openalex.org/W2034301798","https://openalex.org/W2037442588","https://openalex.org/W2045696025","https://openalex.org/W2047169413","https://openalex.org/W2051190059","https://openalex.org/W2056229955","https://openalex.org/W2058096164","https://openalex.org/W2058774752","https://openalex.org/W2059583170","https://openalex.org/W2063753069","https://openalex.org/W2077386452","https://openalex.org/W2087000111","https://openalex.org/W2090983211","https://openalex.org/W2094589757","https://openalex.org/W2095994722","https://openalex.org/W2097304380","https://openalex.org/W2104527243","https://openalex.org/W2114989145","https://openalex.org/W2119921106","https://openalex.org/W2124829852","https://openalex.org/W2125171223","https://openalex.org/W2126486146","https://openalex.org/W2130332090","https://openalex.org/W2130441255","https://openalex.org/W2134208433","https://openalex.org/W2138723251","https://openalex.org/W2139202492","https://openalex.org/W2141075109","https://openalex.org/W2142501126","https://openalex.org/W2144023435","https://openalex.org/W2149667112","https://openalex.org/W2150214660","https://openalex.org/W2158630265","https://openalex.org/W2161350623","https://openalex.org/W2165395398","https://openalex.org/W2169061872","https://openalex.org/W2170034857","https://openalex.org/W2171740113","https://openalex.org/W2286626550","https://openalex.org/W4248033625","https://openalex.org/W6828982987"],"related_works":["https://openalex.org/W7100405476","https://openalex.org/W2026266643","https://openalex.org/W2790760441","https://openalex.org/W3127900406","https://openalex.org/W2588165714","https://openalex.org/W2165395398","https://openalex.org/W1969894990","https://openalex.org/W2948386171","https://openalex.org/W7149295195","https://openalex.org/W2564221105"],"abstract_inverted_index":{"The":[0,19,42],"bone-degrading":[1],"activity":[2],"of":[3,9,26,30,36,47,88,120,135],"osteoclasts":[4,94],"depends":[5],"on":[6,95,117],"the":[7,15,32,48,63,77,83,89,118,124,133,145],"formation":[8,60,140],"a":[10,22,27,129],"cytoskeletal-adhesive":[11],"super-structure":[12],"known":[13],"as":[14],"sealing":[16],"zone":[17],"(SZ).":[18],"SZ":[20,49,111,139],"is":[21],"dynamic":[23],"structure,":[24],"consisting":[25],"condensed":[28],"array":[29],"podosomes,":[31],"elementary":[33],"adhesion-mediating":[34],"structures":[35],"osteoclasts,":[37],"interconnected":[38],"by":[39,104,144],"F-actin":[40],"filaments.":[41],"molecular":[43],"composition":[44],"and":[45,61,68,82,86,113,141],"structure":[46],"were":[50],"extensively":[51],"investigated,":[52],"yet":[53],"despite":[54],"its":[55,66],"major":[56],"importance":[57],"for":[58,132],"bone":[59],"remodelling,":[62],"mechanisms":[64],"underlying":[65],"assembly":[67],"dynamics":[69],"are":[70,102],"still":[71],"poorly":[72],"understood.":[73],"Here":[74],"we":[75,108],"determine":[76],"relations":[78],"between":[79],"matrix":[80],"adhesiveness":[81],"formation,":[84],"stability":[85],"expansion":[87],"SZ.":[90],"By":[91],"growing":[92],"differentiated":[93],"micro-patterned":[96],"glass":[97],"substrates,":[98],"where":[99],"adhesive":[100],"areas":[101],"separated":[103],"non-adhesive":[105],"PLL-g-PEG":[106],"barriers,":[107],"show":[109],"that":[110],"growth":[112],"fusion":[114],"strictly":[115],"depend":[116],"continuity":[119],"substrate":[121],"adhesiveness,":[122],"at":[123],"micrometer":[125],"scale.":[126],"We":[127],"present":[128],"possible":[130],"model":[131],"role":[134],"mechanical":[136],"forces":[137],"in":[138],"reorganization,":[142],"inspired":[143],"current":[146],"data.":[147]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}