{"id":"https://openalex.org/W2037547488","doi":"https://doi.org/10.1016/j.bbapap.2007.10.001","title":"Changing the substrate specificity of creatine kinase from creatine to glycocyamine: Evidence for a highly evolved active site","display_name":"Changing the substrate specificity of creatine kinase from creatine to glycocyamine: Evidence for a highly evolved active site","publication_year":2007,"publication_date":"2007-10-31","ids":{"openalex":"https://openalex.org/W2037547488","doi":"https://doi.org/10.1016/j.bbapap.2007.10.001","mag":"2037547488","pmid":"https://pubmed.ncbi.nlm.nih.gov/17976392"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbapap.2007.10.001","doi":"https://doi.org/10.1016/j.bbapap.2007.10.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbapap.2007.10.001","pdf_url":null,"source":{"id":"https://openalex.org/S4210222880","display_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","issn_l":"1570-9639","issn":["1570-9639","1878-1454"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015381344","display_name":"Michael J. Jourden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118746106","display_name":"College of Wooster","ror":"https://ror.org/029zqs055","country_code":"US","type":"education","lineage":["https://openalex.org/I118746106"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Jourden","raw_affiliation_strings":["Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA","institution_ids":["https://openalex.org/I118746106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048023467","display_name":"Callisia Nathelee Clarke","orcid":"https://orcid.org/0000-0002-5229-961X","observed_orcids":["https://orcid.org/0000-0002-5229-961X"]},"institutions":[{"id":"https://openalex.org/I118746106","display_name":"College of Wooster","ror":"https://ror.org/029zqs055","country_code":"US","type":"education","lineage":["https://openalex.org/I118746106"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Callisia N. Clarke","raw_affiliation_strings":["Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA","institution_ids":["https://openalex.org/I118746106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041091292","display_name":"Allyson K. Palmer","orcid":"https://orcid.org/0000-0001-7505-3455","observed_orcids":["https://orcid.org/0000-0001-7505-3455"]},"institutions":[{"id":"https://openalex.org/I118746106","display_name":"College of Wooster","ror":"https://ror.org/029zqs055","country_code":"US","type":"education","lineage":["https://openalex.org/I118746106"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allyson K. Palmer","raw_affiliation_strings":["Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA","institution_ids":["https://openalex.org/I118746106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004968327","display_name":"Emily J. Barth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118746106","display_name":"College of Wooster","ror":"https://ror.org/029zqs055","country_code":"US","type":"education","lineage":["https://openalex.org/I118746106"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily J. Barth","raw_affiliation_strings":["Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA","institution_ids":["https://openalex.org/I118746106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058585973","display_name":"Rebecca C. Prada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118746106","display_name":"College of Wooster","ror":"https://ror.org/029zqs055","country_code":"US","type":"education","lineage":["https://openalex.org/I118746106"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca C. Prada","raw_affiliation_strings":["Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA","institution_ids":["https://openalex.org/I118746106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082975504","display_name":"Robyn N. Hale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118746106","display_name":"College of Wooster","ror":"https://ror.org/029zqs055","country_code":"US","type":"education","lineage":["https://openalex.org/I118746106"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robyn N. Hale","raw_affiliation_strings":["Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA","institution_ids":["https://openalex.org/I118746106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066402048","display_name":"Dean Fraga","orcid":"https://orcid.org/0000-0002-9933-665X","observed_orcids":["https://orcid.org/0000-0002-9933-665X"]},"institutions":[{"id":"https://openalex.org/I118746106","display_name":"College of Wooster","ror":"https://ror.org/029zqs055","country_code":"US","type":"education","lineage":["https://openalex.org/I118746106"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean Fraga","raw_affiliation_strings":["Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA","institution_ids":["https://openalex.org/I118746106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000679063","display_name":"Mark J. Snider","orcid":"https://orcid.org/0000-0003-1054-1276","observed_orcids":["https://orcid.org/0000-0003-1054-1276"]},"institutions":[{"id":"https://openalex.org/I118746106","display_name":"College of Wooster","ror":"https://ror.org/029zqs055","country_code":"US","type":"education","lineage":["https://openalex.org/I118746106"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Snider","raw_affiliation_strings":["Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA","institution_ids":["https://openalex.org/I118746106"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047935420","display_name":"Paul L. Edmiston","orcid":"https://orcid.org/0000-0001-9536-9887","observed_orcids":["https://orcid.org/0000-0001-9536-9887"]},"institutions":[{"id":"https://openalex.org/I118746106","display_name":"College of Wooster","ror":"https://ror.org/029zqs055","country_code":"US","type":"education","lineage":["https://openalex.org/I118746106"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul L. Edmiston","raw_affiliation_strings":["Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Wooster, 943 College Mall, Wooster, OH 44691, USA","institution_ids":["https://openalex.org/I118746106"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047935420"],"corresponding_institution_ids":["https://openalex.org/I118746106"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":0.6617,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.65836289,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1774","issue":"12","first_page":"1519","last_page":"1527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.08900000154972076,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.02630000002682209,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glycocyamine","display_name":"glycocyamine","score":0.8379999995231628},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/active-site-evolution","display_name":"active site evolution","score":0.6639999747276306},{"id":"https://openalex.org/keywords/phosphagen-kinases","display_name":"phosphagen kinases","score":0.7559999823570251},{"id":"https://openalex.org/keywords/chimeric-enzymes","display_name":"chimeric enzymes","score":0.6140000224113464},{"id":"https://openalex.org/keywords/rational-protein-design","display_name":"rational protein design","score":0.6759999990463257},{"id":"https://openalex.org/keywords/catalytic-promiscuity","display_name":"catalytic promiscuity","score":0.777999997138977},{"id":"https://openalex.org/keywords/enzyme-catalytic-efficiency","display_name":"enzyme catalytic efficiency","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.8191396594047546},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.6499547362327576},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6397507786750793},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6363352537155151},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6215209364891052},{"id":"https://openalex.org/C2779896295","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine","level":2,"score":0.5990689992904663},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5756427645683289},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4852895438671112},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43217337131500244},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38593727350234985},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34580591320991516},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003401","descriptor_name":"Creatine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052283","descriptor_name":"Creatine Kinase, MM Form","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D052283","descriptor_name":"Creatine Kinase, MM Form","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052283","descriptor_name":"Creatine Kinase, MM Form","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbapap.2007.10.001","doi":"https://doi.org/10.1016/j.bbapap.2007.10.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbapap.2007.10.001","pdf_url":null,"source":{"id":"https://openalex.org/S4210222880","display_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","issn_l":"1570-9639","issn":["1570-9639","1878-1454"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","raw_type":"journal-article"},{"id":"pmid:17976392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17976392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309170","display_name":"Florida State University","ror":"https://ror.org/05g3dte14"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W61548541","https://openalex.org/W80995729","https://openalex.org/W145825086","https://openalex.org/W244589956","https://openalex.org/W326933087","https://openalex.org/W1542085789","https://openalex.org/W1571498771","https://openalex.org/W1638372631","https://openalex.org/W1849159432","https://openalex.org/W1916101590","https://openalex.org/W1963831561","https://openalex.org/W1965354567","https://openalex.org/W1969645229","https://openalex.org/W1971428288","https://openalex.org/W1975210435","https://openalex.org/W1983245341","https://openalex.org/W1986005076","https://openalex.org/W1995344463","https://openalex.org/W1995937823","https://openalex.org/W1996128571","https://openalex.org/W1997028350","https://openalex.org/W1998238795","https://openalex.org/W2000879513","https://openalex.org/W2001241436","https://openalex.org/W2010918777","https://openalex.org/W2015380104","https://openalex.org/W2016123989","https://openalex.org/W2017519756","https://openalex.org/W2018949027","https://openalex.org/W2023922395","https://openalex.org/W2045309480","https://openalex.org/W2053329213","https://openalex.org/W2055772661","https://openalex.org/W2056214680","https://openalex.org/W2058315274","https://openalex.org/W2060854559","https://openalex.org/W2070796678","https://openalex.org/W2079635362","https://openalex.org/W2081158065","https://openalex.org/W2091358596","https://openalex.org/W2094326993","https://openalex.org/W2101280466","https://openalex.org/W2111428654","https://openalex.org/W2124241920","https://openalex.org/W2132629607","https://openalex.org/W2142195662","https://openalex.org/W2144699036","https://openalex.org/W2170996473","https://openalex.org/W2178313645","https://openalex.org/W2969273703"],"related_works":["https://openalex.org/W38053852","https://openalex.org/W2055772661","https://openalex.org/W1983245341","https://openalex.org/W2101280466","https://openalex.org/W7160880108","https://openalex.org/W2060311443","https://openalex.org/W2737788517","https://openalex.org/W7111982560","https://openalex.org/W2019544657","https://openalex.org/W1521329999"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
